Application of 16681-70-2, New discoveries in chemical research and development in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[0776] 38-1,2,3-triazole-5-carboxylic acid (3.0 mg, 27f.tmol) was combined with HATU (1 0.1 mg, 27 flillOl) in DMF(0.5 mL); DIPEA ( 4.7 f.LL, 27 f.tmol) was added and the mixturewas stirred for 5 minutes. Compound 2 (12 mg, 27 f.tmol)was dissolved in DMF (0.5 mL) and DIPEA (13.9 f.LL, 80f.tmol) and combined with the activated acid solution. Themixture was stirred for 10 minutes, at which time LCMSindicated the mass of the desired compound. The solvent wasremoved under reduced pressure and the residue was purifiedby reverse phase chromatography to yield Compound b (8mg) as a TFA salt. MS m/z [M+Ht calc’d forC22H33ClFN50 4 , 546.22. found 546.
Future efforts will undeniably focus on the diversification of the new catalytic transformations. These may comprise an expansion of the substrate scope from aromatic and heteroaromatic compounds to other hydrocarbons. Keep reading other articles of 16681-70-2.
Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; Fleury, Melissa; Beausoliel, Anne-Marie; Hughes, Adam D.; Long, Daniel D.; Wilton, Donna A.A.; US2015/210690; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics