Category: Triazoles

I found the field of Thermodynamics; Chemistry very interesting. Saw the article Stability, antibacterial ability, and inhibition of zinc burning of amitrole as thermal stabilizer for transparent poly(vinyl chloride) published in 2019.0. Category: Triazoles, Reprint Addresses Wang, X (corresponding author), Zhejiang Univ Technol, Coll Mat Sci & Engn, Hangzhou 310014, Zhejiang, Peoples R China.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Amitrole is reported as a novel kind of transparent poly(vinyl chloride) (PVC) thermal stabilizer that has both excellent inhibition of zinc burning thermal stability and antibacterial ability in this paper, which provide the possibility of applying the whole PVC industry into medical and food packaging, artificial leather, wire and cable, indoor decoration, and so on. From the results of Congo red test, discoloration test, and dynamic thermal stability test, we could clearly find out that amitrole could effectively replace the unstable chlorine atom and inhibit zinc burning of transparent PVC, while the long-term stability should be improved. Next, the stabilization mechanism of amitrole was also confirmed. The antibacterial activity of amitrole was measured by the bacteriostatic ring experiments. It was observed that the PVC films had good antibacterial properties after modified by amitrole. At last, optimal design of the amitrole/ZnSt(2) (1:1)/ESBO formulation was studied, which have strong potential as thermal stabilizer to prepare super transparency and antibacterial PVC resin.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Chen, S; Wang, YT; An, ZH; Ma, M; Shi, YQ; Wang, X or concate me.. Category: Triazoles

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Umar, T; Shalini, S; Raza, MK; Gusain, S; Kumar, J; Seth, P; Tiwari, M; Hoda, N in [Umar, Tarana; Hoda, Nasimul] Jamia Millia Islamia, Dept Chem, New Delhi 110025, India; [Shalini, Shruti; Gusain, Siddharth; Seth, Prerna; Tiwari, Manisha] Univ Delhi, Dr BR Ambedkar Ctr Biomed Res, New Delhi 110007, India; [Raza, Md Kausar] Indian Inst Sci, Dept Inorgan & Phys Chem, Bangalore 560012, Karnataka, India; [Kumar, Jitendra] Sardar Vallabhbhai Patel Coll, Dept Chem, Bhabua 821101, Kaimur, India; [Kumar, Jitendra] VKSU, Ara 802301, Bihar, India published A multifunctional therapeutic approach: Synthesis, biological evaluation, crystal structure and molecular docking of diversified 1H-pyrazolo[3,4-b]pyridine derivatives against Alzheimer’s disease in 2019.0, Cited 65.0. Computed Properties of C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

2-(piperazin-1-yl)-N-(1H-pyrazolo[3,4-b]pyridin-3-yl)acetamides are described as a new class of selective and potent acetylcholinesterase (AChE) inhibitors and amyloid beta aggregation inhibitors. Formation of synthesized compounds (P1-P9) was justified via H-1 NMR, C-13 NMR, mass spectra and single crystal X-Ray diffraction study. All compounds were evaluated for their acetylcholinesterase and butyrylcholinesterase inhibitory activity, inhibition of self-mediated A beta aggregation and Cu(II)-mediated A beta aggregation. Also, docking study carried out was in concordance with in vitro results. The most potent molecule amongst the derivatives exhibited excellent anti-AChE activity (IC50=4.8 nM). Kinetic study of P3 suggested it to be a mixed type inhibitor. In vitro study revealed that all the compounds are capable of inhibiting self-induced beta-amyloid (A beta) aggregation with the highest inhibition percentage to be 81.65%. Potency of P1 and P3 to inhibit self-induced A beta(1-)(42) aggregation was ascertained by TEM analysis. Compounds were also evaluated for their A beta disaggregation, antioxidation, metal-chelation activity. (C) 2019 Elsevier Masson SAS. All rights reserved.

Computed Properties of C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Umar, T; Shalini, S; Raza, MK; Gusain, S; Kumar, J; Seth, P; Tiwari, M; Hoda, N or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Fandzloch, M; Augustyniak, AW; Dobrzanska, L; Jedrzejewski, T; Sitkowski, J; Wypij, M; Golinska, P in [Fandzloch, Marzena] PAS, Inst Low Temp & Struct Res, Okolna 2, PL-50422 Wroclaw, Poland; [Augustyniak, Adam W.] Univ Wroclaw, Fac Chem, F Joliot Curie 14, PL-50383 Wroclaw, Poland; [Dobrzanska, Liliana] Nicolaus Copernicus Univ Torun, Fac Chem, Gagarina 7, PL-87100 Torun, Poland; [Jedrzejewski, Tomasz] Nicolaus Copernicus Univ Torun, Fac Biol & Vet Sci, Dept Immunol, Lwowska 1, PL-87100 Torun, Poland; [Sitkowski, Jerzy] Natl Inst Med, Chelmska 30-34, PL-00725 Warsaw, Poland; [Sitkowski, Jerzy] Polish Acad Sci, Inst Organ Chem, Kasprzaka 44-52, PL-01224 Warsaw, Poland; [Wypij, Magdalena; Golinska, Patrycja] Nicolaus Copernicus Univ Torun, Fac Biol & Vet Sci, Dept Microbiol, Lwowska 1, PL-87100 Torun, Poland published First dinuclear rhodium(II) complexes with triazolopyrimidines and the of their use in 2020.0, Cited 82.0. Category: Triazoles. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Five novel rhodium(II) complexes of general formula [Rh-2(mu-OOCCH3)(4)L-2], where L is a triazolopyrimidine derivative, in particular dimethyl-1,2,4-triazolo[1,5-a]pyrimidine (dmtp) for (1), 5,7-diethyl-1,2,4-triazolo[1,5a]pyrimidine (detp) for (2), 7-isobutyl-5-methyl-1,2,4-triazolo[1,5-a]pyrimidine (ibmtp) for (3), 7-hydroxy-5methyl-1,2,4-triazolo[1,5-a]pyrimidine (HmtpO) for (4) and 5,7-ditertbutyl-1,2,4-triazolo[1,5-a]pyrimidine (dbtp) for (5) are reported. These first representatives of paddle-wheel dirhodium complexes with triazolopyrimidines have been characterized by IR and NMR spectroscopy as well as by single-crystal X-ray diffraction studies. Three of the new complexes (1), (2) and (5) were thoroughly screened in vitro for their cytotoxicity against human breast cancer cell line MCF-7 and L929 murine fibroblast cells. Favorably, they show significantly less effective inhibition on the cell growth of L929 than cisplatin under identical conditions. Complexes (1) and (5) display moderate cytotoxic activity (IC50 = 16.3-21.5 mu M) against MCF-7 cells which is induced via reactive oxygen species-independent pathways. Extensive studies of rhodium complexes (1), (2) and (5) against microorganisms have shown that the tested compounds exhibit antibacterial activity against Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) while (5) significantly inhibited the growth of Malassezia furfur. The highest antibacterial, and antifungal activity, was observed for (5).

Category: Triazoles. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Fandzloch, M; Augustyniak, AW; Dobrzanska, L; Jedrzejewski, T; Sitkowski, J; Wypij, M; Golinska, P or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article HbWRKY27, a group IIe WRKY transcription factor, positively regulates HbFPS1 expression in Hevea brasiliensis WOS:000596327900012 published article about FARNESYL DIPHOSPHATE SYNTHASE; ZINC-FINGER PROTEIN; ISOPRENOID BIOSYNTHESIS; MOLECULAR CHARACTERIZATION; MEVALONATE PATHWAY; IN-VITRO; GENE; CLONING; PLANT; EVOLUTION in [Qu, Long; Yin, Li-Yan] Hainan Univ, Sch Life & Pharmaceut Sci, Haikou 570228, Hainan, Peoples R China; [Qu, Long; Li, Hui-Liang; Guo, Dong; Wang, Ying; Zhu, Jia-Hong; Peng, Shi-Qing] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Minist Agr, Key Lab Biol & Genet Resources Trop Crops, 4 Xueyuan Rd, Haikou 571101, Hainan, Peoples R China in 2020.0, Cited 46.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Product Details of 61-82-5

Farnesyl pyrophosphate synthase (FPS) is a key enzyme that catalyzes the formation of farnesyl pyrophosphate, the main initiator for rubber chain initiation in Hevea brasiliensis Muell. Arg. The transcriptional regulatory mechanisms of the FPS gene still not well understood. Here, a WRKY transcription factor designated HbWRKY27 was obtained by screening the latex cDNA library applied the HbFPS1 promoter as bait. HbWRKY27 interacted with the HbFPS1 promoter was further identified by individual Y1H and EMSA assays. HbWRKY27 belongs to group IIe WRKY subfamily which contains a typical WRKY domain and C-X5-CX23-HXH motif. HbWRKY27 was localized to the nucleus. HbWRKY27 predominantly accumulated in latex. HbWRKY27 was up-regulated in latex by ethrel, salicylic acid, abscisic acid, and methyl jasmonate treatment. Transient expression of HbWRKY27 led to increasing the activity of the HbFPS1 promoter in tobacco plant, suggesting that HbWRKY27 positively regulates the HbFPS1 expression. Taken together, an upstream transcription factor of the key natural rubber biosynthesis gene HbFPS1 was identified and this study will provide novel transcriptional regulatory mechanisms of the FPS gene in Hevea brasiliensis.

Product Details of 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Qu, L; Li, HL; Guo, D; Wang, Y; Zhu, JH; Yin, LY; Peng, SQ or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Synthesis of co-crystals of anti-cancer nandrolone as a potential leads towards treatment of cancer published in 2021.0. Recommanded Product: 1H-1,2,4-Triazol-5-amine, Reprint Addresses Yousuf, S (corresponding author), Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Sindh, Pakistan.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Co-crystals are emerging as members of supramolecular family having particular practical and fundamental significance for chemists, crystallographers, pharmaceutical scientists, and theoreticians. The presented study is focused to synthesize anti-cancer co-crystals of commercially available nandrolone (1), a synthetic anabolic-androgenic steroidal drug. Co-crystallization is done using economical and green grinding and reflux methods to obtain nandrolone (Nan): salicylic acid (Sal) and nandrolone (Nan): 3-amino-1,2,4-triazole (Triz) co-crystals, in 2:1 and 1:1 stoichiometric ratios, respectively. The structural analysis and characterization were carried out using single-crystal X-ray diffraction, and vibrational spectroscopy. Nandrolone (1) crystallizes in monoclinic P2(1) space group, while the co-crystal-I (Nan:Sal) and co-crystal-II (Nan:Triz), co-crystallized in the orthorhombic P2(1)2(1)2(1) space group. The intermolecular hydrogen bonds O-H center dot center dot center dot O, C-H center dot center dot center dot O, N-H center dot center dot center dot O, O-H center dot center dot center dot N, and N-H center dot center dot center dot N between the active pharmaceutical ingredient (nandrolone) and co-formers (salicylic acid, and 3-amino-1,2,4-triazole) stabilize the structures of cocrystals. In vibrational spectroscopy of co-crystal-I (Nan:Sal), the blue shifts in stretching frequencies of hydroxyl group from 3417.9 cm(-1) to 3427.8 cm(-1) further supported the hydrogen bond interactions between API and co-former. Similarly, in co-crystal-II (Nan:Triz) the NH2 stretching frequency from 3331.4- 3413.4 cm(-1) to 3312.7 cm(-1), supported the interaction of NH2 with API via intermolecular interaction. Nandrolone (1) and both co-crystals were found to be non-cytotoxic against 3T3 normal fibroblast cell line. Nandrolone (IC50 = 1.0 0.1 mu M), co-crystal-I (Nan:Sal) (IC50 = 1.6 +/- 0.3 mu M) and-II (Nan:Triz) (IC50 = 1.8 +/- 0.1 mu M) showed anti-cancer potential against cervical cancer HeLa cell line. While doxorubicin (IC50 = 1.2 +/- 0.2 mu M) was used as standard tested compound. SYNOPSIS Two new non-cytotoxic co-crystals of synthetic anabolic-androgenic steroidal drug nandrolone (Nan) with pharmaceutically acceptable salicylic acid (Sal), and triazole (Triz) were synthesized and their structures were elucidated using single-crystal X-ray diffraction, and vibrational spectroscopy. Quantitative analysis of -OH and -NH2 intermolecular interactions between API and co-former by Hirshfeld surface analysis further supported the role of various functionalities towards the stability of co-crystals. Both co-crystals were found to be non-cytotoxic against 3T3 normal fibroblast cell line. Co-crystal-I (Nan:Sal) and co-crystal-II (Nan:Triz) were found to be selectively active against HeLa cancer cell line (IC50 = 1.6 +/- 0.3 mu M), (IC50 = 1.8 +/- 0.1 mu M). (c) 2020 Elsevier B.V. All rights reserved.

Recommanded Product: 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Iqbal, U; Choudhary, MI; Yousuf, S or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Safety of 1H-1,2,4-Triazol-5-amine. Authors Ben Ali, A; El Bakri, Y; Lai, CH; Sebhaoui, J; El Ghayati, L; Essassi, E; Mague, JT in INT UNION CRYSTALLOGRAPHY published article about in [Ben Ali, Abdelkader] Mohammed V Univ Rabat, Fac Sci, Ctr Sci Mat, Lab Chim Appl Mat, Ave Ibn,BP 1014, Rabat, Morocco; [El Bakri, Youness; Sebhaoui, Jihad; El Ghayati, Lhoussaine; Essassi, El Mokhtar] Univ Mohammed 5, Fac Sci, Ctr Rech Sci Med, URAC 21,Pole Competence Pharmacochim, Av Ibn Battouta,BP 1014, Rabat, Morocco; [Lai, Chin-Hung] Chung Shan Med Univ, Dept Med Appl Chem, Taichung 40241, Taiwan; [Lai, Chin-Hung] Chung Shan Med Univ Hosp, Dept Med Educ, Taichung 40241, Taiwan; [Mague, Joel T.] Tulane Univ, Dept Chem, New Orleans, LA 70118 USA in 2019.0, Cited 38.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

In the title molecule, C13H16N4O3, the mean planes of the phenyl and triazole rings are nearly perpendicular to one another as a result of the intramolecular C-H center dot center dot center dot O and C-H center dot center dot center dot pi(ring) interactions. In the crystal, layers parallel to (101) are generated by O-H center dot center dot center dot N, N-H center dot center dot center dot O and N-H center dot center dot center dot N hydrogen bonds. The layers are connected by inversion-related pairs of C-H center dot center dot center dot O hydrogen bonds. The experimental molecular structure is close to the gas-phase geometryoptimized structure calculated by DFT methods. Hirshfeld surface analysis indicates that the most important interaction involving hydrogen in the title compound is the H center dot center dot center dot H contact. The contribution of the H center dot center dot center dot O, H center dot center dot center dot N, and H center dot center dot center dot H contacts are 13.6, 16.1, and 54.6%, respectively.

Safety of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Ben Ali, A; El Bakri, Y; Lai, CH; Sebhaoui, J; El Ghayati, L; Essassi, E; Mague, JT or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article ANAC017 Coordinates Organellar Functions and Stress Responses by Reprogramming Retrograde Signaling WOS:000466860800052 published article about NAC TRANSCRIPTION FACTOR; GENES-ENCODING MITOCHONDRIAL; UNFOLDED PROTEIN RESPONSE; LEAF SENESCENCE; CHLOROPHYLL DEGRADATION; REGULATORY CASCADE; ARABIDOPSIS; EXPRESSION; GROWTH; ENERGY in [Meng, Xiangxiang; Li, Lu; Narsai, Reena; Xu, Yue; Hartmann, Andreas; Claros, Diego Lozano; Lewsey, Mathew G.; Whelan, James; Berkowitz, Oliver] La Trobe Univ, Australian Res Council, Dept Anim Plant & Soil Sci, Ctr Excellence Plant Energy Biol, Bundoora, Vic 3086, Australia; [De Clercq, Inge] Univ Ghent, Dept Plant Biotechnol & Bioinformat, B-9052 Ghent, Belgium; [De Clercq, Inge] VIB, Ctr Plant Syst Biol, B-9052 Ghent, Belgium; [Custovic, Eddie] La Trobe Univ, Sch Engn & Math Sci, Bundoora, Vic 3086, Australia in 2019.0, Cited 103.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Recommanded Product: 1H-1,2,4-Triazol-5-amine

Mitochondria adjust their activities in response to external and internal stimuli to optimize growth via the mitochondrial retrograde response signaling pathway. The Arabidopsis (Arabidopsis thaliana) NAC domain transcription factor ANAC017 has previously been identified as a regulator of the mitochondrial retrograde response. We show here that overexpression of ANAC017 in Arabidopsis leads to growth retardation, altered leaf development with decreased cell size and viability, and early leaf senescence. RNA sequencing analyses revealed that increased ANAC017 expression leads to higher expression of genes related to mitochondrial stress, cell death/autophagy, and leaf senescence under nonlimiting growth conditions as well as extensive repression of chloroplast function. Gene regulatory network analysis indicated that a complex hierarchy of transcription factors exists downstream of ANAC017. These involve a set of up-regulated ANAC and WRKY transcription factors associated with organellar signaling and senescence. The network also includes a number of ethylene- and gibberellic acid-related transcription factors with established functions in stress responses and growth regulation, which down-regulate their target genes. A number of BASIC LEUCINE-ZIPPER MOTIF transcription factors involved in the endoplasmic reticulum unfolded protein response or balancing of energy homeostasis via the SNF1-RELATED PROTEIN KINASE1 were also down-regulated by ANAC017 overexpression. Our results show that the endoplasmic reticulum membrane tethering of the constitutively expressed ANAC017, and its controlled release, are crucial to fine-tune a fast reactive but potentially harmful signaling cascade. Thus, ANAC017 is a master regulator of cellular responses with mitochondria acting as central sensors.

Recommanded Product: 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Meng, XX; Li, L; De Clercq, I; Narsai, R; Xu, Y; Hartmann, A; Claros, DL; Custovic, E; Lewsey, MG; Whelan, J; Berkowitz, O or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recommanded Product: 1H-1,2,4-Triazol-5-amine. In 2019.0 POLYM DEGRAD STABIL published article about MECHANISM; EFFICIENCY; PENTAERYTHRITOL; INHIBITION; FUSION in [Ma, Biao; Wang, Xu; Lu, Songyan; He, Huiwen; Ma, Meng; Shi, Yanqin; Chen, Si] Zhejiang Univ Technol, Coll Mat Sci & Engn, Hangzhou 310014, Zhejiang, Peoples R China in 2019.0, Cited 30.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

An effectively Zn/Zn stabilizer system instead of traditional Ca/Zn stabilizer system was put forward, which contained a new triazole-based zinc-containing complex (abbreviated as [Zn(ttr)(St)]) and Zinc stearate (ZnSt(2)). Without Ca soap in the system, [Zn(ttr)(St)] itself could effectively absorb HCl and provided PVC with higher transparency and better thermal stability without zinc burning than commercial CaSt(2)/ZnSt(2) stabilizer system, verified by Congo red tests and discoloration tests and dynamic thermal stability analysis. In addition, [Zn(ttr)(St)] could further delay zinc burning of other zinc soaps, constituting Zn/Zn stabilizer system. This is attributed to the strong ability of restricting ZnCl2 of 3-amino-1,2,4-triazole released from [Zn(ttr)(St)] after absorbing HCl. After adding ESBO, PVC stabilized by [Zn(ttr)(St)]/ZnSt(2)/ESBO showed excellent transparency and thermal stability. We believe that [Zn(ttr)(St)] can act as a novel double agent with the stabilization effects of zinc soap and calcium soap at the same time and this Zn/Zn stabilizer system may inaugurate a new stabilizer system for PVC with synergistic effect. (C) 2019 Elsevier Ltd. All rights reserved.

Recommanded Product: 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Ma, B; Wang, X; Lu, SY; He, HW; Ma, M; Shi, YQ; Chen, S or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Authors Yamaguchi, K; Yoshimura, Y; Nakagawa, S; Mezaki, H; Yoshimura, S; Kawasaki, T in OXFORD UNIV PRESS published article about NADPH OXIDASE RBOHD; KINASE BIK1; RICE; RECEPTOR; PROTEIN; BIOGENESIS; EFFECTOR; CLUSTERS; CEBIP; DRE2 in [Yamaguchi, Koji; Yoshimura, Yuya; Nakagawa, Shinya; Mezaki, Hirokazu; Yoshimura, Satomi; Kawasaki, Tsutomu] Kindai Univ, Grad Sch Agr, Dept Adv Biosci, Naka, Nara, Japan in 2019.0, Cited 24.0. COA of Formula: C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

The rice receptor-like cytoplasmic kinase 185 (OsRLCK185) interacts with the chitin receptor complex OsCERK1/CEBiP and positively regulates chitin-induced immune responses including MAP kinase activation, ROS production and defense gene expression. To elucidate the regulatory mechanisms of OsRLCK185-mediated immunity, we searched for interactors of OsRLCK185. OsDRE2a, rice homologs of the yeast Dre2 protein, were identified as novel interactors of OsRLCK185. OsDRE2a interacted with OsRLCK185 at plasma membrane. The conserved cysteine residues in CIAPIN1 domain of OsDRE2a were essential for tight interaction of OsRLCK185. OsDRE2a was phosphorylated by OsRLCK185. The expression of OsDRE2a and OsDRE2b was induced after chitin treatment. Reduction of OsDRE2a and OsDRE2b mRNA levels by RNA interference resulted in the decreased chitin-induced ROS production. Thus, it is likely that OsDRE2 regulates OsRLCK185-mediated immune responses.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Yamaguchi, K; Yoshimura, Y; Nakagawa, S; Mezaki, H; Yoshimura, S; Kawasaki, T or concate me.. COA of Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

HPLC of Formula: C2H4N4. I found the field of Chemistry very interesting. Saw the article Triazole-Modified Molybdenum Oxide with High Proton Conductivity published in 2020.0, Reprint Addresses Lu, Y; Liu, SX (corresponding author), Northeast Normal Univ, Fac Chem, Minist Educ, Key Lab Polyoxometalate Sci, Changchun 130024, Jilin, Peoples R China.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine.

Nowadays, the research of proton conductive materials has been extended from traditional sulfonated polymers to novel crystalline solid materials. It is important but still challenging to develop high-performance proton-conducting materials suitable for proton exchange membrane fuel cells (PEMFCs). Considering the features of molybdenum oxide and triazole in the construction of proton-conducting material, two triazole-modified molybdenum oxides, [MoO3(trz)(0.5)]1and [H(atrz)(4)[(atrz)(2)(gamma-Mo8O26)] . 2H(2)O2(trz=1,2,4-triazole, atrz=3-amino-1,2,4-triazole), were re-synthesized under optimized synthetic conditions, and their proton-conducting performances were investigated.1and2show high proton conductivities of 1.94×10(-2) S cm(-1)(85 degrees C, 95 % RH) and 1.3×10(-3) S cm(-1)(65 degrees C, 95 % RH), respectively.

HPLC of Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Li, Z; Lu, Y; Zhang, S; Sun, XW; Dang, TY; Zhang, Z; Tian, HR; Liu, SX or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics