Category: Triazoles

Hughes, Samantha J. published the artcileFragment based discovery of a novel and selective PI3 kinase inhibitor, COA of Formula: C6H5ClN4, the main research area is PI3 kinase inhibitor imidazopyridine preparation SAR.

We report the use of fragment screening and fragment based drug design to develop a PI3γ kinase fragment hit into a lead. Initial fragment hits were discovered by high concentration biochem. screening, followed by a round of virtual screening to identify addnl. ligand efficient fragments. These were developed into potent and ligand efficient lead compounds using structure guided fragment growing and merging strategies. This led to a potent, selective, and cell permeable PI3γ kinase inhibitor, 12 (I), with good metabolic stability that was useful as a preclin. tool compound

Bioorganic & Medicinal Chemistry Letters published new progress about Drug design. 24415-66-5 belongs to class triazoles, name is 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine, and the molecular formula is C6H5ClN4, COA of Formula: C6H5ClN4.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Xue, Hong published the artcileNew Energetic Salts Based on Nitrogen-Containing Heterocycles, Synthetic Route of 39602-93-2, the main research area is azidotriazole iodomethane quaternization; nitric acid azidotriazole quaternization; perchloric acid azidotriazole quaternization; azidotriazolium energetic salt preparation crystal structure formation enthalpy; imidazolium nitrate preparation energetic salt formation enthalpy thermal stability; methyltetrazolium nitrate preparation energetic salt formation enthalpy thermal stability; perchlorate tetrazolium preparation energetic salt formation enthalpy thermal stability.

New energetic salts were synthesized via the quaternization of azido or nitro derivatives of imidazole, 1,2,4-triazole, and substituted derivatives of tetrazole with nitric or perchloric acid or iodomethane followed by metathesis reaction with silver nitrate or silver perchlorate. The structures of 1,4-dimethyl-3-azido-1,2,4-triazolium nitrate (I, R = Me), 3-azido-1,2,4-triazolium nitrate (I, R = H), 1-methyl-4-amino-1,2,4-triazolium perchlorate (II, R = NH2, X = ClO4-), and 1,4-dimethyl-2-H-1,2,4-triazolium triiodide (II, R = Me, X = I3-) were confirmed by single-crystal X-ray anal. Most of the salts exhibit good thermal stabilities and low m.ps. By using constant volume combustion energies that were determined exptl. using an oxygen bomb calorimeter, the standard molar enthalpies of formation were derived based on designed Hess thermochem. cycles.

Chemistry of Materials published new progress about Explosives. 39602-93-2 belongs to class triazoles, name is 4-Amino-1-methyl-4H-1,2,4-triazol-1-ium iodide, and the molecular formula is C3H7IN4, Synthetic Route of 39602-93-2.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Zhang, Hong published the artcileThe synthesis and energetic properties of pyridinium and triazolium N-(nitrobenzoyl)-imides, Quality Control of 39602-93-2, the main research area is pyridinium triazolium nitrobenzoyl imide energetic property.

Syntheses of nitrogen rich, energetic N-(nitro-substituted-benzoylimino)pyridinium and N-(nitrosubstituted-benzoylimino)1,2,4-triazolium imides are reported and their energetic properties calculated/determined in terms of heats of formation (HOF), densities, detonation parameters, heats of decomposition and heats of combustion.

ARKIVOC (Gainesville, FL, United States) published new progress about Combustion enthalpy. 39602-93-2 belongs to class triazoles, name is 4-Amino-1-methyl-4H-1,2,4-triazol-1-ium iodide, and the molecular formula is C3H7IN4, Quality Control of 39602-93-2.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Xue, Hong published the artcileEnergetic Salts from N-Aminoazoles, Formula: C3H7IN4, the main research area is triazolium amino nitrate perchlorate preparation thermal property thermochem density; tetrazolium amino nitrate perchlorate preparation thermal property thermochem density.

New energetic salts (1-amino-1,2,4-triazolium nitrate and perchlorate, 1-amino-4-methyl-1,2,4-triazolium nitrate and perchlorate, 1,5-diamino-1,2,4-triazolium nitrate and perchlorate, and 2-amino-4,5-dimethyltetrazolium nitrate and perchlorate) were synthesized via the quaternization of the corresponding N-aminoazoles with nitric or perchloric acid or with iodomethane followed by metathesis reaction with silver nitrate or silver perchlorate. The structure of 2-amino-4,5-dimethyltetrazolium nitrate was confirmed by single-crystal X-ray anal. Most of the salts exhibit good thermal stabilities and low m.ps. By using exptl. determined constant volume combustion energies, the standard molar enthalpies of formation were derived on the basis of designed Hess thermochem. cycles.

Inorganic Chemistry published new progress about Combustion enthalpy. 39602-93-2 belongs to class triazoles, name is 4-Amino-1-methyl-4H-1,2,4-triazol-1-ium iodide, and the molecular formula is C3H7IN4, Formula: C3H7IN4.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

McCrary, Parker D. published the artcileHypergolic ionic liquids to mill, suspend, and ignite boron nanoparticles, HPLC of Formula: 39602-93-2, the main research area is energetic hypergolic ionic liquid milling suspension boron nanoparticle ignition.

Boron nanoparticles prepared by milling in the presence of a hypergolic energetic ionic liquid (EIL) are suspendable in the EIL and the EIL retains hypergolicity leading to the ignition of the boron. This approach allows for incorporation of a variety of nanoscale additives to improve EIL properties, such as energetic d. and heat of combustion, while providing stability and safe handling of the nanomaterials.

Chemical Communications (Cambridge, United Kingdom) published new progress about Combustion enthalpy. 39602-93-2 belongs to class triazoles, name is 4-Amino-1-methyl-4H-1,2,4-triazol-1-ium iodide, and the molecular formula is C3H7IN4, HPLC of Formula: 39602-93-2.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Phelan, James P. published the artcileRapid access to diverse, trifluoromethyl-substituted alkenes using complementary strategies, Product Details of C7H6BrN3, the main research area is trifluoromethyl alkene preparation; silyl alc trifluoromethyl cross coupling palladium; Peterson elimination; organotrifluoroborate cross coupling palladium.

Two synergistic approaches to the facile assembly of complex α-trifluoromethyl alkenes are described. Using α-trifluoromethyl-β-silyl alcs. as masked trifluoromethyl alkenes, cross-coupling or related functionalization processes at distal electrophilic sites can be executed without inducing Peterson elimination. Subsequent Lewis acidic activation affords functionalized α-trifluoromethyl alkenes. Likewise, the development of a novel α-trifluoromethylvinyl trifluoroborate reagent complements this approach and allows a one-step cross-coupling of (hetero)aryl halides to access a broad array of complex α-trifluoromethyl alkenes.

Chemical Science published new progress about Addition reaction. 108281-78-3 belongs to class triazoles, name is 6-Bromo-3-methyl-[1,2,4]triazolo[4,3-a]pyridine, and the molecular formula is C7H6BrN3, Product Details of C7H6BrN3.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Jameel, Ehtesham published the artcileRational design, synthesis and biological screening of triazine-triazolopyrimidine hybrids as multitarget anti-Alzheimer agents, Application In Synthesis of 24415-66-5, the main research area is triazine triazolopyrimidine preparation antialzheimer antioxidant SAR mol docking human; ADME analysis; Acetylcholinesterase; Alzheimer’s disease; Butyrylcholinesterase; Molecular docking; Triazine; Triazolopyrimidine quinoline.

A series of triazine-triazolopyrimidine hybrids were designed, synthesized and characterized by various spectral techniques. Among the synthesized compounds, the di-substituted triazine-triazolopyrimidine derivatives I (R1 = 3-F3CC6H4NH2, 4-MeOC6H4NH2, 4-FC6H4NH2, 2-FC6H4NH2) showed better acetylcholinesterase (AChE) inhibitory activity than the corresponding tri-substituted triazine-triazolopyrimidine derivatives Out of the disubstituted triazine-triazolopyrimidine based compounds, I (R1 = 3-F3CC6H4NH2) and I (R1 = 4-MeOC6H4NH2) showed encouraging inhibitory activity on AChE with IC50 values 0.065 and 0.092 μM, resp. and they also demonstrated good inhibition selectivity towards AChE over BuChE by ~28 folds. Furthermore, kinetic anal. and mol. modeling studies of these compounds targeted both catalytic active site as well as peripheral anionic site of AChE. In addition, these derivatives effectively modulated Aβ self-aggregation as investigated through CD spectroscopy, ThT fluorescence assay and electron microscopy. Besides, these compounds exhibited potential antioxidant (2.15 and 2.91 trolox equivalent by ORAC assay) and metal chelating properties. In silico ADMET profiling highlighted that, these novel triazine derivatives have appropriate drug like properties and possess very low toxic effects in the primarily pharmacokinetic study. Overall, the multitarget profile exerted by these novel triazine mols. qualified them as potential anti-Alzheimer drug candidates in AD therapy.

European Journal of Medicinal Chemistry published new progress about Alzheimer disease. 24415-66-5 belongs to class triazoles, name is 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine, and the molecular formula is C6H5ClN4, Application In Synthesis of 24415-66-5.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Kumar, Jitendra published the artcileSynthesis and screening of triazolopyrimidine scaffold as multi-functional agents for Alzheimer’s disease therapies, Application In Synthesis of 24415-66-5, the main research area is triazolopyrimidine quinoline hybrid preparation acetylcholinesterase inhibitory activity Alzheimer; cyanopyridine quinoline hybrid preparation acetylcholinesterase inhibitory activity Alzheimer; Acetylcholinesterase; Alzheimer’s disease; Butyrylcholinesterase; Molecular docking; Quinoline; Triazolopyrimidine.

In present study a series of triazolopyrimidine-quinoline and cyanopyridine-quinoline hybrids were designed, synthesized and evaluated as acetylcholinesterase inhibitors (AChEIs). Mol. docking and scoring was utilized for the design of inhibitors. The mols. were synthesized via an easily accessible, convergent synthetic route. Three triazolopyrimidine based compounds showed nanomolar activity towards acetylcholinesterase. Among them, Et 6-fluoro-4-(4-(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperazin-1-yl)quinoline-3-carboxylate (I), strongly inhibited AChE with IC50 value of 42 nM. Furthermore compound I was identified as most promising compound with 12 fold selectivity against butyrylcholinesterase (BuChE). This compound displayed a composed multitargeted profile with promising inhibition of self-induced and AChE – induced Aβ aggregation and antioxidant activity.

European Journal of Medicinal Chemistry published new progress about Alzheimer disease. 24415-66-5 belongs to class triazoles, name is 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine, and the molecular formula is C6H5ClN4, Application In Synthesis of 24415-66-5.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Kumar, Jitendra published the artcilePyrimidine-Triazolopyrimidine and Pyrimidine-Pyridine Hybrids as Potential Acetylcholinesterase Inhibitors for Alzheimer’s Disease, Name: 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine, the main research area is pyrimidine triazolopyrimidine preparation Alzheimer disease acetylcholinesterase inhibitor.

Synthesis and testing of pyrimidine derivatives in conjugation with triazolopyrimidine I [R = [(6-bromonaphthalen-2-yl)oxy], (4-nitrophenyl)aminyl, (naphthalen-2-yloxy)] based hybrid scaffold of AChE inhibitors for development of new mols. towards the treatment of AD were reported. A multipronged approach employing computational, chem. and biol. approaches was used to find the best inhibitor of AChE. Three mols. (2-(4-(6-chloropyrimidin-4-yl)piperazin-1-yl)nicotinonitrile, I (R = [(6-bromonaphthalen-2-yl)oxy]) and II) derived from this scaffold inhibited AChE in nanomolar to micromolar range. Highest activity was shown by II which has IC50 value of 36 nM. Inhibitory effect of II was stronger for human AChE in neuronal cell extract compared to eelAChE. This activity is comparable to donepezil (IC50 = 38nM) which is considered as good standard among AChE inhibitors. The inhibitory activity of II was also in agreement with mol. simulation studies which showed stable interaction of the II with the catalytic active site as well as peripheral anionic site. Mol. simulation studies also indicated stronger interaction of II with rhAChE than TcAChE. This was later confirmed in studies with neuronal cell extract where compound II showed enzyme inhibition at 25 nM. Further this mol. was not found to be toxic or carcinogenic.

ChemistrySelect published new progress about Alzheimer disease. 24415-66-5 belongs to class triazoles, name is 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine, and the molecular formula is C6H5ClN4, Name: 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Martinez-Viturro, Carlos M. published the artcileDiazaspirononane Nonsaccharide Inhibitors of O-GlcNAcase (OGA) for the Treatment of Neurodegenerative Disorders, Recommanded Product: 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine, the main research area is azaspirononane OGA inhibitor neurodegenerative disorder Alzheimer bacterial hydrolase ortholog.

O-GlcNAcylation is a post-translational modification of tau understood to lower the speed and yield of its aggregation, a pathol. hallmark of Alzheimer’s disease (AD). O-GlcNAcase (OGA) is the only enzyme that removes O-linked N-acetyl-D-glucosamine (O-GlcNAc) from target proteins. Therefore, inhibition of OGA represents a potential approach for the treatment of AD by preserving the O-GlcNAcylated tau protein. Herein, we report the multifactorial optimization of high-throughput screening hit 8 to a potent, metabolically stable, and orally bioavailable diazaspirononane OGA inhibitor (+)-56. The human OGA X-ray crystal structure has been recently solved, but bacterial hydrolases are still widely used as structural homologues. For the first time, we reveal how a nonsaccharide series of inhibitors binds bacterial OGA and discuss the suitability of two different bacterial orthologues as surrogates for human OGA. These breakthroughs enabled structure-activity relationships to be understood and provided context and boundaries for the optimization of druglike properties.

Journal of Medicinal Chemistry published new progress about Alzheimer disease. 24415-66-5 belongs to class triazoles, name is 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine, and the molecular formula is C6H5ClN4, Recommanded Product: 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics