Continuously updated synthesis method about 105020-39-1

According to the analysis of related databases, 105020-39-1, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 105020-39-1, name is Methyl 2-Methyl-1,2,3-triazole-4-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of Methyl 2-Methyl-1,2,3-triazole-4-carboxylate

Step2:; 2-methyl 2H-1 ,2,3-triazole-4-carboxylic acid methyl ester (263 mg, 1 .86 mmol) is charged in a round-bottom flask, then THF (15 mL), 1 M solution NaOH (9.3 mL, 9.3 mmol, 5.0 equiv) and MeOH (5 mL) are measured and mixed in a graduated cylinder, then added to flask. Solution is stirred at room temperature. After 4 h, 1 M HCI is added (10 mL) and solvent is evaporated. EtOAc is added and layers are separated. Solvent is evaporated. Desired product R2I is obtained as a white solid (215 mg, 91 %).1H NMR (400 MHz,DMSO-d6): delta 8.17 (s, 1 H), 4.22 (s, 3H).

According to the analysis of related databases, 105020-39-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; LLINAS-BRUNET , Montse; BORDELEAU, Josee; GODBOUT, Cedrickx; LEBLANC, Melissa; MOREAU, Benoit; O’MEARA, Jeffrey; WO2011/63502; (2011); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics