Category: Triazoles

Quality Control of 1H-1,2,4-Triazol-5-amine. Authors Polunin, KE; Ul’yanov, AV; Polunina, IA; Buryak, AK in MAIK NAUKA/INTERPERIODICA/SPRINGER published article about in [Polunin, K. E.; Ul’yanov, A. V.; Polunina, I. A.; Buryak, A. K.] Russian Acad Sci, Frumkin Inst Phys Chem & Electrochem, Moscow 119071, Russia in 2021.0, Cited 21.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

The construction materials that contacted with unsymmetrical dimethylhydrazine and the desorption solutions obtained when treating the contaminated surface of metals and alloys with water and reagents were studied by chromatography and mass spectrometry. Neutralization of unsymmetrical dimethylhydrazine was studied using ozone and shungite. Ozonation makes it possible to destroy the toxicant molecules chemically and physically adsorbed on the surface of metal constructions, due to which they can be reused and utilized. Shungite effectively adsorbs and catalytically decomposes not only unsymmetrical dimethylhydrazine and its transformation products, but also oligomer compounds formed during the storage of hydrazine fuel. Ozonation of spent shungite can increase the efficiency of destructive processes and completeness of its regeneration.

Quality Control of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Polunin, KE; Ul’yanov, AV; Polunina, IA; Buryak, AK or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Category: Triazoles. Authors Ben Ali, A; El Bakri, Y; Lai, CH; Sebhaoui, J; El Ghayati, L; Essassi, E; Mague, JT in INT UNION CRYSTALLOGRAPHY published article about in [Ben Ali, Abdelkader] Mohammed V Univ Rabat, Fac Sci, Ctr Sci Mat, Lab Chim Appl Mat, Ave Ibn,BP 1014, Rabat, Morocco; [El Bakri, Youness; Sebhaoui, Jihad; El Ghayati, Lhoussaine; Essassi, El Mokhtar] Univ Mohammed 5, Fac Sci, Ctr Rech Sci Med, URAC 21,Pole Competence Pharmacochim, Av Ibn Battouta,BP 1014, Rabat, Morocco; [Lai, Chin-Hung] Chung Shan Med Univ, Dept Med Appl Chem, Taichung 40241, Taiwan; [Lai, Chin-Hung] Chung Shan Med Univ Hosp, Dept Med Educ, Taichung 40241, Taiwan; [Mague, Joel T.] Tulane Univ, Dept Chem, New Orleans, LA 70118 USA in 2019.0, Cited 38.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

In the title molecule, C13H16N4O3, the mean planes of the phenyl and triazole rings are nearly perpendicular to one another as a result of the intramolecular C-H center dot center dot center dot O and C-H center dot center dot center dot pi(ring) interactions. In the crystal, layers parallel to (101) are generated by O-H center dot center dot center dot N, N-H center dot center dot center dot O and N-H center dot center dot center dot N hydrogen bonds. The layers are connected by inversion-related pairs of C-H center dot center dot center dot O hydrogen bonds. The experimental molecular structure is close to the gas-phase geometryoptimized structure calculated by DFT methods. Hirshfeld surface analysis indicates that the most important interaction involving hydrogen in the title compound is the H center dot center dot center dot H contact. The contribution of the H center dot center dot center dot O, H center dot center dot center dot N, and H center dot center dot center dot H contacts are 13.6, 16.1, and 54.6%, respectively.

Category: Triazoles. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Ben Ali, A; El Bakri, Y; Lai, CH; Sebhaoui, J; El Ghayati, L; Essassi, E; Mague, JT or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Improved Antioxidant and Antifungal Activity of Chitosan Derivatives Bearing Urea Groups WOS:000505836700001 published article about IN-VITRO; ENHANCED ANTIOXIDANT; ANTIBACTERIAL; COMPLEXES in [Zhang, Jingjing; Mi, Yingqi; Sun, Xueqi; Chen, Yuan; Miao, Qin; Tan, Wenqiang; Li, Qing; Dong, Fang; Guo, Zhanyong] Chinese Acad Sci, Key Lab Coastal Biol & Bioresource Utilizat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Zhang, Jingjing; Mi, Yingqi; Sun, Xueqi; Chen, Yuan; Miao, Qin; Tan, Wenqiang; Li, Qing; Dong, Fang; Guo, Zhanyong] Chinese Acad Sci, Ctr Ocean Mega Sci, 7 Nanhai Rd, Qingdao 266071, Peoples R China; [Zhang, Jingjing; Mi, Yingqi; Sun, Xueqi; Chen, Yuan; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China in 2020.0, Cited 38.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. HPLC of Formula: C2H4N4

Eight novel chitosan derivatives bearing urea groups are designed and synthesized. Fourier transform infrared spectroscopy, H-1 nuclear magnetic resonance spectrometer, and elemental analysis are performed to confirm the structural characteristics of chitosan derivatives. The antioxidant activities, including superoxide radicals’ scavenging activity, 1,1-diphenyl-2-picrylhydrazyl radicals’ scavenging activity, and hydroxyl radical’ scavenging activity, of the derivatives are explored within different concentrations in the reaction system. In vitro fungicidal activity of these compounds is further tested against Fusarium oxysporum f. sp. niveum, Phomopsis asparagus, F. oxysporum f. sp. cucumebrium Owen, and Botrytis cinerea, respectively, particularly compounds exhibit significant control effect at 1.0 mg mL(-1). The experimental results indicate that the products bearing urea groups show enhanced antifungal property and antioxidant activity compared with pristine chitosan. Meanwhile, their bioactivities follow some regularity on the whole, that is, they are related to the electron-withdrawing property of the different substituted groups of urea. Derivatives with stronger electron-withdrawing property will have higher biological activities. L929 cells are used to carry out cytotoxicity test of chitosan and chitosan derivatives by Cell Counting Kit-8 assay. The results indicate that some of the samples show low cytotoxicity. This research will be helpful to broaden the application of chitosan in materials.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Zhang, JJ; Mi, YQ; Sun, XQ; Chen, Y; Miao, Q; Tan, WQ; Li, Q; Dong, F; Guo, ZY or concate me.. HPLC of Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Heat of Formation of Triazole-Based Salts: Prediction and Experimental Validation WOS:000591762100001 published article about ACCURATE THERMOCHEMICAL PROPERTIES; ENERGETIC MATERIALS APPLICATIONS; NITROGEN-RICH SALTS; SENSITIVITY; PRECURSORS; FAMILY in [Glorian, Julien; Han, Kyung-Tae; Braun, Silke; Baschung, Barbara] French German Res Inst St Louis, Propellant & Energet Mat PEM Grp, 5 Rue Gen Cassagnou, F-68300 St Louis, France in 2021.0, Cited 43.0. HPLC of Formula: C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

This work contributes to the growing interest in predictions linked with energetic salts. A reliable method to accurately compute the heat of formation of triazole-based salts was investigated. Calculations were based on Born-Haber energy cycles: gas-phase enthalpy of ions and lattice enthalpy were calculated separately. Ten triazole-based salts were synthesized and fully characterized. Their heat of combustion was measured by bomb calorimeter. Gas-phase heat of formation of cations and anions were computed at four different levels of theory: B3LYP 6-31G(d,p), CBS-4M, CBS-QB3, and G4. Ionic volumes were calculated at the B3LYP 6-31G(d,p) level with and without corrections. Lattice enthalpy estimations, based on calculated ionic volumes, were performed with the help of Jenkins and Gutowski methods. Combinations of the obtained results (gas-phase enthalpy of ions and lattice enthalpy) were used in the Born-Haber approach to predict solid phase enthalpy of formation of studied energetic salts. Direct comparison with experimental measurements enabled the identification of the most reliable path for energetic salt standard enthalpy of formation prediction.

HPLC of Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Glorian, J; Han, KT; Braun, S; Baschung, B or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Rational Design and Synthesis of Diverse Pyrimidine Molecules Bearing Sulfonamide Moiety as Novel ERK Inhibitors WOS:000502786800074 published article about CARBONIC-ANHYDRASE INHIBITORS; BIOLOGICAL EVALUATION; ANTIPROLIFERATIVE ACTIVITY; ANTIMICROBIAL ACTIVITIES; DERIVATIVES; PYRAZOLE; ANTICANCER; DOCKING; COMPLEXES; RELEASE in [Halawa, Ahmed H.; Elgammal, Walid E.; Hassan, Saber M.; Hassan, Ahmed H.; El-Agrody, Ahmed M.] Al Azhar Univ, Fac Sci, Chem Dept, Cairo 11284, Egypt; [Eskandrani, Areej A.; Okasha, Rawda M.] Taibah Univ, Fac Sci, Chem Dept, Medina 30002, Saudi Arabia; [Hassan, Ahmed H.] Jazan Univ, Fac Sci, Chem Dept, Jazan 45142, Saudi Arabia; [Ebrahim, Hassan Y.] Helwan Univ, Fac Pharm, Pharmacognosy Dept, Cairo 11795, Egypt; [Mehany, Ahmed B. M.] Al Azhar Univ, Fac Sci, Zool Dept, Cairo 11284, Egypt in 2019.0, Cited 65.0. Computed Properties of C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Protein kinases orchestrate diverse cellular functions; however, their dysregulation is linked to metabolic dysfunctions, associated with many diseases, including cancer. Mitogen-Activated Protein (MAP) kinase is a notoriously oncogenic signaling pathway in human malignancies, where the extracellular signal-regulated kinases (ERK1/2) are focal serine/threonine kinases in the MAP kinase module with numerous cytosolic and nuclear mitogenic effector proteins. Subsequently, hampering the ERK kinase activity by small molecule inhibitors is a robust strategy to control the malignancies with aberrant MAP kinase signaling cascades. Consequently, new heterocyclic compounds, containing a sulfonamide moiety, were rationally designed, aided by the molecular docking of the starting reactant 1-(4-((4-methylpiperidin-1-yl)sulfonyl)phenyl)ethan-1-one (3) at the ATP binding pocket of the ERK kinase domain, which was relying on the molecular extension tactic. The identities of the synthesized compounds (4-33) were proven by their spectral data and elemental analysis. The target compounds exhibited pronounced anti-proliferative activities against the MCF-7, HepG-2, and HCT-116 cancerous cell lines with potencies reaching a 2.96 mu M for the most active compound (22). Moreover, compounds 5, 9, 10b, 22, and 28 displayed a significant G2/M phase arrest and induction of the apoptosis, which was confirmed by the cell cycle analysis and the flow cytometry. Thus, the molecular extension of a small fragment bounded at the ERK kinase domain is a valid tactic for the rational synthesis of the ERK inhibitors to control various human malignancies.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Halawa, AH; Eskandrani, AA; Elgammal, WE; Hassan, SM; Hassan, AH; Ebrahim, HY; Mehany, ABM; El-Agrody, AM; Okasha, RM or concate me.. Computed Properties of C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2020.0 PROT MET PHYS CHEM+ published article about VOLATILE; STEEL in [Goncharova, O. A.; Kuznetsov, D. S.; Andreev, N. N.; Kuznetsov, Yu, I; Andreeva, N. P.] Russian Acad Sci, Frumkin Inst Phys Chem & Electrochem, Moscow 119071, Russia in 2020.0, Cited 17.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Category: Triazoles

Using a set of physicochemical (ellipsometry and contact angle measurements), electrochemical (potentiometric anode polarization and electrochemical impedance spectroscopy), and corrosion (periodic moisture condensation test) methods, the properties of adsorption films formed on the AMg6 aluminum alloy surface by the chamber method in vapors of some amines of heterocyclic compounds, carboxylic acids, and their salts are studied. It is established that the use of the studied compounds in the chamber processing of the alloy increases-though not effectively enough-its corrosion resistance in a humid atmosphere. The most promising inhibitors are carboxylic acids themselves; the optimum temperature for surface treatment with them is 140 degrees C. One-hour treatment of steel with pairs of oleic, neodecanoic acid, and carboxylic acid A at this temperature gives rise to the formation of nanoscale adsorption films on the AMg6 alloy, which slightly hydrophilize the surface, but possess a protective aftereffect. Apparently, further improvement of chamber protection methods of the AMg6 alloy should consist in the selection of synergists for chamber corrosion inhibitors of the carboxylate type.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Goncharova, OA; Kuznetsov, DS; Andreev, NN; Kuznetsov, YI; Andreeva, NP or concate me.. Category: Triazoles

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recommanded Product: 1H-1,2,4-Triazol-5-amine. Zorn, KM; Foil, DH; Lane, TR; Russo, DP; Hillwalker, W; Feifarek, DJ; Jones, F; Klaren, WD; Brinkman, AM; Ekins, S in [Zorn, Kimberley M.; Foil, Daniel H.; Lane, Thomas R.; Ekins, Sean] Collaborat Pharmaceut Inc, Raleigh, NC 27606 USA; [Russo, Daniel P.] Rutgers State Univ, Ctr Computat & Integrat Biol, Camden, NJ 08102 USA; [Hillwalker, Wendy; Feifarek, David J.; Jones, Frank; Klaren, William D.; Brinkman, Ashley M.] SC Johnson & Son Inc, Global Prod Safety, Racine, WI 53404 USA published Machine Learning Models for Estrogen Receptor Bioactivity and Endocrine Disruption Prediction in 2020.0, Cited 60.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

The U.S. Environmental Protection Agency (EPA) periodically releases in vitro data across a variety of targets, including the estrogen receptor (ER). In 2015, the EPA used these data to construct mathematical models of ER agonist and antagonist pathways to prioritize chemicals for endocrine disruption testing. However, mathematical models require in vitro data prior to predicting estrogenic activity, but machine learning methods are capable of prospective prediction from the molecular structure alone. The current study describes the generation and evaluation of Bayesian machine learning models grouped by the EPA’s ER agonist pathway model using multiple data types with proprietary software, Assay Central. External predictions with three test sets of in vitro and in vivo reference chemicals with agonist activity classifications were compared to previous mathematical model publications. Training data sets were subjected to additional machine learning algorithms and compared with rank normalized scores of internal five-fold cross-validation statistics. External predictions were found to be comparable or superior to previous studies published by the EPA. When assessing six additional algorithms for the training data sets, Assay Central performed similarly at a reduced computational cost. This study demonstrates that machine learning can prioritize chemicals for future in vitro and in vivo testing of ER agonism.

Recommanded Product: 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Zorn, KM; Foil, DH; Lane, TR; Russo, DP; Hillwalker, W; Feifarek, DJ; Jones, F; Klaren, WD; Brinkman, AM; Ekins, S or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

I found the field of Environmental Sciences & Ecology very interesting. Saw the article Monitoring of pesticides in ambient air: Prioritization of substances published in 2021.0. Computed Properties of C2H4N4, Reprint Addresses Hulin, M (corresponding author), ANSES, Risk Assessment Dept, 14 Rue Pierre & Marie Curie, F-94701 Maisons Alfort, France.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Despite the richness of data collected on pesticide concentrations in ambient air in France, knowledge on this topic remains partial and heterogeneous in the absence of specific regulations. The population exposure remains thus difficult to estimate; therefore it was necessary to define modalities for implementing national monitoring of pesticides in ambient air in metropolitan France and in the overseas territories. The objective of this work was to identify which active substances (a.s.) have to be monitored in priority. As part of a collective expertise, a group of multidisciplinary experts has developed a method to rank active substances authorised as plant protection products, biocides and antiparasitic agents, which were available on the French market in 2015. A 3-steps approach has been developed. The first step consisted of a theoretical approach based on a hierarchy of substances according to four criteria: (a) national uses, (b) emission potential to the air, (c) persistence in the air, and (d) chronic toxicity. The three first criteria give information on their potential to be present in the atmosphere, and the fourth criterion allows to consider their potential of hazard. The second step was an observational approach based on existing database on pesticide air measurements in France. In the third step, both approaches were combined using decision trees to select priority pesticides. Among the 1316 a.s. first identified from the EU Pesticides database, 90 were selected, among which 43 required metrological and/or analytical development. The experts recommended confirming the relevance of performing a longer term monitoring of these a.s. after a one-year exploratory campaign. The proposed method is reproduceable, transparent, easy to update (e.g. in the light of a change in product authorization), and can be adapted to other agricultural and geographical conditions, and objectives (e.g. monitoring of the ecotoxicological effects of pesticides). (C) 2020 Published by Elsevier B.V.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Hulin, M; Leroux, C; Mathieu, A; Gouzy, A; Berthet, A; Boivin, A; Bonicelli, B; Chubilleau, C; Hulin, A; Garziandia, EL; Mamy, L; Millet, M; Pernot, P; Quivet, E; Scelo, AL; Merlo, M; Ruelle, B; Bedos, C or concate me.. Computed Properties of C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recently I am researching about PARKINSONS-DISEASE; ALPHA-SYNUCLEIN; PROTEIN-KINASES; PHOSPHORYLATION; MODEL; CK1; TAU, Saw an article supported by the MIURMinistry of Education, Universities and Research (MIUR) [PRIN2010W4779]; UniTS (FRA2013); MEIC [SAF2012_37979_CO3_01, SAF2016-76693-R]. Formula: C2H4N4. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Redenti, S; Marcovich, I; De Vita, T; Perez, C; De Zorzi, R; Demitri, N; Perez, DI; Bottegoni, G; Bisignano, P; Bissaro, M; Moro, S; Martinez, A; Storici, P; Spalluto, G; Cavalli, A; Federico, S. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Glycogen synthase kinase 3 beta (GSK-3 beta) and casein kinase 1 delta (CK-1 delta) are emerging targets for the treatment of neuroinflammatory disorders, including Parkinson’s disease. An inhibitor able to target these two kinases was developed by docking-based design. Compound 12, 3-(7-amino-5-(cyclohexylamino)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-2-yl)-2-cyanoacrylamide, showed combined inhibitory activity against GSK-3 beta and CK-1 delta [IC50(GSK-3 beta)=0.17 mu m; IC50(CK-1 delta)=0.68 mu m]. In particular, classical ATP competition was observed against CK-1 delta, and a co-crystal of compound 12 inside GSK-3 beta confirmed a covalent interaction between the cyanoacrylamide warhead and Cys199, which could help in the development of more potent covalent inhibitors of GSK-3 beta. Preliminary studies on in vitro models of Parkinson’s disease revealed that compound 12 is not cytotoxic and shows neuroprotective activity. These results encourage further investigations to validate GSK-3 beta/CK-1 delta inhibition as a possible new strategy to treat neuroinflammatory/degenerative diseases.

Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Redenti, S; Marcovich, I; De Vita, T; Perez, C; De Zorzi, R; Demitri, N; Perez, DI; Bottegoni, G; Bisignano, P; Bissaro, M; Moro, S; Martinez, A; Storici, P; Spalluto, G; Cavalli, A; Federico, S or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Bioinspired Construction of a Nanozyme-Based H2O2 Homeostasis Disruptor for Intensive Chemodynamic Therapy WOS:000526392600030 published article about GLUTATHIONE-PEROXIDASE; SUPEROXIDE-DISMUTASE; HYDROGEN-PEROXIDE; CANCER-CELLS; CATALASE; GENERATION; ENZYME; NANOMATERIALS; MECHANISMS; OXIDATION in [Sang, Yanjuan; Cao, Fangfang; Li, Wei; Zhang, Lu; You, Yawen; Deng, Qingqing; Dong, Kai; Ren, Jinsong; Qu, Xiaogang] Chinese Acad Sci, Changchun Inst Appl Chem, Lab Chem Biol, Changchun 130022, Jilin, Peoples R China; [Sang, Yanjuan; Cao, Fangfang; Li, Wei; Zhang, Lu; You, Yawen; Deng, Qingqing; Dong, Kai; Ren, Jinsong; Qu, Xiaogang] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Jilin, Peoples R China; [Sang, Yanjuan; Cao, Fangfang; You, Yawen; Deng, Qingqing] Univ Sci & Technol China, Sch Appl Chem & Engn, Hefei 230026, Anhui, Peoples R China; [Li, Wei; Zhang, Lu] Univ Chinese Acad Sci, Beijing 100039, Peoples R China in 2020.0, Cited 65.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Safety of 1H-1,2,4-Triazol-5-amine

The insufficient intracellular H2O2 level in tumor cells is closely associated with the limited efficacy of chemodynamic therapy (CDT). Despite tremendous efforts, engineering CDT agents with a straightforward and secure H2O2 supplying ability remains a great challenge. Inspired by the balance of H2O2 generation and elimination in cancer cells, herein, a nanozyme-based H2O2 homeostasis disruptor is fabricated to elevate the intracellular H2O2 level through facilitating H2O2 production and restraining H2O2 elimination for enhanced CDT. In the formulation, the disruptor with superoxide dismutase-mimicking activity can convert O-2(center dot-) to H2O2, promoting the production of H2O2. Simultaneously, the suppression of catalase activity and depletion of glutathione by the disruptor weaken the transformation of H2O2 to H2O. Thus, the well-defined system could perturb the H2O2 balance and give rise to the accumulation of H2O2 in cancer cells. The raised H2O2 level would ultimately amplify the Fenton-like reaction-based CDT efficiency. Our work not only paves a way to engineer alternative CDT agents with a H2O2 supplying ability for intensive CDT but also provides new insights into the construction of bioinspired materials.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Sang, YJ; Cao, FF; Li, W; Zhang, L; You, YW; Deng, QQ; Dong, K; Ren, JS; Qu, XG or concate me.. Safety of 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics