Category: Triazoles

Research speed reading in 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 6818-99-1, name is 3-Chloro-1,2,4-triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Product Details of 6818-99-1

A suspension of (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-14-(acetyloxy)- 15-[2-(dimethylamino)-2,3-dimethylbutoxy]-8-[(lR)-1,2-dimethylpropyl]- 1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-l^deltaJOa-tetramethyl–oxo-4H-l^a-propano- 2H-phenanthro[1,2-c]pyran-7-carboxylic acid (the compound of Example 130 in International Patent Publication No. WO 2007/127012, herein incorporated by reference in its entirety; 20 mg, 0.03 mmol), 3-chloro-iH-1,2,4-triazole (26.8 mg, 0.259 mmol) and boron trifluoride etherate (75 muL, 0.592 mmol) in dichloroethane (0.7 mL) was blanketed with nitrogen and placed in a 50C oil bath for 24 hours. The mixture was cooled to room temperature, evaporated and the residual oil was separated by reverse phase EtaPLC using a 19 x 150 mm Sunfire Preparative C18 OBD column. The product containing fractions were evaporated and freeze-dried from a mixture of ethanol and benzene to give EXAMPLE 9A as a white solid (3.4 mg), EXAMPLE 9B as a white solid (2.0 mg) and EXAMPLE 9C as a white solid (2.0 mg).EXAMPLE 9A:1H NMR (CD3OD, 600MHz, ppm) delta 0.70 (d, 3H, Me), 0.77 (d, 3H, Me), 0.80 (s, 3H, Me), 0.86-0.98 (multiple Me signals), 1.09 (s, 3H, Me), 1.16 (s, 3H, Me), 1.18 (s, 3H, Me), 1.29-1.48 (m), 1.52-1.57 (m), 1.70 (s, 3H, Me), 1.67-1.86 (m), 1.94-1.99 (m), 2.20-2.26 (m), 2.52 (dd, 1H, H13), 2.54 (dd, 1H, H13), 2.74 (s, NMe2), 2.80 (s, NMe2), 2.82 (s, NMe2), 2.85 (s, NMe2), 3.09 (s, 1H, H7), 3.58 (d, 1H), 3.62 (dd, 1H), 3.68 (d, 1H), 3.79 (d, 1H), 3.85 (d, 1H), 5.60 (br m, 1H, H14), 5.79 (dd, 1H, H5), 5.80 (dd, 1H, H5), 9.04 (br s, 1H, triazole). Mass spectrum: (ESI) m/z = 715.38 (M+H).EXAMPLE 9B:1H NMR (CD3OD, 600MHz, ppm) delta 0.72 (d, 3H, Me), 0.76 (d, 3H, Me), 0.80 (s, 3H, Me), 0.88 (d, 3H, Me), 0.89 (d, 3H, Me), 0.91 (d, 3H, Me), 0.92 (d, 3H, Me), 0.95 (d, 3H, Me), 0.96 (s, 3H, Me), 1.09 (s, 3H, Me), 1.16 (s, 3H, Me), 1.29-1.48 (m), 1.52-1.57 (m), 1.67 (s, 3H, Me), 1.68-1.86 (m), 1.90-1.99 (m), 2.04-2.09 (m), 2.19-2.26 (m), 2.37 (dd, 1H, H13), 2.39 (dd, 1H, H13), 2.66-2.72 (m), 2.71 (s, NMe2), 2.79 (s, NMe2), 2.81 (d, 1H), 3.09 (s, 1H, H7), 3.17 (d, 1H), 3.57 (d, 1H), 3.60-3.64 (m), 3.68 (dd, 1H), 3.72 (d, 1H), 3.80 (d, 1H), 3.86 (d, 1H), 3.99 (d, 1H), 4.20 (d, 1H), 5.72 (m, 1H, H14), 5.77 (dd, 1H, H5), 8.07 (s, 1H, triazole). Mass spectrum: (ESI) m/z = 715.38 (M+H).EXAMPLE 9C:1H NMR (CD3OD, 600MHz, ppm) 50.72 (d, 3H, Me), 0.75 (d, 3H, Me), 0.77 (d, 3H, Me), 0.80 (s, 3H, Me), 0.86-0.96 (multiple Me signals), (s, 3H, Me), 1.03 (s, 3H, Me), 1.05 (s, 3H, Me), 1.09 (s, 3H, Me), 1.17 (s, 3H, Me), 1.19 (s, 3H, Me), 1.28-1.48 (m), 1.50 (s, 3H, Me), 1.52-1.54 (m), 1.69 (s, 3H, Me), 1.60-1.81 (m), 1.90-1.98 (m), 2.20-2.26 (m), 2.46 (dd, 1H, H13), 2.48 (dd, 1H, H13), 2.76 (s, NMe2), 2.80 (s, NMe2), 2.81 (d, 1H), 3.09 (s, 1H, H7), 3.10 (s, 1H, H7), 3.52-3.68 (m), 3.71-3.90 (m), 5.60 (m, 1H, H14), 5.76 (dd, 1H, H5), 8.63 (s, 1H, triazole).Mass spectrum: (ESI) m/z = 715.38 (M+H).

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 3-Chloro-1,2,4-triazole, in my other articles.

Reference:
Patent; MERCK SHARP & DOHME CORP.; SCYNEXIS, INC.; GREENLEE, Mark, L.; WILKENING, Robert; APGAR, James; SPERBECK, Donald; WILDONGER, Kenneth, James; MENG, Dongfang; PARKER, Dann, L.; PACOFSKY, Gregory, James; HEASLEY, Brian, Haid; MAMAI, Ahmed; NELSON, Kingsley; WO2010/19204; (2010); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application of 956317-36-5, New Advances in Chemical Research in 2021. Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. 956317-36-5, name is 5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid, molecular formula is C10H9N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

A mixture of 12 (1.3 g, 6.3 mmol), HATU(4.7 g, 12.6 mmol) and TEA (1.2 g, 12.6 mmol) in DCM (30 mL) was stirred at r.t. for30 min. Then 23 (1.5 g, 6.3 mmol) was added, the reaction was stirred at r.t. for 1 hr.The mixture was diluted with water and extracted with EtOAc. The organic layers was concentrated and purified by silica gel chromatography (eluting with DCM) to give 24 (1.3 g, yield: 73%). MS (ESI): m/z 424.2 [M + H]+.

We very much hope you enjoy reading the articles and that you will join us to present your own research about 956317-36-5, Happy reading!

Reference:
Article; Wu, Songliang; Sun, Yu; Hu, Yi; Zhang, Hongmei; Hou, Lijuan; Liu, Xing; Li, Yufeng; He, Haiying; Luo, Zhi; Chen, Yuan; Wang, Yuhe; Shi, Weihua; Shen, Liang; Cao, Changqing; Liang, Wei; Xu, Qing; Lv, Qiang; Lan, Jiong; Li, Jian; Chen, Shuhui; Bioorganic and Medicinal Chemistry Letters; vol. 27; 6; (2017); p. 1458 – 1462;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application of 107534-96-3, New discoveries in chemical research and development in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 107534-96-3, name is 3-((1H-1,2,4-Triazol-1-yl)methyl)-1-(4-chlorophenyl)-4,4-dimethylpentan-3-ol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 2 Preparation of 1-Tert-butyl-3-(p-chlorophenyl)-1-(1H-1,2,4-triazol-1-ylmethyl)propyl diphenylborinate STR11 A solution of diphenylborinic acid (0.11 g, 0.60 mmol) in toluene is added to a solution of 1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol (0.21 g, 0.68 mmol) in a 1:1 ether/toluene solution. The reaction mixture is heated at reflux for 3 days with removal of water (Dean Stark), cooled and concentrated in vacuo to obtain a residue. The residue is chromatographed using silica gel and hexane/ethyl acetate solutions to give the title product as a pale yellow solid, mp 197 C.

We very much hope you enjoy reading the articles and that you will join us to present your own research about 107534-96-3, Happy reading!

Reference:
Patent; American Cyanamid Company; US5591726; (1997); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

New discoveries in chemical research and development in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 41253-21-8, name is Sodium 1,2,4-triazol-1-ide belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C2H2N3Na

First, 3.8 g of 1,2,4-triazole were dissolved in 8 ml of NMP at 2O0C. Then,2.2 g of NaOH and 22 ml of NMP were added in portions over 1 hour, maintaining the temperature at less than 350C. The solution was stirred for 2 hours at 20C, and 7.8 g of Na2SO4 were then added. After filtration of the solid, the resulting solution was transferred to a dropping funnel, and added over 75 minutes to a solution of 14 g of crude l,3-benzenediacetonitrile-5-(bromomethyl)-alpha,alpha,alpha’,alpha’ tetramethyl (having a purity of 81.8%, containing: 3,5-bis(2-cyanoisopropyl)toluene 4.0%, l,l-dibromo-3,5-bis(2- cyanoisopropyl)toluene 10.7%, and other impurities 3.5% ) in 20 ml of NMP, cooled to -3O0C. At the end of the addition, the suspension was stirred at -300C for 18 hours, and monitored via HPLC. When the concentration of starting material is less than 0.5 percent, an amount of acetic acid sufficient to give a pH of about 6.5 to about 7.0 is added (an HPLC analysis of the crude reaction mixture showed: residual starting material 0.4%, Anastrozole 68.9%, Isoanastrozole 5.5%, 3,5-bis (2-cyanoisopropyl)toluene 7.5%, 1,1-dibromomethyl- 3,5-bis(2-cyanoisopropyl)benzene, and 15.4%, and other impurities 2.3%.). The mixture is then allowed to warm slowly to 200C, filtered, and 37 ml of toluene, 75 ml of heptane, and 37 ml of water are added. The biphasic system is stirred vigorously for 30 minutes, and the organic layer is then separated. Water, toluene, and heptane in amounts of 25 ml, 25 ml, and 50 ml, respectively, are added to the aqueous phase, and the system is stirred for 30 minutes before the organic phase is separated. Then, 10 ml of toluene and 20 ml of heptane are added to the aqueous phase, and the system is stirred for 30 minutes before the organic phase is separated. Toluene and water, 99 ml and 400 ml, respectively, are added to the aqueous phase, and the resulting biphasic system is stirred for 1 hour. The organic layer is separated and washed 3 times with a mixture of MeOH and water (3 ml and 21 ml, respectively). The final organic phase is concentrated to 45 ml under reduced pressure at 400C, and 45 ml of heptane are added dropwise over 1 hour. The resulting suspension is cooled to 00C, stirred for 1 hour, and filtered. The crude solid is dissolved in toluene (40 ml) at 4O0C, and heptane (40 ml) is slowly added under stirring. The suspension is cooled to 00C, stirred for 1 hour, EPO and filtered. The solid is driejd at 55C under reduced pressure until constant weight is achieved, yielding 5.8 g of product with a purity as follows: Anastrozole 98.45%, Isoanastrozole 0.09%, 3,5-bis (2-cyanoisopropyl)toluene 0.06%, l-bromo-3,5-bis (2- cyanoisopropyl)toluene 0.11%, l,l-dibromo-3,5-bis(2-cyanoisopropyl)toluene 0.07%, other impurities 1.22% are by HPLC.

If you are hungry for even more, make sure to check my other article about 41253-21-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SICOR, INC.; WO2006/108155; (2006); A2;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Research speed reading in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 423165-07-5, name is exo-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of exo-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane

General procedure: To an aqueous solution of active hydrogen containing amide, few drops of aqueous ammonia solution (1 eq.) and secondary amine (1 eq.) were added in drops in an ice-cold solution under constant stirring for dissolution. Aromatic aldehydes dissolved in methanol, added dropwise to the above mixture and stirring was continued for 2 h. The formation of compounds were observed within 30 min. Reaction was monitored by TLC, after completion of reaction, the product was filtered and washed with distilled water and dried at 45-50 C.

The catalyzed pathway has a lower Ea, but the net change in energy that results from the reaction is not affected by the presence of a catalyst. In my other articles, you can also check out more blogs about 423165-07-5

Reference:
Article; Viveka, T. Lakshmi; Sharada, L. Nalanda; Asian Journal of Chemistry; vol. 30; 9; (2018); p. 2029 – 2034;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Research speed reading in 2021. The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic. 15988-11-1, name is 4-Phenyl-1,2,4-triazolidine-3,5-dione belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C8H7N3O2

General procedure: Dimedone (0.14 g, 1 mmol), benzaldehyde (0.1 g, 1 mmol), and 4-phenylurazole (0.177 g, 1 mmol) were mixed with PEG-SO3H (0.6 g, 0.1 mmol) and the obtained mixture was stirred magnetically at 80 C for 40 min. After the completion of the reaction warm water (20 mL) was added and the mixture stirred for about 5 min. The insoluble crude product was filtered and recrystallized from EtOH/H2O 4:1 and the pure product was obtained (0.352 g, 91%). In order to recover the catalyst, the filtrate was dried under reduced pressure and recovered catalyst was washed with diethyl ether and reused after drying under reduced pressure. The equivalent procedure was used for the synthesis of triazolo[1,2-a]indazole-tetraones.

In conclusion, we affirm that quantitative kinetic descriptions of catalytic behavior continue to serve as an indispensable tool to navigate research efforts intended to model. Read on for other articles about 15988-11-1.

Reference:
Article; Hasaninejad, Alireza; Zare, Abdolkarim; Shekouhy, Mohsen; Tetrahedron; vol. 67; 2; (2011); p. 390 – 400;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Reference of 1001401-62-2, New discoveries in chemical research and development in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 1001401-62-2, name is 2-(2H-1,2,3-Triazol-2-yl)benzoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 6: l-(3-(r(3i?,6i? -6-Methyl-l- (r2-(2H-l,2,3-triazol-2-vnphenyllcarbonvUpiperidin-3- yl”|oxy|phenyl)ethanol A solution of l-(3-(((3i?,6i?)-6-methylpiperidine-3-yl)oxy)phenyl)ethanol (0.020 g, 0.085 mmol), 2-(2H-l,2,3-triazol-2-yl)benzoic acid (0.024 g, 0.13 mmol), EDC (0.033 g, 0.17 mmol), 1 -hydroxy-7-azabenzotriazole (0.023 g, 0.17 mmol), and Hunig’s base (0.089 mL, 0.51 mmol) in DMF (1 mL) was stirred at 50 C overnight, then diluted with saturated aqueous sodium bicarbonate and extracted 2x with ethyl acetate. The combined organic fractions were washed with brine, dried over magnesium sulfate, filtered, and concentrated in vacuo. The crude material was purified by silica gel gradient chromatography (0-75% ethyl acetate in hexanes), providing the titled compound as an off-white foam. HRMS m/z (M+H) 407.2069 found, 407.2078 required.

By the way, if you are interested in learning more fun chemistry with your kids, get your hands into one chemistry set now, and start enjoying the best part of chemistry: experiments about 2-(2H-1,2,3-Triazol-2-yl)benzoic acid.

Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; LIVERTON, Nigel, J.; SKUDLAREK, Jason, W.; WO2014/176142; (2014); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Research speed reading in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. category: Triazoles

[0421] To a stirred solution of (2S,4S)-4-amino-5-biphenyl-4-yl-2-ethoxymethylpentanoic acid ethyl ester (17 mg,47 f.tmol) in DMF (0.3 mL), was added lH-1,2,3-triazole-4-carboxylic acid (5.3 mg, 47 f.tmol) and HATU (18 mg, 47f.tmol), followed by DIPEA (25 f.LL, 141 flillOI). The mixturewas stirred for 30 minutes, then concentrated under reducedpressure to yield crude Compound 1, which was used in thenext step without purification.

The catalyzed pathway has a lower Ea, but the net change in energy that results from the reaction is not affected by the presence of a catalyst. In my other articles, you can also check out more blogs about 16681-70-2

Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; Fleury, Melissa; Beausoliel, Anne-Marie; Hughes, Adam D.; Long, Daniel D.; Wilton, Donna A.A.; US2015/210690; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Reference of 41253-21-8, New Advances in Chemical Research in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 41253-21-8, name is Sodium 1,2,4-triazol-1-ide, molecular formula is C2H2N3Na, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

(4) Synthesis of 5-(4-chlorobenzyl)-2,2-bis-methoxymethoxymethyl-1-[1,2,4]triazol-1-ylmethylcyclopentanol (Compound (XXIV), G2=CH2OCH3, Ym=4-Cl, A=N)[1,2,4]-Triazole sodium salt (526 mg, 5.78 mmol) was dissolved in NMP (3 ml), and heated to an internal temperature of 115 degrees C. To this, 1 ml of a solution of 5-chlorobenzyl-2,2-bis-methoxymethoxymethyl-cyclopentanone (Compound No. (Compound (XXII), G2=CH2OCH3, Ym=4-Cl) 1.374g (3.85 mmol) in NMP was added. To this solution, sodium t-butoxide 333mg (3.47 mmol) and TMSOB 1.193 g (6.87 mmol) were added in portions while conducting the reaction at 115 degrees C for 5 hours. After completion of the reaction, the reaction solution was cooled to 35 degrees C, combined with 15 ml of water, and extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous sodium sulfate. The solvent was distilled away and the residue was subjected to silica gel column chromatography (eluent; ethyl acetate) for purification to obtain the desired substance. Product: 680.2 mgYield: 40.2 %Description: Colorless viscous liquid1H-NMR (CDCl3) delta:1.47-1.56 (1 H, m), 1.60-1.80 (2 H, m), 1.73-1.83 (1 H, m), 2.17 (1 H, dd, J = 13.2, 4.0 Hz), 2.22-2.31 (1 H, m), 2.44 (1 H, dd, J = 13.2, 10.3 Hz), 3.31 (3 H, s), 3.33 (1 H, d, J = 9.7 Hz), 3.38 (3 H, s), 3.46 (1 H, d, J = 9.7 Hz), 3.59 (2 H, s), 4.32 (1 H, d, J = 14.2 Hz), 4.41 (1 H, s), 4.45 (1 H, d, J = 6.4 Hz), 4.48 (1 H, d, J = 6.4 Hz), 4.54 (1 H, d, J = 14.2 Hz), 4.64 (2 H, s), 7.04 (2 H, d, J = 8.4 Hz), 7.21 (2 H, d, J = 8.4 Hz), 7.95 (1 H, s), 8.24 (1 H, s).

Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms.In my other articles, you can also check out more blogs about Sodium 1,2,4-triazol-1-ide.

Reference:
Patent; KUREHA CORPORATION; ARAKI, Nobuyuki; YAMAZAKI, Toru; KUSANO, Nobuyuki; IMAI, Eiyu; KANNO, Hisashi; MORI, Masaru; MIYAKE, Taiji; WO2011/70771; (2011); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Related Products of 7170-01-6, New discoveries in chemical research and development in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 7170-01-6, name is 3-Methyl-1H-1,2,4-triazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 3-methyl-lH-l,2,4~triazole (7.3 g, 88 mmol) in DMF (75 mL) was added K2CO3 (60.7 g5 439 mmol) and 2-bromopropionic acid teri-butyl ester (14.6 mL, 88 mmol). The reaction was stirred at room temperature overnight. The mixture was diluted with EtOAc (500 mL), washed with water (x 3) then brine. Dried over MgS04 and concentrated. The residue was purified by column chromatography on silica gel, eluting with EtOAc/isohexane (20 to 100%) to give 13 g of crude product as a 3:1 mixture of regioisomers. The mixture was purified by Cbiralcel OD with a gradient from 4% to 30% IP A/Heptane. Then the first two peaks were separated with Chiracel OD column isocratically eluting with 4% IP A/Heptane. The second peak was collected as the desired single stereoisomer (R or S) (2 -(3 -methyl- 1H- 1,2, 4- triazol-l-yl)propanoic acid iert-butyl ester) (3.5 g, 19%). 1H-NMR (500 MHz, CDC13) delta 8.05 (s, 1 H), 4.90 (q, J – 7 Hz, 1 H), 2.35 (s, 3 H), 1.72 (d, J = 7 Hz, 3 H), 1.40 (s, 9 H). ESI-MS calculated for C10H17N3O2: Exact Mass: 211.13; Found 156.05 (-tBu).

Future efforts will undeniably focus on the diversification of the new catalytic transformations. These may comprise an expansion of the substrate scope from aromatic and heteroaromatic compounds to other hydrocarbons. Keep reading other articles of 7170-01-6.

Reference:
Patent; MERCK SHARP & DOHME CORP.; NAGABUKURO, Hiroshi; EDMONDSON, Scott, D.; SINHAROY, Mary, Struthers; DENNEY, William, S.; FRENKL, Tara, L.; WO2011/43942; (2011); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics