Research speed reading in 2021. Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. 4928-88-5, name is Methyl 1H-1,2,4-triazole-3-carboxylate belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Product Details of 4928-88-5
In a 250 ml of clean three-necked reaction flask provided with a thermometer and mechanical stirrer, add 90 g beta-D-ribofuranose-1,2,3,5-tetraacetate. Oil bath heat until beta-D-ribofuranose-1,2,3,5-tetraacetate is completely melted. Then add 37.8 g 1,2,4-triazolecarboxylic acid methyl ester and 0.6 g bis(4-nitrophenyl)phosphate. Start strirring. At 103 °C maintain temperature and stir for 10 min. At 108 °C high vacuum, react for 2h. Cool to 90 °C, by adding methanol, continue to stir until 50 °C white crystal the storm analyzes right and left of the, in -15 ° C stirring crystallization 4 hours. Filtering, ice-methanol washing, for 65 °C drying, (II) 91.2g obtaining white RBV condensates, yield 84.2percent (with four acetylmethylene ribose idea ), (II) the content of the white RBV condensates to 98.1percent, purity of 99.1percent ( unitary method HPLC chromatographic area),
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 4928-88-5, and we look forward to future research findings.
Reference:
Patent; Hubei Yitai Pharmaceutical Co., Ltd.; Wu, Xiaoyu; Zou, Zude; Xiong, Zuxiang; Huang, Linjun; Guo, Liangchen; Chen, Jin; (6 pag.)CN105732750; (2016); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics