Category: Triazoles

An article Efficient Route for the Synthesis of Diverse Heteroannelated 5-Cyanopyridines WOS:000615971100001 published article about CHLOROTRIMETHYLSILANE-MEDIATED SYNTHESIS in [Mityuk, Andrey P.; Hrebonkin, Andrii; Lebed, Pavlo S.; Volochnyuk, Dmitriy M.; Ryabukhin, Sergey V.] Enamine Ltd, 78 Chervonotkatska Str, Kiev, Ukraine; [Lebed, Pavlo S.; Grabchuk, Galyna P.; Volochnyuk, Dmitriy M.; Ryabukhin, Sergey V.] Taras Shevchenko Natl Univ Kyiv, 60 Volodymyrska Str, Kiev, Ukraine; [Volochnyuk, Dmitriy M.] Natl Acad Sci Ukraine, Inst Organ Chem, 5 Murmanska Str, Kiev, Ukraine in 2021.0, Cited 41.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. HPLC of Formula: C2H4N4

The new efficient, convenient protocol for the synthesis of heteroannelated 3-cyanopyridines and pyrimidines starting from diverse aminoheterocycles and 3,3-dimethoxy-2-formylpropionitrile sodium salt was elaborated. The advantages and improvements of the procedure compared to previously known methods are shown. The scope and limitations of the method are determined. The impact of the structural features on regioselectivity are discussed. The preparativeness, scalability, and application scope of the elaborated protocol are demonstrated by the synthesis of five heteroannelated 3-cyanopyridines in quantities up to 100 grams.

HPLC of Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Mityuk, AP; Hrebonkin, A; Lebed, PS; Grabchuk, GP; Volochnyuk, DM; Ryabukhin, SV or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recently I am researching about ONE-POT SYNTHESIS; MULTICOMPONENT REACTIONS; MESOPOROUS ORGANOSILICA; TIO2 NANOCRYSTALS; DERIVATIVES; EFFICIENT; NANOPARTICLES; SHELL; FRAMEWORK; GREEN, Saw an article supported by the Islamic Azad University, Qom Branch, Qom, I. R. Iran [2016-13929]. Published in WILEY in HOBOKEN ,Authors: Bakhshali-Dehkordi, R; Ghasemzadeh, MA; Safaei-Ghomi, J. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine. COA of Formula: C2H4N4

In this study, quinazolinone derivatives have been synthesized via a suitable and efficient procedure by one-potmulti-component reactions of 3-amino-1,2,4-triazole or 2-aminobenzimidazole, dimedone and aromatic aldehydes in the presence of Fe3O4@TiO2-IL as nanocatalyst under solvent-free condition. The products were prepared in good to excellent yields using Fe3O4@TiO2-IL magnetic nanocatalyst. The Fe3O4@TiO(2)magnetic nanoparticles (MNPs) were prepared using beet juice extract and functionalized with IL based on DABCO. Moreover, the core-shell structured magnetic Fe3O4@TiO2-IL has been characterized by different techniques such as(1)H-NMR, FT-IR, VSM, XRD, SEM, TGA, TEM and EDX. To the best of our knowledge, the prepared ionic liquid displayed a good protective and activator agent for magnetic nanocatalyst.

COA of Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Bakhshali-Dehkordi, R; Ghasemzadeh, MA; Safaei-Ghomi, J or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article A facile and regioselective synthesis of some new pyrimido[4,5-d] [1,2,4]triazolo[1,5-a]pyrimidinediones catalyzed by Zn(BDC)-MOF under ultrasound irradiation WOS:000475344800030 published article about METAL-ORGANIC FRAMEWORKS; IONIC LIQUID; INHIBITORS; DESIGN; DERIVATIVES; EFFICIENT; POTENT; WATER; ACID in [Abdollahi-Basir, Mohammad Hossein; Shirini, Farhad; Tajik, Hassan] Univ Guilan, Coll Sci, Dept Chem, Rasht 4133519141, Iran; [Ghasemzadeh, Mohammad Ali] Islamic Azad Univ, Qom Branch, Dept Chem, Qom, Iran in 2019.0, Cited 31.0. Product Details of 61-82-5. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Zinc terephthalate metal-organic framework catalyzed one-pot, three-component reaction of 3-amino-1H-1,2,4-triazoles, aromatic aldehydes and barbituric acid to prepare some new pyrimido[4,5-d][1,2,4]triazolo[1,5-a]pyrimidinediones. The reactions conducted under ultrasonic irradiation and solvent-free conditions with good to excellent yields of products. The zinc terephthalate metal-organic framework catalyst could be recovered by a simple filtration and applied in consecutive runs with no significant decrease in the yield. The method was demonstrated to be a truly green process with economics and sustainability. (C) 2019 Elsevier B.V. All rights reserved.

Product Details of 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Abdollahi-Basir, MH; Shirini, F; Tajik, H; Ghasemzadeh, MA or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Formula: C2H4N4. Authors Wen, D; Dong, Z; Ao, YY; Xie, KJ; Zhai, ML; Zhao, L in ELSEVIER SCI LTD published article about in [Wen, Di; Dong, Zhen; Xie, Kangjun; Zhao, Long] Huazhong Univ Sci & Technol, Sch Elect & Elect Engn, State Key Lab Adv Electromagnet Engn & Technol, Wuhan 430074, Peoples R China; [Wen, Di; Xie, Kangjun] Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Wuhan 430074, Peoples R China; [Ao, Yinyong] China Acad Engn Phys, Inst Nucl Phys & Chem, Mianyang 621900, Sichuan, Peoples R China; [Zhai, Maolin] Peking Univ, Beijing Natl Lab Mol Sci Radiochem & Radiat Chem, Coll Chem & Mol Engn,Key Lab Fundamental Sci, Key Lab Polymer Chem & Phys,Minist Educ, Beijing 100871, Peoples R China in 2021.0, Cited 53.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Aminotriazole isomers with high nitrogen content show potential affinity for U(VI). Combining the advantages of both aminotriazole and cellulose, two n-aminotriazole isomers modified cellulose microspheres (n-ATARs, n = 3, 4) were newly prepared as adsorbents via radiation technology. Batch adsorption experiments showed that n-ATARs possessed good adsorption capacity of U(VI) in the order of 3-ATAR > 4-ATAR, and the adsorption process followed the Langmuir-Freundlich isotherm model and the pseudo-second-order kinetic model. Both n-ATARs exhibited good selectivity and reusability. Besides, 3-ATAR and 4-ATAR were more suitable for the extraction of trace amount of U(VI) from the contaminated groundwater and the simulated seawater, respectively. The effect of amino position on triazole ring on adsorption behavior of n-ATAR was studied and explained by DFT calculation. Finally, the adsorption mechanism of U(VI) onto n-ATARs was revealed to be inner-sphere complexation via different 1:1 or 1:2 coordination models by FTIR, MS, XPS analysis and DFT calculation.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Wen, D; Dong, Z; Ao, YY; Xie, KJ; Zhai, ML; Zhao, L or concate me.. Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Shvets, EH; Pidvorotnia, AV; Kulyk, OG; Mazepa, AV; Kolosov, MA in [Shvets, Elena H.; Pidvorotnia, Anastasiia, V; Kulyk, Olesia G.; Kolosov, Maksim A.] Kharkov Natl Univ, Sch Chem, UA-61022 Kharkiv, Ukraine; [Mazepa, Alexander, V] NAS Ukraine, AV Bogatsky Physicochem Inst, Odesa, Ukraine published A straightforward synthesis of 5-sulfonamidomethyl substituted 4,7-dihydroazolo[1,5-a]pyrimidines in 2021.0, Cited 31.0. Recommanded Product: 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

4,7-Dihydroazolo[1,5-a]pyrimidin-5-ylmethanesulfonamides are side-products of the three-component Biginelli-like reaction of aminoazoles, aldehydes andN,N-dialkyl-2-ketomethanesulfonamides. Herein, we report a straightforward synthesis of 5-sulfonamidomethyl substituted 4,7-dihydroazolo[1,5-a]pyrimidines by a two-component condensation of aminoazoles andN,N-dialkyl(cinnamoyl)methanesulfonamides in DMF at reflux. The startingN,N-dialkyl-2-ketomethanesulfonamides can be obtained by either lithiation ofN,N-dialkylmethanesulfonamides and reaction with aldehydes followed by oxidation of the resulting alcohols or by Claisen condensation ofN,N-dialkylmethanesulfonamides with the corresponding esters. The chemical structures of all synthesized compounds are supported by(1)H and(13)C NMR-spectroscopy, mass spectrometry and elemental analysis.

Recommanded Product: 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Shvets, EH; Pidvorotnia, AV; Kulyk, OG; Mazepa, AV; Kolosov, MA or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Divalent manganese, cobalt, copper and cadmium complexes of (Z)-N-benzoyl-N ‘-(1H-1,2,4-triazol-3-yl)carbamimidothioic acid: Preparation, characterization, computational and biological studies published in 2021.0. Recommanded Product: 1H-1,2,4-Triazol-5-amine, Reprint Addresses Abu El-Reash, GM (corresponding author), Mansoura Univ, Dept Chem, Fac Sci, POB 70, Mansoura, Egypt.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

In this work, (Z)-N-benzoyl-N ‘-(1H-1,2,4-triazol-3-yl)carbamimidothioic acid and its Mn(II), Co(II), Cu(II) and Cd(II) complexes were introduced for the first time. This carbonyl thiourea ligand was prepared by the reaction of 1H-1,2,4-triazol-3-amine with benzoyl isothiocyanate. The structural elucidation of these compounds was performed using elemental analysis and spectral and magnetic measurements. Octahedral structures of all complexes, except Cd(II) complex with a tetrahedral geometry, were confirmed by applying DFT structural optimization. The thermal decomposition behaviour of metal complexes of carbonyl thiourea ligand is discussed. The calculation of kinetic parameters for prepared complexes (E-a, A, Delta H*, Delta S* and Delta G*) of all thermal degradation stages has been evaluated using two comparable approaches. Antimicrobial and ABTS-antioxidant studies indicated potent activity of Cd(II) complex compared with the other investigated compounds. The cytotoxic activity of the prepared compounds was investigated in vitro. The results indicated potent activity of Mn(II) complex against both HePG2 (liver carcinoma) and MCF-7 (breast carcinoma) cancer cells.

Recommanded Product: 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Majeed, AA; Khalil, MMH; Fetoh, A; Aziz, AAA; Abu El-Reash, GM or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

I found the field of Cell Biology; Endocrinology & Metabolism very interesting. Saw the article US EPA’s regulatory pesticide evaluations need clearer guidelines for considering mammary gland tumors and other mammary gland effects published in 2020.0. HPLC of Formula: C2H4N4, Reprint Addresses Rudel, RA (corresponding author), Silent Spring Inst, Newton, MA 02460 USA.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Breast cancer risk from pesticides may be missed if effects on mammary gland are not assessed in toxicology studies required for registration. Using US EPA’s registration documents, we identified pesticides that cause mammary tumors or alter development, and evaluated how those findings were considered in risk assessment. Of 28 pesticides that produced mammary tumors, EPA’s risk assessment acknowledges those tumors for nine and dismisses the remaining cases. For five pesticides that alter mammary gland development, the implications for lactation and cancer risk are not assessed. Many of the mammary-active pesticides activate pathways related to endocrine disruption: altering steroid synthesis in H295R cells, activating nuclear receptors, or affecting xenobiotic metabolizing enzymes. Clearer guidelines based on breast cancer biology would strengthen assessment of mammary gland effects, including sensitive histology and hormone measures. Potential cancer risks from several common pesticides should be re-evaluated, including: malathion, triclopyr, atrazine, propylene oxide, and 3-iodo-2-propynyl butylcarbamate (IPBC).

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Cardona, B; Rudel, RA or concate me.. HPLC of Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2020.0 DYES PIGMENTS published article about LIGHT-EMITTING-DIODES; BIPOLAR HOST MATERIALS; HIGH-PERFORMANCE RED; HIGHLY EFFICIENT; PHOSPHORESCENT; BLUE; TRIPHENYLAMINE; ACCEPTOR; GREEN; ELECTRON in [Jin, Minmin; Chen, Yi; Song, Wenxian; Su, Jianhua] East China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China; [Jin, Minmin; Chen, Yi; Song, Wenxian; Su, Jianhua] East China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China; [Lian, Hong; Guo, Hongen; Dong, Qingchen] Taiyuan Univ Technol, MOE Key Lab Interface Sci & Engn Adv Mat, 79 Yingze West St, Taiyuan 030024, Shanxi, Peoples R China; [Lian, Hong; Guo, Hongen; Dong, Qingchen] Taiyuan Univ Technol, Res Ctr Adv Mat Sci & Technol, 79 Yingze West St, Taiyuan 030024, Shanxi, Peoples R China; [Huang, Jinhai] Shanghai Taoe Chem Technol Co Ltd, Shanghai, Peoples R China in 2020.0, Cited 34.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Quality Control of 1H-1,2,4-Triazol-5-amine

In this work, seven small molecular compounds named N,N-diphenyl-4-(2-phenylpyrimido [1,2-b]indazol-4-yl) aniline (1), N,N-diphenyl-4-(5-phenylpyrazolo [1,5-a]pyrimidin-7-yl)aniline (2), N,N-diphenyl-4-(5-phenyl[1,2,4]triazolo [1,5-a]pyrimidin-7-yl)aniline (3), 4,4′-(pyrimido [1,2-b]indazole-2,4-diyl)bis (N,N-diphenylaniline) (4), 4,4′-(pyrazolo [1,5-a]pyrimidine-5,7-diyl)bis (N,N-diphenylaniline) (5), 4,4′-([1,2,4]triazolo [1,5-a] pyrimidine-5,7-diyl)bis (N,N-diphenylaniline) (6), N,N-diphenyl-4-(4-phenylpyrimido [1,2-b]indazol-2-yl)aniline (7) with donor-acceptor (D-A) structure were designed and synthesized by employing triphenylamine (TPA) as donor and indazole, pyrazole and/or triazole as acceptor. Systematic study and analysis on thermal, photo physical, electrochemical properties of all compounds were performed. All compounds exhibit good thermal and morphological stabilities with decomposition temperatures (T-d) range from 270 to 462 degrees C, and glass transition temperatures (T-g) range from 78 to 127 degrees C. The investigation of photophysical properties of these compounds revealed that all these compounds are of high photoluminescence quantum yields (PLQY), particularly for compound 6, whose PLQY value was as high as 90.22%. To explore potential applications of these materials in organic light-emitting diodes (OLEDs), two devices with compounds 2 and 5 were fabricated. Both devices show excellent device performances with maximum current efficiency, maximum power efficiency and external quantum efficiency of 15.9 cd A(-1), 10.41 m W-1 and 8.4% for compound 2-based device and 10.1 cd A(-1), 5.81 m W-1 and 5.5% for compound 5-based device, respectively.

Quality Control of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Jin, MM; Chen, Y; Song, WX; Lian, H; Guo, HE; Dong, QC; Huang, JH; Su, JH or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Catalase blockade reduces the pressor response to central cholinergic activation WOS:000498330200029 published article about NICOTINIC ACETYLCHOLINE-RECEPTORS; ENDOGENOUS HYDROGEN-PEROXIDE; CENTRAL ANGIOTENSIN-II; NITRIC-OXIDE; SMOOTH-MUSCLE; RAT-BRAIN; RELEASE; INHIBITION; VASOPRESSIN; EXPRESSION in [Lauar, Mariana R.; Colombari, Debora S. A.; Colombari, Eduardo; De Paula, Patricia M.; De Luca Jr, Laurival A.; Menani, Jose, V] Sao Paulo State Univ UNESP, Dent Sch, Dept Physiol & Pathol, Araraquara, SP, Brazil in 2019.0, Cited 66.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Safety of 1H-1,2,4-Triazol-5-amine

Intracerebroventricular (icv) injection of hydrogen peroxide (H2O2), a reactive oxygen species, or the blockade of catalase (enzyme that degrades H2O2 into H2O and O-2) with icv injection of 3-amino-1,2,4-triazole (ATZ) reduces the pressor effects of angiotensin II also injected icv. In the present study, we investigated the effects of ATZ injected icv or intravenously (iv) on the pressor responses induced by icv injections of the cholinergic agonist carbachol, which similar to angiotensin II induces pressor responses that depend on sympathoexcitation and vasopressin release. In addition, the effects of H2O2 icv on the pressor responses to icv carbachol were also tested to compare with the effects of ATZ. Normotensive non-anesthetized male Holtzman rats (280-300 g, n = 8-9/group) with stainless steel cannulas implanted in the lateral ventricle were used. Previous injection of ATZ (5 nmol/1 mu l) or H2O2 (5 mu mol/1 mu l) icv similarly reduced the pressor responses induced by carbachol (4 nmol/1 mu l) injected icv (13 +/- 4 and 12 +/- 4 mmHg, respectively, vs. vehicle + carbachol: 30 +/- 5 mmHg). ATZ (3.6 mmol/kg of body weight) injected iv also reduced icv carbachol-induced pressor responses (21 +/- 2 mmHg). ATZ icv or iv and H2O2 icv injected alone produced no effect on baseline arterial pressure. The treatments also produced no significant change of heart rate. The results show that ATZ icv or iv reduced the pressor responses to icv carbachol, suggesting that endogenous H2O2 acting centrally inhibits the pressor mechanisms (sympathoactivation and/or vasopressin release) activated by central cholinergic stimulation.

Safety of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Lauar, MR; Colombari, DSA; Colombari, E; De Paula, PM; De Luca, LA; Menani, JV or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2019.0 ENVIRON SCI TECHNOL published article about CARBON-DIOXIDE CAPTURE; ACTIVATED CARBON; WATER-PURIFICATION; DYNAMIC PRINCIPLE; LIQUID WATER; CO2 CAPTURE; REGENERATION; KINETICS; SURFACE; EQUILIBRIUM in [Aumeier, Benedikt M.; Dang, Anh H. Q.; Ohs, Burkhard; Yuece, Sueleyman; Wessling, Matthias] Rhein Westfal TH Aachen, Aachener Verfahrenstech, Chem Proc Engn, Forckenbeckstr 51, D-52074 Aachen, Germany; [Wessling, Matthias] DWI Leibniz Inst Interact Mat, Forckenbeckstr 50, D-52074 Aachen, Germany in 2019.0, Cited 67.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Product Details of 61-82-5

Recently, activated carbon adsorption for water treatment regained substantial attention due to the emerging task to remove trace organic compounds such as pesticides. In many applications, especially in decentralized water treatment, one major drawback of adsorbents is their limited recyclability due to inadequate logistics or uneconomical reactivation. In this lab-scale study, we present the temperature swing adsorption in the aqueous phase that allows the in situ regeneration of fixed-bed adsorbers, and prove its technical feasibility. Complying with circular water economy principles, we eliminated the pivotal need for regular replacement and consumables by employing only clean water instead of dedicated regeneration solutions. Adsorption of the herbicide amitrole in aqueous solution on granular activated carbon was exothermic (Delta H = -14.4 +/- 3.2 kJ mol(-1) for T = 20-94 degrees C) and followed the Freundlich model. The proposed method consisting of a short counterflow flush with liquid water at 125 degrees C effectively regenerated the adsorbent. Hence, we obtained a cyclic steady state operation with breakthrough after 122 +/- 14 bed volumes (at c(out)/c(in) = 0.2), cycle-average rejection of 90 +/- 1%, and water recovery of up to 78 +/- 4%. No thermal aging of adsorbent was observed over the investigated 17 cycles.

Product Details of 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Aumeier, BM; Dang, AHQ; Ohs, B; Yuce, S; Wessling, M or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics