New discoveries in chemical research and development in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 6523-49-5, name is 4-(1,2,4-Triazol-1-yl)aniline belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. 6523-49-5
A mixture of the formamidine from step 1 (528 mg) and 4-triazolylaniline (294 mg) in AcOH (5 ml) was heated to 125 for 3 h. After cooling, the mixture was diluted and basified with IN NaOH (80 ml). The resulting cream ppt was isolated by filtration, and dried to give the title compound (495mg, 70%).1H NMR delta 10.3 (IH, br s), 9.34 (IH, s), 8.9 (IH, s), 8.67 (IH, s), 8.31 (IH, s),8.23 (IH, dd, J 8.85, 1.9Hz), 8.15 (2H, d, J 8.85Hz), 7.92 (4H, m), 7.19 (2H, d, J8.85Hz), 4.2 (2H, m), 2.72 (2H, m), 2.3 (6H, s); LC-MS rt 1.96 m/z 452 ES+.
If you are hungry for even more, make sure to check my other article about 6523-49-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ARROW THERAPEUTICS LIMITED; WO2007/80401; (2007); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics