Category: Triazoles

An article Comparative study between the anti-P. falciparum activity of triazolopyrimidine, pyrazolopyrimidine and quinoline derivatives and the identification of new PfDHODH inhibitors WOS:000600418500073 published article about PLASMODIUM-FALCIPARUM; ANTIMALARIAL in [Silveira, Flavia F.; Hoelz, Lucas V. B.; Boechat, Nubia; Pinheiro, Luiz C. S.] Fiocruz MS, Fundacao Oswaldo Cruz, Inst Tecnol Farmacos Farmanguinhos, Lab Sintese Farmacos, Rua Sizenando Nabuco 100, BR-21041250 Rio De Janeiro, RJ, Brazil; [Silveira, Flavia F.; Albuquerque, Magaly G.; Boechat, Nubia] Univ Fed Rio de Janeiro, PGQu Inst Quim, Programa Posgrad Quim, Rio De Janeiro, RJ, Brazil; [de Souza, Juliana O.; Aguiar, Anna C. C.; Guido, Rafael V. C.] Univ Sao Paulo, Inst Fis Sao Carlos, Av Joao Dagnone 1-100, Sao Carlos, SP, Brazil; [Campos, Vinicius R.] Univ Fed Fluminense, Inst Quim, Dept Quim Organ, Programa Posgrad Quim, Niteroi, RJ, Brazil; [Jabor, Valquiria A. P.; Nonato, M. Cristina] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Ciencias BioMol, Lab Cristalog Prot, Ave Cafe S-N Monte Alegre, BR-14040903 Ribeirao Preto, SP, Brazil in 2021, Cited 39. Category: Triazoles. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

In this work, we designed and synthesized 35 new triazolopyrimidine, pyrazolopyrimidine and quinoline derivatives as P. falciparum inhibitors (3D7 strain). Thirty compounds exhibited anti-P. falciparum activity, with IC50 values ranging from 0.030 to 9.1 mu M. The [1,2,4] triazolo[1,5-a]pyrimidine derivatives were more potent than the pyrazolo[1,5-a]pyrimidine and quinoline analogues. Compounds 20, 21, 23 and 24 were the most potent inhibitors, with IC50 values in the range of 0.030-0.086 mu M and were equipotent to chloroquine. In addition, the compounds were selective, showing no cytotoxic activity against the human hepatoma cell line HepG2. All [1,2,4]triazolo[1,5-a]pyrimidine derivatives inhibited PfDHODH activity in the low micromolar to low nanomolar range (IC50 values of 0.08-1.3 mu M) and did not show significant inhibition against the HsDHODH homologue (0-30% at 50 mu M). Molecular docking studies indicated the binding mode of [1,2,4]triazolo[1,5-a]pyrimidine derivatives to PfDHODH, and the highest interaction affinities for the PfDHODH enzyme were in agreement with the in vitro experimental evaluation. Thus, the most active compounds against P. falciparum parasites 20 (R = CF3, R-1 = F; IC50 = 0.086 mu M), 21 (R = CF3; R-1 = CH3; IC50 = 0.032 mu M), 23, (R = CF3, R-1 = CF3; IC50 = 0.030 mu M) and 24 (R = CF3, 2-naphthyl; IC50 = 0.050 mu M) and the most active inhibitor against PfDHODH 19 (R = CF3, R-1 = Cl; IC50 = 0.08 mu M – PfDHODH) stood out as new lead compounds for antimalarial drug discovery. Their potent in vitro activity against P. falciparum and the selective inhibition of the PfDHODH enzyme strongly suggest that this is the mechanism of action underlying this series of new [1,2,4]triazolo[1,5-a]pyrimidine derivatives. (c) 2020 Elsevier Masson SAS. All rights reserved.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Silveira, FF; de Souza, JO; Hoelz, LVB; Campos, VR; Jabor, VAP; Aguiar, ACC; Nonato, MC; Albuquerque, MG; Guido, RVC; Boechat, N; Pinheiro, LCS or concate me.. HPLC of Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Bioinspired Construction of a Nanozyme-Based H2O2 Homeostasis Disruptor for Intensive Chemodynamic Therapy published in 2020.0. COA of Formula: C2H4N4, Reprint Addresses Ren, JS; Qu, XG (corresponding author), Chinese Acad Sci, Changchun Inst Appl Chem, Lab Chem Biol, Changchun 130022, Jilin, Peoples R China.; Ren, JS; Qu, XG (corresponding author), Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Jilin, Peoples R China.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

The insufficient intracellular H2O2 level in tumor cells is closely associated with the limited efficacy of chemodynamic therapy (CDT). Despite tremendous efforts, engineering CDT agents with a straightforward and secure H2O2 supplying ability remains a great challenge. Inspired by the balance of H2O2 generation and elimination in cancer cells, herein, a nanozyme-based H2O2 homeostasis disruptor is fabricated to elevate the intracellular H2O2 level through facilitating H2O2 production and restraining H2O2 elimination for enhanced CDT. In the formulation, the disruptor with superoxide dismutase-mimicking activity can convert O-2(center dot-) to H2O2, promoting the production of H2O2. Simultaneously, the suppression of catalase activity and depletion of glutathione by the disruptor weaken the transformation of H2O2 to H2O. Thus, the well-defined system could perturb the H2O2 balance and give rise to the accumulation of H2O2 in cancer cells. The raised H2O2 level would ultimately amplify the Fenton-like reaction-based CDT efficiency. Our work not only paves a way to engineer alternative CDT agents with a H2O2 supplying ability for intensive CDT but also provides new insights into the construction of bioinspired materials.

COA of Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Sang, YJ; Cao, FF; Li, W; Zhang, L; You, YW; Deng, QQ; Dong, K; Ren, JS; Qu, XG or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Identifying C2H4N4 structural isomers using fs-laser induced breakdown spectroscopy published in 2020.0. COA of Formula: C2H4N4, Reprint Addresses Shi, JC (corresponding author), Peac Inst Multiscale Sci, Chengdu 610027, Sichuan, Peoples R China.; Shang, YL (corresponding author), Southwest Jiaotong Univ, Key Lab Adv Technol Mat, Minist Educ, Chengdu 610031, Sichuan, Peoples R China.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Four C2H4N4 structural isomers are investigated with fs laser-induced breakdown spectroscopy. Plasma emissions, C I, H-alpha, the CN violet system (B-2 sigma(+)-X-2 sigma(+), Delta nu = 0 sequence) and C-2 swan system (d(3)pi(g)-a(3)pi(u), Delta nu = 0 sequence) are measured. The temporal evolution of the characteristic emission intensity is obtained for each emission and their lifetimes are calculated. The lifetimes of the molecular emissions are much longer than those of the atomic emissions. Characteristic emission intensities and lifetime are correlated with the molecular structures of the four isomers to a certain extent. Plasma temperature is extracted by fitting the spectrum of the CN violet system, B-2 sigma(+)-X-2 sigma(+); Delta nu = 0 sequence, and is weakly correlated with the molecular structures of the four isomers. Using the characteristic emission intensities as input, principal component analysis (PCA) and artificial neural network (ANN) analysis are performed and the individual isomers can be well identified with PCA or ANN.

COA of Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Zhao, YL; Lai, GD; Li, GG; Shang, YL; Shi, JC or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins WOS:000486630100009 published article about KINASE INHIBITORS; STRUCTURAL BASIS; ATPASE; P97; CANCER; MECHANISMS; UBIQUITIN; VCP/P97; SPASTIN; POTENT in [Pisa, Rudolf; Cupido, Tommaso; Steinman, Jonathan B.; Jones, Natalie H.; Kapoor, Tarun M.] Rockefeller Univ, Lab Chem & Cell Biol, New York, NY 10065 USA; [Pisa, Rudolf; Jones, Natalie H.] Rockefeller Univ, Triinst PhD Program Chem Biol, New York, NY 10065 USA; [Steinman, Jonathan B.] Weill Cornell Rockefeller Sloan Kettering Triinst, New York, NY 10065 USA in 2019.0, Cited 45.0. Application In Synthesis of 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Drug-like inhibitors are often designed by mimicking cofactor or substrate interactions with enzymes. However, as active sites are comprised of conserved residues, it is difficult to identify the critical interactions needed to design selective inhibitors. We are developing an approach, named RADD (resistance analysis during design), which involves engineering point mutations in the target to generate active alleles and testing compounds against them. Mutations that alter compound potency identify residues that make key interactions with the inhibitor and predict target-binding poses. Here, we apply this approach to analyze how diaminotriazole-based inhibitors bind spastin, a microtubule-severing AAA (ATPase associated with diverse cellular activities) protein. The distinct binding poses predicted for two similar inhibitors were confirmed by a series of X-ray structures. Importantly, our approach not only reveals how selective inhibition of the target can be achieved but also identifies resistance-conferring mutations at the early stages of the design process.

Application In Synthesis of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Pisa, R; Cupido, T; Steinman, JB; Jones, NH; Kapoor, TM or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Organotin Polymers as Antiviral Agents Including Inhibition of Zika and Vaccinia Viruses WOS:000511519400010 published article about STRUCTURAL-CHARACTERIZATION; ANTICANCER; POLYESTERS; DIHALIDES; ABILITY; ABC/3TC in [Roner, Michael R.; Miller, Lindsey] Univ Texas Arlington, Dept Biol, Arlington, TX 76010 USA; [Carraher, Charles E., Jr.; Mosca, Francisca; Slawek, Paul; Haky, Jerome E.; Frank, Jessica] Florida Atlantic Univ, Dept Chem & Biochem, Boca Raton, FL 33431 USA in 2020.0, Cited 30.0. Recommanded Product: 61-82-5. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

The ability to inhibit two important viruses is described. Two groups of polymers exhibited ability to totally inhibit the Zika virus. These polymers are derived from organotin dihalides and camphoric acid and lamivudine. This is the initial report of complete inhibition of the Zika virus by simple drugs. The ability to inhibit vaccinia virus is also reported. The inhibition of the vaccinia virus is shown by a number of organotin drugs including those also derived from lamivudine and camphoric acid and additional drugs derived from 3-amino-1,2,4-triazole, dicumarol, 4,6-diaminopyridine, alpha-cyano-4-hydroxcinnamic acid, and a variety of organotin polyethers including water soluble polymers derived from poly(ethylene glycol). All the drugs described in these studies are rapidly (< 30 s) synthesized using commercially available reactants at room temperature employing the interfacial reaction system that is employed industrially so that scale up to kilograms is relatively straight forward. Recommanded Product: 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Roner, MR; Carraher, CE; Miller, L; Mosca, F; Slawek, P; Haky, JE; Frank, J or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Computed Properties of C2H4N4. In 2020.0 TETRAHEDRON LETT published article about MULTICOMPONENT REACTIONS; HETEROCYCLIC-SYSTEMS; CONSTRUCTION; UGI; ADDITIONS; ANALOGS; AMINES in [Mohlala, Reagan L.; Coyanis, E. Mabel] MINTEK, Adv Mat Div, Private Bag X3015, ZA-2125 Randburg, South Africa; [Mohlala, Reagan L.; Fernandes, Manuel A.; Bode, Moira L.] Univ Witwatersrand, Sch Chem, Mol Sci Inst, PO Wits, ZA-2050 Johannesburg, South Africa in 2020.0, Cited 60.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

A one-pot reaction of the zwitterion formed from an isocyanide and an acetylenedicarboxylate with different five-membered rings containing both an acidic proton and a suitable nucleophile resulted in the preparation of novel 5-membered ring fused pyrimidine derivatives in yields ranging from 18 to 87%. (C) 2020 Elsevier Ltd. All rights reserved.

Computed Properties of C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Mohlala, RL; Coyanis, EM; Fernandes, MA; Bode, ML or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Category: Triazoles. I found the field of Plant Sciences very interesting. Saw the article Interaction between MdMYB63 and MdERF106 enhances salt tolerance in apple by mediating Na+/H+ transport published in 2020.0, Reprint Addresses Wang, N; Chen, XS (corresponding author), Shandong Agr Univ, Coll Hort Sci, State Key Lab Crop Biol, 61 Daizong Rd, Tai An 271018, Shandong, Peoples R China.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine.

Salt stress is an important environmental factor affecting the growth and production of agricultural crops and fruits worldwide, including apple (Males x domestica). In this study, we demonstrate that a salt-responsive MYB transcription factor (TF), designated as MdMYB63, promotes survival under salt stress. Overexpression of MdMYB63 in apple calli significantly enhanced salt tolerance. Screening of the AP2/ERF family of TFs identified MdERF106 as an interaction partner of MdMYB63. Further analyses showed that the MdMYB63-MdERF106 complex significantly promotes the expression of downstream MdSOS1, thereby improving the Na+ expulsion and salt tolerance of apple. These functional analyses of MdMYB63 have provided valuable insights into the regulatory network of salt tolerance, and lay a theoretical foundation for the cultivation of new salt-tolerant apple varieties.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Yu, L; Liu, WJ; Guo, ZW; Li, ZQ; Jiang, HY; Zou, Q; Mao, ZL; Fang, HC; Zhang, ZY; Wang, N; Chen, XS or concate me.. COA of Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Shahnavaz, Z; Khaligh, NG; Zaharani, L; Johan, MR; Hamizi, NA in [Shahnavaz, Zohreh; Khaligh, Nader Ghaffari; Zaharani, Lia; Johan, Mohd Rafie; Hamizi, Nor Aliya] Univ Malaya, Nanotechnol & Catalysis Res Ctr, Inst Postgrad Studies, 3rd Floor,Block A, Kuala Lumpur 50603, Malaysia published The structure elucidation of new ionic liquid and its application for the synthesis of a series of novel triazolo[1,5-a]pyrimidine scaffolds in 2020.0, Cited 35.0. Formula: C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

In the present study, the chemical structure of 4,4′-trimethylene-N,N’-dipiperidinium chlorosulfonate is elucidated by 1D NMR, and 2D NMR, FTIR, Raman analyses, and Mass spectra. It was indicated that the chlorosulfonic acid could not act as a sulfonating agent in the reaction with secondary amines like TMDP due to due more steric hindrance of the sulfur atom by chlorine and oxygen atoms. Raman and FTIR spectra are demonstrated as two high-value optical techniques to the elucidation and identification of chemical structures that confirmed C3(v) symmetry for chlorosulfonate anion in the ionic liquid. Then, the solvent-catalyst activity of ionic liquid was demonstrated in the one-pot synthesis of a series of novel triazolo-pyrimidines under mild conditions. The ionic liquid was retrieved and reused several times without reducing its catalytic efficiency. (C) 2020 Elsevier B.V. All rights reserved.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Shahnavaz, Z; Khaligh, NG; Zaharani, L; Johan, MR; Hamizi, NA or concate me.. Product Details of 61-82-5

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2020.0 SCI REP-UK published article about FARNESYL DIPHOSPHATE SYNTHASE; ZINC-FINGER PROTEIN; ISOPRENOID BIOSYNTHESIS; MOLECULAR CHARACTERIZATION; MEVALONATE PATHWAY; IN-VITRO; GENE; CLONING; PLANT; EVOLUTION in [Qu, Long; Yin, Li-Yan] Hainan Univ, Sch Life & Pharmaceut Sci, Haikou 570228, Hainan, Peoples R China; [Qu, Long; Li, Hui-Liang; Guo, Dong; Wang, Ying; Zhu, Jia-Hong; Peng, Shi-Qing] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Minist Agr, Key Lab Biol & Genet Resources Trop Crops, 4 Xueyuan Rd, Haikou 571101, Hainan, Peoples R China in 2020.0, Cited 46.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Category: Triazoles

Farnesyl pyrophosphate synthase (FPS) is a key enzyme that catalyzes the formation of farnesyl pyrophosphate, the main initiator for rubber chain initiation in Hevea brasiliensis Muell. Arg. The transcriptional regulatory mechanisms of the FPS gene still not well understood. Here, a WRKY transcription factor designated HbWRKY27 was obtained by screening the latex cDNA library applied the HbFPS1 promoter as bait. HbWRKY27 interacted with the HbFPS1 promoter was further identified by individual Y1H and EMSA assays. HbWRKY27 belongs to group IIe WRKY subfamily which contains a typical WRKY domain and C-X5-CX23-HXH motif. HbWRKY27 was localized to the nucleus. HbWRKY27 predominantly accumulated in latex. HbWRKY27 was up-regulated in latex by ethrel, salicylic acid, abscisic acid, and methyl jasmonate treatment. Transient expression of HbWRKY27 led to increasing the activity of the HbFPS1 promoter in tobacco plant, suggesting that HbWRKY27 positively regulates the HbFPS1 expression. Taken together, an upstream transcription factor of the key natural rubber biosynthesis gene HbFPS1 was identified and this study will provide novel transcriptional regulatory mechanisms of the FPS gene in Hevea brasiliensis.

Category: Triazoles. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Qu, L; Li, HL; Guo, D; Wang, Y; Zhu, JH; Yin, LY; Peng, SQ or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Product Details of 61-82-5. Xie, SF; Huang, LQ; Zhong, L; Lai, BL; Yang, M; Chen, WB; Zhang, YQ; Dong, W in [Xie, Shang-Fang; Huang, Li-Qian; Zhong, Li; Lai, Bi-Lin; Yang, Meng; Chen, Wen-Bin; Dong, Wen] Guangzhou Univ, Sch Chem & Chem Engn, Guangzhou Key Lab Environm Funct Mat & Technol, Guangzhou 510006, Guangdong, Peoples R China; [Zhang, Yi-Quan] Nanjing Normal Univ, Sch Phys Sci & Technol, Jiangsu Key Lab NSLSCS, Nanjing 210023, Jiangsu, Peoples R China published Structures, Single-Molecule Magnets, and Fluorescent Properties of Four Dinuclear Lanthanide Complexes Based on 4-Azotriazolyl-3-hydroxy-2-naphthoic Acid in 2019.0, Cited 67.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Four isostructural dinuclear lanthanide complexes based on 4-azotriazolyl-3-hydroxy-2-naphthoic acid (H(3)ATNA) and 3-hydroxy-2-naphthoic acid (H(2)NA) ligands, {[Ln(2)(HATNA)(2)(HNA)(2)(H2O)(4)].6DMF} (Ln = Dy (1), Tb (2), Sm (3), Eu (4); DMF = N,N-dimethylformamide) have been prepared and characterized by X-ray diffraction crystallography, dc/ac magnetic characterization, and fluorescent spectrometry. The crystallographic data reveal dinuclear lanthanide cores of complexes 1-4, bridged by phenoxo and mu(1,3) carboxyl groups. Each nine-coordinated Ln(III) ion is located in a slightly distorted monocapped square antiprism. The ligand of H(3)ATNA displays a unique antenna effect in complex 4. Complexes 1-3 display only two ligand-centered fluorescent emissive peaks around 450 and 600 nm, and complex 4 shows four characteristic Eu(III)centered emission bands at 593, 618, 653, and 698 nm under excitation at 348 nm. Complex 1 exhibits single-molecule magnet behavior that is rationalized through ab initio calculations.

Product Details of 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Xie, SF; Huang, LQ; Zhong, L; Lai, BL; Yang, M; Chen, WB; Zhang, YQ; Dong, W or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics