Reference of 16681-70-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below.
[0664] To a solution of 3H-[1,2,3]triazole-4-carboxylicacid (77 mg, 688 flillOl) and HATU (130 mg, 344 f.tmol) inDMF (1.5 mL) was added DIPEA (160 f.LL, 920 flillOl). Themixture was stirred at room temperature for 20 minutes, followedby the addition of Compound 11 (140 mg, 210 f.tmol).The mixture was stirred at room temperature for 20 minutes,then the reaction was quenched with 10% aqueous citric acid(15 mL) to pH 4. The mixture was extracted with EtOAc(3×20 mL ), washed with saturated aqueous NaCl (1 0 mL) anddried over MgS04 . The mixture was filtered and the filtratewas evaporated. The residue was purified by flash chromatography(10-100% hexanes/EtOAc gradient over 45 minutes).The fractions containing the desired product were combinedand evaporated. The residue was dried in vacuo at roomtemperature overnight to yield Compound 12 (70 mg). LCMS(ESI): calc. C33H33ClFN50 5 =634.1; obs. rn/z 634.2[M+Ht. Retention time 5.96 min.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-[1,2,3]Triazole-4-carboxylic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; Fleury, Melissa; Beausoliel, Anne-Marie; Hughes, Adam D.; Long, Daniel D.; Wilton, Donna A.A.; US2015/210690; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics