Category: Triazoles

Related Products of 1455-77-2, New Advances in Chemical Research in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 1455-77-2, name is 3,5-Diamino-1,2,4-triazole, molecular formula is C2H5N5, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

General procedure: A solution of 10 mmol of 1,2,4-triazole-3,5-diamine, pyridine-2,6-diamine, or 4-hydroxypyrimidine-2,6-diamine in 50 mL of glacial acetic acid was slowly added to a solution of 20 mmol of phthalic anhydride or tetrachlorophthalic anhydride in 100 mL of glacial acetic acid. The colored solution was refluxed with constant stirring for 8 h at 100 °C (TLC monitoring; MeOH?CH2Cl2, 1 : 4) and poured into cold water. The colored precipitate was filtered off, dried in a vacuum desiccator over fused CaCl2, and recrystallized from DMSO.

By the way, if you are interested in learning more fun chemistry with your kids, get your hands into one chemistry set now, and start enjoying the best part of chemistry: experiments about 3,5-Diamino-1,2,4-triazole.

Reference:
Article; Arif; Nayab, P. Sirajuddin; Rahisuddin; Russian Journal of General Chemistry; vol. 86; 6; (2016); p. 1374 – 1380; Zh. Obshch. Khim.; vol. 86; 6; (2016); p. 1374 – 1380,7;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Research speed reading in 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 1455-77-2, name is 3,5-Diamino-1,2,4-triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C2H5N5

Example 11AEthyl 2-amino-7-(4-cyanophenyl)-5-methyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylateUnder an atmosphere of argon, ethyl 2-(4-cyanobenzylidene)-3-oxobutanoate (12.2 g, 50.1 mmol; preparation see WO 2004/020410-A2, Example 32A) and 1H-1,2,4-triazole-3,5-diamine (6.0 g, 60.5 mmol, 1.2 eq.) were dissolved in DMF (150 ml).Solid sodium bicarbonate (30.7 g, 365.6 mmol, 6 eq.) was added, and the mixture was stirred at 63° C. for 12 h.The mixture was then filtered and the DMF was distilled off from the filtrate under reduced pressure.The residue was suspended in ethanol and stirred, and the product was then filtered off and dried under high vacuum.This gave 12.45 g (76percent of theory) of the title compound.LC-MS (Method 4): Rt=2.29 min; MS (ESIpos): m/z (percent)=325.3 (100) [M+H]+; MS (ESIneg): m/z (percent)=323.3 (100) [M+H]-.1H-NMR (400 MHz, DMSO-d6): delta=1.00 (t, 3H), 2.40 (s, 3H), 3.95 (m, 2H), 5.25 (s, 2H), 6.05 (s, 1H), 7.35 (m, 2H), 7.75 (m, 2H), 10.6 (s, 1H).

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 3,5-Diamino-1,2,4-triazole, in my other articles.

Reference:
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; US2012/4203; (2012); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application of 60166-43-0, New discoveries in chemical research and development in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 60166-43-0, name is 1,4-Dimethyl-1H-1,2,3-triazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1,4-Dimethyl-1H-1,2,3-triazole (0.057 g, 0.588 mmol), potassium acetate (0.192 g,1.960 mmol), PdOAc2 (8.80 mg, 0.039 mmol) and di((3S,5S,7S)-adamantan-1-yl)(butyl)phosphine (cataCXium A) (0.028 g, 0.078 mmol) were suspended in 2- methylbutan-2-ol (2.57 ml, 23.51 mmol) under nitrogen. The reaction mixture was purged with nitrogen for 5 mm and then ()-5-(5-bromo-1-(4,4-difluorocyclohexyl)-1H- benzo[d]imidazol-2-yl)-1-(3,4-difluoro phenyl)pyrrolidin-2-one (0.2 g, 0.392 mmol) was added. The green suspension was heated to 100C for 24h. The reaction was cooledto RT and partitioned between EtOAc (40 mL) and water (30 ml). The organic phase was separated, washed with brine (25 ml) and then dried over MgSO4, filtered and concentrated in vacuo to afford a yellow oil.The crude product was purified by chromatography on silica gel (24 g column, 0-5% MeOH/DCM) to afford (S)-5-(1-(4,4- difluorocyclohexyl)-5 -(1 ,4-dimethyl- 1 H- 1,2,3 -triazol-5 -yl)- 1 H-benzo[d] imidazol-2-yl)-1-(3,4-difluorophenyl)pyrrolidin-2-one (69.5 mg, 33%) as beige solid; Rt 2.02 mm(method 1), mlz 527 (M+H)+ (ES+); 1H NIVIR (d6-DMSO) : 7.86 (ddd, J = 13.3, 7.4,2.7 Hz, 1H), 7.77 (d, J = 1.5 Hz, 1H), 7.67 (d, J = 8.5 Hz, 1H), 7.38 (q, J = 10.6, 9.2 Hz,1H), 7.32 (dd, J = 8.5, 1.7 Hz, 1H), 7.22 – 7.14 (m, 1H), 6.12 – 6.06 (m, 1H), 4.88 – 4.77(m, 1H), 3.90 (s, 3H), 2.81 -2.61 (m, 2H), 2.61 -2.42 (m, 3H), 2.31 -2.21 (m, 3H),2.19 (s, 3H), 2.17- 1.93 (m, 4H).

This is the end of this tutorial post, and I hope it has helped your research about 60166-43-0!

Reference:
Patent; CELLCENTRIC LTD; PEGG, Neil Anthony; TADDEI, David Michel Adrien; SHANNON, Jonathan; PAOLETTA, Silvia; QIN, Ting; HARBOTTLE, Gareth; (95 pag.)WO2018/73587; (2018); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

New discoveries in chemical research and development in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Product Details of 7411-23-6

15.38 g (67.79 mmol) of 3,5-dibromo-1H-1,2,4-triazole, 24.80 g (203.38 mmol) of phenylboronic acid, 7.83 g (6.78 mmol) of tetrakis(triphenylphosphine)palladium(0), and 18.74 g (135.59 mmol) of potassium carbonate were added to a mixed solution including 170 mL of tetrahydrofuran and 70 mL of water and stirred under reflux. After the reaction was completed, the reaction product was cooled to room temperature, and an aqueous solution layer was removed therefrom by extraction. The resultant was filtered under reduced pressure through silica gel, and the filtrate was concentrated under reduced pressure. The product obtained therefrom was separated by silica gel column chromatography to obtain 9.20 g (yield of 61%) of Intermediate (A). (0267) LC-Mass (Calcd: 221.10 g/mol, Found: M+1=222 g/mol)

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 3,5-Dibromo-1H-1,2,4-triazole help many people in the next few years.

Reference:
Patent; Samsung Electronics Co., Ltd.; Samsung SDI Co., Ltd.; KWON, Eunsuk; KIM, Sangmo; KIM, Jongsoo; SON, Jhunmo; JEON, Soonok; CHUNG, Yeonsook; JUNG, Yongsik; CHWAE, Jun; (150 pag.)US2019/334095; (2019); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Research speed reading in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 184177-83-1, name is 1-((2S,3S)-2-(Benzyloxy)pentan-3-yl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C30H35N5O3

100 mL three-neck flask was added 2-[(1S,2S)-1-ethyl-2-benzyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-3H-1,2,4-triazol-3-one (formula III) (6.08 g) and DMSO (30 mL) were dissolved with stirring. A 25% aqueous solution of sodium hydroxide (1.7 mL) was added and the mixture was stirred for 15 min. Add (5R)-5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl 4-methylbenzenesulfonate (formula IV) (6.12 g), the mixture is stirred at 40-50 C for 12-18 h. The reaction mixture was poured into water (60 mL) with vigorous stirring, stirring vigorously for 30 min, suction filtration, the filter cake was washed with water (30 mL), and dried under vacuum at 50 C to obtain 8.83 g of the compound of formula (V), yield 95.6 %.

The catalyzed pathway has a lower Ea, but the net change in energy that results from the reaction is not affected by the presence of a catalyst. In my other articles, you can also check out more blogs about 184177-83-1

Reference:
Patent; Kunming Jida Pharmaceutical Co., Ltd.; Yang Zhuqi; Zhang Poyong; Sun Xiaomei; Wang Lijiang; Zhang Yun; (13 pag.)CN108239077; (2018); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

New discoveries in chemical research and development in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 41253-21-8, name is Sodium 1,2,4-triazol-1-ide belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. 41253-21-8

3-Fluoro-2-l,2,4-triazol-l-yl-benzoniti”ile. A mixture of 2,3- difluorobenzylnitrile (2.27 g, 16.3 mmol) and triazole sodium salt (1.33 g, 14.8 mmol) in tetrahydrofuran (5 mL) and dimethylformamide (10 mL) was stirred at 85 C for 4 h. After concentration, the residue was purified by flash chromatography (SiO2) eluting with 25%-50% ethyl acetate/hexane. The isolated product was recrystallized from hot ethyl acetate/hexane to give the title compound as white needles (1.51 g, 54% yield). 1H-NMR (500 MHz, CDCl3) delta ppm: 8.50 (IH, d, J= 2.4 Hz), 8.25 (IH, s), 7.69-7.67 (IH, m), 7.60-7.57 (2H, m). LCMS [M+H]+ calcd for C9H6N4F: 189.16; found: 189.14.

If you are hungry for even more, make sure to check my other article about 41253-21-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2007/64316; (2007); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

New discoveries in chemical research and development in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 13423-60-4, name is 1-Phenyl-1H-1,2,4-triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. 13423-60-4

To 10 mL of chlorosulfonic acid at 0 C was added 1 g (6.9 mmol) of1-phenyl-1H-1,2,4-triazole, 35. The mixture was stirred overnight andthen cooled to 0 C. The solution was slowly added to ice and extracted3 three times with dichloromethane. The organic layers were combined,dried over sodium sulfate and concentrated to dryness in vacuo to give1 g of a tan solid. The crude sulfonyl chloride was used directlywithout further purification. To a microwave vial was added 25 mg(0.095 mmol) of the sulfonyl chloride, 15 mg (0.11 mmol) of 1,2,3,4-tetrahydroquinoline, 14 mg (0.014 mmol) of triethylamine and 300 muLof acetonitrile. The vial was sealed and heated at 130 C for 30 min. Themixture was diluted with dichloromethane and the organic phase waswashed 2 times with water and brine. The organic layer was dried oversodium sulfate and concentrated in vacuo. The crude sulfonamide waspurified by flash chromatography 0-75% EtOAc/Hexanes.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 1-Phenyl-1H-1,2,4-triazole help many people in the next few years.

Reference:
Article; Okolotowicz, Karl J.; Dwyer, Mary; Ryan, Daniel; Cheng, Jiongjia; Cashman, Emily A.; Moore, Stephanie; Mercola, Mark; Cashman, John R.; Bioorganic and Medicinal Chemistry; vol. 26; 15; (2018); p. 4441 – 4451;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Research speed reading in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 3641-08-5, name is 2H-1,2,4-Triazole-3-carboxamide belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Safety of 2H-1,2,4-Triazole-3-carboxamide

EXAMPLE 4 Preparation of 1(or 2 or 4)-p-Tolylsulfonyl-s-triazole-3-carboxamide To a cooled, stirred mixture of 3.0 g. of 1,2,4-triazole- 3-carboxamide and 5.1 g. of tosyl chloride in 125 ml. of anhydrous ether is added rapidly 2.75 g. of triethylamine. The cooling bath is removed and the mixture is stirred at room temperature for 23 hours. The heterogeneous mixture is filtered and washed successively with ether, cold water and then ether and dried in vacuo for 4.5 hours yielding a crude colorless solid. This solid is heated in about 50 ml. of acetonitrile and the hot mixture is filtered. The filtrate is concentrated to a smaller volume of about 20 ml. in vacuo.

The catalyzed pathway has a lower Ea, but the net change in energy that results from the reaction is not affected by the presence of a catalyst. In my other articles, you can also check out more blogs about 3641-08-5

Reference:
Patent; American Cyanamid Company; US4007198; (1977); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

New discoveries in chemical research and development in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world.956317-36-5, name is 5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. 956317-36-5

To a stirred solution of 7(184 mg,0.86 mmol) in DMF (5 ml) was added 92) (174 mg, 0.86 mmol), EDCI (198 mg, 1.03 mmol), HOAt (140 mg, 1.03 mmol), and N-methylmorpholine(0.5 ml, 4.30 mmol), the resulting mixture was stirred for 16 h at room temperature. The reaction mixture was diluted with EtOAc, sat.NaHCO3 aq, and organic phase was separated, the aqueous mixture was extracted with EtOAc. The organic phase and extracts were combined, dried over Na2SO4, and concentrated in vacuo. The residue was chromatographed on SiO2(Hexane- EtOAc = 2 : 1) to give 8 (300mg,87%) as a colorless oil. The 1H NMR and 13C NMR data for this compound was extremely complicated due to its existence as rotamers.1H NMR (500 MHz, CDCl3):delta 7.92-7.75 (3H, m), 7.33-7.10 (2H, m), 4.87-2.90 (7H, m), 2.41 (3H, s),2.19-1.88 (1H, m), 1.71-1.37 (10H, m), 1.31-1.10 (3H, m); 13C NMR(125 MHz, CDCl3): delta 169.59, 169.43, 168.98, 168.76, 154.89, 154.69,154.44, 138.16, 138.11, 137.81, 135.36, 135.24, 133.65, 133.57, 133.30, 130.12,129.52, 129.44, 129.03, 128.93, 128.27, 128.11, 127.95, 122.22, 122.13, 121.90,121.83, 79.54, 79.39, 52.02, 51.30, 48.16, 47.53, 46.39, 46.16, 45.49, 45.10,44.76, 44.41, 43.40, 42.96, 42.43, 42.03, 41.53, 41.16, 39.44, 36.85, 36.40,35.81, 35.02, 34.76, 34.47, 33.89, 29.40, 28.24, 28.16, 20.73, 20.67, 19.76,19.5517.96, 17.57, 17.33, 16.67; IR (neat): 1683, 1635 cm-1; MS (EI)m/z 399 (M+);HRMS (EI) calcd for C21H29N5O3:399.2270 (M+), found: 399.2273; [alpha]17 D -34.9 (c0.9, CHCl3).

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid ,and how the biochemistry of the body works.

Reference:
Article; Minehira, Daisuke; Takahara, Satoyuki; Adachi, Isao; Toyooka, Naoki; Tetrahedron Letters; vol. 55; 42; (2014); p. 5778 – 5780;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthetic Route of 41253-21-8, New Advances in Chemical Research in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 41253-21-8, name is Sodium 1,2,4-triazol-1-ide, molecular formula is C2H2N3Na, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

With a thermometer,Condenser tube,Add 120ml DMF to the 250ml four-mouth reaction bottle of the stirrerAnd 1,2,4-triazole sodium salt (18.5 g 203 mmol),Add 1-chloro-2-(4-chlorophenyl)-3-cyclopropylbutan-2-ol (44 g, 170 mmol),Heat to 100 C,Reaction 60-100min,Sampling analysis,When the content of 1-chloro-2-(4-chlorophenyl)-3-cyclopropylbutan-2-ol is less than 1%,It is considered as the end of the reaction.Cool to room temperature,The reaction droplets were added to 120 ml of cold water.Stir the precipitated solid,filter,Washed,dry,A cyclic azole solvent having a content of 96% is obtained.The weight yield is 90%.

Future efforts will undeniably focus on the diversification of the new catalytic transformations. These may comprise an expansion of the substrate scope from aromatic and heteroaromatic compounds to other hydrocarbons. Keep reading other articles of 41253-21-8.

Reference:
Patent; Huai’an Guorui Chemical Co., Ltd.; Zhang Pu; Jin Yucun; Li Ming; Chen Chao; Zhong Yu; Chen Mingguang; Wang Fengyun; (12 pag.)CN109400541; (2019); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics