Category: Triazoles

Authors Liu, J; Du, YX; Sun, XD; Feng, ZJ; Ma, XF; Li, JT in ELSEVIER SCIENCE BV published article about IONIC LIQUIDS; ENANTIOMERIC SEPARATION; BETA-CYCLODEXTRINS; ENANTIOSEPARATION; PERFORMANCE; COMPLEXES; MECHANISM; LIGAND; DRUGS; MODEL in [Liu, Jie; Du, Yingxiang; Sun, Xiaodong; Feng, Zijie; Ma, Xiaofei; Li, Jingtang] China Pharmaceut Univ, Dept Analyt Chem, 24 Tongjiaxiang, Nanjing 210009, Jiangsu, Peoples R China; [Du, Yingxiang] China Pharmaceut Univ, Minist Educ, Key Lab Drug Qual Control & Pharmacovigilance, Nanjing 210009, Jiangsu, Peoples R China; [Du, Yingxiang] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China in 2019.0, Cited 39.0. Computed Properties of C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

In this paper, a chiral selector, N-(4-H-1, 2, 4-triazolium)-lactobionamides (LA-ATM), was synthesized and applied for enantioseparation in capillary electrophoresis (CE) for the first time. Compared with lactobionic acid (LA) separation system, enhanced enantioseparation of five tested drugs was achieved in this modification system. In order to achieve good chiral separation, several parameters such as chiral selector concentration, buffer pH, applied voltage as well as the type and proportion of organic modifier were systematically investigated. Molecular modeling was applied to demonstrate the chiral recognition mechanism of the LA-ATM, which well supported the experimental results. Furthermore, a mathematical equation built up based on the molecular mechanics calculations was used in predicting resolution of tested drugs using LA or LA-ATM mediated CE, the predicted result was well correlated with the experimental result. (C) 2019 Published by Elsevier B.V.

Computed Properties of C2H4N4. Welcome to talk about 61-82-5, If you have any questions, you can contact Liu, J; Du, YX; Sun, XD; Feng, ZJ; Ma, XF; Li, JT or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Docking of acetyl-CoA carboxylase to the plastid envelope membrane attenuates fatty acid production in plants WOS:000608522800010 published article about CARRIER PROTEIN; ARABIDOPSIS; SPINACH; LIGHT; BIOSYNTHESIS; WRINKLED1; COENZYME; PHOSPHORYLATION; ACCUMULATION; GENES in [Ye, Yajin; Fedosejevs, Eric T.; Van Doren, Steven R.; Thelen, Jay J.] Univ Missouri, Christopher S Bond Life Sci Ctr, Dept Biochem, 1201 E Rollins, Columbia, MO 65211 USA; [Nikovics, Krisztina; To, Alexandra; Lepiniec, Loic; Baud, Sebastien] Univ Paris Saclay, AgroParisTech, Inst Jean Pierre Bourgin, INRAE,CNRS, F-78000 Versailles, France in 2020.0, Cited 60.0. Name: 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

In plants, light-dependent activation of de novo fatty acid synthesis (FAS) is partially mediated by acetyl-CoA carboxylase (ACCase), the first committed step for this pathway. However, it is not fully understood how plants control light-dependent FAS regulation to meet the cellular demand for acyl chains. We report here the identification of a gene family encoding for three small plastidial proteins of the envelope membrane that interact with the alpha-carboxyltransferase (alpha-CT) subunit of ACCase and participate in an original mechanism restraining FAS in the light. Light enhances the interaction between carboxyltransferase interactors (CTIs) and alpha-CT, which in turn attenuates carbon flux into FAS. Knockouts for CTI exhibit higher rates of FAS and marked increase in absolute triacylglycerol levels in leaves, more than 4-fold higher than in wild-type plants. Furthermore, WRINKLED1, a master transcriptional regulator of FAS, positively regulates CTI1 expression by direct binding to its promoter. This study reveals that in addition to light-dependent activation, envelope docking of ACCase permits fine-tuning of fatty acid supply during the plant life cycle.

Name: 1H-1,2,4-Triazol-5-amine. Welcome to talk about 61-82-5, If you have any questions, you can contact Ye, YJ; Nikovics, K; To, A; Lepiniec, L; Fedosejevs, ET; Van Doren, SR; Baud, S; Thelen, JJ or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Product Details of 61-82-5. Recently I am researching about NANOSHEETS; G-C3N4; NITROGEN; WATER; PERFORMANCE; EVOLUTION; TRANSFORMATIONS; MELAMINE; C3N4; SOFT, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21771061, 21601055]; University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province [UNPYSCT-2017118]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Zhao, C; Li, Q; Xie, Y; Zhang, LP; Xiao, XD; Wang, D; Jiao, YQ; Price, CAH; Jiang, BJ; Liu, J. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

The three-dimensional character of carbon nitride can endow it with a larger specific surface area and more catalytic active sites, which are beneficial for charge and mass transfer to enhance photocatalytic hydrogen production reactions. Herein, we reported the direct assembly of three-dimensional structured carbon nitride from the thermal polymerization of 3-amino-1,2,4-triazole (AT) and melamine molecules. The 3D C3N4 consisted of one-dimensional thick tubes with numbers of thin tubes grown uniformly on their surfaces. It was noted that the assembly was decorated with triazole ring groups that generated a special nitrogen-rich structure, further broadening the visible-light response range. Furthermore, the nitrogen-rich carbon nitride had a large surface area of 71 m(2) g(-1), leading to a significant increase in the number of catalytic active sites. Thus, the photocatalytic hydrogen production rate reached 7.1 mmol g(-1) h(-1), 11.2 times higher than that of bulk C3N4. This work may provide a new strategy to controllably synthesize three-dimensional carbon nitride assemblies for photocatalytic applications.

Product Details of 61-82-5. Welcome to talk about 61-82-5, If you have any questions, you can contact Zhao, C; Li, Q; Xie, Y; Zhang, LP; Xiao, XD; Wang, D; Jiao, YQ; Price, CAH; Jiang, BJ; Liu, J or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

I found the field of Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Chemistry; Food Science & Technology very interesting. Saw the article OsDRE2 contributes to chitin-triggered response through its interaction with OsRLCK185 published in 2019.0. Recommanded Product: 61-82-5, Reprint Addresses Yamaguchi, K; Kawasaki, T (corresponding author), Kindai Univ, Grad Sch Agr, Dept Adv Biosci, Naka, Nara, Japan.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

The rice receptor-like cytoplasmic kinase 185 (OsRLCK185) interacts with the chitin receptor complex OsCERK1/CEBiP and positively regulates chitin-induced immune responses including MAP kinase activation, ROS production and defense gene expression. To elucidate the regulatory mechanisms of OsRLCK185-mediated immunity, we searched for interactors of OsRLCK185. OsDRE2a, rice homologs of the yeast Dre2 protein, were identified as novel interactors of OsRLCK185. OsDRE2a interacted with OsRLCK185 at plasma membrane. The conserved cysteine residues in CIAPIN1 domain of OsDRE2a were essential for tight interaction of OsRLCK185. OsDRE2a was phosphorylated by OsRLCK185. The expression of OsDRE2a and OsDRE2b was induced after chitin treatment. Reduction of OsDRE2a and OsDRE2b mRNA levels by RNA interference resulted in the decreased chitin-induced ROS production. Thus, it is likely that OsDRE2 regulates OsRLCK185-mediated immune responses.

Recommanded Product: 61-82-5. Welcome to talk about 61-82-5, If you have any questions, you can contact Yamaguchi, K; Yoshimura, Y; Nakagawa, S; Mezaki, H; Yoshimura, S; Kawasaki, T or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

COA of Formula: C2H4N4. In 2019.0 CHEM HETEROCYCL COM+ published article about ONE-POT SYNTHESIS; BUILDING-BLOCKS; HYDRAZINE; COMPLEXES; EFFICIENT; DERIVATIVES; LIGAND; YLIDE in [Kudyakova, Yulia S.; Slepukhin, Pavel A.; Burgart, Yanina V.; Saloutin, Victor I.; Bazhin, Denis N.] Russian Acad Sci, Ural Branch, Postovsky Inst Organ Synth, 22 S Kovalevskoi,20 Akad Skaya St, Ekaterinburg 620990, Russia; [Onoprienko, Aleksandra Ya.; Slepukhin, Pavel A.; Burgart, Yanina V.; Saloutin, Victor I.; Bazhin, Denis N.] Ural Fed Univ, 19 Mira St, Ekaterinburg 620002, Russia in 2019.0, Cited 53.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Five- and six-membered fluorine-containing azaheterocycles were synthesized based on available furan-3(2H)-ones, and the influence of the nature of the fluoroalkyl substituent on the direction of the chemical transformations by the action of N,N- and N,O-binucleophiles was revealed.

Welcome to talk about 61-82-5, If you have any questions, you can contact Kudyakova, YS; Onoprienko, AY; Slepukhin, PA; Burgart, YV; Saloutin, VI; Bazhin, DN or send Email.. COA of Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Interaction between MdMYB63 and MdERF106 enhances salt tolerance in apple by mediating Na+/H+ transport WOS:000581918000045 published article about R2R3-MYB TRANSCRIPTION FACTOR; R2R3-TYPE MYB GENE; STRESS TOLERANCE; EXPRESSION; REGULATOR; SALINITY; PATHWAY; FRUIT; SOS1 in [Yu, Lei; Liu, Wenjun; Guo, Zhangwen; Li, Zhiqiang; Jiang, Huiyan; Zou, Qi; Mao, Zuolin; Zhang, Zongying; Wang, Nan; Chen, Xuesen] Shandong Agr Univ, Coll Hort Sci, State Key Lab Crop Biol, 61 Daizong Rd, Tai An 271018, Shandong, Peoples R China; [Fang, Hongcheng] Shandong Agr Univ, Coll Forestry, State Forestry & Grassland Adm Key Lab Silvicultu, Tai An, Shandong, Peoples R China in 2020.0, Cited 34.0. COA of Formula: C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Salt stress is an important environmental factor affecting the growth and production of agricultural crops and fruits worldwide, including apple (Males x domestica). In this study, we demonstrate that a salt-responsive MYB transcription factor (TF), designated as MdMYB63, promotes survival under salt stress. Overexpression of MdMYB63 in apple calli significantly enhanced salt tolerance. Screening of the AP2/ERF family of TFs identified MdERF106 as an interaction partner of MdMYB63. Further analyses showed that the MdMYB63-MdERF106 complex significantly promotes the expression of downstream MdSOS1, thereby improving the Na+ expulsion and salt tolerance of apple. These functional analyses of MdMYB63 have provided valuable insights into the regulatory network of salt tolerance, and lay a theoretical foundation for the cultivation of new salt-tolerant apple varieties.

Welcome to talk about 61-82-5, If you have any questions, you can contact Yu, L; Liu, WJ; Guo, ZW; Li, ZQ; Jiang, HY; Zou, Q; Mao, ZL; Fang, HC; Zhang, ZY; Wang, N; Chen, XS or send Email.. COA of Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Aumeier, BM; Dang, AHQ; Ohs, B; Yuce, S; Wessling, M in [Aumeier, Benedikt M.; Dang, Anh H. Q.; Ohs, Burkhard; Yuece, Sueleyman; Wessling, Matthias] Rhein Westfal TH Aachen, Aachener Verfahrenstech, Chem Proc Engn, Forckenbeckstr 51, D-52074 Aachen, Germany; [Wessling, Matthias] DWI Leibniz Inst Interact Mat, Forckenbeckstr 50, D-52074 Aachen, Germany published Aqueous-Phase Temperature Swing Adsorption for Pesticide Removal in 2019.0, Cited 67.0. SDS of cas: 61-82-5. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Recently, activated carbon adsorption for water treatment regained substantial attention due to the emerging task to remove trace organic compounds such as pesticides. In many applications, especially in decentralized water treatment, one major drawback of adsorbents is their limited recyclability due to inadequate logistics or uneconomical reactivation. In this lab-scale study, we present the temperature swing adsorption in the aqueous phase that allows the in situ regeneration of fixed-bed adsorbers, and prove its technical feasibility. Complying with circular water economy principles, we eliminated the pivotal need for regular replacement and consumables by employing only clean water instead of dedicated regeneration solutions. Adsorption of the herbicide amitrole in aqueous solution on granular activated carbon was exothermic (Delta H = -14.4 +/- 3.2 kJ mol(-1) for T = 20-94 degrees C) and followed the Freundlich model. The proposed method consisting of a short counterflow flush with liquid water at 125 degrees C effectively regenerated the adsorbent. Hence, we obtained a cyclic steady state operation with breakthrough after 122 +/- 14 bed volumes (at c(out)/c(in) = 0.2), cycle-average rejection of 90 +/- 1%, and water recovery of up to 78 +/- 4%. No thermal aging of adsorbent was observed over the investigated 17 cycles.

SDS of cas: 61-82-5. Welcome to talk about 61-82-5, If you have any questions, you can contact Aumeier, BM; Dang, AHQ; Ohs, B; Yuce, S; Wessling, M or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

I found the field of Chemistry; Science & Technology – Other Topics; Engineering very interesting. Saw the article Facile Covalent Crosslinking of Zeolitic Imidazolate Framework/Polydimethylsiloxane Mixed Matrix Membrane for Enhanced Ethanol/Water Separation Performance published in 2020.0. Product Details of 61-82-5, Reprint Addresses Wang, Y (corresponding author), Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Minist Educ, Key Lab Mat Chem Energy Convers & Storage, Wuhan 430074, Peoples R China.; Wang, Y (corresponding author), Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Hubei Key Lab Mat Chem & Serv Failure, Wuhan 430074, Peoples R China.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

The interfacial design is critical in preparing high-performance mixed matrix membranes (MMMs), especially for the separation of larger sized components from mixtures. Herein, a facile and novel strategy was employed to design covalently linked zeolitic imidazolate framework-8-polydimethylsiloxane (ZIF-8@PDMS) MMMs without interfacial defects by a onestep synthesis route for ethanol recovery from ethanol aqueous solution. In this strategy, 3-glycidyloxypropyltrimethoxysilane (GOPTS) worked as the covalent linker of PDMS and amine-functionalized ZIF-8 nanoparticles (AZIF-8) simultaneously. The chemical structures and morphologies of AZIF-8 and AZIF-8@PDMS MMMs were demonstrated by various characterization techniques. The results exhibited that AZIF-8 and the MMMs were successfully prepared and AZIF-8 as the filler displayed better dispersion in the PDMS matrix and compatibility with the PDMS matrix as compared to ZIF-8 or GOPTS-modified ZIF-8 (GZIF-8). Therefore, AZIF-8@PDMS MMMs showed more excellent separation performance than ZIF-8 or GZIF-8-filled MMMs. In particular, AZIF-8@PDMS MMM with 7 wt % AZIF-8 loading exhibited the highest separation factor of 17.7 and a comparable total flux of 585.6 g/m(2) h at 40 degrees C with 5 wt % ethanol aqueous solution, which were improved by 176.6 and 34.5%, respectively, in comparison with the pristine PDMS membrane, breaking the trade-off effect between the flux and separation factor. This study might provide some new insights into the fabrication of high-performance MMMs for pervaporation recovery of various organic systems.

Welcome to talk about 61-82-5, If you have any questions, you can contact Zhu, TY; Yu, X; Yi, M; Wang, Y or send Email.. Product Details of 61-82-5

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Safety of 1H-1,2,4-Triazol-5-amine. In 2020.0 J CHROMATOGR SCI published article about TANDEM MASS-SPECTROMETRY; PERFORMANCE LIQUID-CHROMATOGRAPHY; HUMAN HEALTH-RISK; ORGANOCHLORINE PESTICIDES; TRACE DETERMINATION; POLAR PESTICIDES; HPLC-DAD; PHARMACEUTICALS; RIVER; SPE in [Liu, Shaoying; Huang, Xihui; Hu, Kejun; Jin, Quan] Hangzhou Ctr Dis Control & Prevent, Lab Chem & Phys, Hangzhou, Peoples R China; [Zhu, Guonian] Zhejiang Univ, Inst Pesticide & Environm Toxicol, Hangzhou, Peoples R China in 2020.0, Cited 44.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

A rapid and efficient method based on solid phase extraction and liquid chromatography-tandem mass spectrometry was validated, allowing the determination of the endocrine-disrupting herbicides (acetochlor, alachlor, amitrole and atrazine), fungicides (carbendazim, triadimefon, penconazole and propiconazole), and insecticides (carbaryl and carbofuran) in drinking water. Low method detection limits (0.01-0.64 ng/L) and method quantification limits (0.03-2.13 ng/L) were obtained with satisfactory recoveries and precision for the endocrine-disrupting pesticides. The method was applied for real drinking water samples collected in the area of the city of Hangzhou (Zhejiang, China); the results showed that carbendazim, atrazine and acetochlor were detected in the drinking water samples and acetochlor was the most detected analyte.

Safety of 1H-1,2,4-Triazol-5-amine. Welcome to talk about 61-82-5, If you have any questions, you can contact Liu, SY; Huang, XH; Hu, KJ; Jin, Q; Zhu, GN or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

HPLC of Formula: C2H4N4. In 2020.0 EUR J MED CHEM published article about BIOLOGICAL EVALUATION; AUTOPHAGY; APOPTOSIS; ROS; DESIGN in [Wang, Shuai; Ma, Xu-Bin; Yuan, Xiao-Han; Yu, Bin; Xu, Yi-Chao; Liu, Hong-Min] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China; [Wang, Shuai; Ma, Xu-Bin; Yuan, Xiao-Han; Yu, Bin; Xu, Yi-Chao; Liu, Hong-Min] Zhengzhou Univ, Key Lab Adv Drug Preparat Technol, Mil Educ, Zhengzhou 450001, Peoples R China; [Wang, Shuai] Massachusetts Gen Hosp, Gordon Ctr Med Imaging, Boston, MA 02129 USA; [Wang, Shuai] Harvard Med Sch, Boston, MA 02129 USA in 2020.0, Cited 33.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Mitochondria are known as powerhouse of cells and play the role of a bridge in redox balance, cell apoptosis, and autophagy. ROS accumulation can cause mitochondria damage, while the injured mitochondria will further enhance ROS levels reciprocally. Herein, we synthesized a novel series of [1,2,4] triazolo[1,5-a]pyrimidine-based compounds 4a-4v and tested their anti-proliferation efficacy against gastric cancer cell line MGC-803. Among them, compounds 4o and 4p inhibited gastric cancer cells at micromolar level. Compound 4o caused G2/M arrest and induced mitochondria-dependent apoptosis in MGC-803 and SGC-7901. However, inhibiting apoptosis pathway cannot prevent the inhibitory activity of compound 4o against gastric cancer cell. To our surprising, ROS level was increased by compound 4o and elevation of ROS could be rescued by NAC. In accordance with that, NAC absolutely prevented the anti-proliferation efficacy of compound 4o. We further found that autophagy inhibitor CQ rather than 3-MA partially reversed inhibitory activity of compound 4o in MGC-803 cells. Taken together, compound 4o exhibited its anti-proliferative activity via increasing ROS level and inducing autophagy, thus leading to apoptosis of gastric cancer cells. Therefore, compound 4o may support further development of lead compounds for gastric cancer therapy via mitochondria pathway. (C) 2020 Elsevier Masson SAS. All rights reserved.

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Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics