7411-23-6, The chemical industry reduces the impact on the environment during synthesis 7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole, I believe this compound will play a more active role in future production and life.
To a solution of 2 (15 g, 66.1 mmol) in acetonitrile(80 mL) was slowly added N,N-diisopropylethyamine(8.0 g, 61.9 mmol) followed by benzyl bromide(12.4 g, 5.8 mmol) in dimethyl foramide (15 mL). It was stirred for 12 h at 80C. Progress of the reaction was monitored by TLC. After completion of the reaction, volatiles were evaporated under reduced pressure. Into the residue, water was added and the reaction mass extracted with dichloromethane(3¡Á100 mL). Combined organic phase was dried over anhydrous magnesium sulphate, concentrated todryness and further purified by column chromatography to afford 6 as a white solid (18 g,80% yield). m.p. 67.4-68; IR (KBr): 3088, 2948,1586, 14.96, 1453, 1434, 1416, 1259, 1059 cm-1;1H NMR (400 MHz, CDCl3): 5.32 (s, 2H), 7.31-7.39(m, 5H); 13C NMR (100 MHz, CDCl3): 53.7, 128.0,128.8, 129.0, 129.4, 133.6, 140.3 (1H and 13C patterns match with the litereature value)22.
The chemical industry reduces the impact on the environment during synthesis 3,5-Dibromo-1H-1,2,4-triazole. I believe this compound will play a more active role in future production and life.
Reference:
Article; Roy, Bhairab Nath; Singh, Girij Pal; George, Shaji K.; Lathi, Piyush S.; Agrawal, Manoj K.; Trivedi, Anurag; Mishra, Madhan; Singh, Gajendra; Indian Journal of Chemistry – Section B Organic and Medicinal Chemistry; vol. 53; 5; (2014); p. 610 – 618;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics