Application of 3641-13-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3641-13-2, name is 5-Amino-4H-1,2,4-triazole-3-carboxylic acid belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below.
2-(((3R,4S)-3-fluoropiperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile (70 mg, 0.13 mmol), HATU (100 mg, 0.26 mmol), DIEA (52 mg, 0.4 mmol) and 3-amino-1H-1,2,4-triazole-5-carboxylic acid (34 mg, 0.26 mmol) were dissolved in DMF (4 mL) and stirred at room temperature for 2 hr. The mixture was diluted with DCM and extracted with water. The organic phase was dried over Na2SO4 and concentrated. The residue was purified silica gel column with ESCO system with 5-20% MeOH in CH2Cl2 to give the title compound. 1H NMR (400 MHz, DMSO-d6) delta 12.33 (d, J=7.3 Hz, 1H), 10.12 (d, J=22.3 Hz, 1H), 8.81-8.66 (m, 1H), 8.66-8.42 (m, 2H), 7.71-7.34 (m, 3H), 6.95 (t, J=9.2 Hz, 2H), 6.15 (s, 1H), 5.26-4.85 (m, 2H), 4.51 (m, 4H), 4.17 (s, 1H), 3.73 (m, 1H), 3.60 (m, 1H), 3.45 (m, 1H), 3.12 (m, 4H), 2.41 (m, 4H), 2.12-1.79 (m, 2H). LCMS-ESI+ (m/z): [M+H]+ calcd for C31H33FN12O3: 641.3. found: 641.4
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Amino-4H-1,2,4-triazole-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Gilead Sciences, Inc.; Du, Zhimin; Guerrero, Juan A.; Kaplan, Joshua A.; Knox, JR., John E.; Lo, Jennifer R.; Mitchell, Scott A.; Naduthambi, Devan; Phillips, Barton W.; Venkataramani, Chandrasekar; Wang, Peiyuan; Watkins, William J.; Zhao, Zhongdong; (593 pag.)US2016/96827; (2016); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics