Category: Triazoles

Related Products of 1533519-85-5, New Advances in Chemical Research in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 1533519-85-5, name is Methyl 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate, molecular formula is C18H17N3O2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

In a 100 ml three-necked flask equipped with a stirrer, a thermometer, 25 ml of DMF was added, the intermediate (IV)3.39 g, stirred at room temperature, 0.42 g of sodium hydroxide was added and 1.87 g of NBS was added in portions at 25 C,Add to maintain the stirring for 3 hours; add 50ml of water, then ethyl acetate 50ml x3 extraction, combined organicThe phases were concentrated and the ethyl acetate was removed by adding 25 ml of ethyl acetate / 50 ml of n-hexane to recrystallize,To give the product 3.55 g, i.e. intermediate (V), in a yield of 84.93%.

I am very proud of our efforts over the past few months and hope to Methyl 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate help many people in the next few years.

Reference:
Patent; Chengdu Baoyu Pharmaceutical Co., Ltd.; Lei, Lang; Li, Shanwei; Xiong, Bo; (10 pag.)CN105906576; (2016); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

New discoveries in chemical research and development in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 107534-96-3, name is 3-((1H-1,2,4-Triazol-1-yl)methyl)-1-(4-chlorophenyl)-4,4-dimethylpentan-3-ol belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Safety of 3-((1H-1,2,4-Triazol-1-yl)methyl)-1-(4-chlorophenyl)-4,4-dimethylpentan-3-ol

Complex trans-[PdCl2L2] (I) was prepared at 20by methods A and B at different predetermined Pd(II):L molar ratios. Method A: The batch ratio was Pd(II) : L = 1 : 2.To a magnetically stirred aqueous solution (3 mL) containing K2[PdCl4] (0.30 g, 0.92 mmol), the reagent L (0.57 g, 1.84 mmol) dissolved in acetone (6.5 mL)was added. The brown color of the solution quickly changed to orange. The bulky yellow precipitate was formed in 5 h; in 16 h after the evaporation of acetone,the precipitate was filtered out, washed with water and then hexane, and dried in air. The yield was 97%. Method B: The predetermined ratio was Pd(II) : L =1 : 1. To an aqueous solution (3 mL) containing K2[PdCl4] (0.30 g, 0.92 mmol), the reagent (0.28 g,0.92 mmol) dissolved in acetone (6.5 mL) was added under stirring. A yellow precipitate was formed in few minutes. After stirring for 24 h the precipitate was filtered out, washed with water and hexane, and dried. The yield was 81% based on the reagent.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 3-((1H-1,2,4-Triazol-1-yl)methyl)-1-(4-chlorophenyl)-4,4-dimethylpentan-3-ol help many people in the next few years.

Reference:
Article; Khisamutdinov; Shitikova; Anpilogova; Golubyatnikova; Mulagaleev; Murinov; Russian Journal of Inorganic Chemistry; vol. 60; 5; (2015); p. 638 – 646; Zh. Neorg. Khim.; vol. 60; 5; (2015); p. 710 – 718,9;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Reference of 7411-23-6, New Advances in Chemical Research in 2021. The appropriate choice of redox mediator can avoid electrode passivation and overpotential, which strongly inhibit the efficient activation of substrates in electrolysis. 7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole, molecular formula is C2HBr2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

Intermediate 5 3,5-dibromo-l-(2-methylpropyl)-lH-l,2,4-triazole Sodium te/t-butoxide (699 mg, 7.27 mmol) was added to a solution of 3,5-dibromo-l/-/-l,2,4- triazole (1.5 g, 6.61 mmol) in DMF (10 mL). The mixture was stirred at rt for 10 minutes. 1- Bromo-2-methylpropane (0.8 mL, 7.27 mmol) was added and the mixture was heated at 50C for 4 h and let to rt. Water (100 mL) was added and the mixture was extracted with EtOAc (2 x 50 mL). The organic phase was washed with brine (50 mL) and dried over sodium sulfate and concentrated to give the title compound as a liquid (1.47 g, 79%). XH NMR (400 MHz, CDCI3): delta ppm 0.94 (d, 6 H), 2.21 – 2.32 (m, 1 H), 3.93 (d, 2 H).

Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms.In my other articles, you can also check out more blogs about 3,5-Dibromo-1H-1,2,4-triazole.

Reference:
Patent; ACTURUM LIFE SCIENCE AB; BESIDSKI, Yevgeni; YNGVE, Ulrika; PAULSEN, Kim; LINDE, Christian; MALMBORG, Jonas; WO2014/195322; (2014); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Related Products of 7170-01-6, New Advances in Chemical Research in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 7170-01-6, name is 3-Methyl-1H-1,2,4-triazole, molecular formula is C3H5N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

A mixture of 3-methyl-lH-l,2,4-triazole (15.0 g, 181 mmol), 1,2- difluoro-4-nitrobenzene (28.7 g, 181 mmol), and sodium bicarbonate (15.2 g, 181 mmol) in DMSO (100 mL) was heated at 80 0C for 48 h . The reaction mixture was allowed to cool to rt and was poured into water (800 mL). The aqueous mixture was extracted with EtOAc (3 x 200 mL). The combined organic extracts were sequentially washed with water (500 mL) and brine solution (100 mL). The organic layer was dried over sodium sulfate, filtered, and concentrated in vacuo. The crude reaction mixture was purified using silica gel chromatography (30-80% EtOAc/hexane, linear gradient) to afford two regioisomeric products. Pure fractions of the less polar regioisomer were combined and concentrated to afford l-(2-fluoro- 4-nitrophenyI)-3-methyl-lH-l,2>;4-triazole (7.2 g, 30.8 mmol, 17 % yield) as an off- white solid. Pure fractions of the more polar regioisomer were combined and concentrated to afford l-(2~fluoro-4-nitrophenyl)-5-methyl-lH-l52,4-triazoIe (6.23 g, 28.0 mmol, 15 % yield) as an off-white solid. Data for l-(2-fluoro-4-nitrophenyl)-5-methyHH-l,2,4-triazole: LC-MS(M+H)+ = 223.1. 1HNMR (500 MHz, chloroform-*/) delta ppm 8.18 – 8.24 (m, 2 H) 8.04 (s, 1 H) 7.69 – 7.78 (m, 1 H) 2.47-2.53 (m, 3 H).Data for 1 -(2-fluoro-4-nitrophenyl)-3 -methyl- 1 H- 1 ,2,4-triazole: LC-MS (M+H)+ = 223.1. 1H NMR (500 MHz, chloroform-tO delta ppm 8.73 (d, J-2.7 Hz5I H), 8.15 – 8.26 (m, 3 H), 2.53 (s, 3 H).

Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms.In my other articles, you can also check out more blogs about 3-Methyl-1H-1,2,4-triazole.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; MARCIN, Lawrence, R.; THOMPSON, Lorin, A., III; BOY, Kenneth, M.; GUERNON, Jason, M.; HIGGINS, Mendi, A.; SHI, Jianliang; WU, Yong-Jin; ZHANG, Yunhui; MACOR, John, E.; WO2010/83141; (2010); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Reference of 288-88-0, New Advances in Chemical Research in 2021. The appropriate choice of redox mediator can avoid electrode passivation and overpotential, which strongly inhibit the efficient activation of substrates in electrolysis. 288-88-0, name is 1H-1,2,4-Triazole, molecular formula is C2H3N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

Operating protocol A (82 C., 48 hours) was followed using 117 mg of Chxn-Py-Al (0.4 mmoles), 336 mul of iodobenzene (3 mmoles), 138 mg of 1,2,4-triazole (2 mmoles), 1.042 g of caesium carbonate (3.2 mmoles) and 1.2 ml of DMF. The degree of transformation and selectivity were 100% and 98% respectively. The residue obtained following treatment was purified by silica gel chromatography (eluent: hexane/dichloromethane, 100/0 to 50/50). 264 mg of a dark yellow solid was obtained in a yield of 91%. Pale yellow needles were obtained after re-crystallisation from chloroform. The compound obtained had the following formula: The characteristics were as follows: MPt: 46 C. (CHCl3) (Lit: 46-47 C. given by Micetich, R G; Spevak, P; Hall, T W; Bains, B K; Heterocycles 1985, 23, 1645-1649); 1H NMR/CDCl3: delta8.52 (wide s, 1H, H1), 8.04 (wide s, 1H, H2), 7.53-7.65 (m, 2H, H4,8), 7.26-7.51 (m, 3H, H5,6,7); 13C NMR/CDCl3: delta 152.55 (C1), 140.88 (C2), 139.96 (C3), 129.73 (C5 and C7), 128.15 (C6), 119.99 (C4 and C8); GC/MS: Rt=14.02 min, M/Z=145, purity=100%; Rf=0.21 (eluent: dichloromethane/ethyl acetate, 90/10). Example 1.18; Preparation of 1-phenyl-1H-[1,2,4]triazole; Operating protocol A (82 C., 24 hours) was followed using 117 mg of Chxn-Py-Al (0.4 mmoles), 336 mul of iodobenzene (3 mmoles), 138 mg of 1,2,4-triazole (2 mmoles), 1.042 g of caesium carbonate (3.2 mmoles) and 1.2 ml of DMF. The degree of transformation and selectivity were 79% and 99% respectively. ; Example 1.19; Preparation of 1-phenyl-1H-[1,2,4]triazole; Example 1.18 was repeated, operating at 50 C. (72 hours). The degree of transformation and selectivity for 1-phenyl-1H-[1,2,4-triazole] were 75% and 99% respectively.

The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about 1H-1,2,4-Triazole, hurry up and to see.

Reference:
Patent; Taillefer, Marc; Cristau, Henri-Jean; Cellier, Pascal-Philippe; US2005/234239; (2005); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Research speed reading in 2021. The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic. 64922-04-9, name is Ethyl 1H-1,2,4-triazole-5-carboxylate belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of Ethyl 1H-1,2,4-triazole-5-carboxylate

(C-67) To a suspension of 1H-[1,2,4]triazole-3-carboxylate ethyl ester(Farmako, 1997, 52, p429)(1.0 g, 7.09 mmol)in ethanol(25 ml), were added 20% sodium ethoxide ethanol solution 3.3 ml and 4-fluorobenzylbromide(0.93 ml, 7.46 mmol) under ice-cooling and the mixture was stirred for 1.5 hour, Further, the mixture was stirred at room temperature for 30 minutes and at 80C for 40 minutes.. After cooling, water was added to the solution and the mixture was extracted with ethyl acetate.. The extract was washed with saturated brine and dried, then the solvent was evaporated under reduced pressure.. The residue was purified with silica gel column chromatography(ethyl acetate:n-hexane=1:1-1:3)to give 1-(4-fluorobenzyl)-1H-[1,2,4]triazole-3-carboxylate ethyl ester(754 mg, yield:42%). NNR(CDCl3)delta: 1.44(3H, t, J=7.2Hz), 4.48(2H, t, J=7.2Hz), 5.39(2H, s), 7.00-7.13(2H, m), 7.25-7.34(2H, m), 8.08(1H, s).

In conclusion, we affirm that quantitative kinetic descriptions of catalytic behavior continue to serve as an indispensable tool to navigate research efforts intended to model. Read on for other articles about 64922-04-9.

Reference:
Patent; SHIONOGI & CO., LTD.; EP1422218; (2004); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Research speed reading in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 7170-01-6, name is 3-Methyl-1H-1,2,4-triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. 7170-01-6

b) Trityl chloride (19.0 g) was added portionwise to a stirred solution of 3-methyl-1,2,4-triazole (5.6 g, commercial) and triethylamine (9.5 ml) in dichloromethane (200 ml). The mixture was diluted with dichloromethane (100 ml), washed with water (50 ml), dried over magnesium sulphate and evaporated under reduced pressure to give 1-trityl-3-methyl-1,2,4-triazole (19.0 g).

In conclusion, we affirm that quantitative kinetic descriptions of catalytic behavior continue to serve as an indispensable tool to navigate research efforts intended to model. Read on for other articles about 7170-01-6.

Reference:
Patent; Zeneca Limited; US5393732; (1995); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Related Products of 184177-83-1, New discoveries in chemical research and development in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 184177-83-1, name is 1-((2S,3S)-2-(Benzyloxy)pentan-3-yl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The 35.01 kg dimethyl sulfoxide, the mass concentration is 50% aqueous sodium hydroxide solution (sodium hydroxide 1.24 kg dissolved in pure water 1.24 kg, the mass concentration of the refer to sodium hydroxide of the quality of the sodium hydroxide solution the percentage of the total mass of the), adding 50L glass in the reactor, stirring solution cleaning, then adding 5.31 kg compound (III), stirring 20 – 30 minutes, adding 4.60 kg (3S, 5R) – toluene -4 – sulfonic acid 5 – (2, 4 – difluorophenyl) -5 – (1H – 1, 2, 4 – triazole -1 – yl) methyl tetrahydrofuran -3 – yl methyl ester (IV). After the completion of the feeding, temperature control 25 ± 5 C reaction 8 – 12 hours. TLC monitoring reaction, after the reaction. Control the temperature 20 – 30 C, the reaction with the sampler to 53.05 kg purification of water 100L glass reactor (rotational speed 200 – 300 rpm, dropping time 0.5 – 1.0 hours), continuously stirred for 0.5 – 1 hour. Centrifugal then adding to the basic solvent-free outflow; cake purified water 10.61 kg rear plate the basic solvent-free centrifugal to flow out. The centrifugal solid all input 50L glass in the reactor, adding 23.79 kg ethyl acetate, stirring until the solid completely dissolved. Layered, collecting the upper organic phase. Add silica gel 1.06 kg, heating to 50 – 60 C stirring 0.5 – 1 hour, cooled to 15 – 25 C, filtering. The filtrate batch transfer to 20L in the rotary evaporating bottle, at the vacuum degree of – 0.08 – – 0.1 mpa lower, control temperature 50 ± 10 C, concentrated to remove the ethyl acetate, to the solvent-free steam. To obtain brown oily matter. The oil of transfer to the 50L glass in the reactor, adding ethyl acetate 23.79 kg, heating to 50 ± 5 C, adds by drops positively hexane 36.71 kg (the dropping time 0.5 – 1.0 hours). Lowering the temperature to 20 ± 5 C stirring 2 – 3 hours, centrifugal to the solvent-free outflow, filter cake using mixed solvent (ethyl acetate 4.76 kg hexane 7.34 kg) leaching, centrifugal then adding to the solvent-free outflow. The centrifugal throughout the batch of wet product at the vacuum degree of – 0.08 – – 0.1 mpa lower, control temperature 40 – 50 C decompression drying 6 – 10 hours. A gray solid 6.00 kg compound (II). HPLC purity: 96.1%, yield: 73.4%.

By the way, if you are interested in learning more fun chemistry with your kids, get your hands into one chemistry set now, and start enjoying the best part of chemistry: experiments about 1-((2S,3S)-2-(Benzyloxy)pentan-3-yl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one.

Reference:
Patent; Shanghai Bozhi Yan Xin Pharmaceutical Co., Ltd.; Ying Shuhuan; Pi Hongjun; Liu Zhenfeng; Chen Jian; Qiao Yanhe; (12 pag.)CN106749207; (2017); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Related Products of 4928-87-4, New Advances in Chemical Research in 2021. The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic,A common heterocyclic compound, 4928-87-4, name is 1,2,4-Triazole-3-carboxylic acid, molecular formula is C3H3N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

Take 0 · 15g (0.31 mmol)The intermediate 27 was dissolved in 30 ml of CHCl, and 0 · lg (0.52 mmol) of EDCI was added to obtain 0.2 g (0.27 mmol) of 1,2,4-triazol-3- Formic acid, stirred at room temperature12h, TLC detection. The reaction was completed and the crude product was dried and purified by silica gel column chromatography (eluent: methanol / dichloromethane / aqueous ammonia = 50:500: 1,7: ¥: ¥) to give a white solid. Example 21 Target product 0.1 g Yield 55.5%

Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms.In my other articles, you can also check out more blogs about 1,2,4-Triazole-3-carboxylic acid.

Reference:
Patent; Beijing Foreland Pharma Co., Ltd; Zhang, Xingmin; Wang, Ensi; Niu, Shengxiu; Guo, Jing; Dai, Zhuolin; Zheng, Nan; Ji, Qi; Li, Qinyan; Liang, Tie; (109 pag.)CN104411706; (2016); B;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthetic Route of 10570-40-8, New Advances in Chemical Research in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 10570-40-8, name is 4-Methyl-4H-1,2,4-triazole, molecular formula is C3H5N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

Step 2. 40 mmol of 4-methyl-1,2,4-triazole and 80 mmol of ethyl chloride were stirred at 60 C under nitrogen atmosphere, and quaternized and refluxed for 24 h to cause quaternization reaction.The reaction product was washed with n-hexane and rotary evaporated to give a pale yellow liquid.1,2-Diethyl-4-methyl-1,2,4-triazole chloride 7.80 g

The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about 4-Methyl-4H-1,2,4-triazole, hurry up and to see.

Reference:
Patent; Nanjing Tech University; Guan Guofeng; Ding Jing; He Yuting; Li Xue; Yuan Dashui; Wan Hui; Wang Lei; (9 pag.)CN108250227; (2018); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics