Application of 22300-52-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 22300-52-3, name is 4,5-Dibromo-2H-1,2,3-triazole belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below.
Into a 5000-mL 3-necked round-bottom flask, was placed 4,5-dibromo-2H-1,2,3-triazole (301 g, 1.33 mol, 1.00 equiv), potassium carbonate (92.5 g, 669.27 mmol, 0.50 equiv) and NMP (3000 mL). This was followed by the addition of 1-chloropropan-2-one (148 g, 1.60 mol, 1.21 equiv) dropwise with stirring at 0¡ã C. The resulting solution was stirred overnight at room temperature. The reaction was then quenched by the addition of 9000 mL of water. The solid was collected by filtration and dried in an oven. This resulted in 346 g (92percent) of 1-(dibromo-2H-1,2,3-triazol-2-yl)propan-2-one as a white solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4,5-Dibromo-2H-1,2,3-triazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Gilead Apollo, LLC; Ghosh, Shomir; Greenwood, Jeremy Robert; Harriman, Geraldine C.; Leit De Moradei, Silvana Marcel; (290 pag.)US2017/166584; (2017); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics