Category: Triazoles

Lu, Qixing; Wang, Tao; Wu, Qian; Cheng, Lijing; Luo, Han; Liu, Lei; Chu, Guobiao; Wang, Lufeng; Li, Baosheng published an article in 2022, the title of the article was C-H heteroarylation of aromatics via catalyst free SN2′ coupling cycloaromatization.Product Details of 5301-96-2 And the article contains the following content:

The construction of a carbon-carbon bond is the most fundamental aspect of synthetic chem. In this study, authors developed a catalyst-free SN2′ reaction of β-OTf-substituted enamides with aromatics to obtain aryl-substituted aza-1,4-dicarbonyl compounds that can be in situ transformed into aryl-imidazole, aryl-thiazole, and aryl-oxazole in one-pot operation, thus achieving C-H heteroarylation of aromatics This simple, efficient, clean and scalable strategy, which provides difficult-to-realize biaryl products, is compatible with various aromatics having varying complexities. This method can be used for the late-stage modification of various com. pharmaceuticals or functional materials and offers an orthogonal approach for constructing biaryl compounds The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Product Details of 5301-96-2

The Article related to aromatic compound heteroarylation coupling cycloaromatization, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Product Details of 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Li, Si-Yuan; Guan, Zhen-Yu; Xue, Jing; Zhang, Guang-Yi; Guan, Xiao-Yu; Deng, Qing-Hai published an article in 2020, the title of the article was Practical copper-catalyzed chloronitration of alkenes with TMSCl and guanidine nitrate.Application of 5301-96-2 And the article contains the following content:

A novel and practical chloronitration of alkenes in the presence of easily available TMSCl and guanidine nitrate was developed by using cheap copper sulfate pentahydrate as the catalyst. A variety of vic-chloronitro compounds were directly synthesized in good to excellent yields on up to 100 mmol scale under mild reaction conditions, and the resulting products could be smoothly transformed into the corresponding nitroalkenes and diverse nitro compounds bearing a vicinal nucleophilic “C”, “N” or “S” unit. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Application of 5301-96-2

The Article related to nitroalkene preparation, alkene guanidine nitrate chloronitration, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Application of 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On April 2, 2021, Fang, Wenkui; Li, Guanqun; Cai, Yuting; Pan, Xiang; Zhu, Wenhao; Wang, Yang; Wang, Zengquan published a patent.Quality Control of 6,8-Dichloro-[1,2,4]triazolo[1,5-a]pyrazine The title of the patent was Preparation of triazolopyrazine compound as Tyk2 specific inhibitor for prevention and/or treatment of autoimmune diseases and related inflammatory skin diseases. And the patent contained the following:

The present invention relates to the preparation of triazolopyrazine compound as Tyk2 specific inhibitor for prevention and/or treatment of autoimmune diseases and related inflammatory skin diseases. In particular, the triazole pyrazine compound I (wherein, W = (un)substituted aryl or heteroaryl; X = C or N; R = H or any substituent group such as halogen, cyanide, amino, alkyl, alkoxy, cyanoalkyl etc) or its stereoisomers, geometric isomers, tautomers, hydrates, solvates and pharmaceutically acceptable salts or prodrugs were prepared The inventive compound can be used as a Tyk2 specific inhibitor which can provide a more targeted medicament for an autoimmune inflammatory disease driven by an IL-23/Th17 axis and diseases such as rheumatoid arthritis, psoriasis, compulsive spondylitis, Sjogren’s syndrome, lupus erythematosus, inflammatory bowel disease, Behcet’s disease, Covid-19 severe pneumonia can be safely and effectively treated. The experimental process involved the reaction of 6,8-Dichloro-[1,2,4]triazolo[1,5-a]pyrazine(cas: 2092807-41-3).Quality Control of 6,8-Dichloro-[1,2,4]triazolo[1,5-a]pyrazine

The Article related to triazolopyrazine compound preparation tyk2 inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Quality Control of 6,8-Dichloro-[1,2,4]triazolo[1,5-a]pyrazine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On June 16, 2022, Fang, Wenkui; Li, Guanqun; Cai, Yuting; Pan, Xiang; Zhu, Wenhao; Wang, Yang; Wang, Zengquan published a patent.Electric Literature of 2092807-41-3 The title of the patent was Preparation of triazolopyrazine compound as Tyk2 specific inhibitor for prevention and/or treatment of autoimmune diseases and related inflammatory skin diseases. And the patent contained the following:

A triazolo pyrazine compound, wherein the triazolo pyrazine compound is a compound as represented by formula I as follows, or a stereoisomer, a geometrical isomer, a tautomer, a hydrate, a solvate, and a pharmaceutically acceptable salt or a prodrug thereof, wherein W is selected from a substituted or unsubstituted aryl or heteroaryl, X is C or N, and R is H or any substituent group. When the triazolo pyrazine compound provided by the invention is used as a Tyk2 specific inhibitor, a more targeted drug can be provided for autoimmune inflammatory diseases driven by an IL-23/Th17 axis, and the compound can be used for treating rheumatoid arthritis, psoriasis, ankylosing spondylitis, sicca syndrome, lupus erythematosus, inflammatory bowel disease, Behcet’s disease, severe COVID-19 pneumonia and other diseases more safely and effectively. The experimental process involved the reaction of 6,8-Dichloro-[1,2,4]triazolo[1,5-a]pyrazine(cas: 2092807-41-3).Electric Literature of 2092807-41-3

The Article related to triazolopyrazine compound preparation tyk2 inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Electric Literature of 2092807-41-3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On January 1, 2014, He, Yun; Sun, Erxiao; Zhao, Yi; Hai, Li; Wu, Yong published an article.Formula: C9H9N3 The title of the article was The one-pot synthesis of 4-aryl-1H-1,2,3-triazoles without azides and metal catalization. And the article contained the following:

In this study, a new methodol. for the one-pot synthesis of 4-aryl-1H-1,2,3-triazoles, e.g., I (R = H, Me, Cl, F, NO2, CN), from arylglyoxaldoxime semicarbazones is presented. 4-Aryl-1,2,3-triazoles were obtained in moderate to good yields via sodium dithionite and O2, which are all efficient, safe and inexpensive reagents. This reaction is more suitable for large-scale syntheses than those using hydrazoic acid, sodium azide, or organic azides. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Formula: C9H9N3

The Article related to arylglyoxaldoxime semicarbazone oxidative heterocyclization sodium dithionite oxygen, aryl triazole preparation, dithionite oxygen oxidative heterocyclization mediator, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Formula: C9H9N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On January 16, 2015, Quan, Xue-Jing; Ren, Zhi-Hui; Wang, Yao-Yu; Guan, Zheng-Hui published an article.Name: 4-(p-Tolyl)-1H-1,2,3-triazole The title of the article was p-Toluenesulfonic Acid Mediated 1,3-Dipolar Cycloaddition of Nitroolefins with NaN3 for Synthesis of 4-Aryl-NH-1,2,3-triazoles [Erratum to document cited in CA161:682131]. And the article contained the following:

On page 5730, structure 4a in Scheme 2 was published incorrectly, and subsequent text corresponding to this Structure is also incorrect; the correct structure, name, and text are given. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Name: 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to erratum aryltriazole preparation toluenesulfonic acid mediated dipolar cycloaddition, dipolar cycloaddition nitroolefin sodium azide aryltriazole preparation erratum, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Name: 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On September 21, 2018, Sun, Jun; Mou, Chengli; Wang, Zhongyao; He, Fangcheng; Wu, Jian; Chi, Yonggui Robin published an article.Quality Control of (R)-5-Benzyl-2-mesityl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate The title of the article was Carbene-Catalyzed [4 + 2] Cycloadditions of Vinyl Enolate and (in Situ Generated) Imines for Enantioselective Synthesis of Quaternary α-Amino Phosphonates. And the article contained the following:

A carbene-catalyzed enantioselective addition of enals to five-membered cyclic imines is developed. The reaction gives chiral quaternary α-amino phosphonates bearing tetrasubstituted C centers with excellent enantioselectivities. The imine substrates can be generated in situ from the corresponding amines under an oxidative condition that is compatible with the carbene catalysis. Thus, a 1-pot cross-dehydrogenative-coupling (CDC) reaction between enals and amines is also realized with high enantioselectivity remaining. The method provides quick enantioselective access to amino phosphonates with potential applications in medicines and pesticides. The experimental process involved the reaction of (R)-5-Benzyl-2-mesityl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate(cas: 1469801-67-9).Quality Control of (R)-5-Benzyl-2-mesityl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate

The Article related to carbene catalyzed cycloaddition vinyl enolate imine, ketiminophosphonate cyclic preparation cycloaddition vinyl enolate carbene catalyst, quaternary alpha amino phosphonate preparation, crystal structure benzoisothiazolopyridinylphosphonate quaternary alpha amino phosphonate, mol structure benzoisothiazolopyridinylphosphonate quaternary alpha amino phosphonate and other aspects.Quality Control of (R)-5-Benzyl-2-mesityl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On March 3, 2010, Grimster, Neil; Zhang, Li; Fokin, Valery V. published an article.Reference of 4-(p-Tolyl)-1H-1,2,3-triazole The title of the article was Synthesis and Reactivity of Rhodium(II) N-Triflyl Azavinyl Carbenes. And the article contained the following:

Highly reactive rhodium(II) N-trifluoromethylsulfonyl azavinyl carbenes are formed in situ from NH-1,2,3-triazoles, triflic anhydride, and rhodium carboxylates. They rapidly and selectively react with olefins, providing cyclopropane carboxaldehydes and 2,3-dihydropyrroles in generally excellent yields and high enantio- and diastereoselectivity. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Reference of 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to triazole triflic anhydride chiral rhodium carboxylate catalyst, rhodium azavinyl carbene triflyl derivative formation alkene cyclopropanation, cyclopropane carboxaldehyde stereoselective preparation, alkene rhodium triflyl azavinyl carbene dipolar cycloaddition, dihydropyrrole derivative regioselective preparation and other aspects.Reference of 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On January 14, 2015, Goodman, C. Guy; Walker, Morgan M.; Johnson, Jeffrey S. published an article.Computed Properties of 1469801-67-9 The title of the article was Enantioconvergent Synthesis of Functionalized γ-Butyrolactones via (3 + 2)-Annulation. And the article contained the following:

A dynamic kinetic resolution of β-halo α-keto esters, RO2CC(:O)CHXR’ [R = Me, Bu-t, R’ = CH2Ph, X = Cl; R = Bu-t, R’ = Ph, Me, CH2CH2Me, CH2CCSiMe3, (CH2)3OCH2Ph; R = Bu-t, R’ = Ph, X = F] in an asym. homoenolate reaction is described. A chiral N-hetereocyclic carbene catalyzes the a3 → d3-umpolung addition of α,β-enals to racemic α-keto esters, forming γ-butyrolactones I [R1 = Ph, C6H4OMe-4, C6H4Cl-4, C6H4Me-4, C6H4Me-3, thien-2-yl, furan-2-yl, CH:CHPh-(E), CO3Et] and II [R2 = Ph, Me, CH2CH:CH2, CH2CCSiMe3, (CH2)3OCH2Ph, X = Cl; R = Ph, X = F] with three contiguous stereocenters. The addition occurs with high regio-, diastereo-, and enantiocontrol. This methodol. constitutes an intermol. DKR process to set three stereocenters during the key bond forming event. The experimental process involved the reaction of (R)-5-Benzyl-2-mesityl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate(cas: 1469801-67-9).Computed Properties of 1469801-67-9

The Article related to butyrolactone gamma derivative enantioconvergent annulation synthesis, halo keto ester dynamic kinetic resolution asym homoenolate reaction, alkenal annulation halo keto ester hetereocyclic carbene catalyst, regioselective annulation halo keto ester alkenal hetereocyclic carbene catalyst and other aspects.Computed Properties of 1469801-67-9

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Vorona, Svetlana V.; Zevatskii, Yuri E.; Myznikov, Leonid V. published an article in 2019, the title of the article was Zinc (II) Chloride as Phase Transfer Catalyst and as Catalyst of Cycloaddition Azide Ion to Heterocumulenes and Terminal Alkynes in Organic Solvents.Name: 4-(p-Tolyl)-1H-1,2,3-triazole And the article contains the following content:

The system of NaN3-ZnCl2 in organic solvents was effective for azide ion cycloaddition to heterocumulenes and terminal alkynes. The reaction proceeded readily in the case of heterocumulenes, so these transformations fall into the category of click reactions. The study on the reaction mechanism showed that role of zinc salt consists in transferring azide ion to the organic phase and decreasing the energy barrier of nucleophilic addition of azide ion to the unsaturated substrate. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Name: 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to isothiocyanate sodium azide zinc chloride catalyst cycloaddition, thiotetrazole preparation, carbodiimide sodium azide zinc chloride catalyst cycloaddition, aminotetrazole preparation, terminal alkyne sodium azide zinc chloride catalyst regioselective cycloaddition, triazole preparation and other aspects.Name: 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics