Category: Triazoles

Enantioconvergent Synthesis of Functionalized γ-Butyrolactones via (3 + 2)-Annulation [Erratum to document cited in CA162:137454] was written by Goodman, C. Guy;Walker, Morgan M.;Johnson, Jeffrey S.. And the article was included in Journal of the American Chemical Society in 2015.Product Details of 1631733-83-9 The following contents are mentioned in the article:

Some of the catalyst identifiers (A-G) used in the Supporting Information did not match those shown in the paper; the Supporting Information has been updated. The authors were made aware of several relevant publication involving enantioconvergent proline-catalyzed aldol reactions of chiral racemic electrophiles and provide the relevant citation information. This study involved multiple reactions and reactants, such as (S)-5-Isopropyl-2-mesityl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c][1,4]oxazin-2-ium tetrafluoroborate (cas: 1631733-83-9Product Details of 1631733-83-9).

(S)-5-Isopropyl-2-mesityl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c][1,4]oxazin-2-ium tetrafluoroborate (cas: 1631733-83-9) belongs to triazole derivatives. The many free lone pairs in triazoles make them useful as coordination compounds, although not typically as haptic ligands. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeProduct Details of 1631733-83-9

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Rational design of a fluopyram hapten and preparation of bioconjugates and antibodies for immunoanalysis was written by Ceballos-Alcantarilla, E.;Agullo, C.;Abad-Fuentes, A.;Abad-Somovilla, A.;Mercader, J. V.. And the article was included in RSC Advances in 2015.Recommanded Product: 156311-83-0 The following contents are mentioned in the article:

A fluopyram hapten was designed in which insignificant electronic and structural modifications were foreseen and all potentially interacting chem. moieties were maintained. This hapten was prepared by total synthesis and three immunol. active bioconjugates were obtained and characterized. High-affinity and specific antibodies to fluopyram were raised. This study involved multiple reactions and reactants, such as ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0Recommanded Product: 156311-83-0).

((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. Triazoles consist of a five-membered ring containing three nitrogen atoms and are biologically active, especially as antifungal, antimicrobial and enzyme inhibitors. Due to the structural characteristics, both 1,2,3- and 1,2,4-triazoles are able to accommodate a broad range of substituents (electrophiles and nucleophiles) around the core structures and pave the way for the construction of diverse novel bioactive molecules.Recommanded Product: 156311-83-0

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Microwave-assisted coupling of carboxylic acids to a polymer bound hydrazine linker was written by Lindquist, Charlotta;Tedebark, Ulf;Ersoy, Oguz;Somfai, Peter. And the article was included in Synthetic Communications in 2003.Synthetic Route of C17H27F6N7OP2 The following contents are mentioned in the article:

A set of carboxylic acids, all being potential scaffolds for combinatorial chem. or peptide synthesis, were coupled to a polymer bound aryl hydrazine linker using microwave irradiation in good yields. Improved yields and reduced reaction times were achieved by using microwave-assisted heating compared to conventional heating. This study involved multiple reactions and reactants, such as ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0Synthetic Route of C17H27F6N7OP2).

((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. Many triazoles are versatile, biologically active compounds commonly used as fungicides and plant retardants. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeSynthetic Route of C17H27F6N7OP2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthesis of vaniprevir (MK-7009): Lactamization to prepare a 20-membered macrocycle [Erratum to document cited in CA155:407318] was written by Song, Zhiguo J.;Tellers, David M.;Journet, Michel;Kuethe, Jeffrey T.;Lieberman, David;Humphrey, Guy;Zhang, Fei;Peng, Zhihui;Waters, Marjorie S.;Zewge, Daniel;Nolting, Andrew;Zhao, Dalian;Reamer, Robert A.;Dormer, Peter G.;Belyk, Kevin M.;Davies, Ian W.;Devine, Paul N.;Tschaen, David M.. And the article was included in Journal of Organic Chemistry in 2011.SDS of cas: 156311-83-0 The following contents are mentioned in the article:

On page 7804, the title, the first sentence of the Abstract and, the second paragraph of the Introduction contained an error; the correction is given. On page 7805, the paragraph headed with “Palladium-Mediated Macrocyclization” contained a text error; the correction is given. This study involved multiple reactions and reactants, such as ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0SDS of cas: 156311-83-0).

((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. The triazole ring is a relatively stable functional group, and the triazole bond can be used for a variety of applications, such as replacing the phosphate backbone of DNA. Due to the structural characteristics, both 1,2,3- and 1,2,4-triazoles are able to accommodate a broad range of substituents (electrophiles and nucleophiles) around the core structures and pave the way for the construction of diverse novel bioactive molecules.SDS of cas: 156311-83-0

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

dsDNA-triggered energy transfer and lanthanide sensitization processes. Luminescent probing of specific A/T sequences was written by Vazquez, Olalla;Sanchez, Mateo I.;Mascarenas, Jose L.;Vazquez, M. Eugenio. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2010.Application of 156311-83-0 The following contents are mentioned in the article:

Orthogonal attachment of a DOTA[Ln³⁺] complex or a coumarin fluorophore to appropriately functionalized bis-4-aminobenzamidines yields compounds that experience A/T-selective, dsDNA-dependent energy transfer processes, and elicit long wavelength emission of light. This study involved multiple reactions and reactants, such as ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0Application of 156311-83-0).

((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. However, triazoles are also useful in bioorthogonal chemistry, because the large number of nitrogen atoms causes triazoles to react similar to azides. Many triazoles have antifungal effects: the triazole antifungal drugs include fluconazole, isavuconazole, itraconazole, voriconazole, pramiconazole, ravuconazole, and posaconazole and triazole plant-protection fungicides include epoxiconazole, triadimenol, myclobutanil, propiconazole, prothioconazole, metconazole, cyproconazole, tebuconazole, flusilazole and paclobutrazol.Application of 156311-83-0

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthesis of heterocyclic compounds. III. Aryl-1,2,4-triazoles was written by Khan, Misbahul Ain;Polya, J. B.. And the article was included in Revista Latinoamericana de Quimica in 1972.Safety of 2-(1,2,4-Triazol-1-yl)aniline The following contents are mentioned in the article:

The aryltriazoles I-III (R = H, o-, p-NO2, o-, m-, p-Ph) were prepared An RC6H4NHNH2 reacted with Me2NCH:NCH:N+Me2 Cl- to give I. RC6H4NH2 condensed with HCONHNHCHO to give II. The Gomberg-Bauchmann arylation reaction of III (R = NH2) gave III (R = Ph, o-NO2C6H4, p-NO2C6H4). This study involved multiple reactions and reactants, such as 2-(1,2,4-Triazol-1-yl)aniline (cas: 39876-84-1Safety of 2-(1,2,4-Triazol-1-yl)aniline).

2-(1,2,4-Triazol-1-yl)aniline (cas: 39876-84-1) belongs to triazole derivatives. The many free lone pairs in triazoles make them useful as coordination compounds, although not typically as haptic ligands. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.Safety of 2-(1,2,4-Triazol-1-yl)aniline

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Advantageous applications of azabenzotriazole (triazolopyridine)-based coupling reagents to solid-phase peptide synthesis was written by Carpino, Louis;El-Faham, Ayman;Minor, Charles A.;Albericio, Fernando. And the article was included in Journal of the Chemical Society, Chemical Communications in 1994.HPLC of Formula: 156311-83-0 The following contents are mentioned in the article:

1-Hydroxy-7-azabenzotriazole (HOAt) and its corresponding uronium and phosphonium salts are shown to be superior to their benzotriazole analogs in solid-phase peptides synthesis, thereby making possible the automated synthesis of peptides containing hindered amino acids. This study involved multiple reactions and reactants, such as ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0HPLC of Formula: 156311-83-0).

((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. Triazoles consist of a five-membered ring containing three nitrogen atoms and are biologically active, especially as antifungal, antimicrobial and enzyme inhibitors. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.HPLC of Formula: 156311-83-0

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Total synthesis of anti-tuberculosis natural products Ilamycins E₁ and F was written by Cheng, Yingying;Tang, Shoubin;Guo, Yian;Ye, Tao. And the article was included in Organic Letters in 2018.Reference of 156311-83-0 The following contents are mentioned in the article:

The first total synthesis of the potent anti-tuberculosis cyclopeptide natural products Ilamycins E₁ and F was achieved. This highly convergent strategy consists of the synthesis of the two units (I) (Teoc = CO₂(CH₂)₂TMS) and (II) (TBDPS = tert-butyltriphenylsilyl; TMSE = O(CH₂)₂TMS) and linking them together to form the macrocyclic lactam. The upper unit I was prepared from tryptophan in five steps, and the lower unit II was prepared from glutamic acid in thirteen steps. Conversion of Ilamycin F, the most abundant of the cyclopeptides, into the more active congener, Ilamycin E₁, was also accomplished. This would provide sufficient material of Ilamycin E₁ for more extensive biol. studies. This study involved multiple reactions and reactants, such as ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0Reference of 156311-83-0).

((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. However, triazoles are also useful in bioorthogonal chemistry, because the large number of nitrogen atoms causes triazoles to react similar to azides.Triazole heterocyclic structures are found to form many weak nonbond interactions with the receptors and enzymes in biological systems.Reference of 156311-83-0

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Thermal Stability Assessment of Peptide Coupling Reagents Commonly Used in Pharmaceutical Manufacturing was written by Sperry, Jeffrey B.;Minteer, Christopher J.;Tao, JingYa;Johnson, Rebecca;Duzguner, Remzi;Hawksworth, Michael;Oke, Samantha;Richardson, Paul F.;Barnhart, Richard;Bill, David R.;Giusto, Robert A.;Weaver, John D.. And the article was included in Organic Process Research & Development in 2018.Name: ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) The following contents are mentioned in the article:

Amide couplings are one of, if not the most common, chem. reactions performed in the pharmaceutical industry. Many amide bonds are generated with the help of highly active peptide coupling reagents. These reagents garnered wide use in the pharmaceutical industry, but many contain high-energy functional groups. As a result, significant time is spent assessing the thermal stability of these reagents before scale-up commences. This work assessed the thermal stability of 45 common peptide coupling reagents by differential scanning calorimetry and accelerating rate calorimetry. Those compounds flagged as potentially impact-sensitive or potentially explosive were tested by drop-hammer and explosivity screening techniques. The data are presented to drive development of these reactions toward the use of one of the more thermally stable reagents. This study involved multiple reactions and reactants, such as ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0Name: ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V)).

((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. However, triazoles are also useful in bioorthogonal chemistry, because the large number of nitrogen atoms causes triazoles to react similar to azides. Due to the structural characteristics, both 1,2,3- and 1,2,4-triazoles are able to accommodate a broad range of substituents (electrophiles and nucleophiles) around the core structures and pave the way for the construction of diverse novel bioactive molecules.Name: ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V)

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

3-Nitro-1,2,4-triazol-1-yl-tris(pyrrolidin-1-yl)phosphonium hexafluorophosphate (PyNTP) as a condensing reagent for solid-phase peptide synthesis was written by Saito, Keita;Wada, Takeshi. And the article was included in Tetrahedron Letters in 2014.Reference of 156311-83-0 The following contents are mentioned in the article:

Solid-phase oligopeptide synthesis has been well developed and most short oligo-peptides can now be easily synthesized. However, when a desired oligopeptide forms a secondary structure or includes less reactive amino acids such as aminoisobutyric acid, its terminal amino groups become less reactive and synthesis of the desired oligo-peptides becomes difficult. To expand the number of synthetic peptide sequences, we have developed efficient coupling conditions using 3-nitro-l,2,4-triazol-l-yl-tris(pyrrolidin-1-yl)phosphonium hexafluorophosphate (PyNTP) as a highly reactive condensing reagent on an un-swellable solid support. PyNTP demonstrated higher reactivity than conventional condensing reagents and the optical purity of the synthesized oligo-peptides was sufficiently high for application to general oligopeptide synthesis. This study involved multiple reactions and reactants, such as ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0Reference of 156311-83-0).

((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior pharmacological applications. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeReference of 156311-83-0

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics