These common heterocyclic compound, 7170-01-6, name is 3-Methyl-1H-1,2,4-triazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 7170-01-6
To a solution of Compound A (11.00 g, 132.39 mmol) at 110 C was added Compound 1 (5.00 g,27.38 mmol) (Scheme 1). The mixture was stirred at 140 C for 16 hours under N2. TLC (petroleumether/ethyl acetate = 1:1, Rf = 0.3) indicated ?30% of Reactant 1 remained, and one major new spotwith larger polarity was detected. The residue was purified by column chromatography (SiO2,petroleum ether/ethyl acetate = 2/1 to 1:1) to give Compound 2 (3.00 g, 13.09 mmol, 47.80% yield) asa white solid. 1H-NMR (ET5676-11-P1B, 400 MHz, CDCl3): 10.25 (br. s., 1 H), 9.08 (s, 1 H), 7.56 (s, 1H), 7.38 (t, J = 2.8 Hz, 1 H), 6.71 (t, J = 2.6 Hz, 1 H), 4.04 (s, 3 H),
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 7170-01-6.
Reference:
Article; Cocklin, Simon; Karadsheh, Rama; Meuser, Megan E.; Molecules; vol. 25; 6; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics