Category: Triazoles

Electric Literature of C2H3N3In 2022 ,《Rational design of Striga hermonthica-specific seed germination inhibitors》 was published in Plant Physiology. The article was written by Zarban, Randa A.; Hameed, Umar F. Shahul; Jamil, Muhammad; Ota, Tsuyoshi; Wang, Jian You; Arold, Stefan T.; Asami, Tadao; Al-Babili, Salim. The article contains the following contents:

The obligate hemiparasitic weed Striga hermonthica grows on cereal roots and presents a severe threat to global food security by causing enormous yield losses, particularly in sub-Saharan Africa. The rapidly increasing Striga seed bank in infested soils provides a major obstacle in controlling this weed. Striga seeds require host-derived strigolactones (SLs) for germination, and corresponding antagonists could be used as germination inhibitors. Recently, we demonstrated that the common detergent Triton X-100 is a specific inhibitor of Striga seed germination by binding noncovalently to its receptor, S. hermonthica HYPO-SENSITIVE TO LIGHT 7 (ShHTL7), without blocking the rice (Oryza sativa) SL receptor DWARF14 (OsD14). Moreover, triazole ureas, the potent covalently binding antagonists of rice SL perception with much higher activity toward OsD14, showed inhibition of Striga but were less specific. Considering that Triton X-100 is not suitable for field application and by combining structural elements of Triton and triazole urea, we developed two hybrid compounds, KK023-N1 and KK023-N2, as potential Striga-specific germination inhibitors. Both compounds blocked the hydrolysis activity of ShHTL7 but did not affect that of OsD14. Binding of KK023-N1 diminished ShHTL7 interaction with S. hermonthica MORE AXILLARY BRANCHING 2, a major component in SL signal transduction, and increased ShHTL7 thermal specificity. Docking studies indicate that KK023-N1 binding is not covalent but is caused by hydrophobic interactions. Finally, in vitro and greenhouse tests revealed specific inhibition of Striga seed germination, which led to a 38% reduction in Striga infestation in pot experiments These findings reveal that KK023-N1 is a potential candidate for combating Striga and a promising basis for rational design and development of further Striga-specific herbicides.1H-1,2,3-Triazole(cas: 288-36-8Electric Literature of C2H3N3) was used in this study.

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Electric Literature of C2H3N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2022,Huang, Wenhuan; Qiu, Qiang; Yang, Xiufang; Zuo, Shouwei; Bai, Jianan; Zhang, Huabin; Pei, Ke; Che, Renchao published an article in Nano-Micro Letters. The title of the article was 《Ultrahigh density of atomic CoFe-electron synergy in noncontinuous carbon matrix for highly efficient magnetic wave adsorption》.Formula: C2H3N3 The author mentioned the following in the article:

Improving the atom utilization of metals and clarifying the M-M’ interaction is both greatly significant in assembling high-performance ultra-light electromagnetic wave-absorbing materials. Herein, a high-temperature explosion strategy has been successfully applied to assemble the hierarchical porous carbon sponge with Co-Fe decoration via the pyrolysis of the energetic metal organic framework. The as-constructed hybrid displays a superior reflection loss (RL) value of – 57.7 dB and a specific RL value of – 192 dB mg-1 mm-1 at 12.08 GHz with a layer thickness of 2.0 mm (loading of 15 wt%). The off-axis electron hologram characterizes the highly distributed numerous polarized nanodomain variable capacitors, demonstrating the dipole and interfacial polarization along the edges of the nanopores. More importantly, the X-ray absorption spectroscopy anal. verifies the mutual interaction between the metal cluster and carbon matrix and the electronic coupling responsible for the greatly improved electromagnetic wave absorption. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole(cas: 288-36-8Formula: C2H3N3)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Formula: C2H3N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Singh, Amrit; Singh, Amritpal; Amanjot; Singh, Kulvinder; Singh, Gurjaspreet; Saroa, Amandeep published their research in Structural Chemistry in 2021. The article was titled 《Role of non-conventional hydrogen bonding in controlling regioselectivity for nucleophilic aromatic substitution of 4,6-dinitroisoindoline-1,3-dione with 1,2,3-triazole isomers: a computational studies》.Electric Literature of C2H3N3 The article contains the following contents:

Abstract: The nucleophilic aromatic substitution reactions of 4,6-dinitroisoindoline-1,3-dione with 1,2,3-triazole isomers, i.e., 1H-1,2,3-triazole and 2H-1,2,3-triazole, have been investigated theor. using DFT/B3LYP calculations employing 6-31G(d,p) basis set in gas phase as well as in solvent phase. The computational studies have supported the formation of transition states via one-step concerted mechanism for the nucleophilic aromatic displacement of nitro groups with 1,2,3-triazoles rather than intermediate formation via two-step addition-elimination mechanism. The amination of 4,6-dinitroisoindoline-1,3-dione with 1,2,3-triazole isomers have revealed regioselectivity of peri-attack despite sterically favorable para-attack. The regioselectivity is attributed to the stabilization of the transition state through intra-mol. hydrogen bond C-H···O=C. This work presents the role of C-H bond as an effective hydrogen bond donor. The mol. interactions through hydrogen bonding have been investigated using AIM method. This work shall result in the synthesis of new regioselective 1,2,3-triazole-derived phthalimide compounds possessing potential biol. candidature. The experimental part of the paper was very detailed, including the reaction process of 1H-1,2,3-Triazole(cas: 288-36-8Electric Literature of C2H3N3)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Electric Literature of C2H3N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

The author of 《A lysosome-targetable fluorescent probe for imaging ONOO- in living cells and animals》 were Feng, Weiyong; Feng, Guoqiang. And the article was published in Dyes and Pigments in 2019. Name: ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V) The author mentioned the following in the article:

Peroxynitrite (ONOO-) is one of the most important reactive oxygen species (ROS) in living systems and its subcellular detection is very important. In this research, a lysosome-targetable fluorescent probe for detection of exogenous and endogenous peroxynitrite in living systems was developed. This probe exhibits not only fast (25 s), highly sensitive (detection limit = 16 nM), and highly selective red to near-IR fluorescent turn-on responses for ONOO- in the solution, but also excellent imaging ability for ONOO- in living cells and animals with low cytotoxicity. Moreover, this probe is lysosome-targetable and can be used for imaging lysosomal ONOO- in living cells. Overall, this work provides a new powerful fluorescent turn-on probe for detection of lysosomal peroxynitrite in living systems. In the experimental materials used by the author, we found ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Name: ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V))

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It acts as a substitute for (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent.Name: ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

The author of 《Characterization, bioactivity and pharmacokinetic study of a novel carbohydrate-peptide polymer: Glycol-split heparin-endostatin2 (GSHP-ES2)》 were Sun, Feng; Wang, Zhendong; Yang, Zhifang; Li, Yan; Cui, Huifei; Liu, Chunhui; Gao, Dezong; Wang, Fengshan; Tan, Haining. And the article was published in Carbohydrate Polymers in 2019. Recommanded Product: ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V) The author mentioned the following in the article:

Endostatin (ES) has attracted considerable attention for the treatment of anti-angiogenesis-related disorders. An 11-amino-acid peptide (ES2, IVRRADRAAVP) from the amino terminal of ES is of interest because it is the main active fragment of ES. However, both ES and ES2 have a poor stability and a short half-life, and other disadvantages need to be further resolved. Thus, we conjugated ES2 to glycol-split heparin derivatives (GSHPs) to yield the polymer-peptide conjugate, GSHP-ES2. This study showed that GSHP-ES2 exhibited increased stability, a wider pH activity range, better inhibition of endothelial cell proliferation, migration and tube formation in vitro, better anti-angiogenic activity and a longer half-life in vivo compared with ES2. These results also indicate that GSHP-ES2 has good potential for the treatment of angiogenesis-related diseases, either alone or in combination with other chems. In the experiment, the researchers used many compounds, for example, ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Recommanded Product: ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V))

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It acts as a substitute for (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent.Recommanded Product: ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2018,Facciotti, Camilla; Saggiomo, Vittorio; Bunschoten, Anton; Fokkink, Remco; Hove, Jan Bart ten; Wang, Junyou; Velders, Aldrik H. published 《Cyclodextrin-based complex coacervate core micelles with tuneable supramolecular host-guest, metal-to-ligand and charge interactions》.Soft Matter published the findings.SDS of cas: 510758-28-8 The information in the text is summarized as follows:

Micelles have been recognized as versatile platforms for different biomedical applications, from bioimaging to drug delivery. Complex coacervate core micelles present great advantages compared to traditional micelles, however controlling the number of charges per core-unit and the stability is still a challenge. We here present cyclodextrin-based complex coacervate core micelles where the charge per core-unit can be straightforwardly tuned by cyclodextrin host-guest interactions. By varying the ratio between two adamantane guest mols., 1-adamantanecarboxylic acid and 1,3-adamantanediacetic acid, the charge of the monomeric core-units can be finely tuned from 6- to 9-. By adding an adamantane bislinker, monomeric core-units can be combined together in dimeric and polymeric structures, increasing the micelles’ stability. The orthogonal supramol. host-guest and coordination-chem. allows for well-controlled cyclodextrin-based complex coacervate core micelles that offer a versatile platform for designing future, e.g., responsive systems. In the experimental materials used by the author, we found Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8SDS of cas: 510758-28-8)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.SDS of cas: 510758-28-8Polytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Kalita, Sourav; Kalita, Sujan; Paul, Ashim; Shah, Manisha; Kumar, Sachin; Mandal, Bhubaneswar published their research in RSC Chemical Biology in 2021. The article was titled 《Site-specific single point mutation by anthranilic acid in hIAPP8-37 enhances anti-amyloidogenic activity》.Category: triazoles The article contains the following contents:

Amylin or hIAPP, together with insulin, plays a significant role in glucose metabolism However, it undergoes β-sheet rich amyloid formation associated with pancreatic β-cell dysfunction leading to type-2 diabetes (T2D). Recent studies suggest that restricting β-sheet formation in it may halt amyloid formation, which may limit the risk for the disease. Several peptide-based inhibitors have been reported to prevent aggregation. However, most of them have limitations, including low binding efficiency, active only at higher doses, poor solubility, and proteolytic degradation Insertion of non-coded amino acids renders proteolytically stable peptides. We incorporated a structurally rigid β-amino acid, Anthranilic acid (Ant), at different sites within the central hydrophobic region of hIAPP and developed two singly mutated hIAPP8-37 peptidomimetics. These peptidomimetics inhibited the amyloid formation of hIAPP substantially even at low concentration, as evident from in vitro ThT, CD, FT-IR, TEM, and Congo red staining birefringence results. These peptidomimetics also disrupted the preformed aggregates formed by hIAPP into non-toxic species. These β-amino acid-based peptidomimetics can be an attractive scaffold for therapeutic design towards T2D or other protein misfolding diseases. The experimental part of the paper was very detailed, including the reaction process of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Category: triazoles)

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is a peptide coupling reagent. Can be used in the preparation of phenyl esters of amino acids which have been shown to be valuable as blocked derivatives of amino acids in the field of peptide synthesis.Category: triazoles

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Synthesis, distribution analysis and mechanism studies of N-acyl glucosamine-bearing oleanolic saponins》 was published in Bioorganic Chemistry in 2020. These research results belong to Juang, Yu-Pu; Lin, You-Yu; Chan, She-Hung; Chang, Chun-Kai; Shie, Jiun-Jie; Hsieh, Yves S. Y.; Guh, Jih-Hwa; Liang, Pi-Hui. Reference of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine The article mentions the following:

A series of N-acyl glucosamine-bearing triterpenoid saponins has been synthesized with cytotoxic activities evaluated against HL-60, PC-3, HCT-116, and CT-26 tumor cells. Saponins incorporated an oleanolic acid (OA) triterpenoidal core exhibited the highest cytotoxic activity. To study the influence of the lengths of acyl-carbon chain on N-position of glucosamine, cells were treated with 28-propargylamides and then reacted with an azido-fluorogenic probe under CuAAC click reactions to visualize the intact distributions of these compounds by confocal microscopy and flow cytometry; it was found that cytotoxic-active compounds (30-32) located in the cytosol and inactive compounds bearing longer carbon chains (33-35) were impenetrable across cell membranes. Our study demonstrated the defined lipophilic acyl-carbon chain length can precisely regulate the cytotoxic activity of saponins, which is useful for the future development of cytotoxic agents. Furthermore, using quant. proteomics and immuno-labeling, the mechanism of cytotoxicity induced by the synthetic saponin after membrane penetration could be a result of activation of death receptor pathway and inhibition of PI3K/Akt/mTOR pathway. The experimental part of the paper was very detailed, including the reaction process of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Reference of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Reference of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)aminePolytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2019,ChemistrySelect included an article by Topchiy, Maxim A.; Ageshina, Alexandra A.; Chesnokov, Gleb A.; Sterligov, Grigorii K.; Rzhevskiy, Sergey A.; Gribanov, Pavel S.; Osipov, Sergey N.; Nechaev, Mikhail S.; Asachenko, Andrey F.. Application In Synthesis of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine. The article was titled 《Alkynyl- or Azido-Functionalized 1,2,3-Triazoles: Selective MonoCuAAC Promoted by Physical Factors》. The information in the text is summarized as follows:

In this present work, the possibility of selectivity control for mono addition in the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction of sym. diazides or diacetylenes in equimolar amounts based on phys. rather than chem. factors was proposed and investigated. Single cycloaddition in the CuAAC reaction of sym. diazides or diynes could be achieved by (a) precipitation of the monoaddn. product, from nonpolar solvent heptane and (b) the reaction halt after formation of monoaddn. product due to increase of the viscosity in solvent-free procedure. Thus, two new green one-step methods for the synthesis of alkynyl- or azido-functionalized 1,2,3-triazoles I [R = n-Pr, SiMe3, Ph, etc.; R1 = CH2CO2Et, Ph, Bn, etc.] were devised. By using these methods 17 compounds were obtained with good to excellent yields. In addition to this study using Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine, there are many other studies that have used Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Application In Synthesis of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine) was used in this study.

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Application In Synthesis of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)aminePolytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Evaluation of N-binding through N1, N2 or N3 of 4-R-1,2,3-Triazolate to [CuCO]+ Complexes》 was written by Franco, Mauricio P.; Carvalho, Beatriz B.; Ribeiro, Marcos A.; Spada, Rene F. K.. Electric Literature of C2H3N3This research focused ontriazole copper complex isomer substituent effect. The article conveys some information:

We computationally investigated eight 4-R-1,2,3-triazolates and their three possible N-binding modes. Optimization of the pre-ligands to verify NPA charges were done with M06-2X/def2-TZVPP. The complexes with [CuCO]+ were optimized with M06 L/def2-TZVPP and the electronic energies were improved with DLPNO-CCSD(T)/cc-pVTZ. Our calculations with pre-ligands indicated the NPA charge of N2 as less neg. than N1 and N3 by at least ∼0.100 e. Taking into account the complexes energies and vibrations, coordination via N2 is the most stable among all three nitrogens in gas-phase by at least, 8 kJ/mol and the vibrational anal. of the νCO indicates linkage isomer N2 as the best electron d. donor among the three linkage isomers. The results exhibit a fine-tuning of ligand donation properties that can be achieved by selecting different R groups in 4-R-1,2,3-triazoles. In the experiment, the researchers used 1H-1,2,3-Triazole(cas: 288-36-8Electric Literature of C2H3N3)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Electric Literature of C2H3N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics