Category: Triazoles

In 2019.0 J HETEROCYCLIC CHEM published article about PYRIMIDINE DERIVATIVES; CONVENIENT; INHIBITORS; UTILITY; HETEROCYCLES; ANTICANCER; THIAZOLES; ANALOGS; DESIGN in [Abdelhamid, Abdou O.; Gomha, Sobhi M.; El-Enany, Waleed A. M. A.] Cairo Univ, Fac Sci, Dept Chem, Giza, Egypt; [Gomha, Sobhi M.] Islamic Univ Almadinah Almonawara, Fac Sci, Dept Chem, Almadinah Almonawara 42351, Saudi Arabia in 2019.0, Cited 48.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Computed Properties of C2H4N4

Sodium salt of 3-hydroxy-1-(1-aryl-5-methylpyrazolyl)propenone derivatives was used as a precursor for synthesis of various fused azolopyrimidine ring systems as pyrazolopyrimidines, triazolopyrimidines, and pyrimidobenzimidazoles following many procedures. The identity of the prepared compounds was elucidated by their spectral data and elemental analyses. The in vitro antimicrobial activity of 13 new compounds was evaluated, and many derivatives showed good to moderate activity.

Welcome to talk about 61-82-5, If you have any questions, you can contact Abdelhamid, AO; Gomha, SM; El-Enany, WAMA or send Email.. Computed Properties of C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

HPLC of Formula: C2H4N4. In 2020.0 RUSS J ORG CHEM+ published article about DENSITY-FUNCTIONAL THERMOCHEMISTRY; BEARING BRIDGEHEAD NITROGEN; SPECTROSCOPIC CHARACTERIZATION; SMALL-MOLECULE; POTENT; OPTIMIZATION; INHIBITORS; AMETOCTRADIN; POLYMERASE; AGENTS in [Mohamed, H. S.] Beni Suef Univ, Res Inst Med & Aromat Plants, Bani Suwayf 62511, Egypt; [Abdel-Latif, M. K.; Ahmed, S. A.] Beni Suef Univ, Fac Sci, Dept Chem, Bani Suwayf 62511, Egypt in 2020.0, Cited 41.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Treatment of 3-methylcyclohexanone with ethyl formate in the presence of sodium methoxide afforded sodium (2-methyl-6-oxocyclohexylidene)methanolate which reacted with aminopyrazoles, aminotriazole, and aminotetrazole to produce fused quinazoline derivatives; its reactions with cyanothioacetamide, cyanoacetamide, and cyanoacetohydrazide gave tetrahydroquinoline-3-carbonitrile derivatives. The reactions of 8-methyl-2-sulfanyl-5,6,7,8-tetrahydroquinoline-3-carbonitrile with alkylating agents led to the formation of thieno[2,3-b]quinoline derivatives. DFT computational studies of the synthesized compounds were carried out using B3LYP/6-311+G** and HF/6-311+G** approximations. The calculated HOMO and LUMO energies showed that charge transfer occurs in their molecules.

Welcome to talk about 61-82-5, If you have any questions, you can contact Mohamed, HS; Abdel-Latif, MK; Ahmed, SA or send Email.. HPLC of Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Authors Sadek, KU; Abdel-Hameed, AM; Abdelnabi, HA; Meleigy, Y in WALTER DE GRUYTER GMBH published article about ALPHA-AMINO NITRILES; MULTICOMPONENT REACTIONS; NATURAL-PRODUCTS; IMIDAZOLES; ALDEHYDES in [Sadek, Kamal Usef; Abdel-Hameed, Afaf Mohamed; Abdelnabi, Hisham A.; Meleigy, Yasser] Menia Univ, Fac Sci, Chem Dept, Al Minya 61519, Egypt in 2019.0, Cited 28.0. Quality Control of 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

A highly efficient multi-component one-pot synthesis of novel 1H-imidazo[1,2-a]imidazole-3-amine and imidazo[2,1-c][1,2,4]triazole-5-amine derivatives has been developed through the reaction of easily available aromatic aldehydes, benzoyl cyanide and either 2-aminoimidazole-4,5-dicarbonitrile or 3-amino-1,2,4-triazole in pyridine under controlled microwave heating. The process is environmentally friendly, is operationally simple, with short reaction time and with high yields.

Welcome to talk about 61-82-5, If you have any questions, you can contact Sadek, KU; Abdel-Hameed, AM; Abdelnabi, HA; Meleigy, Y or send Email.. Quality Control of 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Category: Triazoles. In 2020.0 CATAL LETT published article about CHEMICAL FIXATION; CO2; PERFORMANCE; SEPARATION; POLYMER; MOF; MG in [Luo, Zhiqiang; Wang, Jun; He, Yanqing; Ao, Qiong; Deng, Qiang; Zeng, Zheling] Nanchang Univ, Minist Educ, Key Lab Poyang Environm & Resource Utilizat, Nanchang 330031, Jiangxi, Peoples R China; [Luo, Zhiqiang; Wang, Jun; He, Yanqing; Ao, Qiong; Deng, Qiang; Zeng, Zheling] Nanchang Univ, Sch Resource Environm & Chem Engn, Nanchang 330031, Jiangxi, Peoples R China; [Wang, Hongming] Nanchang Univ, Inst Adv Study, Nanchang 330031, Jiangxi, Peoples R China; [Deng, Shuguang] Arizona State Univ, Sch Engn Matter Transport & Energy, 551 E Tyler Mall, Tempe, AZ 85287 USA in 2020.0, Cited 31.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Developing highly efficient heterogeneous catalysts for cycloaddition of CO2 and epoxides to produce cyclic carbonates is promising but challenging. In this work, a novel three-dimensional metal organic framework (MOF) with cylinder pore systems and unsaturated Zn sites has been demonstrated as potent candidate in CO2 fixation at mild and solvent-free conditions. The Zn(atz)(bdc)(0.5), where atz = aminotriazole and H(2)bdc = terephthalic, exhibits microporous nature that can regulate the catalytic interaction of active centers and substrates. The structure stability has been systematically investigated and proven to be sufficient for practical application. Furthermore, the cooperative effects of porosity, CO2 binding affinity, activation centers, and synergism with co-catalyst have been deeply investigated. Moreover, high propylene epoxide conversion (97%) and selectivity (> 99%) have been achieved at mild conditions (60 degrees C and 1 MPa) with excellent cycle stability. Owing to the well-defined pore system, an obvious substrates selectivity has been clearly observed. A possible catalytic mechanism has been proposed and verified by DFT calculations. Furthermore, the prepared Zn-MOF can also be used as an efficient heterogeneous catalyst for the reaction of epoxides with alcohols to produce beta-alkoxy alcohol. [GRAPHICS] .

Welcome to talk about 61-82-5, If you have any questions, you can contact Luo, ZQ; Wang, J; He, YQ; Ao, Q; Deng, Q; Zeng, ZL; Wang, HM; Deng, SG or send Email.. Category: Triazoles

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Nagarkoti, S; Dubey, M; Sadaf, S; Awasthi, D; Chandra, T; Jagavelu, K; Kumar, S; Dikshit, M in [Nagarkoti, Sheela; Dubey, Megha; Sadaf, Samreen; Awasthi, Deepika; Jagavelu, Kumaravelu; Kumar, Sachin] Cent Drug Res Inst, CSIR, Pharmacol Div, Lucknow, Uttar Pradesh, India; [Chandra, Tulika] King Georges Med Univ, Lucknow, Uttar Pradesh, India; [Dikshit, Madhu] Translat Hlth Sci & Technol Inst, NCR Biotech Sci Cluster, THSTI Natl Chair, 3rd Milestone,Faridabad Gurgaon Expressway, Faridabad 121001, Haryana, India published Catalase S-Glutathionylation by NOX2 and Mitochondrial-Derived ROS Adversely Affects Mice and Human Neutrophil Survival in 2019.0, Cited 70.0. SDS of cas: 61-82-5. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Neutrophil survival and oxidative stress during inflammatory conditions are linked to tissue damage. The present study explores less understood role of catalase, the enzyme catalysing hydrogen peroxide decomposition, in neutrophil survival/death. Importantly, inhibition of catalase activity following S-glutathionylation in the PMA, NO, or zymosan-activated neutrophils or treatment with catalase inhibitor led to neutrophil death. On the contrary, introducing reducing environment by TCEP rescued catalase activity and significantly improved neutrophil survival. Furthermore, augmentation in ROS generation by NOX-2 activation or induction of mitochondrial ROS by Antimycin-A induced catalase S-glutathionylation and cell death, which was prevented in the neutrophil cytosolic factor1 (NCF-1-/-) cells or was rescued by MitoTEMPO, a mitochondrial ROS scavenger, thus, suggesting a correlation between catalase S-glutathionylation/activity inhibition and reduced neutrophil survival. Altogether, enhanced NOX2 activation/mitochondrial dysfunction led to reduced survival of human and mice neutrophils, due to H2O2 accumulation, S-glutathionylation of catalase, and reduction in its enzymatic activity. The present study thus demonstrated mitigation of catalase activity under oxidative stress-impacted neutrophil survival.

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Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Docking of acetyl-CoA carboxylase to the plastid envelope membrane attenuates fatty acid production in plants WOS:000608522800010 published article about CARRIER PROTEIN; ARABIDOPSIS; SPINACH; LIGHT; BIOSYNTHESIS; WRINKLED1; COENZYME; PHOSPHORYLATION; ACCUMULATION; GENES in [Ye, Yajin; Fedosejevs, Eric T.; Van Doren, Steven R.; Thelen, Jay J.] Univ Missouri, Christopher S Bond Life Sci Ctr, Dept Biochem, 1201 E Rollins, Columbia, MO 65211 USA; [Nikovics, Krisztina; To, Alexandra; Lepiniec, Loic; Baud, Sebastien] Univ Paris Saclay, AgroParisTech, Inst Jean Pierre Bourgin, INRAE,CNRS, F-78000 Versailles, France in 2020.0, Cited 60.0. SDS of cas: 61-82-5. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

In plants, light-dependent activation of de novo fatty acid synthesis (FAS) is partially mediated by acetyl-CoA carboxylase (ACCase), the first committed step for this pathway. However, it is not fully understood how plants control light-dependent FAS regulation to meet the cellular demand for acyl chains. We report here the identification of a gene family encoding for three small plastidial proteins of the envelope membrane that interact with the alpha-carboxyltransferase (alpha-CT) subunit of ACCase and participate in an original mechanism restraining FAS in the light. Light enhances the interaction between carboxyltransferase interactors (CTIs) and alpha-CT, which in turn attenuates carbon flux into FAS. Knockouts for CTI exhibit higher rates of FAS and marked increase in absolute triacylglycerol levels in leaves, more than 4-fold higher than in wild-type plants. Furthermore, WRINKLED1, a master transcriptional regulator of FAS, positively regulates CTI1 expression by direct binding to its promoter. This study reveals that in addition to light-dependent activation, envelope docking of ACCase permits fine-tuning of fatty acid supply during the plant life cycle.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. SDS of cas: 61-82-5

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Category: Triazoles. Recently I am researching about QUANTUM-CHEMICAL CALCULATIONS; CARBONIC-ANHYDRASE-IX; SULFAMETHAZINE SCHIFF-BASE; HUMAN THYMIDYLATE SYNTHASE; DENSITY-FUNCTIONAL THEORY; CRYSTAL-STRUCTURE; ANTIMICROBIAL ACTIVITY; VIBRATIONAL-SPECTRA; BROMOBENZENE DERIVATIVES; SULFONAMIDE DERIVATIVES, Saw an article supported by the . Published in ELSEVIER SCIENCE BV in AMSTERDAM ,Authors: Fahim, AM; Shalaby, MA. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

The reaction of N-(4-acetylphenyl)benzene sulphonamide derivatives 3a and 3b with N,N dimethyl formamide dimethyl acetal (DMF-DMA) afford acryloyl(phenyl)benzenesulfonamide derivatives 4a and 4b; respectively. The chemical reactivity of enaminonitriles 4a and 4b towards hydrazine hydrate or hydroxylamine was studied for synthesizing of pyrazolyl and isoxazolyl-phenyl benzenesulfonamide derivatives 5a,b and 6a,b; respectively. Also, the treatment of enaminonitriles 4a and 4b with thiosemicarbazide or heterocyclic amines derivatives afford the novel sulfonamide derivatives. Furthermore, the reactivity of acetylsulfonamide derivatives towards nitrogen nucleophiles and dimedone afforded novel benzene sulfonamide compounds. Some of the synthesized chlorinated compounds exhibited excellent in vitro antitumor activity against HepG2 and MCF-7 cell lines. Additionally, further studies were carried out on one of the most effective compounds, 4-chloro-N-(4-(isoxazole-3-yl)phenyl) benzenesulfonamide 6a (ISP), to evaluate its potential interaction against KSHV thymidylate synthase complex. The comprehensive theoretical and experimental mechanical studies of compound 6a (ISP) were compatible with elemental analysis, FTIR, H-1 NMR and MS spectral data. The optimized molecular structure and the harmonic vibrational frequencies were examined via Density functional theory (DFT)/B3LYP/6-31G(d) and Hartree-Fock HF/6-31G(d) energies. (C) 2018 Elsevier B.V. All rights reserved.

Category: Triazoles. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Wang, X; Ma, B; Wang, YT; Lu, SY; Ma, M; Shi, YQ; Chen, S in [Wang, Xu; Ma, Biao; Wang, Yating; Lu, Songyan; Ma, Meng; Shi, Yanqin; Chen, Si] Zhejiang Univ Technol, Coll Mat Sci & Engn, Hangzhou 310014, Zhejiang, Peoples R China published A new theory of two-step stabilization mechanism for triazole-based zinc-containing complex as thermal stabilizer for polyvinyl chloride) in 2019.0, Cited 31.0. Safety of 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

A totally new theory of two-step stabilization mechanism for triazole-based zinc-containing complex (abbreviated as (Zn(ttr)(OAc)]) was proposed through several designed experiments. [Zn(ttr)(OAc)] strongly absorbed HCl at the beginning, and then broke down into 3-amino-1,2,4-triazole which could further stabilized PVC. The structure of [Zn(ttr)(OAc)] was characterized by FTIR spectroscopy, elemental analysis and SEM. Then, Congo red tests and discoloration tests verified [Zn(ttr)(OAc)] could absorb HCl effectively, but PVC showed poor initial whiteness, which further proved above -mentioned stabilization mechanism. Moreover, [Zn(ttr)(OAc)] combined with ZnSt(2) and dibenzoyl methane (DBM) effectively improved the initial color of PVC samples and provided PVC with shorter plasticizing time and longer dynamic thermal stability time than commercial stabilizer 1086F, confirmed by discoloration tests and dynamic thermal stability analysis. We believe [Zn(ttr)(OAc)]/ZnSt(2)/DBM stabilizer system can be used as a commercial stabilizer and the stabilization mechanism of [Zn(ttr)(OAc)] may provide a new way to stabilize PVC. (C) 2019 Published by Elsevier Ltd.

Safety of 1H-1,2,4-Triazol-5-amine. Welcome to talk about 61-82-5, If you have any questions, you can contact Wang, X; Ma, B; Wang, YT; Lu, SY; Ma, M; Shi, YQ; Chen, S or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Preparation and characterization of a novel DABCO-based ionic liquid supported on Fe3O4@TiO(2)nanoparticles and investigation of its catalytic activity in the synthesis of quinazolinones published in 2020.0. Name: 1H-1,2,4-Triazol-5-amine, Reprint Addresses Ghasemzadeh, MA (corresponding author), Islamic Azad Univ, Qom Branch, Dept Chem, Qom, Iran.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

In this study, quinazolinone derivatives have been synthesized via a suitable and efficient procedure by one-potmulti-component reactions of 3-amino-1,2,4-triazole or 2-aminobenzimidazole, dimedone and aromatic aldehydes in the presence of Fe3O4@TiO2-IL as nanocatalyst under solvent-free condition. The products were prepared in good to excellent yields using Fe3O4@TiO2-IL magnetic nanocatalyst. The Fe3O4@TiO(2)magnetic nanoparticles (MNPs) were prepared using beet juice extract and functionalized with IL based on DABCO. Moreover, the core-shell structured magnetic Fe3O4@TiO2-IL has been characterized by different techniques such as(1)H-NMR, FT-IR, VSM, XRD, SEM, TGA, TEM and EDX. To the best of our knowledge, the prepared ionic liquid displayed a good protective and activator agent for magnetic nanocatalyst.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. Name: 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Zurlinden, TJ; Saili, KS; Baker, NC; Toimela, T; Heinonen, T; Knudsen, TB in [Zurlinden, Todd J.; Saili, Katerine S.; Knudsen, Thomas B.] US EPA, Off Res & Dev, Ctr Computat Toxicol & Exposure, Res Triangle Pk, NC USA; [Baker, Nancy C.] Leidos, Alexandria, VA USA; [Toimela, Tarja; Heinonen, Tuula] Tampere Univ, Fac Med & Hlth Technol, FICAM, Tampere, Finland published A cross-platform approach to characterize and screen potential neurovascular unit toxicants in 2020.0, Cited 79.0. Name: 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Development of the neurovascular unit (NVU) is a complex, multistage process that requires orchestrated cell signaling mechanisms across several cell types and ultimately results in formation of the blood-brain barrier. Typical high-throughput screening (HTS) assays investigate single biochemical or single cell responses following chemical insult. As the NVU comprises multiple cell types interacting at various stages of development, a methodology combining high-throughput results across pertinent cell-based assays is needed to investigate potential chemical-induced disruption to the development of this complex cell system. To this end, we implemented a novel method for screening putative NVU disruptors across diverse assay platforms to predict chemical perturbation of the developing NVU. HTS assay results measuring chemical-induced perturbations to cellular key events across angiogenic and neurogenic outcomes in vitro were combined to create a cell-based prioritization of NVU hazard. Chemicals were grouped according to similar modes of action to train a logistic regression literature model on a training set of 38 chemicals. This model utilizes the chemical-specific pairwise mutual information score for PubMed MeSH annotations to represent a quantitative measure of previously published results. Taken together, this study presents a methodology to investigate NVU developmental hazard using cell-based HTS assays and literature evidence to prioritize screening of putative NVU disruptors towards a knowledge-driven characterization of neurovascular developmental toxicity. The results from these screening efforts demonstrate that chemicals representing a range of putative vascular disrupting compound (pVDC) scores can also produce effects on neurogenic outcomes and characterizes possible modes of action for disrupting the developing NVU.

Welcome to talk about 61-82-5, If you have any questions, you can contact Zurlinden, TJ; Saili, KS; Baker, NC; Toimela, T; Heinonen, T; Knudsen, TB or send Email.. Name: 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics