Category: Triazoles

Zhao, YL; Lai, GD; Li, GG; Shang, YL; Shi, JC in [Zhao, Y. L.; Shi, J. C.] Peac Inst Multiscale Sci, Chengdu 610027, Sichuan, Peoples R China; [Lai, G. D.; Li, G. G.; Shang, Y. L.] Southwest Jiaotong Univ, Key Lab Adv Technol Mat, Minist Educ, Chengdu 610031, Sichuan, Peoples R China; [Lai, G. D.] Southwest Jiaotong Univ, Sch Phys Sci & Technol, Chengdu 610031, Peoples R China published Identifying C2H4N4 structural isomers using fs-laser induced breakdown spectroscopy in 2020.0, Cited 48.0. Product Details of 61-82-5. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Four C2H4N4 structural isomers are investigated with fs laser-induced breakdown spectroscopy. Plasma emissions, C I, H-alpha, the CN violet system (B-2 sigma(+)-X-2 sigma(+), Delta nu = 0 sequence) and C-2 swan system (d(3)pi(g)-a(3)pi(u), Delta nu = 0 sequence) are measured. The temporal evolution of the characteristic emission intensity is obtained for each emission and their lifetimes are calculated. The lifetimes of the molecular emissions are much longer than those of the atomic emissions. Characteristic emission intensities and lifetime are correlated with the molecular structures of the four isomers to a certain extent. Plasma temperature is extracted by fitting the spectrum of the CN violet system, B-2 sigma(+)-X-2 sigma(+); Delta nu = 0 sequence, and is weakly correlated with the molecular structures of the four isomers. Using the characteristic emission intensities as input, principal component analysis (PCA) and artificial neural network (ANN) analysis are performed and the individual isomers can be well identified with PCA or ANN.

Product Details of 61-82-5. Welcome to talk about 61-82-5, If you have any questions, you can contact Zhao, YL; Lai, GD; Li, GG; Shang, YL; Shi, JC or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

I found the field of Biochemistry & Molecular Biology; Chemistry; Polymer Science very interesting. Saw the article Screening and analysis of agouti signaling protein interaction partners in Pelodiscus sinensis suggests a role in lipid metabolism published in 2020.0. Category: Triazoles, Reprint Addresses Si, YX (corresponding author), Zhejiang Chinese Med Univ, Sch Basic Med Sci, Hangzhou 310053, Peoples R China.; Qian, GY (corresponding author), Zhejiang Wanli Univ, Coll Biol & Environm Sci, Ningbo 315100, Peoples R China.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Agouti signaling protein (ASP) is a secreted paracrine protein that has been widely reported to function in melanogenesis and obesity and could potentially be a core protein that regulates the color and fatty phenotype of P. sinensis. In this study, we screened out interacting proteins of ASP by combined co-immunoprecipitation mass spectrometry (CoIP-MS), yeast two hybrid (Y2H) analysis, and computational predictions. We performed docking of ASP with its well-known receptor melanocortin receptor 4 (MC4R) to predict the binding capacity and to screen out actual ASP interacting proteins, CoIP-MS was performed where identified 32 proteins that could bind with ASP and Y2H confirmed seven proteins binding with ASP directly. CoIP-MS and Y2H screening results including PPI prediction revealed that vitronectin (VIN), apolipoprotein Al (AP0A1), apolipoprotein B (APOB), and filamin B (FLNB) were the key interacting proteins of ASP. VTN, AP0A1, and APOB are functional proteins in lipid metabolism and various skin disorders, suggesting ASP may function in lipid metabolism through these partners. This study provided protein-protein interaction information of ASP, and the results will promote further research into the diverse roles of ASP, as well as its binding partners, and their function in different strains of P. sinensis. (C) 2019 Published by Elsevier B.V.

Category: Triazoles. Welcome to talk about 61-82-5, If you have any questions, you can contact Zhang, LL; Yin, SJ; Zheng, XY; Chen, XW; Wang, Q; Park, YD; Qian, GY; Si, YX or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Formula: C2H4N4. In 2021.0 APPL ORGANOMET CHEM published article about METAL-COMPLEXES; CU(II) COMPLEXES; ANTIOXIDANT; NI(II); CO(II); HYDRAZIDE; SPECTRA; CD(II); MODELS; ZN(II) in [Majeed, Abdulnasir A.; Khalil, Mostafa M. H.; Abdel Aziz, Ayman A.] Ain Shams Univ, Dept Chem, Fac Sci, Cairo, Egypt; [Fetoh, Ahmed; Abu El-Reash, G. M.] Mansoura Univ, Dept Chem, Fac Sci, POB 70, Mansoura, Egypt in 2021.0, Cited 64.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

In this work, (Z)-N-benzoyl-N ‘-(1H-1,2,4-triazol-3-yl)carbamimidothioic acid and its Mn(II), Co(II), Cu(II) and Cd(II) complexes were introduced for the first time. This carbonyl thiourea ligand was prepared by the reaction of 1H-1,2,4-triazol-3-amine with benzoyl isothiocyanate. The structural elucidation of these compounds was performed using elemental analysis and spectral and magnetic measurements. Octahedral structures of all complexes, except Cd(II) complex with a tetrahedral geometry, were confirmed by applying DFT structural optimization. The thermal decomposition behaviour of metal complexes of carbonyl thiourea ligand is discussed. The calculation of kinetic parameters for prepared complexes (E-a, A, Delta H*, Delta S* and Delta G*) of all thermal degradation stages has been evaluated using two comparable approaches. Antimicrobial and ABTS-antioxidant studies indicated potent activity of Cd(II) complex compared with the other investigated compounds. The cytotoxic activity of the prepared compounds was investigated in vitro. The results indicated potent activity of Mn(II) complex against both HePG2 (liver carcinoma) and MCF-7 (breast carcinoma) cancer cells.

Formula: C2H4N4. Welcome to talk about 61-82-5, If you have any questions, you can contact Majeed, AA; Khalil, MMH; Fetoh, A; Aziz, AAA; Abu El-Reash, GM or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

SDS of cas: 61-82-5. Li, C; Gao, YT; Xia, XF; Zhu, JW; Wang, X; Fu, YS in [Li, Chun; Gao, Yanting; Xia, Xifeng; Zhu, Junwu; Wang, Xin; Fu, Yongsheng] Nanjing Univ Sci & Technol, Minist Educ, Key Lab Soft Chem & Funct Mat, Nanjing 210094, Peoples R China published Hierarchically Structured Two-Dimensional Bimetallic CoNi-Hexaaminobenzene Coordination Polymers Derived from Co(OH)(2) for Enhanced Oxygen Evolution Catalysis in 2020.0, Cited 68.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Conjugated coordination polymers (CPs) with designable and predictable structures have drawn tremendous attention in recent years. However, the poor electrical conductivity and low structural stability seriously restrict their practical applications in electronic devices. Herein, the rational design and synthesis of a hierarchically structured 2D bimetallic CoNi-hexaaminobenzene CPs derived from Co(OH)(2) are reported as an efficient oxygen evolution reaction (OER) self-supported electrode. The as-obtained electrode possesses high electrochemical surface area and intrinsic activity, exhibiting high electrochemical catalytic activity, favorable reaction kinetics performance, and strong durability compared with those of the powder catalysts. As a result, the electrode delivers low overpotential of 219 mV @ 10 mA cm(-2) and Tafel slope of 42 mV dec(-1) as well as 91.3% retention of current density after 24 h of reaction time. The results of density functional theory computations reveal that the synergistic effect of Co and Ni plays an important role in OER. This work not only presents a strategy to fabricate advanced self-supported electrodes with abundant and dense active sites, but also promotes the development of conjugated CPs for electrocatalysis.

SDS of cas: 61-82-5. Welcome to talk about 61-82-5, If you have any questions, you can contact Li, C; Gao, YT; Xia, XF; Zhu, JW; Wang, X; Fu, YS or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2020.0 MOL DIVERS published article about FUNCTIONALIZED MCM-41; BIOLOGICAL EVALUATION; DERIVATIVES in [Akrami, Sedigheh; Karami, Bahador; Farahi, Mahnaz] Univ Yasuj, Dept Chem, Yasuj 7591874831, Iran in 2020.0, Cited 36.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Safety of 1H-1,2,4-Triazol-5-amine

Herein, an effectual, quick and novel method is described for the synthesis of new triazolo[1,5-a]pyrimidine, triazolo[5,1-b][1,3] thiazine and pyrazolo[1,5-a]pyrimidine derivatives. This series of fused six-member rings to triazole and pyrazole was prepared via the catalyst-free reaction of dialkyl acetylenedicarboxylates and 3-substituted 1H-1,2,4-triazole or 3-amino-1H-pyrazole-4-carbonitrile. The structures of the prepared products were deduced from their Fourier-transform infrared, elemental analysis and proton and carbon-13 nuclear magnetic resonance spectral data. Graphical abstract A novel and green method is described for the synthesis of new triazolo[1,5-a]pyrimidine, triazolo[5,1-b][1,3] thiazine and pyrazolo[1,5-a]pyrimidine derivatives. [GRAPHICS] .

Safety of 1H-1,2,4-Triazol-5-amine. Welcome to talk about 61-82-5, If you have any questions, you can contact Akrami, S; Karami, B; Farahi, M or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application In Synthesis of 1H-1,2,4-Triazol-5-amine. Recently I am researching about BINDING PROTEINS ZFP36L1; SECONDARY WALL FORMATION; WOOD FORMATION; GLUCURONOXYLAN BIOSYNTHESIS; TRANSCRIPTION FACTORS; CELL-PROLIFERATION; GENE-EXPRESSION; HD-ZIP; ARABIDOPSIS; GROWTH, Saw an article supported by the . Published in WILEY in HOBOKEN ,Authors: Tang, XF; Wang, D; Liu, Y; Lu, MZ; Zhuang, YM; Xie, Z; Wang, CP; Wang, SM; Kong, YZ; Chai, GH; Zhou, GK. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Wood (secondary xylem) formation in tree species is dependent on auxin-mediated vascular cambium activity in stems. However, the complex regulatory networks underlying xylem formation remain elusive. Xylem development in Populus was characterized based on microscopic observations of stem sections in transgenic plants. Transcriptomic, quantitative real-time PCR, chromatin immunoprecipitation PCR, and electrophoretic mobility shift assay analyses were conducted to identify target genes involved in xylem development. Yeast two-hybrid, pull-down, bimolecular fluorescence complementation, and co-immunoprecipitation assays were used to validate protein-protein interactions. PaC3H17 and its target PaMYB199 were found to be predominantly expressed in the vascular cambium and developing secondary xylem in Populus stems and play opposite roles in controlling cambial cell proliferation and secondary cell wall thickening through an overlapping pathway. Further, PaC3H17 interacts with PaMYB199 to form a complex, attenuating PaMYB199-driven suppression of its xylem targets. Exogenous auxin application enhances the dual control of the PaC3H17-PaMYB199 module during cambium division, thereby promoting secondary cell wall deposition. Dual regulation of xylem formation by an auxin-mediated PaC3H17-PaMYB199 module represents a novel regulatory mechanism in Populus, increasing our understanding of the regulatory networks involved in wood formation.

Application In Synthesis of 1H-1,2,4-Triazol-5-amine. Welcome to talk about 61-82-5, If you have any questions, you can contact Tang, XF; Wang, D; Liu, Y; Lu, MZ; Zhuang, YM; Xie, Z; Wang, CP; Wang, SM; Kong, YZ; Chai, GH; Zhou, GK or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Name: 1H-1,2,4-Triazol-5-amine. Authors Liu, XT; Xing, SS; Xu, YT; Chen, RQ; Lin, C; Guo, LQ in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Liu, Xiaotao; Xing, Shanshan; Guo, Liangqia] Fuzhou Univ, Coll Chem, Fujian Prov Key Lab Anal & Detect Technol Food Sa, Minist Educ,Key Lab Analyt Sci Food Safety & Biol, Fuzhou 350116, Peoples R China; [Xu, Yuanteng; Lin, Chang] Fujian Med Univ, Affiliated Hosp 1, Dept Otorhinolaryngol, Fuzhou 350005, Peoples R China; [Chen, Ruiqing] Fujian Med Univ, Affiliated Hosp 1, Cent Lab, Fuzhou 350005, Peoples R China in 2021.0, Cited 40.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Graphitic carbon nitride (g-C3N4) has been shown as a promising visible-light photosensitizer for photodynamic therapy (PDT) application. Nevertheless, its therapeutic efficiency is limited by the low efficiency of visible-light utilization. To overcome this issue, 3-amino-1,2,4-triazole-derived graphitic carbon nitride nanosheets (g-C3N5 NSs) are prepared for PDT application. The addition of nitrogen-rich triazole group into the g-C3N4 motif significantly makes the light absorption of g-C3N5 NSs red-shift with the band gap down to 1.95 eV, corresponding to a absorption edge at a wavelength of 636 nm. g-C3N5 NSs generate superoxide anion radicals (O-2(center dot-)) and singlet oxygen (O-1(2)) under the irradiation of a low-intensity white light emitting diode. Owing to the high efficiency of visible-light utilization, g-C3N5 NSs show about 9.5 fold photocatalytic activity of g-C3N4 NSs. In vitro anticancer studies based on the results of CCK-8 assay, Calcein-AM/PI cell-survival assay and photo-induced intracellular ROS level analysis in living HeLa cells demonstrate the potential of g-C3N5 NSs as a low-toxic and biocompatible high-efficient photosensitizer for PDT. (C) 2020 Elsevier B.V. All rights reserved.

Name: 1H-1,2,4-Triazol-5-amine. Welcome to talk about 61-82-5, If you have any questions, you can contact Liu, XT; Xing, SS; Xu, YT; Chen, RQ; Lin, C; Guo, LQ or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recently I am researching about ABSCISIC-ACID; NATURAL VARIATION; PROTEIN; ABI3; GERMINATION; PROMOTER; RELEASE; GENE; 8′-HYDROXYLASES; IDENTIFICATION, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31670323, 31000123]; Shenzhen City Science and Technology Program [JCYJ20160530192105268, JCYJ20180306173702268]; Dapeng New District Science and Technology Program [KY20160205, RCTD20180102]. Published in OXFORD UNIV PRESS INC in CARY ,Authors: Liu, F; Zhang, H; Ding, L; Soppe, WJJ; Xiang, Y. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine. Name: 1H-1,2,4-Triazol-5-amine

ODR1 negatively controls seed dormancy by interacting with the transcription factor bHLH57 and preventing its induction of NCED6 and NCED9 expression and ABA biosynthesis. The control of seed dormancy by abscisic acid (ABA) has been extensively studied, but the underlying mechanism is not fully understood. Here, we report the characterization of two ABA-related seed dormancy regulators in Arabidopsis (Arabidopsis thaliana): ODR1 (for reversal of rdo5), an ortholog of the rice (Oryza sativa) Seed dormancy4 (Sdr4), and the basic helix-loop-helix transcription factor bHLH57. ODR1, whose transcript levels are directly suppressed by the transcription factor ABA INSENSITIVE3 (ABI3), negatively regulates seed dormancy by affecting ABA biosynthesis and ABA signaling. By contrast, bHLH57 positively regulates seed dormancy by inducing the expression of the genes 9-CIS-EPOXYCAROTENOID DIOXYGENASE6 (NCED6) and NCED9, which encode ABA biosynthetic enzymes, and thus leads to higher ABA levels. ODR1 interacts with bHLH57 and inhibits bHLH57-modulated NCED6 and NCED9 expression in the nucleus. bhlh57 loss-of-function alleles can partially counteract the enhanced NCED6 and NCED9 expression seen in odr1 mutants and can therefore rescue their associated hyper-dormancy phenotype. Thus, we identified a novel ABI3-ODR1-bHLH57-NCED6/9 network that provides insights into the regulation of seed dormancy by ABA biosynthesis and signaling.

Name: 1H-1,2,4-Triazol-5-amine. Welcome to talk about 61-82-5, If you have any questions, you can contact Liu, F; Zhang, H; Ding, L; Soppe, WJJ; Xiang, Y or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Kolodziej, B; Morawiak, M; Schilf, W; Kamienski, B in [Kolodziej, Beata] West Pomeranian Univ Technol, Fac Chem Technol & Engn, Dept Inorgan & Analyt Chem, Al Piastow 42, PL-71065 Szczecin, Poland; [Morawiak, Maja; Schilf, Wojciech; Kamienski, Bohdan] Polish Acad Sci, Inst Organ Chem, Ul Kasprzaka 44-52, PL-01224 Warsaw, Poland; [Kamienski, Bohdan] Polish Acad Sci, Inst Phys Chem, Ul Kasprzaka 44-52, PL-01224 Warsaw, Poland published Structure investigations of Schiff bases derived from 3-amino-1H-1,2,4-triazole in 2019.0, Cited 62.0. Formula: C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

In the present paper, twelve Schiff bases derived from 3-amino-1H-1,2,4-triazole (ATz) and various benzaldehydes, and salicylaldehydes were synthesized. The H-1, C-13, and N-15 NMR data are discussed in relation to the structure of ATz and its imine products. In addition, X-ray, ATR-FTIR, and UV-Vis analytical techniques are used for structure elucidation of ATz-based Schiff bases. It was found that the starting material, 3-amino-1H-1,2,4-triazole, exists as tautomeric mixture of three forms (Graphical Abstract) in solution, whereas in the solid state (C-13 and N-15 CPMAS data) potentially tautomeric proton is located on nitrogen atom traditionally marked as N-2 (Graphical Abstract, 2N-H structure). All investigated Schiff bases derived from salicylaldehydes exist in both phases as tautomeric equilibrium mixtures, where enol-imine forms are dominated structures. The positions of those equilibria only very slightly depend on substituents in phenol ring. Generally, the contributions of keto-amine forms in the solid state are higher comparing with DMSO solutions. (C) 2019 Published by Elsevier B.V.

Formula: C2H4N4. Welcome to talk about 61-82-5, If you have any questions, you can contact Kolodziej, B; Morawiak, M; Schilf, W; Kamienski, B or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2020.0 HYPERTENS RES published article about RENIN-ANGIOTENSIN SYSTEM; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; ANTEROVENTRAL 3RD-VENTRICLE AV3V; SYMPATHETIC-NERVE ACTIVITY; OXIDATIVE STRESS; RENAL-HYPERTENSION; PRESSOR-RESPONSES; BLOOD-PRESSURE; RENOVASCULAR HYPERTENSION; CARDIOVASCULAR-RESPONSES in [Lauar, Mariana R.; Colombari, Debora S. A.; Colombari, Eduardo; De Paula, Patricia M.; De Luca Jr, Laurival A.; Menani, Jose, V] Sao Paulo State Univ, Dent Sch, Dept Physiol & Pathol, UNESP, Araraquara, SP, Brazil; [Blanch, Graziela T.] Pontifical Catholic Univ Goias, Sch Med Pharm & Biomed, Goiania, Go, Brazil in 2020.0, Cited 69.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. COA of Formula: C2H4N4

Intracerebroventricular (icv) injection of hydrogen peroxide (H2O2) or the increase of endogenous H2O2 centrally produced by catalase inhibition with 3-amino-1,2,4-triazole (ATZ) injected icv reduces the pressor responses to central angiotensin II (ANG II) in normotensive rats. In the present study, we investigated the changes in the arterial pressure and in the pressor responses to ANG II icv in spontaneously hypertensive rats (SHRs) and 2-kidney, 1-clip (2K1C) hypertensive rats treated with H2O2 injected icv or ATZ injected icv or intravenously (iv). Adult male SHRs or Holtzman rats (n = 5-10/group) with stainless steel cannulas implanted in the lateral ventricle were used. In freely moving rats, H2O2 (5 mu mol/1 mu l) or ATZ (5 nmol/1 mu l) icv reduced the pressor responses to ANG II (50 ng/1 mu l) icv in SHRs (11 +/- 3 and 17 +/- 4 mmHg, respectively, vs. 35 +/- 6 mmHg) and 2K1C hypertensive rats (3 +/- 1 and 16 +/- 3 mmHg, respectively, vs. 26 +/- 2 mmHg). ATZ (3.6 mmol/kg of body weight) iv alone or combined with H2O2 icv also reduced icv ANG II-induced pressor response in SHRs and 2K1C hypertensive rats. Baseline arterial pressure was also reduced (-10 to -15 mmHg) in 2K1C hypertensive rats treated with H2O2 icv and ATZ iv alone or combined and in SHRs treated with H2O2 icv alone or combined with ATZ iv. The results suggest that exogenous or endogenous H2O2 acting centrally produces anti-hypertensive effects impairing central pressor mechanisms activated by ANG II in SHRs or 2K1C hypertensive rats.

COA of Formula: C2H4N4. Welcome to talk about 61-82-5, If you have any questions, you can contact Lauar, MR; Blanch, GT; Colombari, DSA; Colombari, E; De Paula, PM; De Luca, LA; Menani, JV or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics