Triazoles -| Page 126 of 762

Mayer, Ursula’s team published research in Zeitschrift fuer Hygiene und Infektionskrankheiten in 1962 | 92276-38-5

Zeitschrift fuer Hygiene und Infektionskrankheiten published new progress about Salmonella typhimurium. 92276-38-5 belongs to class triazoles, and the molecular formula is C5H3BrN4, Reference of 92276-38-5.

Mayer, Ursula published the artcile< Catalase activity and resistance of Salmonella typhimurium against spiramycin>, Reference of 92276-38-5, the main research area is .

Of 11 strains of S. typhimurium, of known catalase activity and virulence, those rich in catalase were resistant or only moderately sensitive to spiramycin while those with low catalase content were all sensitive.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Chojnacki, K’s team published research in Bioorganic Chemistry in 2021-01-31 | 92276-38-5

Bioorganic Chemistry published new progress about Crystal structure. 92276-38-5 belongs to class triazoles, and the molecular formula is C5H3BrN4, SDS of cas: 92276-38-5.

Chojnacki, K.; Lindenblatt, D.; Winska, P.; Wielechowska, M.; Toelzer, C.; Niefind, K.; Bretner, M. published the artcile< Synthesis, biological properties and structural study of new halogenated azolo[4,5-b]pyridines as inhibitors of CK2 kinase>, SDS of cas: 92276-38-5, the main research area is halogenated azolopyridine synthesis anticancer CK2 kinase inhibition; ATP-Competitive inhibitors; Casein Kinase CK2; Protein Kinase PIM1; Structural study.

The new halogenated 1H-triazolo[4,5-b]pyridines and 1H-imidazo[4,5-b]pyridines were synthesized as analogs of known CK2 inhibitors: 4,5,6,7-tetrabromo-1H-benzotriazole (TBBt) and 4,5,6,7-tetrabromo-1H-benzimidazole (TBBi). Their influence on the activity of recombinant human CK2α, CK2α’ and PIM1 kinases was determined The most active inhibitors were di- and trihalogenated 1H-triazolo[4,5-b]pyridines I-III with IC50 values 2.56, 3.82 and 3.26μM resp. for CK2α. Furthermore, effect on viability of cancer cell lines MCF-7 (human breast adenocarcinoma) and CCRF-CEM (T lymphoblast leukemia) of all final compounds was evaluated. Finally, three crystal structures of complexes of CK2α1-335 with inhibitors I-III were obtained. In addition, new protocol was used to obtain high-resolution crystal structures of CK2α’Cys336Ser in complex with four inhibitors I-IV.

Bioorganic Chemistry published new progress about Crystal structure. 92276-38-5 belongs to class triazoles, and the molecular formula is C5H3BrN4, SDS of cas: 92276-38-5.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Julia, Sebastian’s team published research in Organic Preparations and Procedures International in 1984-10-31 | 88088-95-3

Organic Preparations and Procedures International published new progress about Phase-transfer substitution reaction catalysts. 88088-95-3 belongs to class triazoles, and the molecular formula is C19H13N9, Synthetic Route of 88088-95-3.

Julia, Sebastian; Del Mazo, Jose Maria; Avila, Luis; Elguero, Jose published the artcile< Improved synthesis of polyazolylmethanes under solid-liquid phase-transfer catalysis>, Synthetic Route of 88088-95-3, the main research area is polyazolylmethane; pyrazolylmethane; tripyrazolylmethane.

Di(azolyl)methanes, Tri(azolyl)methanes, and tetra(azolyl)methanes were prepared by treating the azole with H2CCl2, HCCl3, or CCl4 in presence of phase transfer catalysts. Thus, 24 mmol pyrazole was treated with 120 mmol K2CO3 and and 1.2 mmol Bu4N+HSO4- in refluxing HCCl3 (25 mL) overnight to give the tripyrazolylmethane I.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Epstein, Samuel S’s team published research in Journal of Protozoology in 1963 | 92276-38-5

Journal of Protozoology published new progress about 92276-38-5. 92276-38-5 belongs to class triazoles, and the molecular formula is C5H3BrN4, COA of Formula: C5H3BrN4.

Epstein, Samuel S.; Timmis, Geoffrey M. published the artcile< Simple antimetabolites of vitamin B12>, COA of Formula: C5H3BrN4, the main research area is .

Nearly 300 compounds (mostly benzimidazoles, diazabenzimidazoles, purines, azapurines, pteridines, azapteridines, pyrimidines, nicotinamide and p-aminobenzoic acid derivatives, imidazoles, and alloxans) which bear no structural analogy to vitamin B12 (I), were tried as antimetabolites for the I on Euglena gracilis. For 43 compds, less than 500 γ/ml. produced a 50% inhibition of growth when the I concentration was 10-11 g./ml.; 10 of these compounds produced competitive antagonism as evidenced by the reversibility of their inhibition by higher (10-10-10-9 g./ml.) concentration of I. It is suggested that such simple metabolites as above may act indirectly by interfering with cofactors concerned with the utilization of I.

Journal of Protozoology published new progress about 92276-38-5. 92276-38-5 belongs to class triazoles, and the molecular formula is C5H3BrN4, COA of Formula: C5H3BrN4.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Elguero, J’s team published research in Magnetic Resonance in Chemistry in 1987-03-31 | 88088-95-3

Magnetic Resonance in Chemistry published new progress about NMR (nuclear magnetic resonance). 88088-95-3 belongs to class triazoles, and the molecular formula is C19H13N9, Reference of 88088-95-3.

Elguero, J.; Claramunt, R. M.; Garceran, R.; Julia, S.; Avila, L.; Del Mazo, J. M. published the artcile< Carbon-13 NMR study of polyphenyl-, poly-N-azolyl- and poly-N-benzazoyl-methanes>, Reference of 88088-95-3, the main research area is NMR carbon azolylmethane; methane derivative NMR carbon.

13C NMR chem. shifts of 69 substituted methanes (general formula R1R2R3R4C, where R1, R2, R3, R4 = H, C6H5, Cl, OH, OR, imidazol-1-yl, pyrazol-1-yl, 1,2,4-triazol-1-yl, benzimidazol-1-yl, indazol-1-yl, indazol-2-yl, benzotriazol-1-yl and benzotriazol-2-yl) are reported. The effects of the various N-substituents on the 13C chem. shifts of the heterocyclic nuclei are reported. The chem. shifts of the methane C atom are discussed using an interactive model. Some 1H-13C coupling constants have been measured.

Magnetic Resonance in Chemistry published new progress about NMR (nuclear magnetic resonance). 88088-95-3 belongs to class triazoles, and the molecular formula is C19H13N9, Reference of 88088-95-3.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Miles, Dillon H’s team published research in ACS Medicinal Chemistry Letters in 2020-11-12 | 92276-38-5

ACS Medicinal Chemistry Letters published new progress about Antitumor agents. 92276-38-5 belongs to class triazoles, and the molecular formula is C5H3BrN4, Recommanded Product: 6-Bromo-3H-[1,2,3]triazolo[4,5-b]pyridine.

Miles, Dillon H.; Yan, Xuelei; Thomas-Tran, Rhiannon; Fournier, Jeremy; Sharif, Ehesan U.; Drew, Samuel L.; Mata, Guillaume; Lawson, Kenneth V.; Ginn, Elaine; Wong, Kent; Soni, Divyank; Dhanota, Puja; Shaqfeh, Stefan G.; Meleza, Cesar; Chen, Ada; Pham, Amber T.; Park, Timothy; Swinarski, Debbie; Banuelos, Jesus; Schindler, Ulrike; Walters, Matthew J.; Walker, Nigel P.; Zhao, Xiaoning; Young, Stephen W.; Chen, Jie; Jin, Lixia; Leleti, Manmohan Reddy; Powers, Jay P.; Jeffrey, Jenna L. published the artcile< Discovery of Potent and Selective 7-Azaindole Isoindolinone-Based PI3Kγ Inhibitors>, Recommanded Product: 6-Bromo-3H-[1,2,3]triazolo[4,5-b]pyridine, the main research area is cancer immunotherapy immunomodulation PI3K gamma inhibitor azaindole selective.

The successful application of immunotherapy in the treatment of cancer relies on effective engagement of immune cells in the tumor microenvironment. Phosphoinositide 3-kinase γ (PI3Kγ) is highly expressed in tumor-associated macrophages, and its expression levels are associated with tumor immunosuppression and growth. Selective inhibition of PI3Kγ offers a promising strategy in immuno-oncol., which has led to the development of numerous potent PI3Kγ inhibitors with variable selectivity profiles. To facilitate further investigation of the therapeutic potential of PI3Kγ inhibition, we required a potent and PI3Kγ-selective tool compound with sufficient metabolic stability for use in future in vivo studies. Herein, we describe some of our efforts to realize this goal through the systematic study of SARs within a series of 7-azaindole-based PI3Kγ inhibitors. The large volume of data generated from this study helped guide our subsequent lead optimization efforts and will inform further development of PI3Kγ-selective inhibitors for use in immunomodulation.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Dale, Harvey J. A.’s team published research in Journal of the American Chemical Society in 2019 | CAS: 288-36-8

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties COA of Formula: C2H3N3

《Taming Ambident Triazole Anions: Regioselective Ion Pairing Catalyzes Direct N-Alkylation with Atypical Regioselectivity》 was written by Dale, Harvey J. A.; Hodges, George R.; Lloyd-Jones, Guy C.. COA of Formula: C2H3N3This research focused ontriazole regioselective alkylation organocatalysis ion pairing. The article conveys some information:

Controlling the regioselectivity of ambident nucleophiles toward alkylating agents is a fundamental problem in heterocyclic chem. Unsubstituted triazoles are particularly challenging, often requiring inefficient stepwise protection-deprotection strategies and prefunctionalization protocols. Herein we report on the alkylation of archetypal ambident 1,2,4-triazole, 1,2,3-triazole, and their anions, analyzed by in situ 1H/19F NMR, kinetic modeling, diffusion-ordered NMR spectroscopy, X-ray crystallog., highly correlated coupled-cluster computations [CCSD(T)-F12, DF-LCCSD(T)-F12, DLPNO-CCSD(T)], and Marcus theory. The resulting mechanistic insights allow design of an organocatalytic methodol. for ambident control in the direct N-alkylation of unsubstituted triazole anions. Amidinium and guanidinium receptors are shown to act as strongly coordinating phase-transfer organocatalysts, shuttling triazolate anions into solution The intimate ion pairs formed in solution retain the reactivity of liberated triazole anions but, by virtue of highly regioselective ion pairing, exhibit alkylation selectivities that are completely inverted (1,2,4-triazole) or substantially enhanced (1,2,3-triazole) compared to the parent anions. The methodol. allows direct access to 4-alkyl-1,2,4-triazoles (rr up to 94:6) and 1-alkyl-1,2,3-triazoles (rr up to 99:1) in one step. Regioselective ion pairing acts in effect as a noncovalent in situ protection mechanism, a concept that may have broader application in the control of ambident systems. In the part of experimental materials, we found many familiar compounds, such as 1H-1,2,3-Triazole(cas: 288-36-8COA of Formula: C2H3N3)

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Leigh, David A.’s team published research in Journal of the American Chemical Society in 2019 | CAS: 510758-28-8

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) is a polytriazolylamine ligand which stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Product Details of 510758-28-8

Product Details of 510758-28-8In 2019 ,《Stereoselective Synthesis of Molecular Square and Granny Knots》 was published in Journal of the American Chemical Society. The article was written by Leigh, David A.; Pirvu, Lucian; Schaufelberger, Fredrik. The article contains the following contents:

The authors report on the stereoselective synthesis of both mol. granny and square knots through the use of lanthanide-complexed overhand knots of specific handedness as three-crossing “”entanglement synthons””. The composite knots are assembled by combining two entanglement synthons (of the same chirality for a granny knot; of opposite handedness for a square knot) in three synthetic steps: first, a CuAAC reaction joins together one end of each overhand knot. Ring-closing olefin metathesis (RCM) then affords the closed-loop knot, locking the topol. This allows the lanthanide ions necessary for stabilizing the entangled conformation of the synthons to subsequently be removed. The composite knots were characterized by 1H and 13C NMR spectroscopy and mass spectrometry and the chirality of the knot stereoisomers compared by CD. The synthetic strategy of combining building blocks of defined stereochem. (here overhand knots of Λ- or Δ-handed entanglement) is reminiscent of the chiron approach of using minimalist chiral synthons in the stereoselective synthesis of mols. with multiple asym. centers. In the experimental materials used by the author, we found Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Product Details of 510758-28-8)

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Lai, Thu Hang’s team published research in International Journal of Molecular Sciences in 2021 | CAS: 56602-33-6

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It acts as a substitute for (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent.Reference of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)

Lai, Thu Hang; Toussaint, Magali; Teodoro, Rodrigo; Dukic-Stefanovic, Sladjana; Kranz, Mathias; Deuther-Conrad, Winnie; Moldovan, Rares-Petru; Brust, Peter published an article in 2021. The article was titled 《Synthesis and biological evaluation of a novel 18F-labeled radiotracer for PET imaging of the adenosine A2A receptor》, and you may find the article in International Journal of Molecular Sciences.Reference of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V) The information in the text is summarized as follows:

The adenosine A2A receptor (A2AR) has emerged as a potential non-dopaminergic target for the treatment of Parkinson’s disease and, thus, the non-invasive imaging with positron emission tomog. (PET) is of utmost importance to monitor the receptor expression and occupancy during an A2AR-tailored therapy. Aiming at the development of a PET radiotracer, we herein report the design of a series of novel fluorinated analogs (TOZ1-TOZ7) based on the structure of the A2AR antagonist tozadenant, and the preclin. evaluation of [18F]TOZ1. Autoradiog. proved A2AR-specific in vitro binding of [18F]TOZ1 to striatum of mouse and pig brain. Investigations of the metabolic stability in mice revealed parent fractions of more than 76% and 92% of total activity in plasma and brain samples, resp. Dynamic PET/magnetic resonance imaging (MRI) studies in mice revealed a brain uptake but no A2AR-specific in vivo binding. In the experiment, the researchers used many compounds, for example, ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Reference of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V))

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Wagner, Nicolai’s team published research in Angewandte Chemie, International Edition in 2018 | CAS: 510758-28-8

In 2018,Angewandte Chemie, International Edition included an article by Wagner, Nicolai; Stephan, Milena; Hoeglinger, Doris; Nadler, Andre. Electric Literature of C30H30N10. The article was titled 《A Click Cage: Organelle-Specific Uncaging of Lipid Messengers》. The information in the text is summarized as follows:

Lipid messengers exert their function on short time scales at distinct subcellular locations, yet most exptl. approaches for perturbing their levels trigger cell-wide concentration changes. Herein, we report on a coumarin-based photocaging group that can be modified with organelle-targeting moieties by click chem. and thus enables photorelease of lipid messengers in distinct organelles. We show that caged arachidonic acid and sphingosine derivatives can be selectively delivered to mitochondria, the ER, lysosomes, and the plasma membrane. By comparing the cellular calcium transients induced by localized uncaging of arachidonic acid and sphingosine, we show that the precise intracellular localization of the released second messenger is crucial for the signaling outcome. Ultimately, we anticipate that this new class of caged compounds will greatly facilitate the study of cellular processes on the organelle level. The experimental part of the paper was very detailed, including the reaction process of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Electric Literature of C30H30N10)

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics