Reference of 16681-65-5, New Advances in Chemical Research in 2021.In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 16681-65-5, name is 1-Methyl-1H-1,2,3-triazole, molecular formula is C3H5N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
To a solution of 1 -methyl- lH-l,2,3-triazole (860 mg, 10.4 mmol) in THF (10 mL) at -78 C, was added dropwise -BuLi (5.0 mL, 12.4 mmol, 2.5 M). The mixture was stirred at -78 C for 2 hours before addition of Bu3SnCl (3.7 g, 11.4 mmol). The mixture was stirred at -78 C for 1 hour and then room temperature for 1 hour. The mixture was concentrated under vacuum and hexane was added. The insoluble material was filtered and the filtrate was concentrated under vacuum to afford l-methyl-5-(tributylstannyl)-lH-l ,2,3-triazole (3.1 g, 80 %) as yellow oil which was used directly in the next step.
This is the end of this tutorial post, and I hope it has helped your research about 16681-65-5!
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; CHEN, Jinhua; DING, Charles Z.; DRAGOVICH, Peter; FAUBER, Benjamin; GAO, Zhenting; LABADIE, Sharada; LAI, Kwong Wah; PURKEY, Hans Edward; ROBARGE, Kirk; WEI, Binqing; ZHOU, Aihe; WO2015/140133; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics