Cox, Jason M. published the artcileThe discovery of novel 5,6,5- and 5,5,6-tricyclic pyrrolidines as potent and selective DPP-4 inhibitors, Application of 5-Cyclopropyl-4H-1,2,4-triazol-3-amine, the main research area is tricyclic pyrrolidine preparation DPP4 inhibitor structure diabetes; Dipeptidyl peptidase IV (DPP-4); Omarigliptin; Sitagliptin; Type 2 diabetes mellitus.
Novel potent and selective 5,6,5- and 5,5,6-tricyclic pyrrolidine dipeptidyl peptidase IV (DPP-4) inhibitors were identified. Structure-activity relationship (SAR) efforts focused on improving the intrinsic DPP-4 inhibition potency, increasing protease selectivity, and demonstrating clean ion channel and cytochrome P 450 profiles while trying to achieve a pharmacokinetic profile suitable for once weekly dosing in humans.
Bioorganic & Medicinal Chemistry Letters published new progress about Antidiabetic agents. 502546-41-0 belongs to class triazoles, name is 5-Cyclopropyl-4H-1,2,4-triazol-3-amine, and the molecular formula is C5H8N4, Application of 5-Cyclopropyl-4H-1,2,4-triazol-3-amine.
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics