Electric Literature of 4928-87-4, New Advances in Chemical Research in 2021.In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 4928-87-4, name is 1,2,4-Triazole-3-carboxylic acid, molecular formula is C3H3N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
Step 5: Preparation of 1-(5-((1 R,3s,5S)-8-(4H-1 ,2,4-triazole-3-carbonyl)-8- azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(1 -methyl-1 H-pyrazol-3-yl)pyridin- yl)pyrazolo[1 ,5-a]pyrimidin-6-yl)ethanone 1 H-1 ,2,4-triazole-3-carboxylic acid (58.0 mg, 0.51 mmol), EDC (133.7 mg, 0.70 mmol), HOBt (94.5 mg, 0.70 mmol) and DIEA (730 uL, 4.20 mmol) were added to a mixture of 1-(7-amino-5-((1 R,3s,5S)-8-azabicyclo[3.2.1]octan-3-yl)-3-(6-(1- methyl-1 H-pyrazol-3-yl)pyridin-3-yl)pyrazolo[1 ,5-a]pyrimidin-6-yl)ethanone (207.7 mg, 0.47 mmol) in DMF (5 mL) and the mixture was stirred at room temperature for 1 h. Purification with prep-LC provided 1-(5-((1 R,3s,5S)-8-(4H-1 ,2,4-triazole-3- carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)-7-amino-3-(6-(1 -methyl-1 H-pyrazol-3- yl)pyridin-3-yl)pyrazolo[1 ,5-a]pyrimidin-6-yl)ethanone.
Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms.In my other articles, you can also check out more blogs about 1,2,4-Triazole-3-carboxylic acid.
Reference:
Patent; MERCK SHARP & DOHME CORP.; SCHERING CORPORATION; SIDDIQUI, M. Arshad; NAN, Yang; PATEL, Mehul, F.; REDDY, Panduranga Adulla P.; MANSOOR, Umar Faruk; MENG, Zhaoyang; VITHARANA, Lalanthi Dilrukshi; ZHAO, Lianyun; MANDAL, Amit, K.; LIU, Duan; TANG, Shuyi; MCRINER, Andrew; BELANGER, David, B.; CURRAN, Patrick, J.; DAI, Chaoyang; ANGELES, Angie, R.; YANG, Liping; DANIELS, Matthew Hersh; WO2011/90935; (2011); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics