Category: Triazoles

Tian, Ruilin; Samelson, Avi J.; Rezelj, Veronica V.; Chen, Merissa; Ramadoss, Gokul N.; Guo, Xiaoyan; Kain, Alice Mac; Tran, Quang Dinh; Lim, Shion A.; Lui, Irene; Nunez, James; Rockwood, Sarah J.; Liu, Na; Carlson-Stevermer, Jared; Oki, Jennifer; Maures, Travis; Holden, Kevin; Weissman, Jonathan S.; Wells, James A.; Conklin, Bruce; Vignuzzi, Marco; Kampmann, Martin published an article in 2021, the title of the article was BRD2 inhibition blocks SARS-CoV-2 infection in vitro by reducing transcription of the host cell receptor ACE2.Reference of (2S,4R)-1-((2S)-2-(tert-butyl)-15-((6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,14-dioxo-6,10-dioxa-3,13-diazapentadecan-1-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide And the article contains the following content:

SARS-CoV-2 infection of human cells is initiated by the binding of the viral Spike protein to its cell-surface receptor ACE2. We conducted an unbiased CRISPRi screen to uncover druggable pathways controlling Spike protein binding to human cells. We found that the protein BRD2 is an essential node in the cellular response to SARS-CoV-2 infection. BRD2 is required for ACE2 transcription in human lung epithelial cells and cardiomyocytes, and BRD2 inhibitors currently evaluated in clin. trials potently block endogenous ACE2 expression and SARS-CoV-2 infection of human cells. BRD2 also controls transcription of several other genes induced upon SARS-CoV-2 infection, including the interferon response, which in turn regulates ACE2 levels. It is possible that the previously reported interaction between the viral E protein and BRD2 evolved to manipulate the transcriptional host response during SARS-CoV-2 infection. Together, our results pinpoint BRD2 as a potent and essential regulator of the host response to SARS-CoV-2 infection and highlight the potential of BRD2 as a novel therapeutic target for COVID-19. The experimental process involved the reaction of (2S,4R)-1-((2S)-2-(tert-butyl)-15-((6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,14-dioxo-6,10-dioxa-3,13-diazapentadecan-1-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide(cas: 1949837-12-0).Reference of (2S,4R)-1-((2S)-2-(tert-butyl)-15-((6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,14-dioxo-6,10-dioxa-3,13-diazapentadecan-1-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide

The Article related to brd2 inhibitor ace2 transcription regulation sars cov2 coronavirus covid19, Biochemical Genetics: Genomic Processes and other aspects.Reference of (2S,4R)-1-((2S)-2-(tert-butyl)-15-((6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,14-dioxo-6,10-dioxa-3,13-diazapentadecan-1-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Ma, Jiliang; Peng, Xinwen; Zhong, Linxin; Sun, Runcang published an article in 2018, the title of the article was Sulfonation of carbonized xylan-type hemicellulose: a renewable and effective biomass-based biocatalyst for the synthesis of O- and N-heterocycles.HPLC of Formula: 5301-96-2 And the article contains the following content:

The application of biomass-based carbonaceous solid acids in catalysis is attracting increasing attention in the field of chem. In this study, a heterogeneous carbon-based solid acid biocatalyst (CXH-SO3H) with regular spherical structure was synthesized from xylan-type hemicellulose (XH) by a simple two-step method. The catalyst was successfully applied in the synthesis of O- and N-heterocycles with yields of 80-99% and 60-97%, resp. In view of environment and economy, CXH-SO3H shows the merits of environmental friendliness, easy operation, simple work-up, excellent yields, and the avoidance of use of organic solvents and expensive catalysts. Moreover, the as-synthesized solid acid catalyst could be used for several cycles without significant loss in its catalytic activity. The results of FT-IR, XRD, and SEM showed that no distinct differences in physico-chem. structures of CXH-SO3H were observed Thus, the eco-friendly CXH-SO3H catalyst is a promising candidate for green synthesis of O- and N-heterocycles from low-cost feed-stocks and has good prospect in partially substituting com. available solid and liquid acid catalysts and precious metal catalysts. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).HPLC of Formula: 5301-96-2

The Article related to sulfonation carbonized xylan hemicellulose renewable biocatalyst o n heterocycle, Cellulose, Lignin, Paper, and Other Wood Products: Cellulose and other aspects.HPLC of Formula: 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Wang, Liang; Zhu, Kai-qiang; Wu, Wen-ting; Chen, Qun; He, Ming-yang published an article in 2015, the title of the article was n-Bu4NI-catalyzed direct amination of ethers with aryl tetrazoles and triazoles via cross-dehydrogenative coupling reaction.HPLC of Formula: 5301-96-2 And the article contains the following content:

An efficient, metal-free protocol for direct amination of ethers with aryl tetrazoles and triazoles has been developed using tetrabutylammonium iodide (TBAI) as a catalyst and tert-Bu hydroperoxide (t-BuOOH) as an oxidant. A series of ethers, aryl tetrazoles as well as triazoles are tolerated in this system, giving the corresponding products in moderate to good yields. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).HPLC of Formula: 5301-96-2

The Article related to amination ether aryltetrazole aryltriazole cross dehydrogenative coupling, metal free amination tetrabutylammonium iodide catalyst tertbutyl hydroperoxide oxidant, Heterocyclic Compounds (More Than One Hetero Atom): General and other aspects.HPLC of Formula: 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On April 7, 1998, Bolkan, Steven A.; Dunn, Steve published a patent.Synthetic Route of 5301-96-2 The title of the patent was Aqueous metal cleaner having an anticorrosion system. And the patent contained the following:

The title composition is composed of an alk. metal salt, a surfactant, and a corrosion inhibitor with a pH ∼7.5 to <10, preferably silicate free, of a combination of a triazole compound and an alkali metal borate. The use of 1,2,3-benzotriazole (Cobratec) and borax prevent discoloration of steel in addition to providing an anticorrosive effect at mild pH levels. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Synthetic Route of 5301-96-2

The Article related to aqueous cleaning composition corrosion inhibitor, borate alkali triazole corrosion inhibitor, mild alk aqueous cleaner copper, Surface Active Agents and Detergents: Cleaning Compositions and other aspects.Synthetic Route of 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On May 3, 2019, Yang, Yong-Zheng; Song, Ren-Jie; Li, Jin-Heng published an article.HPLC of Formula: 5301-96-2 The title of the article was Intermolecular Anodic Oxidative Cross-Dehydrogenative C(sp3)-N Bond-Coupling Reactions of Xanthenes with Azoles. And the article contained the following:

A new anode strategy for accessing xanthen-9-azoles via an electrochem. C(sp3)-H/N-H cross-coupling of xanthenes with azoles is described. This reaction proceeds efficiently with a broad scope of both xanthenes and N-H-free azoles under metal- and addnl. oxidant-free conditions and represents a new access to direct incorporation of important N-heterocycle units into the resulting xanthenes. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).HPLC of Formula: 5301-96-2

The Article related to xanthenazole preparation electrochem cross coupling xanthene azole, intermol anodic oxidative cross dehydrogenative coupling, Heterocyclic Compounds (More Than One Hetero Atom): General and other aspects.HPLC of Formula: 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On April 4, 2019, Ge, Jhih Kuei; Lee, Yi-Chia; Liu, Wen Dar; Kuo, Chi-Hsien published a patent.COA of Formula: C9H9N3 The title of the patent was Stripper solutions and methods of using stripper solutions. And the patent contained the following:

The invention relates to a stripper solution for removing a resist from a substrate, comprising one or more than one organic solvent, water, hydroxylamine or one or more than one derivative of hydroxylamine, one or more than one corrosion inhibitor, optional one or more than one surfactant, and one or more than one quaternary ammonium hydroxide, wherein the quaternary ammonium hydroxide has the formula: R2-N(R1)(R3)-R4, wherein R1, R2, R3, and R4 are alkyl groups, benzyl, aryl groups, or a combination thereof having collectively at least 5 carbons. The invention also relates to a method for removing a resist from a substrate, comprising; (a) providing a substrate having a resist thereon; (b) contacting the substrate with a stripper solution for a time sufficient to remove the resist; (c) removing the substrate from the stripping solution; and {d} rinsing the stripper solution from the substrate with a solvent. An electronic device prepared according to the inventive method is also claimed. The invention also claims a method for preparing a stripper solution, comprising: (a) providing a container; (b) providing components of the stripper solution composition; and (c) adding components of stripper solution to container to provide contents. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).COA of Formula: C9H9N3

The Article related to cleaning composition stripper photoresist removal electronic device fabrication, Surface Active Agents and Detergents: Cleaning Compositions and other aspects.COA of Formula: C9H9N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On April 4, 2019, Ge, Jhih Kuei; Lee, Yi-Chia; Liu, Wen Dar; Kuo, Chi-Hsien published a patent.Related Products of 5301-96-2 The title of the patent was Stripper solutions and methods of using stripper solutions. And the patent contained the following:

The invention relates to a stripper solution for removing a resist from a substrate, comprising one or more than one organic solvent, water, hydroxylamine or one or more than one derivative of hydroxylamine, one or more than one corrosion inhibitor, optional one or more than one surfactant, and one or more than one quaternary ammonium hydroxide, wherein the quaternary ammonium hydroxide has the formula: R2-N(R1)(R3)-R4, wherein R1, R2, R3, and R4 are alkyl groups, benzyl, aryl groups, or a combination thereof having collectively at least 5 carbons. The invention also relates to a method for removing a resist from a substrate, comprising; (a) providing a substrate having a resist thereon; (b) contacting the substrate with a stripper solution for a time sufficient to remove the resist; (c) removing the substrate from the stripping solution; and {d} rinsing the stripper solution from the substrate with a solvent. An electronic device prepared according to the inventive method is also claimed. The invention also claims a method for preparing a stripper solution, comprising: (a) providing a container; (b) providing components of the stripper solution composition; and (c) adding components of stripper solution to container to provide contents. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Related Products of 5301-96-2

The Article related to cleaning composition stripper photoresist removal electronic device fabrication, Surface Active Agents and Detergents: Cleaning Compositions and other aspects.Related Products of 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Tome, A. C. published an article in 2004, the title of the article was Product class 13: 1,2,3-triazoles.Computed Properties of 5301-96-2 And the article contains the following content:

A review. Methods to prepare 1,2,3-triazoles are reviewed including cyclization, aromatization, ring transformation and substituent modification. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Computed Properties of 5301-96-2

The Article related to review triazole preparation cyclization aromatization ring transformation, Heterocyclic Compounds (More Than One Hetero Atom): Reviews and other aspects.Computed Properties of 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On December 31, 2018, Lee, Dong-Hwan; Hasanuzzaman, M.; Kwon, Daeho; Choi, Hye-Young; Kim, So Myoung; Kim, Dong Jin; Kang, Dong Ju; Hwang, Tae-Ho; Kim, Hyung-Hoi; Shin, Ho Jung; Shin, Jae-Gook; Oh, Sangtae; Lee, Seokjoon; Kim, So Won published an article.Recommanded Product: 5301-96-2 The title of the article was 10-Phenyltriazoyl Artemisinin is a Novel P-glycoprotein Inhibitor that Suppresses the Overexpression and Function of P-glycoprotein. And the article contained the following:

The effect of drugs on ATP-binding cassette transporters, especially permeability-glycoprotein (P-gp), is an important consideration during new anti-cancer drug development. In this context, the effects of a newly synthesized artemisinin derivative, 10-(4-phenyl-1H-1,2,3- triazol)-artemisinin (5a), were evaluated on P-gp expression and function. Reverse transcript polymerase chain reaction and immunoblotting techniques were used to determine the effect of 5a on P-gp expression in LS174T cells. In addition, the ability of 5a to work as either a substrate or an inhibitor of P-gp was investigated through different methods. The results revealed that 5a acts as a novel P-gp inhibitor that dually suppresses the overexpression and function of P-glycoprotein. Co-treatment of LS174T cell line, human colon adenocarcinoma cell line, with 5a and paclitaxel recovered the anticancer effect of paclitaxel by controlling the acquired drug resistance pathway. The overexpression of P-gp induced by rifampin and paclitaxel in a colorectal cell line was suppressed by 5a which could be a novel inhibitory substrate inhibiting the transport of paclitaxel by P-gp. The results revealed that 5a can be classified as a type B P-gp inhibitor (with both substrate and inhibitor activities) with an addnl. function of suppressing P-gp overexpression. The results might be clin. useful in the development of anticancer drugs against cancers with multidrug resistance. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Recommanded Product: 5301-96-2

The Article related to glycoprotein inhibitor anticancer agent colon adenocarcinoma, artemisinin, immunoblotting techniques, p-glycoprotein, paclitaxel, rifampin, triazolyl artemisinin., Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Recommanded Product: 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Chen, Xingkuan; Fang, Xinqiang; Chi, Yonggui Robin published an article in 2013, the title of the article was cis-Enals in N-heterocyclic carbene-catalyzed reactions: distinct stereoselectivity and reactivity.Product Details of 1469801-67-9 And the article contains the following content:

The first successful generation of cis-homoenolate equivalent from cis-enals under the catalysis of N-heterocyclic carbenes (NHCs) has been realized. The cis-homoenolate intermediates undergo effective reactions with α,β-unsaturated imines to afford chiral cyclic ketone products, e.g., I and II. Compared to the trans-enals, cis-enals show different stereoselectivities and new reactivity patterns. The experimental process involved the reaction of (R)-5-Benzyl-2-mesityl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate(cas: 1469801-67-9).Product Details of 1469801-67-9

The Article related to enal imine cyclization heterocyclic carbene, cyclic ketone stereoselective preparation, heterocyclic carbene stereoselective cyclization catalyst, Heterocyclic Compounds (One Hetero Atom): Ethylene Oxides and other aspects.Product Details of 1469801-67-9

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics