Highly functionalized 3,4,5-trisubstituted 1,2,4-triazoles for future use as ligands in coordination polymers was written by Laessig, Daniel;Lincke, Joerg;Krautscheid, Harald. And the article was included in Tetrahedron Letters in 2010.Formula: C9H7N3O2 This article mentions the following:
An optimized synthesis of 3,4,5-trisubstituted 1,2,4-triazoles, which can be used as linkers for metal organic frameworks (MOFs), is described. The substituents in 3- and 5-position of the triazole have a significant impact on the torsion angles between the aromatic rings and therefore influence on solubility and coordination behavior of these ligands. In the experiment, the researchers used many compounds, for example, 4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2Formula: C9H7N3O2).
4-(4H-1,2,4-Triazol-4-yl)benzoic acid (cas: 157069-48-2) belongs to triazole derivatives. However, triazoles are also useful in bioorthogonal chemistry, because the large number of nitrogen atoms causes triazoles to react similar to azides. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeFormula: C9H7N3O2
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics