Triazoles -| Page 313 of 762

Brief introduction of C2H4N4

Safety of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Wu, CB; Yu, GH; Yin, Y; Wang, YZ; Chen, L; Han, Q; Tang, JW; Wang, B or concate me.

An article Mesoporous Polymeric Cyanamide-Triazole-Heptazine Photocatalysts for Highly-Efficient Water Splitting WOS:000558656000001 published article about GRAPHITIC CARBON NITRIDE; HYDROGEN EVOLUTION; FACILE SYNTHESIS; SEMICONDUCTORS; REDUCTION; NITROGEN; PERFORMANCE; PRECURSORS; NANOSHEETS; STRATEGY in [Wu, Chongbei; Yu, Guanhang; Yin, Yue; Wang, Yuze; Chen, Li; Han, Qing; Wang, Bo] Beijing Inst Technol, Key Lab Cluster Sci, Key Lab Photoelect Electrophoton Convers Mat, Minist Educ China,Sch Chem & Chem Engn, Beijing 100081, Peoples R China; [Tang, Junwang] UCL, Dept Chem Engn, London WC1E 7JE, England in 2020.0, Cited 65.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Safety of 1H-1,2,4-Triazol-5-amine

Conjugated polymers are promising light harvesters for water reduction/oxidation due to their simple synthesis and adjustable bandgap. Herein, both cyanamide and triazole functional groups are first incorporated into a heptazine-based carbon nitride (CN) polymer, resulting in a mesoporous conjugated cyanamide-triazole-heptazine polymer (CTHP) with different compositions by increasing the quantity of cyanamide/triazole units in the CN backbone. Varying the compositions of CTHP modulates its electronic structures, mesoporous morphologies, and redox energies, resulting in a significantly improved photocatalytic performance for both H(2)and O(2)evolution under visible light irradiation. A remarkable H(2)evolution rate of 12723 mu mol h(-1)g(-1)is observed, resulting in a high apparent quantum yield of 11.97% at 400 nm. In parallel, the optimized photocatalyst also exhibits an O(2)evolution rate of 221 mu mol h(-1) g(-1), 9.6 times higher than the CN counterpart, with the value being the highest among the reported CN-based bifunctional photocatalysts. This work provides an efficient molecular engineering approach for the rational design of functional polymeric photocatalysts.

Safety of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Wu, CB; Yu, GH; Yin, Y; Wang, YZ; Chen, L; Han, Q; Tang, JW; Wang, B or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

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HPLC of Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Ma, HF; Li, WB; Ablajan, K or concate me.

In 2019.0 CHINESE J ORG CHEM published article about SOLVENT-FREE SYNTHESIS; CONVENIENT; TRIAZOLOQUINAZOLINONE; 3-COMPONENT; SYSTEMS in [Ma, Huifang; Li, Wenbo; Ablajan, Keyume] Xinjiang Univ, Coll Chem & Chem Engn, Key Lab Oil & Gas Fine Chem, Minist Educ & Xinjiang Uyghur Autonomous Reg, Urumqi 830046, Peoples R China in 2019.0, Cited 27.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. HPLC of Formula: C2H4N4

Under the catalysis of solid acidic ion exchange resin Amberlyst-15, using ethanol as solvent, aromatic aldehyde, beta-ketoester, and 3-amino-1,2,4-triazole or 2-aminobenzo as starting materials, a series of triazolo[1,5-a]pyrimidine derivatives 5a similar to 5m and dihydrobenzo[4,5]imidazo[1,2-a]pyrimidines 6a similar to 6g were synthesized by three-component one-pot reaction of imidazole derivatives. The method is simple and efficient, and has short reaction time, simple post-treatment and wide application range of the substrate. The catalyst can be recycled for 4 times without the significant decrease of catalytic activity. It conforms to the basic standard of green chemistry.

HPLC of Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Ma, HF; Li, WB; Ablajan, K or concate me.

Discovery of 61-82-5

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Wang, Z; Yu, Z; Kang, DW; Zhang, J; Tian, Y; Daelemans, D; De Clercq, E; Pannecouque, C; Zhan, P; Liu, XY or concate me.. HPLC of Formula: C2H4N4

An article Design, synthesis and biological evaluation of novel acetamide-substituted doravirine and its prodrugs as potent HIV-1 NNRTIs WOS:000455855200001 published article about REVERSE-TRANSCRIPTASE INHIBITOR; COLORIMETRIC ASSAY; PATENT EVALUATION; DISCOVERY; STRATEGIES; GW678248 in [Wang, Zhao; Yu, Zhao; Kang, Dongwei; Zhang, Jian; Tian, Ye; Zhan, Peng; Liu, Xinyong] Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Dept Med Chem,Key Lab Chem Biol, 44 West Culture Rd, Jinan 250012, Shandong, Peoples R China; [Daelemans, Dirk; De Clercq, Erik; Pannecouque, Christophe] Katholieke Univ Leuven, Lab Virol & Chemotherapy, Rega Inst Med Res, Herestr 49 Postbus 1043 09-A097, B-3000 Leuven, Belgium in 2019.0, Cited 30.0. HPLC of Formula: C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

A novel series of acetamide-substituted derivatives and two prodrugs of doravirine were designed and synthesized as potent HIV-1 NNRTIs by employing the structure-based drug design strategy. In MT-4 cell-based assays using the MTT method, it was found that most of the new compounds exhibited moderate to excellent inhibitory potency against the wild-type (WT) HIV-1 strain with a minimum EC50 value of 54.8 nM. Among them, the two most potent compounds 8i (EC50 = 59.5 nM) and 8k (EC50 = 54.8 nM) displayed robust activity against WT HIV-1 with double-digit nanomolar EC50 values, being superior to lamivudine (3TC, EC50= 12.8 mu M) and comparable to doravirine (EC50= 13 nM). Besides, 8i and 8k shown moderate activity against the double RT mutant (K103N + Y181C) HIV-1 RES056 strain. The HIV-1 RT inhibition assay further validated the binding target. Molecular simulation of the representative compounds was employed to provide insight on their structure-activity relationships (SARs) and direct future design efforts. Finally, the aqueous solubility and chemical stability of the prodrugs 9 and 10 were investigated in detail.

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Recommanded Product: 1H-1,2,4-Triazol-5-amine. I found the field of Chemistry; Polymer Science very interesting. Saw the article Preparation of 2,6-diurea-chitosan oligosaccharide derivatives for efficient antifungal and antioxidant activities published in 2020.0, Reprint Addresses Guo, ZY (corresponding author), Chinese Acad Sci, Key Lab Coastal Biol & Bioresource Utilizat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine.

In this study, 2-urea-chitosan oligosaccharide derivatives (2-urea-COS derivatives) and 2,6-diurea-chitosan oligosaccharide derivatives (2,6-diurea-COS derivatives) were successfully designed and synthesized via intermediate 2-methoxyformylated chitosan oligosaccharide. All samples were characterized and compared based on FT-IR, H-1 NMR spectroscopy, and elemental analysis. The antifungal effects of COS derivatives were tested against Fusarium oxysporum f. sp. niveum, Phomopsis asparagus, and Botrytis cinereal. Their antioxidant properties, including superoxide radicals’ scavenging activity, hydroxyl radicals’ scavenging activity, and DPPH radicals’ scavenging activity were also explored within different concentrations. COS derivatives bearing urea groups showed improved bioactivity compared with pristine COS and 2,6-diurea-COS derivatives had a higher biological activity than 2-urea-COS derivatives in tested concentrations. Additionally, L929 cells were used to carry out cytotoxicity test of COS and COS derivatives by CCK-8 assay. The results indicated that some of samples showed low cytotoxicity. These findings offered a suggestion that COS derivatives bearing urea groups are promising biological materials.

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Computed Properties of C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Kachaeva, MV; Pilyo, SG; Hartline, CB; Harden, EA; Prichard, MN; Zhirnov, VV; Brovarets, VS or concate me.

Computed Properties of C2H4N4. In 2019.0 MED CHEM RES published article about GANCICLOVIR; INHIBITION; MUTATIONS in [Kachaeva, Maryna V.; Pilyo, Stepan G.; Zhirnov, Victor V.; Brovarets, Volodymyr S.] NAS Ukraine, VP Kukhar Inst Bioorgan Chem & Petrochem, Dept Chem Bioact Nitrogen Containing Heterocycl B, 1 Murmanskaya Str, UA-02094 Kiev, Ukraine; [Hartline, Caroll B.; Harden, Emma A.; Prichard, Mark N.] Univ Alabama Birmingham, Dept Pediat, Birmingham, AL 35233 USA in 2019.0, Cited 34.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Ten 5-functionalized derivatives of 1,3-oxazole-4-carboxylate and 1,3-oxazole-4-carbonitrile were synthesized and their antiviral activities against the human cytomegalovirus (HCMV) were evaluated in vitro. Bioassays showed that seven compounds exhibited considerably higher antiviral activity (EC50:<0.05M) against a normal laboratory HCMV strain (AD-169) in human foreskin fibroblast cells than Ganciclovir (EC50=0.32M), an anti-HCMV agent in clinical use. Additionally, the HCMV-resistant isolate (GDGr K-17) was tested for sensitivity to 1,3-oxazole derivatives with most antiviral potency against the strain AD169. A one of them (5-((2-hydroxyethyl)(methyl)amino)-2-(4-methylphenyl)-1,3-oxazole-4-carbonitrile) showed very high potency (EC50:<0.05; CC50: >150 mu M, and SI50=3125) towards the resistant isolate compared to standard drugs Cidofovir (EC50=0.10 mu M, CC50: >30 mu M and SI50: <4). But, in contrast to the primary assays, the antiviral activity of these compounds against both the normal strain and the resistant isolate of HCMV were considerably less than one of Cidofovir in secondary assay. These results provided evidence that derivatives of 1,3-oxazole could be useful for developing new anti-HCMV drugs. Computed Properties of C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Kachaeva, MV; Pilyo, SG; Hartline, CB; Harden, EA; Prichard, MN; Zhirnov, VV; Brovarets, VS or concate me.

The important role of C2H4N4

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Badran, A; El-Gohary, NM; Ibrahim, MA; Hashiem, SH or concate me.. Application In Synthesis of 1H-1,2,4-Triazol-5-amine

An article Reactivity of some 3-substituted-6,8-dimethylchromones toward some nucleophilic reagents WOS:000521606600001 published article about RING-CLOSURE REACTIONS; ANTIANAPHYLACTIC AGENTS; 3-SUBSTITUTED CHROMONES; ANTITUMOR-ACTIVITY; FACILE SYNTHESIS; ANTIOXIDANT; COMPLEXES; CU(II); SERIES in [Badran, Al-Shimaa; El-Gohary, Nasser M.; Ibrahim, Magdy A.; Hashiem, Salsabeel H.] Ain Shams Univ, Fac Educ, Dept Chem, Cairo 11711, Egypt in 2020.0, Cited 36.0. Application In Synthesis of 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

The reactivity of 3-substituted-6,8-dimethylchromone derivatives 1-5 was investigated toward selected nucleophilic reagents namely; 3-amino-1,2,4-triazole, 2-aminobenzimidazole, 7-chloro-4-hydrazinoquinoline, and 5,6-diphenyl-3-hydrazino-1,2,4-triazine. These nucleophiles were allowed to react with 6,8-dimethylchromone-3-carboxaldehyde (1) through condensation with the aldehyde group with opening of gamma-pyrone ring giving compounds 6, 7, 10, and 11. Reactions with 6,8-dimethylchromone-3-carbonitrile (2), and 6,8-dimethylchromone-3-carboxylic acid (3) occur via attack at position 2 in both compounds followed by cycloaddition onto the nitrile function (in case of carbonitrile 2) or decarboxylation and cyclocondensation with the carbonyl group (in case of carboxylic acid 3). The current nucleophilic reagents reacted with simple condensation products 4 and 5, in boiling dioxane, through nucleophilic addition at the exocyclic vinyl bond followed by addition at the C(sic)N group giving 6,8-dimethylchromone linked various heterocyclic systems 20-27.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Badran, A; El-Gohary, NM; Ibrahim, MA; Hashiem, SH or concate me.. Application In Synthesis of 1H-1,2,4-Triazol-5-amine

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Recommanded Product: 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Jog, KV; Sierra-Alvarez, R; Field, JA or concate me.

An article Rapid biotransformation of the insensitive munitions compound, 3-nitro-1,2,4-triazol-5-one (NTO), by wastewater sludge WOS:000528211000001 published article about 2,4-DINITROANISOLE DNAN; BIODEGRADATION; DEGRADATION; REDUCTION; NITROAROMATICS; TRANSFORMATION; ENERGETICS; TOXICITY; IMX-101 in [Jog, Kalyani, V; Sierra-Alvarez, Reyes; Field, Jim A.] Univ Arizona, Dept Chem & Environm Engn, Tucson, AZ 85721 USA in 2020.0, Cited 40.0. Recommanded Product: 61-82-5. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

As the use of the new insensitive munitions compound 3-nitro-1,2,4-triazol-5-one (NTO) increases, wastewaters, runoff and groundwater containing NTO will be generated. Little is known about the fate of NTO during biological wastewater treatment. The objective of this study was to explore the ability of wastewater sludges to promote the biotransformation of NTO. Three different sludges, i.e., anaerobic granular sludge, anaerobic digested sludge, and return activated sludge, were used to study the biotransformation of NTO under anaerobic conditions. Three different electron donor amendments were compared- hydrogen, ethanol, and acetate. Mixed microbial communities in each of the three sludge sources were effective in the reductive biotransformation of NTO. 3-amino-1,2,4-triazol-5-one (ATO) was observed as the major product of NTO biotransformation. The highest maximum specific rate of NTO reduction, about 120 mg NTO/g volatile suspended solids/d, was observed in anaerobic granular sludge with hydrogen or ethanol supplied as electron donors. NTO biotransformation to ATO by anaerobic digested sludge was also studied under denitrifying conditions. In this case, reduction of NTO started only after complete denitrification of added nitrate. An important implication of this paper is that sludge from wastewater treatment plants can rapidly and readily reduce NTO to ATO. [GRAPHICS] .

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About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Zhang, QM; Li, D; Cao, XK; Gu, HX; Deng, W or concate me.. Recommanded Product: 61-82-5

In 2019.0 ANAL CHEM published article about SERS DETECTION; NANOPARTICLES; POINT; PRECONCENTRATION; MOLECULES; FILMS in [Zhang, Qinmei; Li, Dan; Cao, Xiukai; Deng, Wei] Shanghai Inst Technol, Sch Chem & Environm Engn, 100 Haiquan Rd, Shanghai 201418, Peoples R China; [Gu, Haixin] Shanghai Fire Res Inst MEM, 918 Minjing Rd, Shanghai 200438, Peoples R China in 2019.0, Cited 36.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Recommanded Product: 61-82-5

Development of flexible surface-enhanced Raman spectroscopy (SERS) substrate with controllable hot spots has spurred increasing interest because of its unique structure and plasmonic properties. Here, charged poly(vinyl alcohol) microgels containing silver nanoparticles are developed by using microfluidic emulsification to produce a smart SERS sensor with charge screening and signals amplification. Importantly, this charged microgel enables the selective concentration of counter-charged molecules and induces the formation of assembled arrays at an immiscible liquid-liquid interface because of the electrostatic interaction. The SERS-active microgels arrays possess controllable structures and facilitate on-site determination of charged pesticides with an enhancement factor of 5.0 x 10(5). Such nanostructures present the ease of assembly, stability, and reproducibility which allow multiplex detection of analytes at aqueous and organic phases without any pretreatment of complex matrix samples. The interfacial sensing platform for on-site SERS analysis of charged pesticides will open vast possibilities for a wide range of in-field applications.

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An update on the compound challenge: C2H4N4

Name: 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Yuan, S; Wang, SX; Zhao, M; Zhang, DQ; Chen, JJ; Li, JX; Zhang, JY; Song, YH; Wang, JY; Yu, B; Liu, HM or concate me.

Name: 1H-1,2,4-Triazol-5-amine. Yuan, S; Wang, SX; Zhao, M; Zhang, DQ; Chen, JJ; Li, JX; Zhang, JY; Song, YH; Wang, JY; Yu, B; Liu, HM in [Yuan, Shuo; Wang, Sixi; Zhao, Min; Zhang, Danqing; Chen, Jinjie; Li, Jian-Xin; Zhang, Jingya; Song, Yihui; Wang, Jinyi; Yu, Bin; Liu, Hongmin] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China published Bronsted acid-promoted ‘on-water’ C(sp(3))-H functionalization for the synthesis of isoindolinone/[1,2,4]triazolo[1,5-a]pyrimidine derivatives targeting the SKP2-CKS1 interaction in 2020.0, Cited 33.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

The isoindolinone and biaryl scaffolds are prevalent in natural products and drug molecules, which have showed broad and interesting biological activities. The efficient construction of such hybridized molecules and biological evaluation are of great interest to medicinal chemistry community. In this communication, we report an efficient Bronsted acid-promoted C(sp(3))-H functionalization approach that enables the rapid construction of biologically important isoindolinone/[1,2,4]triazolo[1,5-a]pyrimidine hybrids from 5-methyl-7-(2,4,6-trimethoxyphenyl)-[1,2,4]triazolo[1,5-a]pyrimidine, 2-formylbenzoic acid and various anilines. The title compounds were generated in high to excellent yields (up to 96%) regardless of the electronic nature and steric effects of the substituents. In this reaction, an isoindolinone scaffold, one C-C single bond, and two C-N bonds were formed simultaneously with high atom economy. In this work, we have envisioned that the methyl group linked to the electron-deficient N-heterocycles could be used as a new synthetic handle for late-state diversification and may have broad applications in the field of organic and medicinal chemistry. Besides, the title compounds have exhibited promising activity against the SKP2-CKS1 interaction. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

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Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Yu, L; Liu, WJ; Guo, ZW; Li, ZQ; Jiang, HY; Zou, Q; Mao, ZL; Fang, HC; Zhang, ZY; Wang, N; Chen, XS or concate me.

Yu, L; Liu, WJ; Guo, ZW; Li, ZQ; Jiang, HY; Zou, Q; Mao, ZL; Fang, HC; Zhang, ZY; Wang, N; Chen, XS in [Yu, Lei; Liu, Wenjun; Guo, Zhangwen; Li, Zhiqiang; Jiang, Huiyan; Zou, Qi; Mao, Zuolin; Zhang, Zongying; Wang, Nan; Chen, Xuesen] Shandong Agr Univ, Coll Hort Sci, State Key Lab Crop Biol, 61 Daizong Rd, Tai An 271018, Shandong, Peoples R China; [Fang, Hongcheng] Shandong Agr Univ, Coll Forestry, State Forestry & Grassland Adm Key Lab Silvicultu, Tai An, Shandong, Peoples R China published Interaction between MdMYB63 and MdERF106 enhances salt tolerance in apple by mediating Na+/H+ transport in 2020.0, Cited 34.0. Formula: C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Salt stress is an important environmental factor affecting the growth and production of agricultural crops and fruits worldwide, including apple (Males x domestica). In this study, we demonstrate that a salt-responsive MYB transcription factor (TF), designated as MdMYB63, promotes survival under salt stress. Overexpression of MdMYB63 in apple calli significantly enhanced salt tolerance. Screening of the AP2/ERF family of TFs identified MdERF106 as an interaction partner of MdMYB63. Further analyses showed that the MdMYB63-MdERF106 complex significantly promotes the expression of downstream MdSOS1, thereby improving the Na+ expulsion and salt tolerance of apple. These functional analyses of MdMYB63 have provided valuable insights into the regulatory network of salt tolerance, and lay a theoretical foundation for the cultivation of new salt-tolerant apple varieties.