Application of 7170-01-6, New Advances in Chemical Research in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 7170-01-6, name is 3-Methyl-1H-1,2,4-triazole, molecular formula is C3H5N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
Compound 10 (62.0 g, 115 mmol), Pd2 (dba) 3 (21.0 g, 22.9 mmol), dppf (14.0 g,25.2mmol), Cs2CO3 (112g, 344mmol),3-Methyl-1H-1,2,4-triazole (21.0 g, 252 mmol) was mixed in toluene (600 mL), stirred and warmed to reflux for 4 hr.After cooling, tap water (600 mL) was added and liquid separation was carried out. The organic phase is dried,Crystallization from petroleum ether gave compound 11 (41.9 g, 77.5%).
I am very proud of our efforts over the past few months and hope to 3-Methyl-1H-1,2,4-triazole help many people in the next few years.
Reference:
Patent; Liu Fengjuan; (8 pag.)CN108623631; (2018); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics