These common heterocyclic compound, 10570-40-8, name is 4-Methyl-4H-1,2,4-triazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 4-Methyl-4H-1,2,4-triazole
Step 2. 40 mmol of 4-methyl-1,2,4-triazole and 120 mmol of propargyl chloride were stirred under nitrogen at 90 C, and condensed and refluxed for 48 h to complete the quaternization reaction.The reaction product is washed with carbon tetrachloride and steamed to obtain a pale yellow liquid.1,2-Dipropargyl-4-methyl-1,2,4-triazole chloride 8.35 g.
The synthetic route of 4-Methyl-4H-1,2,4-triazole has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Nanjing Tech University; Guan Guofeng; Ding Jing; He Yuting; Li Xue; Yuan Dashui; Wan Hui; Wang Lei; (9 pag.)CN108250227; (2018); A;,
1,2,3-Triazole – Wikipedia,
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