These common heterocyclic compound, 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C3H3N3O2
lH-l,2,3-triazole-5-carboxylic acid (3.1 mg, 27 muiotaetaomicron) was combined with HATU (10.4 mg, 27 muiotaetaomicron) in DMF (0.5 mL), and stirred for 10 minutes. DIPEA (4.8 mu, 27 Mmol) was added and the resulting mixture was stirred for 1 minute. Compound 2 (12 mg 27 muiotaetaomicron) dissolved in DMF (1 mL) was combined with added DIPEA (14.4 mu, 82 muiotaetaomicron) followed by addition of the activated acid solution. The resulting mixture was stirred for 30 minutes then purified by reverse phase chromatography (0-100% EtOAc/hexanes to yield Compound 3 (10
The synthetic route of 1H-[1,2,3]Triazole-4-carboxylic acid has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; FLEURY, Melissa; BEAUSOLIEL, Anne-Marie; HUGHES, Adam D.; LONG, Daniel D.; WILTON, Donna A.A.; WO2015/116786; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics