Category: Triazoles

Authors Zhang, JH; Jin, B; Peng, RF; Niu, CH; Xiao, LPC; Guo, ZC; Zhang, QC in ROYAL SOC CHEMISTRY published article about SENSITIVITY; COCRYSTAL; SALTS; DESIGN in [Zhang, Jinhao; Jin, Bo; Peng, Rufang; Niu, Chunhuan; Xiao, Lipengcheng; Guo, Zhicheng; Zhang, Qingchun] Southwest Univ Sci & Technol, State Key Lab Environm Friendly Energy Mat, Mianyang 621010, Sichuan, Peoples R China in 2019.0, Cited 40.0. Product Details of 61-82-5. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

The layer-by-layer assembly of molecules is ubiquitous in nature. Highly ordered structures formed in this manner often exhibit fascinating material properties. A layer hydrogen bonding pairing approach allows the development of tunable energetic materials with targeted properties. A series of unusual energetic compounds based on 1H,1 ‘ H-5,5 ‘-bistetrazole-1,1 ‘-diolate (1), such as the salts of 3-amino-1,2,4-triazolium (2), aminoguanidinium (3), and hydrazinium (4), and the cocrystals of 4-amino-1H-pyrazole (5), 2-methylimidazole (6), and imidazole (7), were synthesized using this strategy. The structures of the obtained products 2-7 were fully characterized by elemental analysis, IR spectroscopy, H-1 NMR and C-13 NMR spectroscopy, and single-crystal X-ray analysis. Their thermal decomposition behavior was studied by differential scanning calorimetry and thermogravimetry. Their mechanical sensitivities and detonation performances were also analyzed in detail. Results show that products 2-7 exhibit higher density, better detonation performances, and more excellent sensitivities than those of the same species of cation salts previously reported.

Product Details of 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Zhang, JH; Jin, B; Peng, RF; Niu, CH; Xiao, LPC; Guo, ZC; Zhang, QC or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Rational Design and Synthesis of Diverse Pyrimidine Molecules Bearing Sulfonamide Moiety as Novel ERK Inhibitors WOS:000502786800074 published article about CARBONIC-ANHYDRASE INHIBITORS; BIOLOGICAL EVALUATION; ANTIPROLIFERATIVE ACTIVITY; ANTIMICROBIAL ACTIVITIES; DERIVATIVES; PYRAZOLE; ANTICANCER; DOCKING; COMPLEXES; RELEASE in [Halawa, Ahmed H.; Elgammal, Walid E.; Hassan, Saber M.; Hassan, Ahmed H.; El-Agrody, Ahmed M.] Al Azhar Univ, Fac Sci, Chem Dept, Cairo 11284, Egypt; [Eskandrani, Areej A.; Okasha, Rawda M.] Taibah Univ, Fac Sci, Chem Dept, Medina 30002, Saudi Arabia; [Hassan, Ahmed H.] Jazan Univ, Fac Sci, Chem Dept, Jazan 45142, Saudi Arabia; [Ebrahim, Hassan Y.] Helwan Univ, Fac Pharm, Pharmacognosy Dept, Cairo 11795, Egypt; [Mehany, Ahmed B. M.] Al Azhar Univ, Fac Sci, Zool Dept, Cairo 11284, Egypt in 2019.0, Cited 65.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Recommanded Product: 1H-1,2,4-Triazol-5-amine

Protein kinases orchestrate diverse cellular functions; however, their dysregulation is linked to metabolic dysfunctions, associated with many diseases, including cancer. Mitogen-Activated Protein (MAP) kinase is a notoriously oncogenic signaling pathway in human malignancies, where the extracellular signal-regulated kinases (ERK1/2) are focal serine/threonine kinases in the MAP kinase module with numerous cytosolic and nuclear mitogenic effector proteins. Subsequently, hampering the ERK kinase activity by small molecule inhibitors is a robust strategy to control the malignancies with aberrant MAP kinase signaling cascades. Consequently, new heterocyclic compounds, containing a sulfonamide moiety, were rationally designed, aided by the molecular docking of the starting reactant 1-(4-((4-methylpiperidin-1-yl)sulfonyl)phenyl)ethan-1-one (3) at the ATP binding pocket of the ERK kinase domain, which was relying on the molecular extension tactic. The identities of the synthesized compounds (4-33) were proven by their spectral data and elemental analysis. The target compounds exhibited pronounced anti-proliferative activities against the MCF-7, HepG-2, and HCT-116 cancerous cell lines with potencies reaching a 2.96 mu M for the most active compound (22). Moreover, compounds 5, 9, 10b, 22, and 28 displayed a significant G2/M phase arrest and induction of the apoptosis, which was confirmed by the cell cycle analysis and the flow cytometry. Thus, the molecular extension of a small fragment bounded at the ERK kinase domain is a valid tactic for the rational synthesis of the ERK inhibitors to control various human malignancies.

Recommanded Product: 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Halawa, AH; Eskandrani, AA; Elgammal, WE; Hassan, SM; Hassan, AH; Ebrahim, HY; Mehany, ABM; El-Agrody, AM; Okasha, RM or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Lee, YR; Do, XH; Hwang, SS; Baek, KY in [Lee, Yu-Ri; Do, Xuan Huy; Hwang, Seung Sang; Baek, Kyung-Youl] Korea Inst Sci & Technol, Mat Architecturing Res Ctr, Seoul 02792, South Korea; [Do, Xuan Huy; Baek, Kyung-Youl] Korea Univ Sci & Technol, KIST Sch, Div Nano Informat Technol, Seoul 02792, South Korea; [Baek, Kyung-Youl] Korea Res Inst Chem Technol, Ctr Convergent Chem Proc, 141 Gajeong Ro, Daejeon 34114, South Korea published Dual-functionalized ZIF-8 as an efficient acid-base bifunctional catalyst for the one-pot tandem reaction in 2021.0, Cited 29.0. Application In Synthesis of 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

An acid-base bifunctional zeolitic imidazolate framework catalyst (ZIF8-A61-SO3H) with amine and sulfonic acid groups was successfully prepared through simple two step post-synthetic modification: preparation of aminefunctionalized ZIF-8 with amine contents of 61% (ZIF8-A61) by the ligand exchange of 2-mIM with 3-amino1,2,4-triazole (Atz), followed by the sulfonic acid functionalization by the ring-opening reaction of 1,3-propanesultone with -NH2 groups in ZIF8-A61. Amine-functionalized ZIF8-A materials with difference amine contents (15%, 34%, and 61%, respectively) were also prepared by controlling the synthesis time. All obtained ZIF catalysts evaluated as a heterogeneous catalyst for one-pot deacetalization-Knoevenagel condensation tandem reaction. Compared with ZIF-8 and amine-functionalized ZIF-8 catalysts, ZIF8-A61-SO3H catalyst showed good catalytic performance with 100% conversion of the reactant and 98% selectivity of the final Knoevenagel product. An enhanced catalytic activity can be attributed to the co-existence of site-isolated acid-base groups on the ZIF8-A61-SO3H catalyst in close proximity. The heterogeneous nature of the catalytic system was confirmed by a hot-filtering test and the catalyst also exhibited reusable in the five repeated cycles. A plausible catalytic mechanism of deacetalization-Knoevenagel condensation reaction over ZIF8-A61-SO3H was also proposed.

Application In Synthesis of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Lee, YR; Do, XH; Hwang, SS; Baek, KY or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recommanded Product: 61-82-5. Authors Zhou, SR; Dong, Z; Yang, R; Wang, XY; Ye, ZW in WILEY-V C H VERLAG GMBH published article about in [Zhou, Shengren; Dong, Zhen; Yang, Rui; Wang, Xieyang; Ye, Zhiwen] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Peoples R China in 2021.0, Cited 24.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Two energetic compounds, erythritol tetranitrocarbamate (ETNC) and pentaerythritol tetranitrocarbamate (PETNC), and their salts, were synthesized in three steps, characterized and compared. All synthesized compounds were characterized by IR, DSC and multinuclear NMR spectroscopy. Four compounds were further investigated by single crystal X-ray diffraction. All nonmetal salts show extremely low mechanical sensitivity (IS >= 30 J; FS >= 360 N). The heats of formation were calculated using Gaussian 09, and the detonation performances were calculated using EXPLO 5. Although these nonmetal salts are lower than the neutral compounds ETNC (D: 7960 m s(-1), P: 27.4 GPa) and PETNC (D: 7629 m s(-1), P: 24.3 GPa), they possess high detonation performances that are better than TNT. Erythritol-based and corresponding pentaerythritol-based energetic materials were compared in terms of their thermostability, detonation velocity and detonation pressure. They were also compared in their respective series. ETNC and PETNC and their salts have short preparation steps and are easy to isolate in high yields, and thus have promising potential applications as explosives.

Recommanded Product: 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Zhou, SR; Dong, Z; Yang, R; Wang, XY; Ye, ZW or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Formula: C2H4N4. Authors Mu, YZ; Maharjan, Y; Dutta, RK; Wei, XF; Kim, JH; Son, J; Park, C; Park, R in PUBLIC LIBRARY SCIENCE published article about in [Mu, Yizhu; Maharjan, Yunash; Dutta, Raghbendra Kumar; Wei, Xiaofan; Kim, Jin Hwi; Son, Jinbae; Park, Channy; Park, Raekil] Gwangju Inst Sci & Technol, Dept Biomed Sci & Engn, Gwangju, South Korea in 2021.0, Cited 36.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Peroxisomes are metabolically active organelles which are known to exert anti-inflammatory effects especially associated with the synthesis of mediators of inflammation resolution. However, the role of catalase and effects of peroxisome derived reactive oxygen species (ROS) caused by lipid peroxidation through 4-hydroxy-2-nonenal (4-HNE) on lipopolysaccharide (LPS) mediated inflammatory pathway are largely unknown. Here, we show that inhibition of catalase by 3-aminotriazole (3-AT) results in the generation of peroxisomal ROS, which contribute to leaky peroxisomes in RAW264.7 cells. Leaky peroxisomes cause the release of matrix proteins to the cytosol, which are degraded by ubiquitin proteasome system. Furthermore, 3-AT promotes the formation of 4HNE-I kappa B alpha adduct which directly interferes with LPS induced NF-kappa B activation. Even though, a selective degradation of peroxisome matrix proteins and formation of 4HNE- I kappa B alpha adduct are not directly related with each other, both of them are could be the consequences of lipid peroxidation occurring at the peroxisome membrane.

Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Mu, YZ; Maharjan, Y; Dutta, RK; Wei, XF; Kim, JH; Son, J; Park, C; Park, R or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recently I am researching about DESIGN; INHIBITOR; POTENT; 5-AMINOPYRAZOLE; ANAGLIPTIN; DINACICLIB; ESSRAMYCIN; PYRAZOLE, Saw an article supported by the . Published in SPRINGER in NEW YORK ,Authors: Gol, RM; Khatri, TT; Barot, VM. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine. Computed Properties of C2H4N4

Efficient and regioselective on-water synthesis of variously substituted 5-amino-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carbonitriles and 5-amino-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitriles using 1,8-diazabicyclo[5.4.0]undec-7-ene as catalyst has been demonstrated. The reaction of 2-benzylidenemalononitriles and 3-aryl-1H-pyrazol-5-amines or 1H-1,2,4-triazol-5-amine allows to obtain the respective pyrazolo[1,5-a]pyrimidines and [1,2,4]triazolo[1,5-a]pyrimidines in high yields up to 93%. Main advantages of the developed synthetic protocol are application of water as environmentally friendly solvent, short reaction times, simple workup procedure that often does not require further purification of products, and broad substrate scope.

Computed Properties of C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Gol, RM; Khatri, TT; Barot, VM or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recommanded Product: 1H-1,2,4-Triazol-5-amine. Authors Kovygin, YA; Vandyshev, DY; Ledenyova, IV; Kosheleva, EA; Polikarchuk, VA; Kozaderov, OA; Shikhaliev, KS in SPRINGER published article about in [Kovygin, Yu A.; Vandyshev, D. Yu; Ledenyova, I., V; Kosheleva, E. A.; Polikarchuk, V. A.; Kozaderov, O. A.; Shikhaliev, Kh S.] Voronezh State Univ, 1 Univ Skaya Pl, Voronezh 394018, Russia in 2021.0, Cited 36.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

A convenient method for the synthesis of 2-(2-R-5-oxo-6,7-dihydro-4H-[1,2,4]triazolo-[1,5-a]pyrimidin-6-yl)acetanilides based on the regioselective domino reaction of N-arylitaconimides with substituted 3-aminotriazoles was proposed. Presumably, the reaction pathway includes the conjugated aza-addition of the endo-nucleophilic center of triazole to imide, followed by the recyclization of the intermediate to triazolo[1,5-a]pyrimidine.

Recommanded Product: 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Kovygin, YA; Vandyshev, DY; Ledenyova, IV; Kosheleva, EA; Polikarchuk, VA; Kozaderov, OA; Shikhaliev, KS or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Category: Triazoles. Recently I am researching about BIOLOGICAL-ACTIVITIES; DERIVATIVES; BENZOFURAN, Saw an article supported by the . Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Ibrahim, MA; Allehyani, ES. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

The chemical behavior of 4,9-dimethoxy-5-oxo-5H-furo[3,2-g]-chromene-6-carbonitrile (khellin-6-carbonitrile) (1) was examined towards a variety of nitrogen nucleophiles. Some novel Schiff bases 5-7 were prepared from reaction of carbonitrile 1 with some heterocyclic amines. Treatment of carbonitrile 1 with some hydrazine derivatives in boiling ethanol afforded pyrazole derivatives 8-13. Khellin-6-carbonitrile (1) reacted with hydrazine hydrate and phenylhydrazine in acetic acid to afford angular heteroannulated furo[3′,2′:6,7]-chromeno [4,3-c]pyrazol-4(1H)-one derivatives 14 and 15. Triazolo[1,5-a]pyrimidine 16 and pyrimido[1,2-a]benzimidazole 17 were synthesized through ring opening and recyclization reactions of compound 1 with 3-amino-1,2,4-triazole and 2-aminobenzimidazole, respectively. Reaction of compound 1 with guanidine and cyanoguanidine in ethanolic potassium hydroxide solution resulted in ring conversion giving the novel angular furo [3 ‘,2’ :6,7] chromeno [4,3-d]pyrimidin-5-ones 18 and 19. The antimicrobial activity of the prepared compounds appeared distinguish activity against the selected microorganisms.

Category: Triazoles. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Ibrahim, MA; Allehyani, ES or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Formula: C2H4N4. I found the field of Metallurgy & Metallurgical Engineering very interesting. Saw the article Chamber Protection of Copper from Atmospheric Corrosion by Compounds of the Triazole Class published in 2020.0, Reprint Addresses Kuznetsov, YI (corresponding author), Russian Acad Sci, AN Frumkin Inst Phys Chem & Electrochem, Moscow 119071, Russia.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine.

Using a set of physicochemical (ellipsometry and contact angle measurements), electrochemical (electrochemical impedance spectroscopy and polarization measurements), and corrosion (periodic moisture condensation and salt fog tests) methods, the properties of adsorption films formed on copper by the chamber method from vapors of benzotriazol (BTA), 1H-1,2,4-triazole, tolyltriazole (TTA), 5-chloro-1,2,3-benzotriazole (CBTA), 3-amino-1H-1,2,4-triazole, and 4-amino-1H-1,2,4-triazole at a temperature of 100 degrees C are studied. It is shown that 1-h chamber treatment of copper with vapors of these compounds leads to the formation of nanoscale hydrophobic adsorption films on it, which inhibits the thermal growth of oxides, but stabilizes the passive state of the metal and increases its corrosion resistance. Among these different triazole compounds tested as chamber corrosion inhibitors, BTA and its substituted derivatives are distinguished. After a 1-h chamber treatment of copper, the protective aftereffect of the adsorption films of triazole derivatives grows symbatically with their saturated vapor pressure at the chamber treatment temperature, i.e., in the following increasing order: CBTA < TTA < BTA. This may indicate that the equilibrium adsorption films do not have time to form at 100 degrees C on the metal within this time period. After a prolonged (24 h or more) chamber treatment of copper with vapors of substituted benzotriazoles, equilibrium adsorption films of inhibitors are formed on it. In this case, the influence of the chamber inhibitor properties on their protective aftereffect alternates. Under such conditions, the least volatile and most hydrophobic substituted benzotriazole, i.e., CBTA, provide the best metal protection. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Goncharova, OA; Luchkin, AY; Andreev, NN; Kuznetsov, YI; Andreeva, NP or concate me.. Product Details of 61-82-5

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Authors Sun, GC; Hu, Y; Sha, YY; Shi, CD; Yin, G; Zhang, HP; Liu, HJ; Liu, Q in ELSEVIER SCIENCE SA published article about ENERGY-STORAGE; ELECTROCHEMICAL PROPERTIES; POLYMER; ELECTRODES; CAPACITY; PERFORMANCE; CARBONYL; MOLECULES; COMPOUND in [Sun, Guangchi; Sha, Yanyong; Shi, Changdong; Zhang, Hanping; Liu, Qi] Changzhou Univ, Sch Petrochem Engn, Jiangsu Key Lab Adv Catalyt Mat & Technol, 1 Gehu Rd, Changzhou 213164, Jiangsu, Peoples R China; [Sun, Guangchi; Sha, Yanyong; Shi, Changdong; Zhang, Hanping; Liu, Qi] Changzhou Univ, Jiangsu Prov Key Lab Fine Petrochem Engn, 1 Gehu Rd, Changzhou 213164, Jiangsu, Peoples R China; [Hu, Yao; Liu, Hong-Jiang] Shanghai Univ, Coll Sci, Dept Chem, 99 Shangda Rd, Shanghai 200444, Peoples R China; [Yin, Gui; Liu, Qi] Nanjing Univ, State Key Lab Coordinat Chem, Nanjing 210093, Jiangsu, Peoples R China in 2019.0, Cited 58.0. HPLC of Formula: C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

A new naphthalenediimide derivative, 2, 7-di (1, 2, 4-triazolyl) benzophenanthroline-tetraone (3-DTBPT) is synthesized by the condensation reaction of 1, 4, 5, 8-naphthalenetetracarboxylic anhydride (NTCDA) and 3-amino-1, 2, 4-triazole (3-AT). The 3-DTBPT material is characterized by Fourier transform infrared spectrum, X-ray diffraction, thermogravimetric analysis, solid state NMR spectra, field emission scanning electron microscopy, elemental analysis and Brunauer-Emmett-Teller surface. 3-DTBPT is insoluble in organic electrolyte. When used as a cathode material of lithium-ion batteries, 3-DTBPT exhibits an excellent cyclic stability, keeping a specific capacity of 110 mA h g(-1) and a nearly 94.8% capacity retention after 50 cycles at 50 mA g(-1). Our work provides an effective route for overcoming the dissolution problem of organic electrode materials and obtains a potential material for the long-cycle-life and flexible organic rechargeable batteries.

HPLC of Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Sun, GC; Hu, Y; Sha, YY; Shi, CD; Yin, G; Zhang, HP; Liu, HJ; Liu, Q or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics