In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1001401-62-2 as follows. name: 2-(2H-1,2,3-Triazol-2-yl)benzoic acid
A solution of 2-(2H-l,2,3-triazol-2-yl)benzoic acid (P. Coleman, J. Schreier,WO2007/126934) (500 mg, 2.64 mmol) in SOCl2(5 mL) was heated to refluxed for 1 hour, cooled and concentrated in vacuo. The oil was dissolved in toluene (5 mL) and added to a solution of ((3i?,6i?)-6-methylpiperidin-3-yl)methanol hydrochloride (M. Giradin et al, Org. Proc. Res. Dev. 2013, 17, 61-68) (437 mg, 2.65 mmol) in toluene (5 mL), then aq. sodium hydroxide (5.3 mL, 1 mol/L) was added. The mixture was stirred at 10C for 12 h, poured into water (5 mL) and extracted with EtOAc (5 mL x 3). The combined organic layers were dried over Na2S04, filtered and concentrated in vacuo and the residue purified by chromatography on silica (petroleum ether: EtOAc =5: 1 to petroleum ether: EtOAc =1 :1) to afford the title compound. LRMS m/z (Mu+Eta) 301.2 found, 301.2 required.
According to the analysis of related databases, 1001401-62-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP & DOHME CORP.; LIVERTON, Nigel; BESHORE, Douglas C.; KUDUK, Scott D.; LUO, Yunfu; MENG, Na; YU, Tingting; WO2015/20933; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics