Category: Triazoles

An article Redox-dependent catalase mimetic cerium oxide-based nanozyme protect human hepatic cells from 3-AT induced acatalasemia WOS:000459837800071 published article about PEROXIDASE-LIKE ACTIVITY; OXIDATIVE STRESS; 1-CYS PEROXIREDOXIN; NANOPARTICLES; ANTIOXIDANTS; GLUTATHIONE; INHIBITION; ACTIVATION; EXPRESSION; MECHANISM in [Singh, Ragini; Singh, Sanjay] Ahmedabad Univ, Sch Arts & Sci, Div Biol & Life Sci, Cent Campus, Ahmadabad 380009, Gujarat, India in 2019.0, Cited 46.0. Computed Properties of C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Recently, CeNPs have emerged as an effective therapeutic agent due to their redox-active nature encompassing the ability to switch between +4 or +3 oxidation states of surface Ce atoms. CeNPs with predominantly high Ce +4 oxidation state have been shown to exhibit biological catalase enzyme-like activity. Catalase enzyme is naturally present in mammalian cells and facilitates the protection from reactive oxygen species (ROS), generated due to decomposition of hydrogen peroxide (H2O2). Inactivation of cellular catalase enzyme is known to cause several diseases such as acatalasemia, type 2 diabetes mellitus, and vitiligo. In this study, we have artificially inhibited the activity of cellular catalase enzyme from human liver cells (WRL-68) using 3-Amino-1,2,4-Triazole (3-AT). Further, CeNPs was used for imparting protective effect against the deleterious effects of elevated cellular H2O2 concentration. Our results suggest that CeNPs (+ 4) can protect hepatic cells from cytotoxicity and genetic damage from the high concentrations of H2O2 in the absence of functional catalase enzyme. CeNPs were efficiently internalized in WRL-68 cells and effectively scavenge the free radicals generated due to elevated H2O2 inside the cells. Additionally, CeNPs were also shown to protect cells from undergoing early apoptosis and DNA damage induced due to the 3-AT exposure. Moreover, CeNPs did not elicit the natural antioxidant defense system of the cells even in the absence of functional catalase enzyme, suggesting that the observed protection was due to the H2O2 degradation activity of CeNPs (+4). Our finding substantiates the reinforcement of CeNPs as pharmacological agents for the treatment of diseases related to nonfunctional biological catalase enzyme in the mammalian cells.

Computed Properties of C2H4N4. Welcome to talk about 61-82-5, If you have any questions, you can contact Singh, R; Singh, S or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

I found the field of Engineering; Polymer Science very interesting. Saw the article Double network anion exchange membrane with excellent flexibility and stability published in 2019.0. Application In Synthesis of 1H-1,2,4-Triazol-5-amine, Reprint Addresses Wang, Z (corresponding author), Changchun Univ Technol, Adv Inst Mat Sci, Changchun 130012, Jilin, Peoples R China.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

A double-network anion exchange membrane (TA/AT-PEK/PVA-x) was prepared by Br-PEK and PVA, 3-amino-1,2,4 triazole forms a cross-linking structure with PVA under the action of 1,4-phthalaldehyde and then triazole can be linked with Br-PEK. The structure of membranes was verified by FT-IR. The composite membrane is uniform and smooth can be seen from the scanning electron microscope (SEM) and exhibit good hydrophilic/hydrophobic micro-phase separation structure proved by Transmission electron micrograph (TEM). The ionic conductivity of TA/AT-PEK/PVA-0.15 is 0.062 S/cm at 80 degrees C. With the addition of PVA within a certain range, the water uptake, swelling ratio hydroxide conductivity and alkaline stability are increase. The membranes are more flexible. After immersing in 4M NaOH solutions for 240 h at 80 degrees C, it remains at least 65% of its initial hydroxide ion conductivity of TA/AT-PEK/PVA-0.3 membrane. With the increasing number of water molecules solvating the hydroxide, its nucleophilicity and basicity were hindered, which enhance alkaline stability of anion exchange membranes.

Application In Synthesis of 1H-1,2,4-Triazol-5-amine. Welcome to talk about 61-82-5, If you have any questions, you can contact Du, XM; Wang, Z; Zhang, HY; Liu, WC; Chen, ZY; Xu, JM or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Wang, S; Shen, DD; Zhao, LJ; Yuan, XH; Cheng, JL; Yu, B; Zheng, YC; Liu, HM in [Yu, Bin; Zheng, Yichao; Liu, Hongmin] Zhengzhou Univ, Key Lab Technol Drug Preparat, Minist Educ China, Zhengzhou 450001, Peoples R China; Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China published Discovery of [1,2,4]triazolo[1,5-a]pyrimidine derivatives as new bromodomain-containing protein 4 (BRD4) inhibitors in 2020, Cited 47. Computed Properties of C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Targeting bromodomain-containing protein 4 (BRD4) has been proved to be an effective strategy for cancer therapy. To date, numerous BRD4 inhibitors and degraders have been identified, some of which have advanced into clinical trials. In this work, a focused library of new [1,2,4]triazolo[1,5-a]pyrimidine derivatives were discovered to be able to inhibit BRD4. WS-722 inactivated BRD4 (BD1/BD2), BRD2 (BD1 BD2) and BRD3 (BD1/BD2) broadly with the IC50 values less than 5 mu mol/L. Besides, WS-722 inhibited growth of THP-1 cells with an IC50 value of 3.86 mu mol/L. Like (+)-JQ1, WS-722 inhibited BRD4 in a reversible manner and enhanced protein stability. Docking studies showed that WS-722 occupied the central acetyl-lysine (Kac) binding cavity and formed a hydrogen bond with Asn140. In THP-1 cells, WS-722 showed target engagement to BRD4. Cellular effects of WS-722 on THP-1 cells were also examined, showing that WS-722 could block c-MYC expression, induce G0/G1 phase arrest and p21 up-regulation, and promote differentiation of THP-1 cells. BRD4 inhibition by WS-722 resulted in cell apoptosis and up-regulated expression of cleaved caspased-3/7 and PARP in THP-1 cell lines. The [1,2,4]triazolo[1,5-a] pyrimidine is a new template for the development of new BRD4 inhibitors. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Computed Properties of C2H4N4. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

HPLC of Formula: C2H4N4. In 2020.0 CHEM ENG J published article about METAL-ORGANIC FRAMEWORKS; ENZYME IMMOBILIZATION; COMPLEXES; CATALYSTS; CAPTURE; ZINC; 1-HYDROXYBENZOTRIAZOLE; PERFORMANCE; CHALLENGES; MOLECULE in [Liang, Shan; Wu, Xiao-Ling; Zong, Min-Hua; Lou, Wen-Yong] South China Univ Technol, Sch Food Sci & Engn, Lab Appl Biocatalysis, Guangzhou 510640, Peoples R China; [Lou, Wen-Yong] South China Univ Technol, Guangdong Prov Key Lab Green Proc Nat Prod & Prod, Guangzhou 510640, Peoples R China in 2020.0, Cited 58.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Artificial enzyme mimics have recently emerged as alternative biocatalysts for overcoming the intrinsic fragility of natural enzyme in practical applications. However, current researches regarding mimetic enzymes are still confined to very few reaction types, with artificial oxidoreductases as dominance. Herein, inspired by nature, we designed and fabricated a range of Zn-Triazole coordination polymers (ZnTazs) that presented similar co-ordination structures with the active site of natural carbonic anhydrase. (CA II). These synthesized compounds exhibited inherently mimetic function with natural CA for catalyzing the hydrolysis of p-nitrophenyl acetate (p-NPA). Especially, the initial hydrolysis rate (V-0) of p-NPA catalyzed by ZnTaz-1 (Zn-5(bta)(6)(NO3)(4) center dot H2O) and ZnTaz-2 (Zn-3(OH)(2)(btca)(2) center dot DMF center dot 4 H2O) reached 42.1 and 73.8 nM.s(-1), respectively. Meanwhile, ZnTaz-1 and ZnTaz-2 showed favorable recyclability, and excellent stability towards various pH values and organic solvents, which are of great significance for practical employment. Moreover, they could also promote the efficient hydration and sequestration of greenhouse gas CO2 in aqueous medium. Based on this work, we aim to provide more theoretical and practical basis for rational design of CA mimics from the inspiration of natural enzyme, as well as propose a potential strategy for tackling the CO2 crisis.

HPLC of Formula: C2H4N4. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application In Synthesis of 1H-1,2,4-Triazol-5-amine. In 2019.0 J SOLID STATE ELECTR published article about REDUCED GRAPHENE OXIDE; GOLD NANOPARTICLES; NANOCOMPOSITES; OXIDATION; BEHAVIOR; TETRAAMINOPHTHALOCYANINE; NANOSHEETS; REDUCTION; NANOTUBES; OXYGEN in [Mafuwe, Peter T.; Moyo, Mambo; Mugadza, Tawanda; Shumba, Munyaradzi] Midlands State Univ, Dept Chem Technol, Sensors Lab, P Bag 9055,Senga Rd, Gweru, Zimbabwe; [Nyoni, Steven] Chinhoyi Univ Technol, Dept Chem, Chinhoyi, Zimbabwe in 2019.0, Cited 37.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Cobalt oxide nanoparticles were anchored on polyaniline-appended cobalt phthalocyanine and used to modify glassy carbon electrodes for enhanced electrocatalytic oxidation of amitrole. The modified electrodes were characterised by cyclic voltammetry, electrochemical impedance spectroscopy and scanning electron microscopy. Cyclic voltammetry, linear sweep voltammetry, chronoamperometry and differential pulse voltammetry were used to evaluate the electrocatalytic behaviour of the designed sensors. Catalytic rate constant of 6.26×10(5)M(-1)s(-1) and apparent electron transfer rate constant of 8.84×10(-3)cms(-1) were observed on CoTCPc-PANI-Co3O4NP-GCE. The adsorption equilibrium constant and Gibbs energy were 4.8×10(1)M(-1) and -12.1kJmol(-1), respectively, confirming substrate adsorption during a spontaneous reaction on the surface of the modified electrode. The limit of detection and limit of quantification were 6.61×10(-8)M and 2×10(-7)M, respectively, for the electrocatalytic detection of amitrole and only suffered 4% signal loss after repetitive ten runs in 1mM amitrole.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. Application In Synthesis of 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Formula: C2H4N4. Authors Yildirim, C; Ozkaya, B; Bal, R in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Yildirim, Caner; Ozkaya, Beytullah; Bal, Ramazan] Gaziantep Univ, Fac Med, Dept Physiol, TR-27310 Gaziantep, Turkey in 2021.0, Cited 100.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

ATP-sensitive potassium (K-ATP) channels and transient receptor potential melastatin 2 (TRPM2) channels are commonly expressed both pre- and postsynaptically in the central nervous system (CNS). We hypothesized that K-ATP and TRPM2 may couple metabolic status to the resting membrane potential of octopus neurons of the mouse ventral cochlear nucleus (VCN). Therefore, we studied the expression of K-ATP channels and TRPM2 channels in octopus cells by immunohistochemical techniques and their contribution to neuronal electrical properties by the electrophysiological patch clamp technique. In immunohistochemical staining of octopus cells, labelling with Kir6.2 and SUR1 antibodies was strong, and labelling with the SUR2 antibody was moderate, but labelling with Kir6.1 was very weak. Octopus cells had intense staining with TRPM2 antibodies. In patch clamp recordings, bath application of KATP channel agonists H2O2 (880 mu M), ATZ (1 mM), cromakalim (50 mu M), diazoxide (200 mu M), NNC 55-0118 and NN 414 separately resulted in hyperpolarizations of resting potential to different extents. Application of 8-Bro-cADPR (50 mu M), a specific antagonist of TRPM2 channels, in the presence of H2O2 (880 mu M) resulted in further hyperpolarization by approximately 1 mV. The amplitudes of H2O2-induced outward K-ATP currents and ADPR-induced inward currents were 206.1 +/- 31.5 pA (n = 4) and 136.8 +/- 22.4 pA, respectively, at rest. Their respective reversal potentials were -77 +/- 2.6 mV (n = 3) and -6.3 +/- 2.9 (n = 3) and -6.3 +/- 2.9 (n = 3). In conclusion, octopus cells appear to possess both K-ATP channels and TRPM2-like channels. K-ATP might largely be constituted by SUR1-Kir6.2 subunits and SUR2-Kir6.2 subunits. Both K-ATP and TRPM2-like channels might have a modulatory action in setting the membrane potential.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2020.0 J AM CHEM SOC published article about GLUTATHIONE-PEROXIDASE; SUPEROXIDE-DISMUTASE; HYDROGEN-PEROXIDE; CANCER-CELLS; CATALASE; GENERATION; ENZYME; NANOMATERIALS; MECHANISMS; OXIDATION in [Sang, Yanjuan; Cao, Fangfang; Li, Wei; Zhang, Lu; You, Yawen; Deng, Qingqing; Dong, Kai; Ren, Jinsong; Qu, Xiaogang] Chinese Acad Sci, Changchun Inst Appl Chem, Lab Chem Biol, Changchun 130022, Jilin, Peoples R China; [Sang, Yanjuan; Cao, Fangfang; Li, Wei; Zhang, Lu; You, Yawen; Deng, Qingqing; Dong, Kai; Ren, Jinsong; Qu, Xiaogang] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Jilin, Peoples R China; [Sang, Yanjuan; Cao, Fangfang; You, Yawen; Deng, Qingqing] Univ Sci & Technol China, Sch Appl Chem & Engn, Hefei 230026, Anhui, Peoples R China; [Li, Wei; Zhang, Lu] Univ Chinese Acad Sci, Beijing 100039, Peoples R China in 2020.0, Cited 65.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Formula: C2H4N4

The insufficient intracellular H2O2 level in tumor cells is closely associated with the limited efficacy of chemodynamic therapy (CDT). Despite tremendous efforts, engineering CDT agents with a straightforward and secure H2O2 supplying ability remains a great challenge. Inspired by the balance of H2O2 generation and elimination in cancer cells, herein, a nanozyme-based H2O2 homeostasis disruptor is fabricated to elevate the intracellular H2O2 level through facilitating H2O2 production and restraining H2O2 elimination for enhanced CDT. In the formulation, the disruptor with superoxide dismutase-mimicking activity can convert O-2(center dot-) to H2O2, promoting the production of H2O2. Simultaneously, the suppression of catalase activity and depletion of glutathione by the disruptor weaken the transformation of H2O2 to H2O. Thus, the well-defined system could perturb the H2O2 balance and give rise to the accumulation of H2O2 in cancer cells. The raised H2O2 level would ultimately amplify the Fenton-like reaction-based CDT efficiency. Our work not only paves a way to engineer alternative CDT agents with a H2O2 supplying ability for intensive CDT but also provides new insights into the construction of bioinspired materials.

Welcome to talk about 61-82-5, If you have any questions, you can contact Sang, YJ; Cao, FF; Li, W; Zhang, L; You, YW; Deng, QQ; Dong, K; Ren, JS; Qu, XG or send Email.. Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

I found the field of Chemistry; Energy & Fuels; Engineering very interesting. Saw the article Characterization and potential utilization of extracts and pyrolyzates from Jasminum nudiflorum Lindl. Bark published in 2021. Name: 1H-1,2,4-Triazol-5-amine, Reprint Addresses Peng, WX (corresponding author), Henan Agr Univ, Henan Prov Engn Res Ctr Biomass Value Added Prod, Zhengzhou 450002, Peoples R China.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Utilization of lignocellulosic biomass is increasingly important. Jasminum nudiflorum Lindl. (JNL) is a widely cultivated landscape plant in China. To evaluate the chemical components, pyrolysis characteristics as well as the potential values of JNL bark for utilization, the components were extracted using methanol, ethanol, and benzene/ethanol (2:1, v/v) and pyrolyzed from room temperature to 300 ?C, respectively. Many components were detected in the extracts and the pyrolyzates of JNL bark and their chemical properties were analyzed. The compounds identified in the extracts and the pyrolyzates of JNL bark included acids, aldehydes, alcohols, esters, ketones, aromatics, saccharides, olefins, and nitrogen-containing compounds. Some of the identified compounds, such as urs-12-en-28-al, 3-(acetyloxy)-, (3.beta.)-, 5-hydroxymethylfurfural, and vanillin, are widely used in the medical, energy, and food industries. The pyrolysis of JNL bark using thermogravimetric (TG) analyzer showed the highest reaction rate occurred at between 200 and 300 ?C where the maximum mass loss was observed. According to the Coats-Redfern method, the calculated apparent activation energy (E) and pre-exponential factor (A) of the pyrolysis process of JNL bark were 52.04 kJ mol- 1 and 3.14 ? 105 min-1, respectively. This research provides information on the components and pyrolysis characteristics of JNL bark, which shows great potential for application in medical, food, and chemical industries.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. Name: 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

COA of Formula: C2H4N4. Recently I am researching about QUANTUM-CHEMICAL CALCULATIONS; CARBONIC-ANHYDRASE-IX; SULFAMETHAZINE SCHIFF-BASE; HUMAN THYMIDYLATE SYNTHASE; DENSITY-FUNCTIONAL THEORY; CRYSTAL-STRUCTURE; ANTIMICROBIAL ACTIVITY; VIBRATIONAL-SPECTRA; BROMOBENZENE DERIVATIVES; SULFONAMIDE DERIVATIVES, Saw an article supported by the . Published in ELSEVIER SCIENCE BV in AMSTERDAM ,Authors: Fahim, AM; Shalaby, MA. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

The reaction of N-(4-acetylphenyl)benzene sulphonamide derivatives 3a and 3b with N,N dimethyl formamide dimethyl acetal (DMF-DMA) afford acryloyl(phenyl)benzenesulfonamide derivatives 4a and 4b; respectively. The chemical reactivity of enaminonitriles 4a and 4b towards hydrazine hydrate or hydroxylamine was studied for synthesizing of pyrazolyl and isoxazolyl-phenyl benzenesulfonamide derivatives 5a,b and 6a,b; respectively. Also, the treatment of enaminonitriles 4a and 4b with thiosemicarbazide or heterocyclic amines derivatives afford the novel sulfonamide derivatives. Furthermore, the reactivity of acetylsulfonamide derivatives towards nitrogen nucleophiles and dimedone afforded novel benzene sulfonamide compounds. Some of the synthesized chlorinated compounds exhibited excellent in vitro antitumor activity against HepG2 and MCF-7 cell lines. Additionally, further studies were carried out on one of the most effective compounds, 4-chloro-N-(4-(isoxazole-3-yl)phenyl) benzenesulfonamide 6a (ISP), to evaluate its potential interaction against KSHV thymidylate synthase complex. The comprehensive theoretical and experimental mechanical studies of compound 6a (ISP) were compatible with elemental analysis, FTIR, H-1 NMR and MS spectral data. The optimized molecular structure and the harmonic vibrational frequencies were examined via Density functional theory (DFT)/B3LYP/6-31G(d) and Hartree-Fock HF/6-31G(d) energies. (C) 2018 Elsevier B.V. All rights reserved.

COA of Formula: C2H4N4. Welcome to talk about 61-82-5, If you have any questions, you can contact Fahim, AM; Shalaby, MA or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recently I am researching about GENE-EXPRESSION; STRESS-RESPONSE; ARABIDOPSIS; CATALASE; TOLERANCE; BINDING; PLANTS; FAMILY; HOMEOSTASIS; CAT2, Saw an article supported by the . Category: Triazoles. Published in WILEY in HOBOKEN ,Authors: Zhao, Q; Hu, RS; Liu, D; Liu, X; Wang, J; Xiang, XH; Li, YY. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Drought stress often limits plant growth and global crop yields. Catalase (CAT)-mediated hydrogen peroxide (H2O2) scavenging plays an important role in the adaptation of plant stress responses, but the transcriptional regulation of the CAT gene in response to drought stress is not well understood. Here, we isolated an APETALA2/ETHYLENE-RESPONSIVE FACTOR (AP2/ERF) domain-containing transcription factor (TF), NtERF172, which was strongly induced by drought, abscisic acid (ABA) and H2O2, from tobacco (Nicotiana tabacum) by yeast one-hybrid screening. NtERF172 localized to the nucleus and acted as a transcriptional activator. Chromatin immunoprecipitation, yeast one-hybrid assays, electrophoretic mobility shift assays and transient expression analysis assays showed that NtERF172 directly bound to the promoter region of the NtCAT gene and positively regulated its expression. Transgenic plants overexpressing NtERF172 displayed enhanced tolerance to drought stress, whereas suppression of NtERF172 decreased drought tolerance. Under drought stress conditions, the NtERF172-overexpressed lines showed higher catalase activity and lower accumulation of H2O2 compared with wild-type (WT) plants, while the NtERF172-silenced plants showed the inverse correlation. Exogenous application of amino-1,2,4-triazole (3-AT), an irreversible CAT inhibitor, to the NtERF172-overexpression lines showed decreased catalase activity and drought tolerance, and increased levels of cellular H2O2. Knockdown of NtCAT in the NtERF172-overexpression lines displayed a more drought stress-sensitive phenotype than NtERF172-overexpression lines. We propose that NtERF172 acts as a positive factor in drought stress tolerance, at least in part through the regulation of CAT-mediated H2O2 homeostasis.

Welcome to talk about 61-82-5, If you have any questions, you can contact Zhao, Q; Hu, RS; Liu, D; Liu, X; Wang, J; Xiang, XH; Li, YY or send Email.. Category: Triazoles

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics