Application of 1001401-62-2, New Advances in Chemical Research in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 1001401-62-2, name is 2-(2H-1,2,3-Triazol-2-yl)benzoic acid, molecular formula is C9H7N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
Asolution of 2- (2H-1, 2, 3-triazol-2-yl) benzoic acid (6.8 g, 36 mmol) in SOCl2(30 mL) was stirred at RT for 30 mins. The solvent was removed in vacuo. To asolution of the product from Step 2 (6.0 g, 36 mmol) in dry toluene (50 mL) wasadded 1 N aqueous NaOH (73 mL, 0.073 mol) at 0 and asolution of the above residue in toluene (30 mL) dropwise . The resultingmixture was stirred at RT overnight and extracted with EtOAc (100 mL x 3) . Thecombined organic layers were washed with brine, dried over Na2SO4,filtered, and concentrated in vacuo to give the title compound as an oil, whichwas used without further purification. LRMS m/z (M+H) 508.1 found, 508.2required
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Reference:
Patent; MERCK SHARP & DOHME CORP.; LIVERTON, Nigel; KUDUK, Scott D.; LUO, Yunfu; (47 pag.)WO2016/65587; (2016); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics