Category: Triazoles

The author of 《γ-(S)-Guanidinylmethyl-Modified Triplex-Forming Peptide Nucleic Acids Increase Hoogsteen-Face Affinity for a MicroRNA and Enhance Cellular Uptake》 were Taehtinen, Ville; Verhassel, Alejandra; Tuomela, Johanna; Virta, Pasi. And the article was published in ChemBioChem in 2019. Application of 56602-33-6 The author mentioned the following in the article:

γ-Modified (i.e., (S)-aminomethyl, (S)-acetamidomethyl, (R)-4-(hydroxymethyl)triazol-1-ylmethyl, and (S)-guanidinylmethyl) triplex-forming peptide nucleic acids (TFPNAs) were synthesized and the effect of the backbone modifications on the binding to a miR-215 model was studied. Among the modifications, an appropriate pattern of three γ-(S)-guanidinylmethyl modifications increased the affinity and Hoogsteen-face selectivity for the miR-215 model without ternary (PNA)2/RNA complex formation. Moreover, the γ-(S)-guanidinylmethyl groups were observed to facilitate internalization of the TFPNAs into living PC-3 prostate cancer cells. The experimental process involved the reaction of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Application of 56602-33-6)

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It acts as a substitute for (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent.Application of 56602-33-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2019,RSC Advances included an article by Peterson, Anna; Kaasik, Mikk; Metsala, Andrus; Jarving, Ivar; Adamson, Jasper; Kanger, Tonis. Formula: C30H30N10. The article was titled 《Tunable chiral triazole-based halogen bond donors: assessment of donor strength in solution with nitrogen-containing acceptors》. The information in the text is summarized as follows:

Strong halogen bond (XB) donors were needed for the activation of neutral substrates. It was demonstrated that XB donor properties of iodo-triazoles could be significantly enhanced by quaternization in combination with varying the counterion and aromatic substituent, exemplified by association constants with quinuclidine as high as 1.1 × 104 M-1. In the experiment, the researchers used many compounds, for example, Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Formula: C30H30N10)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Formula: C30H30N10Polytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2019,Organic Letters included an article by Wang, Jing-Hao; Lei, Tao; Nan, Xiao-Lei; Wu, Hao-Lin; Li, Xu-Bing; Chen, Bin; Tung, Chen-Ho; Wu, Li-Zhu. Recommanded Product: 1H-1,2,3-Triazole. The article was titled 《Regioselective Ortho Amination of an Aromatic C-H Bond by Trifluoroacetic Acid via Electrochemistry》. The information in the text is summarized as follows:

Aryl ethers such as anisole underwent regioselective electrochem. ortho-amination/arylation with pyrazoles and aromatic nitrogen heterocycles mediated by trifluoroacetic acid (TFA) in an undivided cell to give arylpyrazoles such as 1-(2-methoxyphenyl)pyrazole and arylated nitrogen heterocycles. The results came from multiple reactions, including the reaction of 1H-1,2,3-Triazole(cas: 288-36-8Recommanded Product: 1H-1,2,3-Triazole)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Recommanded Product: 1H-1,2,3-Triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2018,Mishra, Vandana; Rathore, Ishan; Arekar, Anagha; Sthanam, Lakshmi Kavitha; Xiao, Huogen; Kiso, Yoshiaki; Sen, Shamik; Patankar, Swati; Gustchina, Alla; Hidaka, Koushi; Wlodawer, Alexander; Yada, Rickey Y.; Bhaumik, Prasenjit published 《Deciphering the mechanism of potent peptidomimetic inhibitors targeting plasmepsins – biochemical and structural insights》.FEBS Journal published the findings.Product Details of 56602-33-6 The information in the text is summarized as follows:

Malaria is a deadly disease killing worldwide hundreds of thousands people each year and the responsible parasite has acquired resistance to the available drug combinations. The four vacuolar plasmepsins (PMs) in Plasmodium falciparum involved in Hb (Hb) catabolism represent promising targets to combat drug resistance. High antimalarial activities can be achieved by developing a single drug that would simultaneously target all the vacuolar PMs. We have demonstrated for the first time the use of soluble recombinant plasmepsin II (PMII) for structure-guided drug discovery with KNI inhibitors. Compounds used in this study (KNI-10742, 10743, 10395, 10333, and 10343) exhibit nanomolar inhibition against PMII and are also effective in blocking the activities of PMI and PMIV with the low nanomolar Ki values. The high-resolution crystal structures of PMII-KNI inhibitor complexes reveal interesting features modulating their differential potency. Important individual characteristics of the inhibitors and their importance for potency have been established. The alkylamino analog, KNI-10743, shows intrinsic flexibility at the P2 position that potentiates its interactions with Asp132, Leu133, and Ser134. The phenylacetyl tripeptides, KNI-10333 and KNI-10343, accommodate different ρ-substituents at the P3 phenylacetyl ring that determine the orientation of the ring, thus creating novel hydrogen-bonding contacts. KNI-10743 and KNI-10333 possess significant antimalarial activity, block Hb degradation inside the food vacuole, and show no cytotoxicity on human cells; thus, they can be considered as promising candidates for further optimization. Based on our structural data, novel KNI derivatives with improved antimalarial activity could be designed for potential clin. use. Database : Structural data are available in the PDB under the accession numbers 5YIE, 5YIB, 5YID, 5YIC, and 5YIA. The experimental process involved the reaction of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Product Details of 56602-33-6)

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It acts as a substitute for (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent.Product Details of 56602-33-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2018,Huang, Rong; Li, Zhihong; Sheng, Yao; Yu, Jianghui; Wu, Yue; Zhan, Yuexiong; Chen, Hongli; Jiang, Biao published 《N-Methyl-N-phenylvinylsulfonamides for Cysteine-Selective Conjugation》.Organic Letters published the findings.Recommanded Product: Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine The information in the text is summarized as follows:

Use of N-methyl-N-phenylvinylsulfonamides to perform chemoselective modification of cysteine-containing peptides and proteins is reported. Probes linked to the drug were applicable to prepare antibody-drug conjugates (ADCs). The drug-antibody ratio for ADCs was controlled by rationally tuning the electron deficiency and linker hydrophilicity of the probes. In the experimental materials used by the author, we found Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Recommanded Product: Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Recommanded Product: Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)aminePolytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2017,Ozdemir, Tugba; Lu, Yu-Chen; Kolemen, Safacan; Tanriverdi-Ecik, Esra; Akkaya, Engin U. published 《Generation of Singlet Oxygen by Persistent Luminescent Nanoparticle-Photosensitizer Conjugates: A Proof of Principle for Photodynamic Therapy without Light》.ChemPhotoChem published the findings.Quality Control of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V) The information in the text is summarized as follows:

The broader application of photodynamic therapy as a treatment procedure for cancer is hampered by the limited penetration of light through mammalian tissues. Since the photosensitized generation of cytotoxic singlet oxygen requires effective excitation of the tumor-localized photosensitizer, photodynamic action can only be guaranteed for the first few millimeters of the irradiated tissues. In this work, we demonstrated that the phenomenon of persistent luminescence, i.e., delayed emission from certain metal-ion excited states (with crystal defects acting as energy traps), can provide an alternative excitation possibility. Thus, persistent luminescent nanoparticles functionalized by FRET-matching Bodipy sensitizers (FRET=Foerster resonance energy transfer) were excited in situ before administration into a cell culture or an organism. It was found that this system continues to produce singlet oxygen regardless of their location and without any need for continuous photonic excitation. In the part of experimental materials, we found many familiar compounds, such as ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Quality Control of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V))

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It is also used as a precursor for the synthesis of phenyl esters of amino acids.Quality Control of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2017,’t Hart, Peter; Wood, Thomas M.; Tehrani, Kamaleddin Haj Mohammad Ebrahim; van Harten, Roel M.; Sleszynska, Malgorzata; Rentero Rebollo, Inmaculada; Hendrickx, Antoni P. A.; Willems, Rob J. L.; Breukink, Eefjan; Martin, Nathaniel I. published 《De novo identification of lipid II binding lipopeptides with antibacterial activity against vancomycin-resistant bacteria》.Chemical Science published the findings.Reference of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V) The information in the text is summarized as follows:

Creative strategies for identifying new antibiotics are essential to addressing the looming threat of a post-antibiotic era. We here report the use of a targeted peptide phage display screen as a means of generating novel antimicrobial lipopeptides. Specifically, a library of phage displayed bicyclic peptides was screened against a biomol. target based on the bacterial cell wall precursor lipid II. In doing so we identified unique lipid II binding peptides that upon lipidation were found to be active against a range of Gram-pos. bacteria including clin. relevant strains of vancomycin resistant bacteria. Optimization of the peptide sequence led to variants with enhanced antibacterial activity and reduced hemolytic activity. Biochem. experiments further confirm a lipid II mediated mode of action for these new-to-nature antibacterial lipopeptides. In addition to this study using ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V), there are many other studies that have used ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Reference of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)) was used in this study.

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It acts as a substitute for (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent.Reference of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

SDS of cas: 510758-28-8In 2021 ,《Local Cross-Coupling Activity of Azide-Hexa(ethylene glycol)-Terminated Self-Assembled Monolayers Investigated by Atomic Force Microscopy》 was published in Langmuir. The article was written by Lebitania, Julie Ann; Inada, Natsumi; Morimoto, Masayuki; You, Jiaxun; Shahiduzzaman, Md.; Taima, Tetsuya; Hirata, Kaito; Fukuma, Takeshi; Ohta, Akio; Asakawa, Tsuyoshi; Asakawa, Hitoshi. The article contains the following contents:

Azide-oligo(ethylene glycol)-terminated self-assembled monolayers (N3-OEG-SAMs) are promising interfacial structures for surface functionalization. Its many potential applications include chem./bio-sensing and construction of surface models owing to its cross-coupling activity that originates from the azide group and oligo(ethylene glycol) (OEG) units for non-specific adsorption resistance. However, there are only a few studies and limited information, particularly on the mol.-scale structures and local cross-coupling activities of N3-OEG-SAMs, which are vital to understanding its surface properties and interfacial mol. design. In this study, mol.-scale surface structures and cross-coupling activity of azide-hexa(ethylene glycol)-terminated SAMs (N3-EG6-SAMs) were investigated using frequency modulation at. force microscopy (FM-AFM) in liquid The N3-EG6-SAMs were prepared on Au(111) substrates through the self-assembly of 11-azido-hexa(ethylene glycol)-undecane-1-thiol (N3-EG6-C11-HS) mols. obtained from a liquid phase. Subnanometer-resolution surface structures were visualized in an aqueous solution using a laboratory-built FM-AFM instrument. The results show a well-ordered mol. arrangement in the N3-EG6-SAM and its clean surfaces originating from the adsorption resistance property of the terminal EG6 units. Surface functionalization by the cross-coupling reaction of copper(I)-catalyzed azide-alkyne cycloaddition was observed, indicating a structural change in the form of fluctuating structures and island-shaped structures depending on the concentration of the alkyne mols. The FM-AFM imaging enabled to provide information on the relationship between the surface structures and cross-coupling activity. These findings provide mol.-scale information on the functionalization of the N3-EG6-SAMs, which is helpful for the interfacial mol. design based on alkanethiol SAMs in many applications. The results came from multiple reactions, including the reaction of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8SDS of cas: 510758-28-8)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) is a polytriazolylamine ligand which stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.SDS of cas: 510758-28-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Related Products of 288-36-8In 2020 ,《Imidazole-Selective Alkyne Hydroamination under Physiological Conditions》 appeared in Organic Letters. The author of the article were Kang, Hyung-Joon; Lee, Joon-Ho; Kim, Dong-Hyun; Cho, Cheon-Gyu. The article conveys some information:

Imidazole-selective intermol. hydroamination reaction has been discovered. This unprecedented additive-free addition reaction proceeds in an exclusively regioselective and stereoselective manner with high atom economy under extremely mild reaction conditions. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole(cas: 288-36-8Related Products of 288-36-8)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Related Products of 288-36-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2022,Salinas-Torres, Angelica; Portilla, Jaime; Rojas, Hugo; Becerra, Diana; Castillo, Juan-Carlos published an article in Molbank. The title of the article was 《Synthesis, Spectroscopic Analysis, and In Vitro Anticancer Evaluation of 2-(Phenylsulfonyl)-2H-1,2,3-triazole》.Application of 288-36-8 The author mentioned the following in the article:

The 1,2,3-triazole derivatives containing the sulfonyl group have proved their biol. importance in medicinal chem. and drug design. In this sense, the regioselective synthesis of 2-(phenylsulfonyl)-2H-1,2,3-triazole in good yield through a classical sulfonamidation reaction of 1H-1,2,3-triazole with benzenesulfonyl chloride in dichloromethane using a slight excess of triethylamine at 20° for 3 h is described. This procedure is distinguished by its short reaction time, high yield, excellent regioselectivity, clean reaction profile, and operational simplicity. The sulfonamide exhibited moderate activity against UO-31 renal, SNB-75 central nervous system, HCT-116 colon, and BT-549 breast cancer cell lines, with growth inhibition percentages (GI%) ranging from 10.83% to 17.64%. The experimental part of the paper was very detailed, including the reaction process of 1H-1,2,3-Triazole(cas: 288-36-8Application of 288-36-8)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Application of 288-36-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics