Adding a certain compound to certain chemical reactions, such as: 1455-77-2, name is 3,5-Diamino-1,2,4-triazole, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1455-77-2, SDS of cas: 1455-77-2
Example 9A(rac)-2-Amino-7-[4-cyano-2-(methylsulfonyl)phenyl]-5-methyl-4,7-dihydro[1,2,4]triazolo[1,5-a]-pyrimidine-6-carbonitrileUnder argon, 4-(2-cyano-3-oxobut-1-en-1-yl)-3-(methylsulfonyflbenzonitrile (1.0 g, 3.65 mmol), 3,5-diaminotriazole (1.08 g, 10.94 mmol, 3.0 eq.), D,L-proline (214 mg, 2.55 mmol, 0.7 eq.) and molecular sieve (4 A, 0.5 g) were suspended in a mixture of pyridine (20 ml) and DMF (30 ml) and stirred for 3 d.More 3,5-diaminotriazole (361 mg, 3.64 mmol, 1 eq.) was added, and the mixture was stirred for a further 5 d.The reaction mixture was then filtered and the filtrate was concentrated under reduced pressure (intermediate 4-[2-cyano-1-(3,5-diamino-1H-1,2,4-triazol-1-yl)-3-oxobutyl]-3-(methylsulfonyl)benzonitrile).Toluene (68 ml), pyridine (55 ml) and 4-toluenesulfonic acid monohydrate (100 mg, 0.53 mmol, 0.14 eq.) were added to the intermediate, and the mixture was heated under reflux (1 h).The reaction mixture was then concentrated under reduced pressure and the residue was dried under high vacuum.Ethanol (30 ml) was added, the residue was suspended and stirred in an ultrasonic bath and the solid was then filtered off and finally dried under high vacuum.This gave 673 mg (50percent of theory) of the title compound.LC-MS (Method 7): Rt=1.00 min; MS (ESIpos): m/z (percent)=356.1 (100) [M+H]+; MS (ESIneg): m/z (percent)=354.2 (100) [M-H]-.1H-NMR (400 MHz, DMSO-d6): delta=2.15 (s, 3H), 3.55 (s, 3H), 5.40 (m, 2H), 7.05 (s, 1H), 7.75 (m, 1H), 8.25 (m, 1H), 8.35 (s, 1H), 11.05 (s, 1H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Diamino-1,2,4-triazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; US2012/4203; (2012); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics