Triazoles

Toxicological role of an acyl glucuronide metabolite in diclofenac-induced acute liver injury in mice was written by Oda, Shingo;Shirai, Yuji;Akai, Sho;Nakajima, Akira;Tsuneyama, Koichi;Yokoi, Tsuyoshi. And the article was included in Journal of Applied Toxicology in 2017.Reference of 1614-12-6 This article mentions the following:

The acyl glucuronide (AG) metabolites of carboxylic acid-containing drugs are potentially chem. reactive and are suggested to be implicated in toxicity, including hepatotoxicity, nephrotoxicity and drug hypersensitivity reactions. However, it remains unknown whether AG formation is related to toxicity in vivo. In this study, we sought to determine whether AG is involved in the pathogenesis of liver injury using a mouse model of diclofenac (DIC)-induced liver injury. Mice that were administered DIC alone exhibited significantly increased plasma alanine aminotransferase levels, whereas mice that were pretreated with the UDP-glucuronosyltransferase inhibitor (-)-borneol (BOR) exhibited suppressed alanine aminotransferase levels at 3 and 6 h after DIC administration although not significant at 12 h. The plasma DIC-AG concentrations were significantly lower in BOR- and DIC-treated mice than in mice treated with DIC alone. The mRNA expression levels of chemokine (C-X-C motif) ligand 1 (CXCL1), CXCL2 and the neutrophil marker CD11b were reduced in the livers of mice that had been pretreated with BOR compared to those that had been administered DIC alone, whereas mRNA expression of the macrophage marker F4/80 was not altered. An immunohistochem. anal. at 12 h samples revealed that the numbers of myeloperoxidase- and lymphocyte antigen 6 complex-pos. cells that infiltrated the liver were significantly reduced in BOR- and DIC-treated mice compared to mice that were treated with DIC alone. These results indicate that DIC-AG is partly involved in the pathogenesis of DIC-induced acute liver injury in mice by activating innate immunity and neutrophils. Copyright © 2016 John Wiley & Sons, Ltd. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Reference of 1614-12-6).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Triazoles exhibit substantial isomerism, depending on the positioning of the nitrogen atoms within the ring. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.Reference of 1614-12-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthesis of ¹⁸F-difluoromethylarenes using arylboronic acids, ethyl bromofluoroacetate and [¹⁸F]fluoride was written by Sap, Jeroen B. I.;Wilson, Thomas C.;Kee, Choon Wee;Straathof, Natan J. W.;am Ende, Christopher W.;Mukherjee, Paramita;Zhang, Lei;Genicot, Christophe;Gouverneur, Veronique. And the article was included in Chemical Science in 2019.HPLC of Formula: 179056-04-3 This article mentions the following:

Herein, the radiosynthesis of ¹⁸F-difluoromethylarenes RCHF¹⁸F (R = 4-C₂H₅, 4-OC₆H₅, 3,5-CH₃, etc.) via the assembly of three components, a boron reagent, Et bromofluoroacetate, and cyclotron-produced non-carrier added [¹⁸F]fluoride was reported. The two key steps are a copper-catalyzed cross-coupling reaction, and a Mn-mediated ¹⁸F-fluorodecarboxylation. In the experiment, the researchers used many compounds, for example, 4-(2H-1,2,3-Triazol-2-yl)benzaldehyde (cas: 179056-04-3HPLC of Formula: 179056-04-3).

4-(2H-1,2,3-Triazol-2-yl)benzaldehyde (cas: 179056-04-3) belongs to triazole derivatives. The triazole ring is a relatively stable functional group, and the triazole bond can be used for a variety of applications, such as replacing the phosphate backbone of DNA. Both the triazoles and their derivatives have significant biological properties including antimicrobial, antiviral, antitubercular, anticancer, anticonvulsant, analgesic, antioxidant, anti-inflammatory, and antidepressant activities.HPLC of Formula: 179056-04-3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Biodegradation of bisphenol a by Sphingobium sp. YC-JY1 and the essential role of cytochrome P450 monooxygenase was written by Jia, Yang;Eltoukhy, Adel;Wang, Junhuan;Li, Xianjun;Hlaing, Thet Su;Aung, Mar Mar;Nwe, May Thet;Lamraoui, Imane;Yan, Yanchun. And the article was included in International Journal of Molecular Sciences in 2020.Name: 1H-Benzo[d][1,2,3]triazol-1-amine This article mentions the following:

Bisphenol A (BPA) is a widespread pollutant threatening the ecosystem and human health. An effective BPA degrader YC-JY1 was isolated and identified as Sphingobium sp. The optimal temperature and pH for the degradation of BPA by strain YC-JY1 were 30°C and 6.5, resp. The biodegradation pathway was proposed based on the identification of the metabolites. The addition of cytochrome P 450 (CYP) inhibitor 1-aminobenzotriazole significantly decreased the degradation of BPA by Sphingobium sp. YC-JY1. Escherichia coli BL21 (DE3) cells harboring pET28a-bisdAB achieved the ability to degrade BPA. The bisdB gene knockout strain YC-JY1ΔbisdB was unable to degrade BPA indicating that P 450 bisdB was an essential initiator of BPA metabolism in strain YC-JY1. For BPA polluted soil remediation, strain YC-JY1 considerably stimulated biodegradation of BPA associated with the soil microbial community. These results point out that strain YC-JY1 is a promising microbe for BPA removal and possesses great application potential. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Name: 1H-Benzo[d][1,2,3]triazol-1-amine).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Many triazoles are versatile, biologically active compounds commonly used as fungicides and plant retardants. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.Name: 1H-Benzo[d][1,2,3]triazol-1-amine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Utilization of cationic microporous metal-organic framework for efficient Xe/Kr separation was written by Gong, Lingshan;Liu, Ying;Ren, Junyu;Al-Enizi, Abdullah M.;Nafady, Ayman;Ye, Yingxiang;Bao, Zongbi;Ma, Shengqian. And the article was included in Nano Research in 2022.Name: 4-(4H-1,2,4-Triazol-4-yl)benzoic acid This article mentions the following:

The separation of xenon/krypton (Xe/Kr) mixtures plays a vital role in the industrial process of manufacturing high-purity xenon. Compared with energy-intensive cryogenic distillation, porous materials based on phys. adsorption are very promising in the low-cost and energy-saving separation processes. Herein, we show that a cationic metal-organic framework (named as FJU-55) exhibits highly efficient Xe/Kr separation performance, which can be attributable to its uniform three-dimensional (3D) interconnection channels and the electro-pos. features as the host framework. Moreover, FJU-55 demonstrates good Xe adsorption capacity of 1.41 mmol/g and excellent Xe/Kr selectivity of 10 (298 K and 100 kPa), together with a high Qst value of 39.4 kJ/mol at low coverage area. The superior Xe/Kr separation performance of FJU-55 was further confirmed by the dynamic breakthrough experiments Results obtained via mol. modeling studies have revealed that the suitable pore size and abundant accessible aromatic ligands in FJU-55 could offer strong multiple C-H^..Xe interactions, which play a collaborative role in this challenging gas separation task. In the experiment, the researchers used many compounds, for example, 4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2Name: 4-(4H-1,2,4-Triazol-4-yl)benzoic acid).

4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents. Many triazoles have antifungal effects: the triazole antifungal drugs include fluconazole, isavuconazole, itraconazole, voriconazole, pramiconazole, ravuconazole, and posaconazole and triazole plant-protection fungicides include epoxiconazole, triadimenol, myclobutanil, propiconazole, prothioconazole, metconazole, cyproconazole, tebuconazole, flusilazole and paclobutrazol.Name: 4-(4H-1,2,4-Triazol-4-yl)benzoic acid

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

A series of Zn(II) and Cd(II) coordination compounds based on 4-(4H-1,2,4-triazol-4-yl)benzoic acid: synthesis, structure and photoluminescence properties was written by Yang, Li-Bo;Wang, Hong-Can;Fang, Xiao-Dan;Chen, Si-Jin;Xu, Quan-Qing;Zhu, Ai-Xin;Yang, Zhi. And the article was included in CrystEngComm in 2016.Product Details of 157069-48-2 This article mentions the following:

Seven coordination compounds, namely [Zn(4-tba)₂(H₂O)₂] (1), [Zn(4-tba)Cl]·CH₃OH (2), [Zn(4-tba)₂] (3), [Zn(4-tba)₂]·DMA·3.5H₂O (4), [Cd(4-tba)₂]·DMF·3.6H₂O (5), [Cd(4-tba)₂] (6) and [Cd₅Cl₄(4-tba)₆]·1.5DMF·4H₂O (7) (4-Htba = 4-(4H-1,2,4-triazol-4-yl)benzoic acid, DMA = N,N-dimethylacetamide and DMF = N,N-dimethylformamide), have been synthesized under hydro/solvothermal conditions by using a triazolate-carboxylate bifunctional organic ligand, 4-Htba. Complexes 1 and 2 exhibit a mononuclear motif and a two-dimensional (2D) network with sql topol., resp., whereas 3-6 display different interpenetrating structures. Compound 3 shows a 2-fold interpenetrating 2D net with sql topol., 4 and 5 display uninodal 4-connected 4-fold interpenetrating 3D nets with dia (6⁶) topol. belonging to class Ia and class IIIa, resp., and compound 6 exhibits a 5-fold interpenetrating dia net. Complex 7 exhibits a non-interpenetrating 3D framework constructed from decanuclear cadmium-chloride chain units and 4-tba ligands with various coordination modes. All the complexes were characterized using single-crystal X-ray diffraction, powder X-ray diffraction (PXRD), IR spectroscopy and elemental analyses. In addition, the thermogravimetric anal. and solid-state photoluminescence results for 1–7 were also investigated. In the experiment, the researchers used many compounds, for example, 4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2Product Details of 157069-48-2).

4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2) belongs to triazole derivatives. Many triazoles are versatile, biologically active compounds commonly used as fungicides and plant retardants. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeProduct Details of 157069-48-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Two mechanisms provide tolerance to cyhalofop-butyl in pond lovegrass [Eragrostis japonica (Thunb.) Trin.] was written by Liu, Ying;Wang, Hao;Gao, Haitao;Zhu, Guangtao;Peng, Zhen;Li, Jun;Dong, Liyao. And the article was included in Pesticide Biochemistry and Physiology in 2022.Electric Literature of C6H6N4 This article mentions the following:

Pond lovegrass [Eragrostis japonica (Thunb.) Trin.] is an annual grass weed of rice fields worldwide. Cyhalofop-Bu has been widely used for controlling annual grass weeds in rice fields. However, E. japonica is tolerant to cyhalofop-Bu. The ED values of cyhalofop-Bu for 29 E. japonica populations causing 50% inhibition of fresh weight (GR50: 130.15 to 187.61 g a.i. ha^-1) were much higher than the recommended dose of cyhalofop-Bu (75 g a.i. ha^-1) in the field. The mechanisms of tolerance to cyhalofop-Bu in E. japonica were identified. In vitro activity assays revealed that the cyhalofop-Bu concentration required to inhibit 50% of the acetyl-CoA carboxylase (ACCase) activity (IC₅₀) was 6.22-fold higher in E. japonica than that in the cyhalofop-butyl-susceptible Chinese sprangletop [Leptochloa chinensis (L.) Nees]. However, mutations in the ACCase gene, previously found to endow target-site resistance in weeds, were not detected in the sequences obtained. Addnl., the expression level of genes encoding ACCase in E. japonica was found to be as similar to L. chinensis. Tolerance was reduced by two cytochrome P 450 monooxygenases (Cyt P450s) inhibitors (1-aminobenzotriazole and piperonyl butoxide) and the activity of NADPH-dependent cytochrome P 450 reductase in E. japonica was approx. 4.46-fold higher than that of L. chinensis after cyhalofop-Bu treatment. Taken together, it is concluded that two co-existing mechanisms, an insensitive target ACCase and an enhanced metabolism mediated by Cyt P450s, endow tolerance to cyhalofop-Bu in E. japonica. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Electric Literature of C6H6N4).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. The triazole ring is a relatively stable functional group, and the triazole bond can be used for a variety of applications, such as replacing the phosphate backbone of DNA. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeElectric Literature of C6H6N4

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Tetraaquabis[4-(4H-1,2,4-triazol-4-yl)benzoato-κN¹]manganese(II) decahydrate was written by Piao, Ying Ai;Xuan, Zhen Yu. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2011.Formula: C9H7N3O2 This article mentions the following:

In the title compound, [Mn(C₉H₆N₃O₂)₂(H₂O)₄]·10H₂O, the Mn^II ion is coordinated by two N atoms from two 4-(4H-1,2,4-triazol-4-yl)benzoate ligands and four water mols. in a distorted octahedral geometry. The Mn^II ion and two coordinated water mols. lie on a twofold rotation axis. The water mols. are involved in O-H···N and O-H···O hydrogen bonds with the triazole N atoms and carboxylate O atoms, yielding a three-dimensional supramol. network. π-π Interactions between the benzene rings [centroid-centroid distance = 3.836(9) Å] are observed In the experiment, the researchers used many compounds, for example, 4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2Formula: C9H7N3O2).

4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2) belongs to triazole derivatives. The triazole ring is a relatively stable functional group, and the triazole bond can be used for a variety of applications, such as replacing the phosphate backbone of DNA. Both the triazoles and their derivatives have significant biological properties including antimicrobial, antiviral, antitubercular, anticancer, anticonvulsant, analgesic, antioxidant, anti-inflammatory, and antidepressant activities.Formula: C9H7N3O2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Diaquabis[4-(4H-1,2,4-triazol-4-yl)benzoato-κ²O,O’]cobalt(II), and the cadmium(II) and copper(II) analogues: new self-complementary hydrogen-bond donor/acceptor modules for designing hydrogen-bonded frameworks was written by Lukashuk, Liliana V.;Lysenko, Andrey B.;Rusanov, Eduard B.;Chernega, Alexander N.;Domasevitch, Konstantin V.. And the article was included in Acta Crystallographica, Section C: Crystal Structure Communications in 2007.Category: triazoles This article mentions the following:

In the isostructural title complexes, [M(C₉H₆N₃O₂)₂(H₂O)₂] [M = Co^II, (I), Cd^II, (II), and Cu^II, (III); the metal centers reside on a twofold axis in the space group C2/c for (I) and (II)], the metal centers are surrounded by four O atoms from two O,O’-bidentate carboxylate groups and by two trans-coordinated aqua ligands, forming a distorted octahedral environment. The mols. possess four hydrogen-bond donor (two aqua ligands) and four hydrogen-bond acceptor sites (two triazole groups), and aggregate by self-association, forming two-dimensional hydrogen-bonded frameworks [via O-H…N interactions; O…N = 2.749(3)-2.872(3) Å]. The layers are parallel and are tightly packed with short interlayer distances of 4.93, 4.95, and 5.01 Å for (I), (II), and (III), resp. In the experiment, the researchers used many compounds, for example, 4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2Category: triazoles).

4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2) belongs to triazole derivatives. Many triazoles are versatile, biologically active compounds commonly used as fungicides and plant retardants. Both the triazoles and their derivatives have significant biological properties including antimicrobial, antiviral, antitubercular, anticancer, anticonvulsant, analgesic, antioxidant, anti-inflammatory, and antidepressant activities.Category: triazoles

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Cobalt(II)-Lanthanide(III) Heterometallic Metal-Organic Frameworks with Unique (6,6)-Connected Nia Topologies with 1H-1,2,3-Triazole-4,5-dicarboxylic Acid: Syntheses, Structures and Magnetic Properties was written by Zou, Ji-Yong;Shi, Wei;Xu, Na;Gao, Hong-Ling;Cui, Jian-Zhong;Cheng, Peng. And the article was included in European Journal of Inorganic Chemistry in 2014.Application of 4546-95-6 This article mentions the following:

Four isostructural cobalt(II)-lanthanide(III) heterometallic metal-organic frameworks (MOFs), formulated as {[(CH₃)₂NH₂]₃[Co₃Ln(tda)₃(HCOO)₃]·2H₂O·0.75DMF}_n [Ln = Eu (Co-Eu), Gd (Co-Gd), Tb (Co-Tb), and Dy (Co-Dy); H₃tda = 1H-1,2,3-triazole-4,5-dicarboxylic acid] were successfully synthesized and structurally characterized. In these Co-Ln heterometallic MOFs, three neighboring Co^II ions are connected by HCOO^– anions to form triangular [Co₃(HCO₂)₃]³⁺ clusters. The equivalent triangular [Co₃(HCO₂)₃]³⁺ clusters are connected by six tda^3- anions to generate a 1D trigonal prismatic chain, which are further interconnected through Ln^III ions to give unique 3D (6,6)-connected nia nets with the Schlaefli symbol of (4¹² 6³) (4⁹ 6⁶). The magnetic properties of the four isostructural Co-Ln heterometallic MOFs also were studied. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Application of 4546-95-6).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Triazoles exhibit substantial isomerism, depending on the positioning of the nitrogen atoms within the ring. Due to the structural characteristics, both 1,2,3- and 1,2,4-triazoles are able to accommodate a broad range of substituents (electrophiles and nucleophiles) around the core structures and pave the way for the construction of diverse novel bioactive molecules.Application of 4546-95-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthesis and Reactivity of Rhodium(II) N-Triflyl Azavinyl Carbenes was written by Grimster, Neil;Zhang, Li;Fokin, Valery V.. And the article was included in Journal of the American Chemical Society in 2010.Electric Literature of C5H7N3O2 This article mentions the following:

Highly reactive rhodium(II) N-trifluoromethylsulfonyl azavinyl carbenes are formed in situ from NH-1,2,3-triazoles, triflic anhydride, and rhodium carboxylates. They rapidly and selectively react with olefins, providing cyclopropane carboxaldehydes and 2,3-dihydropyrroles in generally excellent yields and high enantio- and diastereoselectivity. In the experiment, the researchers used many compounds, for example, Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7Electric Literature of C5H7N3O2).

Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7) belongs to triazole derivatives. Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior pharmacological applications. Many triazoles have antifungal effects: the triazole antifungal drugs include fluconazole, isavuconazole, itraconazole, voriconazole, pramiconazole, ravuconazole, and posaconazole and triazole plant-protection fungicides include epoxiconazole, triadimenol, myclobutanil, propiconazole, prothioconazole, metconazole, cyproconazole, tebuconazole, flusilazole and paclobutrazol.Electric Literature of C5H7N3O2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics