In 2017,Fay, Francois; Hansen, Line; Hectors, Stefanie J. C. G.; Sanchez-Gaytan, Brenda L.; Zhao, Yiming; Tang, Jun; Munitz, Jazz; Alaarg, Amr; Braza, Mounia S.; Gianella, Anita; Aaronson, Stuart A.; Reiner, Thomas; Kjems, Joergen; Langer, Robert; Hoeben, Freek J. M.; Janssen, Henk M.; Calcagno, Claudia; Strijkers, Gustav J.; Fayad, Zahi A.; Perez-Medina, Carlos; Mulder, Willem J. M. published 《Investigating the Cellular Specificity in Tumors of a Surface-Converting Nanoparticle by Multimodal Imaging》.Bioconjugate Chemistry published the findings.Application of 56602-33-6 The information in the text is summarized as follows:
Active targeting of nanoparticles through surface functionalization is a common strategy to enhance tumor delivery specificity. However, active targeting strategies tend to work against long polyethylene glycol’s shielding effectiveness and associated favorable pharmacokinetics. To overcome these limitations, we developed a matrix metalloproteinase-2 sensitive surface-converting polyethylene glycol coating. This coating prevents nanoparticle-cell interaction in the bloodstream, but, once exposed to matrix metalloproteinase-2, i.e., when the nanoparticles accumulate within the tumor interstitium, the converting polyethylene glycol coating is cleaved, and targeting ligands become available for binding to tumor cells. In this study, we applied a comprehensive multimodal imaging strategy involving optical, nuclear, and magnetic resonance imaging methods to evaluate this coating approach in a breast tumor mouse model. The data obtained revealed that this surface-converting coating enhances the nanoparticle’s blood half-life and tumor accumulation and ultimately results in improved tumor-cell targeting. Our results show that this enzyme-sp. surface-converting coating ensures a high cell-targeting specificity without compromising favorable nanoparticle pharmacokinetics. After reading the article, we found that the author used ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Application of 56602-33-6)
((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is a peptide coupling reagent. Can be used in the preparation of phenyl esters of amino acids which have been shown to be valuable as blocked derivatives of amino acids in the field of peptide synthesis.Application of 56602-33-6
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics