Category: Triazoles

Authors Pawlik, A; Ruminowicz-Stefaniuk, M; Frac, M; Mazur, A; Wielbo, J; Janusz, G in PUBLIC LIBRARY SCIENCE published article about CELLOBIOSE DEHYDROGENASE; PHENOTYPE MICROARRAYS; BROWN-ROT; DEGRADATION; LACCASE; DIVERSITY; MECHANISMS; ENZYMES in [Pawlik, Anna; Ruminowicz-Stefaniuk, Marta; Janusz, Grzegorz] Marie Curie Sklodowska Univ, Dept Biochem, Lublin, Poland; [Frac, Magdalena] Polish Acad Sci, Inst Agrophys, Lublin, Poland; [Mazur, Andrzej; Wielbo, Jerzy] Marie Curie Sklodowska Univ, Dept Genet & Microbiol, Lublin, Poland in 2019.0, Cited 47.0. Recommanded Product: 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Cerrena unicolor is a wood-degrading basidiomycete with ecological and biotechnological importance. Comprehensive Biolog-based analysis was performed to assess the metabolic capabilities and sensitivity to chemicals of C. unicolor FCL139 growing in various sawdust substrates and light conditions. The metabolic preferences of the fungus towards utilization of specific substrates were shown to be correlated with the sawdust medium applied for fungus growth and the light conditions. The highest catabolic activity of C. unicolor was observed after fungus precultivation on birch and ash sawdust media. The fungus growing in the dark showed the highest metabolic activity which was indicated by capacity to utilize a broad spectrum of compounds and the decomposition of 74/95 of the carbon sources. In all the culture light conditions, p-hydroxyphenylacetic acid was the most readily metabolized compound. The greatest tolerance to chemicals was also observed during C. unicolor growth in darkness. The fungus was the most sensitive to nitrogen compounds and antibiotics, but more resistant to chelators. Comparative analysis of C. unicolor and selected wood-decay fungi from different taxonomic and ecological groups revealed average catabolic activity of the fungus. However, C. unicolor showed outstanding capabilities to catabolize salicin and arbutin. The obtained picture of C. unicolor metabolism showed that the fungus abilities to decompose woody plant material are influenced by various environmental factors.

Welcome to talk about 61-82-5, If you have any questions, you can contact Pawlik, A; Ruminowicz-Stefaniuk, M; Frac, M; Mazur, A; Wielbo, J; Janusz, G or send Email.. Recommanded Product: 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recommanded Product: 1H-1,2,4-Triazol-5-amine. I found the field of Science & Technology – Other Topics; Research & Experimental Medicine very interesting. Saw the article Zinc oxide nanoparticles attenuate hepatic steatosis development in high-fat-diet fed mice through activated AMPK signaling axis published in 2019.0, Reprint Addresses Mondal, P (corresponding author), Indian Inst Technol Mandi, Sch Basic Sci, Mandi, Himachal Prades, India.; Ghosh, D (corresponding author), ITTR, CSIR, Lucknow, Uttar Pradesh, India.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine.

Insulin resistance is thought to be a common link between obesity and Non-Alcoholic Fatty Liver Disease (NAFLD). NAFLD has now reached epidemic status worldwide and identification of molecules or pathways as newer therapeutic strategies either to prevent or overcome insulin resistance seems critical. Dysregulated hepatic lipogenesis (DNL) is a hallmark of NAFLD in humans and rodents. Therefore, reducing DNL accretion may be critical in the development of therapeutics of NAFLD. In our in vivo model (high-fat-diet fed [HFD] obese mice) we found Zinc oxide nanoparticles (ZnO NPs) significantly decreased HFD-induced hepatic steatosis and peripheral insulin resistance. This protective mechanism of ZnO NPs was signaled through hepatic SIRT1-LKB1-AMPK which restricted SREBP-lc within the cytosol limiting its transcriptional ability and thereby ameliorating HFD mediated DNL. These observations indicate that ZnO NP can serve as a therapeutic strategy to improve the physiological homeostasis during obesity and its associated metabolic abnormalities. (C) 2019 Elsevier Inc. All rights reserved.

Recommanded Product: 1H-1,2,4-Triazol-5-amine. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

COA of Formula: C2H4N4. Recently I am researching about CAPILLARY-ELECTROPHORESIS; PRECOLUMN DERIVATIZATION; LIQUID-CHROMATOGRAPHY; HERBICIDE AMITROLE; WATER SAMPLES; NANOPARTICLES; PESTICIDES; URAZOLE, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21605008, 21575018, 21735001, 21705010]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2019JJ30025]. Published in SPRINGER WIEN in WIEN ,Authors: Li, YN; Luo, GY; Qing, ZH; Li, XX; Zou, Z; Yang, R. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

A colorimetric and visual assay is described for the herbicide aminotriazole (ATZ). It is based on the etching of gold nanorods (AuNRs) by iodine which is formed on oxidation of iodide via H2O2. Longitudinal etching of the AuNRs occurs quickly and is accompanied by a color change from dark blue to red. In the absence of ATZ and the presence of active catalase (CAT), H2O2 is quickly decomposed into water, and the AuNRs will not be etched. In thepresence of ATZ, CAT is partially deactivated, and this affects the amount of available H2O2 and, consequently, of the iodine. Hence, the color is significantly changed. The color changes can be easily detected with bare eyes. The assay has a linear response in the 5 to 70 mu M concentration range, with a detection limit of 1.3 mu M and high selectivity for ATZ. It was applied to the determination of ATZ in water and food samples.

COA of Formula: C2H4N4. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2019.0 RSC ADV published article about CHROMONE-3-CARBOXYLIC ACID; REGIOSELECTIVE ACCESS; REARRANGEMENT; (+)-LAURENCIN; CYCLIZATIONS; ANNULATION; FRAMEWORK; ETHERS in [Abozeid, Mohamed Ahmed; El-Sawi, Aya Atef; Elmorsy, Mohamed Ramadan; Abdel-Rahman, Abdel-Rahman Hassan; El-Desoky, El-Sayed Ibrahim] Mansoura Univ, Fac Sci, Dept Chem, Mansoura 35516, Egypt; [Abdelmoteleb, Mohamed] Univ Nebraska, Dept Food Sci & Technol, FARRP, Lincoln, NE 68583 USA; [Abdelmoteleb, Mohamed] Mansoura Univ, Fac Sci, Dept Bot, Mansoura 35516, Egypt in 2019.0, Cited 37.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. SDS of cas: 61-82-5

A new promising protocol has been developed for the synthesis of scarce oxocine derivatives 3a-e and 6 through addition of amine-based nucleophiles such as hydroxylamine hydrochloride, primary amine and hydrazide to chromonylidene benzothiazol-2-ylacetonitrile 2 in refluxing dioxane under metal free reaction conditions in moderate to good yields. Other nitrogen nucleophiles such as piperidine, hydrazine and thiosemicarbazide failed to afford the corresponding oxocinols, and instead pyridine derivatives 7, 8 and 10 were obtained exclusively. Predictive study for the biological activities using PASS (prediction of activity spectra for biologically active substances) online software showed optimistic activities for oxocinols 3a-e in the treatment of cancer, influenza A and microbial infections. Additionally, DFT studies of oxocine derivatives 3a-e and 6 indicated the presence of required thermodynamics parameters for the application in dye-sensitized solar cells (DSSCs).

SDS of cas: 61-82-5. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Computed Properties of C2H4N4. In 2019.0 J MOL STRUCT published article about DENSITY-FUNCTIONAL THEORY; ANTIMICROBIAL EVALUATION; REGIOSELECTIVE SYNTHESIS; VERSATILE PRECURSORS; MOLECULAR-STRUCTURE; CRYSTAL-STRUCTURE; INHIBITORS; DOCKING; OPTIMIZATION; HETEROCYCLES in [Farag, Ahmad M.] Cairo Univ, Dept Chem, Fac Sci, Giza 12613, Egypt; [Fahim, Asmaa M.] Natl Res Ctr Dokki, Dept Green Chem, POB 12622, Cairo, Egypt in 2019.0, Cited 66.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

The utility of the enaminonitriles 3a and 3b for the synthesis of the pyrazole derivatives 5a,b, 7a,b, diaminopyrimidine derivatives 9,11, pyrazolo[1,5-alpha]pyrimidines 12,15, triazolo[4,3-alpha]pyrimidines 13,16, imidazo[1,2-alpha]pyrimidine derivatives 14 and 17, was explored. Most of the synthesized compounds showed excellent in vitro antitumor activity against MCF-7 cell line. They also exhibted high antimicrobial and antioxidant activities. Density functional theory (DFT) calculations at the B3LYP/6-31G level of theory have been carried out to investigate the equilibrium geometry of the novel phenylpyrazolo[1,5-alpha]pyrimidin-6-yl)methanone derivative 12 and phenylpyrazolo[1,5-alpha]pyrimidine derivative 15. The structure-activity relationship (SAR) has been used to correlate the biological activity with the appropriate quantum such as total energy. The energy of the HOMO and LUMO and Mulliken atomic charges were also calculated. (C) 2018 Elsevier B.V. All rights reserved.

Computed Properties of C2H4N4. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Name: 1H-1,2,4-Triazol-5-amine. In 2020.0 J AM CHEM SOC published article about GLUTATHIONE-PEROXIDASE; SUPEROXIDE-DISMUTASE; HYDROGEN-PEROXIDE; CANCER-CELLS; CATALASE; GENERATION; ENZYME; NANOMATERIALS; MECHANISMS; OXIDATION in [Sang, Yanjuan; Cao, Fangfang; Li, Wei; Zhang, Lu; You, Yawen; Deng, Qingqing; Dong, Kai; Ren, Jinsong; Qu, Xiaogang] Chinese Acad Sci, Changchun Inst Appl Chem, Lab Chem Biol, Changchun 130022, Jilin, Peoples R China; [Sang, Yanjuan; Cao, Fangfang; Li, Wei; Zhang, Lu; You, Yawen; Deng, Qingqing; Dong, Kai; Ren, Jinsong; Qu, Xiaogang] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Jilin, Peoples R China; [Sang, Yanjuan; Cao, Fangfang; You, Yawen; Deng, Qingqing] Univ Sci & Technol China, Sch Appl Chem & Engn, Hefei 230026, Anhui, Peoples R China; [Li, Wei; Zhang, Lu] Univ Chinese Acad Sci, Beijing 100039, Peoples R China in 2020.0, Cited 65.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

The insufficient intracellular H2O2 level in tumor cells is closely associated with the limited efficacy of chemodynamic therapy (CDT). Despite tremendous efforts, engineering CDT agents with a straightforward and secure H2O2 supplying ability remains a great challenge. Inspired by the balance of H2O2 generation and elimination in cancer cells, herein, a nanozyme-based H2O2 homeostasis disruptor is fabricated to elevate the intracellular H2O2 level through facilitating H2O2 production and restraining H2O2 elimination for enhanced CDT. In the formulation, the disruptor with superoxide dismutase-mimicking activity can convert O-2(center dot-) to H2O2, promoting the production of H2O2. Simultaneously, the suppression of catalase activity and depletion of glutathione by the disruptor weaken the transformation of H2O2 to H2O. Thus, the well-defined system could perturb the H2O2 balance and give rise to the accumulation of H2O2 in cancer cells. The raised H2O2 level would ultimately amplify the Fenton-like reaction-based CDT efficiency. Our work not only paves a way to engineer alternative CDT agents with a H2O2 supplying ability for intensive CDT but also provides new insights into the construction of bioinspired materials.

Welcome to talk about 61-82-5, If you have any questions, you can contact Sang, YJ; Cao, FF; Li, W; Zhang, L; You, YW; Deng, QQ; Dong, K; Ren, JS; Qu, XG or send Email.. Name: 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

SDS of cas: 61-82-5. Authors Cen, HY; Chen, ZY in ELSEVIER published article about in [Cen, Hongyu; Chen, Zhenyu] Huazhong Univ Sci & Technol, Hubei Key Lab Mat Chem & Serv Failure, Sch Chem & Chem Engn, Wuhan 430074, Peoples R China in 2021.0, Cited 53.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Functionalized graphene oxide (FGO) were synthesized and investigated as corrosion inhibitors of carbon steel in this research. The inhibition behavior of FGO in CO2-saturated NaCl solution was studied via weight loss, surface characterizations, and electrochemical measurements. Results confirm that FGO could protect metal effectively and the inhibition efficiency showed the extreme effect as the increase of FGO concentration, reaching a maximum of 83.4% at 20 mg/L. FGO can adsorb on carbon steel via the functionalized groups and form the hydrophobic cover layer on the metal surface by the lamellar nanoparticles.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. SDS of cas: 61-82-5

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

HPLC of Formula: C2H4N4. Pogaku, V; Krishnan, R; Basavoju, S in [Pogaku, Vinay; Basavoju, Srinivas] Natl Inst Technol, Dept Chem, Warangal 506004, Telangana, India; [Krishnan, R.] Birla Inst Technol & Sci Pilani, Dept Chem, Hyderabad Campus, Hyderabad 500078, India published Synthesis and biological evaluation of new benzo[d][1,2,3]triazol-1-yl-pyrazole-based dihydro-[1,2,4]triazolo[4,3-a]pyrimidines as potent antidiabetic, anticancer and antioxidant agents in 2021.0, Cited 37.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

A series of new benzo[d][1,2,3]triazol-1-yl-pyrazole-based dihydro-[1,2,4]triazolo[4,3-a]pyrimidine derivatives 4a-p were synthesized and well characterized by using IR, H-1,C-13 NMR and mass spectral data. Finally, the structure of the compound 4l was solved unambiguously by single-crystal X-ray diffraction (SXRD) which confirms all the structures 4a-p. The in vitro alpha-glucosidase inhibition, anticancer (A549 and MCF-7 cell lines) and antioxidant studies of the title compounds 4a-pwere screened. Among all the compounds, 4g, 4h and 4n exhibited significant alpha-glucosidase inhibition activity with the IC(50)values 20.12 +/- 0.19 mu M, 21.55 +/- 0.46 mu M and 24.92 +/- 0.98 mu M. Similarly, the compounds 4h, 4d and 4e showed potent anticancer activity against A549 (human lung carcinoma) cell line with IC(50)values 3.64 mu M, 4.73 mu M and 4.56 mu M, respectively, whereas the compounds 4c and 4 o displayed potent anticancer activity against human breast cancer (MCF-7) cell line with IC50 values of 2.66 mu M and 2.11 mu M. In addition, the antioxidant activity revealed that the compounds 4e and 4h exhibited potent antioxidant activity (IC50: 4.25 mu M and 5.40 mu M). To determine the safety profile of the most active compounds4c,4d,4e,4g,4h,4n and 4o were tested against non-cancer HEK293 cell line (human embryonic kidney 293), results in the lower toxicity of these compounds. [GRAPHICS] .

HPLC of Formula: C2H4N4. Welcome to talk about 61-82-5, If you have any questions, you can contact Pogaku, V; Krishnan, R; Basavoju, S or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article SIRT3 Transfection of Aged Human Bone Marrow-Derived Mesenchymal Stem Cells Improves Cell Therapy-Mediated Myocardial Repair WOS:000529988600001 published article about TRANSPLANTATION; SURVIVAL; HEART; GENE; MITOCHONDRIA; METABOLISM; ACTIVATION; INFARCTION; EFFICACY; HOMOLOG in [Zhang, Dong-Yang; Xu, Rong-Jian; Jiao, Wen-Jie] Qingdao Univ, Affiliated Hosp, Dept Thorac Surg, Qingdao 266000, Peoples R China; [Zhang, Dong-Yang; Gao, Tong; Sun, Lu; Zhang, Chun-Feng; Bai, Long; Chen, Wei; Liu, Kai-Yu; Zhou, Yang; Jiao, Xuan; Zhang, Gui-Huan; Tian, Hai] Harbin Med Univ, Affiliated Hosp 2, Future Med Lab, Harbin, Peoples R China; [Gao, Tong; Sun, Lu; Zhang, Chun-Feng; Bai, Long; Chen, Wei; Liu, Kai-Yu; Zhou, Yang; Jiao, Xuan; Zhang, Gui-Huan; Tian, Hai] Harbin Med Univ, Affiliated Hosp 2, Dept Cardiovasc Surg, Harbin 150086, Peoples R China; [Guo, Rui-Lin; Li, Jing-Xuan; Gao, Ying] Harbin Med Univ, Clin Coll 2, Harbin, Peoples R China in 2020.0, Cited 37.0. HPLC of Formula: C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Sirtuin 3 (SIRT3) is a deacetylase important for antioxidant protection, cell longevity, and aging. We hypothesized that SIRT3 improve oxidative resistance of aged cells and improve cell therapy in aged patients. In vitro, the proliferation and oxidative resistance of human mesenchymal stem cells (hMSCs) significantly declined with age. The expression and activity of antioxidant enzymes, including catalase (CAT) and manganese superoxide dismutase (MnSOD), increased after transfection of SIRT3 in hMSCs from older donors (O-hMSCs). The protein level of Forkhead box O3a (FOXO3a) in nucleus increased after SIRT3 overexpression. The antioxidant capacity of O-hMSCs increased after SIRT3 overexpression. 3-Amino-1,2,4-triazole (3-AT, CAT inhibitor) or diethyldithiocarbamate (DETC, SOD inhibitor) that was used to inhibit CAT or SOD activity significantly blocked the antioxidant function of SIRT3. When two inhibitors were used together, the antioxidant function of SIRT3 almost disappeared. Following myocardial infarction and intramyocardial injections of O-hMSCs in rats in vivo, the survival rate of O-hMSCs increased by SIRT3 transfection. The cardiac function of rats was improved after SIRT3-overexpressed O-hMSC transplantation. The infarct size, collagen content, and expression levels of matrix metalloproteinase 2 (MMP2) and MMP9 decreased. Besides, the protein level of vascular endothelial growth factor A and vascular density increased after cell transplantation with SIRT3-modified O-hMSCs. These results indicate that damage resistance of hMSCs decline with age and SIRT3 might protect O-hMSCs against oxidative damage by activating CAT and MnSOD through transferring FOXO3a into nucleus. Meanwhile, the therapeutic effect of aged hMSC transplantation can be improved by SIRT3 overexpression.

Welcome to talk about 61-82-5, If you have any questions, you can contact Zhang, DY; Gao, T; Xu, RJ; Sun, L; Zhang, CF; Bai, L; Chen, W; Liu, KY; Zhou, Y; Jiao, X; Zhang, GH; Guo, RL; Li, JX; Gao, Y; Jiao, WJ; Tian, H or send Email.. HPLC of Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Functional Impacts of the BRCA1-mTORC2 Interaction in Breast Cancer WOS:000504428300058 published article about HISTONE H2AX; BRCT DOMAINS; S-PHASE; DNA; PROTEIN; REPAIR; MDC1; LOCALIZATION; LIGASE; REGION in [Krieger, Kimiko L.; Hu, Wen-Feng; Ripperger, Tyler; Woods, Nicholas T.] Univ Nebraska Med Ctr, Fred & Pamela Buffett Canc Ctr, Eppley Inst Res Canc & Allied Dis, Omaha, NE 68198 USA; [Hu, Wen-Feng] Univ Nebraska Med Ctr, Coll Med, Dept Emergency Med, Omaha, NE 68198 USA; [Ripperger, Tyler] Univ Arizona, Dept Immunobiol, Coll Med, Tucson, AZ 85724 USA in 2019.0, Cited 43.0. Category: Triazoles. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Deleterious mutations in Breast Cancer 1 (BRCA1) are associated with an increased risk of breast and ovarian cancer. Mutations in the tandem BRCA1 C-terminal (tBRCT) protein domain disrupt critical protein interactions required for the faithful repair of DNA through homologous recombination, which contributes to oncogenesis. Our studies have identified RICTOR, PRR5, and SIN1 subunits of the mammalian target of rapamycin complex 2 (mTORC2) as interacting partners with the tBRCT domain of BRCA1 leading to the disruption of the mTORC2 complex. However, the interplay between mTORC2 signaling and BRCA1 function in the DNA damage response (DDR) remains to be determined. In this study, we used protein interaction assays to determine the binary interactions between the tBRCT domain and mTORC2 subunits, evaluated the impact of mTOR inhibition on the transcriptional function of the tBRCT, evaluated the impact of mTOR signaling on BRCA1 recruitment to DNA damage-induced foci and determined the breast cancer cell line response to mTOR inhibition dependent upon BRCA1 expression and mutation. This study determined that PRR5, RICTOR, and SIN1 could each independently interact with the BRCA1 tBRCT. Inhibition of mTORC1, but not mTORC1/2, increases BRCA1 transcriptional activation activity. Treatment with pan-mTOR inhibitor PP242 diminishes DNA damage-induced gamma H2AX and BRCA1 foci formation. Breast cancer cells lacking expression of functional BRCA1 are more sensitive to mTOR inhibitors. These data suggest that mTOR signaling is required for BRCA1 response to DNA damage and breast cancer cells lacking BRCA1 are more sensitive to pan-mTOR inhibition. This work suggests chemotherapeutic strategies using mTOR inhibitors could be tailored for patients that lack functional BRCA1.

Welcome to talk about 61-82-5, If you have any questions, you can contact Krieger, KL; Hu, WF; Ripperger, T; Woods, NT or send Email.. Category: Triazoles

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics