Category: Triazoles

Recommanded Product: 3-Nitro-1-tosyl-1H-1,2,4-triazoleOn November 15, 1980 ,《Synthesis of the 3′-terminal decaribonucleoside nonaphosphate of yeast alanine transfer ribonucleic acid》 appeared in Tetrahedron. The author of the article were Jones, S. S.; Rayner, B.; Reese, C. B.; Ubasawa, A.; Ubasawa, M.. The article conveys some information:

The yeast decaribonucleotide UpCpGpUpCpCpApCpCpA was prepared from the 5 nucleosides I (R = 4-N-benzoylcytosin-1-yl, 2-N-benzoylguanin-9-yl), II (R = 6-N-benzoyladenin-9-yl, uracil-1-yl), and III (R = 6-N-benzoyladenin-9-yl) by the phosphotriester method. The use of o-dibromomethylbenzoyl as a protecting group in oligoribonucleotide synthesis is described. The internucleotide linkages were protected by o-chlorophenyl groups, which were readily removed by the N1,N1,N3,N3-tetramethylguanidinium salt of syn-4-nitrobenzaldoxime. The 1st phosphorylation step was carried out by treatment with o-chlorophenylphosphorodi(1,2,4-triazolide) followed by H2O and Et3N. The triazole IV was used as the activating agent in the 2nd phosphorylation step. In the part of experimental materials, we found many familiar compounds, such as 3-Nitro-1-tosyl-1H-1,2,4-triazole(cas: 77451-51-5Recommanded Product: 3-Nitro-1-tosyl-1H-1,2,4-triazole)

3-Nitro-1-tosyl-1H-1,2,4-triazole(cas: 77451-51-5) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Recommanded Product: 3-Nitro-1-tosyl-1H-1,2,4-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Synthesis and characterization of a new ion-imprinted polymer for the selective separation of thorium(IV) ions at high acidity》 was written by Liang, Hele; Chen, Qingde; Ma, Jingyuan; Huang, Yuying; Shen, Xinghai. Application of 56602-33-6This research focused onthorium ion imprinted polymer synthesis acidity. The article conveys some information:

A new ion-imprinted polymer (IIP) was synthesized by thermal copolymerization of bis(2-methacryloxyethyl) phosphate as functional ligand and ethylene glycol dimethacrylate as crosslinker in the presence of Th4+ as a template ion. The molar ratio of the functional ligand to Th4+ was optimized to be 4 by 31P NMR titration, elemental anal., and EXAFS, which was verified by comparing the adsorption capacities and selectivities of IIPs with different composition Thorium(IV) ions were leached out using 0.1 mol L-1 EDTA disodium salt and the prepared IIP was characterized by infra-red spectroscopy, thermogravimetric anal. and Brunauer-Emmett-Teller surface area measurement. It was found that the IIP could extract Th4+ from high acidity solution The maximum adsorption capacity was as high as 33.3 mg g-1 in 1.0 mol L-1 HCl. Even in 6.0 mol L-1 HCl, its adsorption capacity was still considerable. Moreover, the IIP exhibited good selectivity towards Th4+, especially in the presence of competing ions such as La3+, Eu3+, Yb3+, UO22+, and Fe3+.((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Application of 56602-33-6) was used in this study.

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It is also used as a precursor for the synthesis of phenyl esters of amino acids.Application of 56602-33-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Gas-phase UV absorption spectra and OH-oxidation kinetics of 1H-1,2,3-triazole and pyrazole》 was written by Samir, Brahim; Kalalian, Carmen; Roth, Estelle; Salghi, Rachid; Chakir, Abdelkhaleq. Safety of 1H-1,2,3-TriazoleThis research focused ontriazole pyrazole oxidation kinetics mechanism gas phase UV spectra. The article conveys some information:

In this work, we report the gas phase UV absorption spectra and the kinetics of the OH-oxidation of 1H-1,2,3-triazole and pyrazole. UV spectra were determined between 200 and 250 nm, at 350 ± 2 K and at pressures between 0.09 and 0.3 Torr. The reported maximal UV absorption cross sections are (cm2 per mol.): σ206 nm, 1H-1H-1,2,3-triazole = 2.04 x 10-18 and σ203 nm, pyrazole = 5.44 x 10-18. The very low absorption capacity of these compounds beyond 240 nm indicates that their atm. photodissociation is negligible. The OH-oxidation of these species was performed in an atm. simulation chamber coupled to an FTIR spectrometer and to a GC/MS over the temperature range 298-357 K and at atm. pressure. Experiments were conducted in relative mode using benzaldehyde, trans-2-hexenal and heptane as references The obtained rate constants at 298 K were (x10-11 cm3 per mol. per s): k(OH + 1H-1,2,3-triazole) = 2.16 ± 0.41; k(OH + pyrazole) = 2.94 ± 0.42. These results were compared to those available in the literature and discussed in terms of structure-reactivity and temperature dependency. Their tropospheric lifetimes with respect to reaction with OH radicals were then estimated In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole(cas: 288-36-8Safety of 1H-1,2,3-Triazole)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Safety of 1H-1,2,3-Triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

SDS of cas: 510758-28-8In 2021 ,《A multidrug-resistant P-glycoprotein assembly revealed by tariquidar-probe′s super-resolution imaging》 was published in Nanoscale. The article was written by Chen, Junling; Li, Hongru; Wu, Qiang; Zhao, Tan; Xu, Haijiao; Sun, Jiayin; Liang, Feng; Wang, Hongda. The article contains the following contents:

As an efflux pump, P-glycoproteins (P-gps) are over-expressed in many cancer cell types to confer them with multi-drug resistance. Many studies have focused on elucidating their mol. structure or protein expression; however, the relationship between the mol. assembly and dysfunction remains unclear. Super-resolution microscope is an excellent imaging tool to reveal the mol. biol. details, but its high-quality imaging often suffers from the labeling method currently available. In this work, by exploiting its specificity and small size, tariquidar (specific inhibitor of P-gp) was modified by TAMRA to form a small chem. probe of P-gp. By direct stochastic optical reconstruction microscopic (dSTORM) imaging, tariquidar-TAMRA was first revealed to possess a higher labeling superiority and high binding specificity. Then, with the application of tariquidar-TAMRA labeling, we found that P-gps accumulate into larger and denser clusters on cancer cells and drug-resistant cells than on normal cells and drug-sensitive cells, indicating that P-gps can facilitate the pumping efficiency by aggregating together to form functional platforms. Moreover, these specific distribution patterns might serve as potential biomarkers for tumor and drug therapy screening.Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8SDS of cas: 510758-28-8) was used in this study.

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) is a polytriazolylamine ligand which stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.SDS of cas: 510758-28-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Amphiphilic drug-peptide-polymer conjugates based on poly(ethylene glycol) and hyperbranched polyglycerol for epidermal growth factor receptor targeting: the effect of conjugate aggregation on in vitro activity》 was written by Petho, Lilla; Kasza, Gyorgy; Lajko, Eszter; Lang, Orsolya; Kohidai, Laszlo; Ivan, Bela; Mezo, Gabor. Computed Properties of C12H22F6N6OP2 And the article was included in Soft Matter in 2020. The article conveys some information:

In our present work, epidermal growth factor receptor targeting drug-peptide conjugates were prepared using GE11 and D4 peptides. To ensure the drug release, the cathepsin B labile GFLG spacer was incorporated between the targeting peptide and the drug mol. (daunomycin), which significantly increased the hydrophobicity and thereby decreased the water solubility of the conjugates. To overcome the solubility problem, drug-peptide-polymer conjugates with systematic structural variations were prepared, by linking poly(ethylene glycol) (PEG) or a well-defined amino-monofunctional hyperbranched polyglycerol (HbPG) directly or via a pentaglycine spacer to the targeting peptides. The results of the in vitro cell viability and cellular uptake measurements on HT-29 human colon adenocarcinoma cells proved that the HbPG and the PEG highly influenced the biol. activity. The conjugation of the hydrophilic polymer resulted in the amphiphilic character of the conjugates, which led to self-aggregation and nanoparticle formation that decreased the cellular uptake above a specific aggregation concentration The hydrodynamic volume and the different polymer chain topol. of the linear PEG and the compact hyperbranched HbPG also played an important role in the biol. activity. The investigation of the colloidal properties is inevitable for the better understanding of the biol. activity, which can reveal the structure-activity relationship of amphiphilic drug-peptide-polymer conjugates for efficient tumor targeting. In the part of experimental materials, we found many familiar compounds, such as ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Computed Properties of C12H22F6N6OP2)

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It is also used as a precursor for the synthesis of phenyl esters of amino acids.Computed Properties of C12H22F6N6OP2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Electrochemical Decarboxylative N-Alkylation of Heterocycles》 was written by Sheng, Tao; Zhang, Hai-Jun; Shang, Ming; He, Chi; Vantourout, Julien. C.; Baran, Phil. S.. Computed Properties of C2H3N3 And the article was included in Organic Letters in 2020. The article conveys some information:

An operationally simple method to employ nonactivated carboxylic acids as alkylating agents in the N-alkylation of heterocycles is reported through an electrochem. driven anodic decarboxylative process. A wide substrate scope across a range of heterocycles is demonstrated along with a series of applications that significantly reduce the step count required to access such medicinally relevant structures. In the experiment, the researchers used 1H-1,2,3-Triazole(cas: 288-36-8Computed Properties of C2H3N3)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Computed Properties of C2H3N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《ab-initio study of hydrogen bond networks in 1,2,3-triazole phases》 was written by Peschel, Christopher; Dressler, Christian; Sebastiani, Daniel. Reference of 1H-1,2,3-TriazoleThis research focused ontriazole hydrogen bond; ab-initio molecular dynamics; crystal structure; diffusion coefficient; fuel cell; hydrogen bond network; pi-pi-stacking; proton conductivity; tautomerism. The article conveys some information:

The research in storage and conversion of energy is an everlasting process. The use of fuel cells is very tempting but up to now there are still several conceptual challenges to overcome. Especially, the requirement of liquid water causes difficulties due to the temperature limit. Therefore, imidazoles and triazoles are increasingly investigated in a manifold of exptl. and theor. publications as they are both very promising in overcoming this problem. Recently, triazoles were found to be superior to imidazoles in proton conduction. An ab-initio mol. dynamics simulation of pure triazole phases for investigating the behavior of both tautomer species of the triazole mol. has never been done. In this work, we investigate the structural and dynamical properties of two different solid phases and the liquid phase at two different temperatures We are able to show how the distinct tautomers contribute to the mechanism of proton conduction, to compute dynamical properties of the four systems and to suggest a mechanism of reorientation in solid phase. The results came from multiple reactions, including the reaction of 1H-1,2,3-Triazole(cas: 288-36-8Reference of 1H-1,2,3-Triazole)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Reference of 1H-1,2,3-Triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

COA of Formula: C2H3N3In 2020 ,《Effect of Pore Size on the Separation of Ethylene from Ethane in Three Isostructural Metal Azolate Frameworks》 appeared in Inorganic Chemistry. The author of the article were Jiang, Xue; Zhang, Tao; Cao, Jian-Wei; Zhao, Chong-Kai; Yang, Rong; Zhang, Qiu-Yu; Chen, Kai-Jie. The article conveys some information:

The pore-size effect on ethane adsorption and ethane/ethylene separation in three isostructural metal azolate frameworks (MAF-123-Mn/Zn/Cu) were thoroughly investigated. MAF-123-Mn/Zn/Cu were synthesized by the solvothermal method on a gram scale. Decreasing the pore size from 6.1 to 4.9 Å leads to an increase in the ethane adsorption energy from 23 to 27.5 kJ mol-1 and further ethane/ethylene separation efficiency. Mol. simulations revealed that a shorter ethane-framework interaction distance in MAF-123-Zn than that in MAF-123-Mn is responsible for the increased adsorption energy. Dynamic breakthrough experiments manifest that these metal azolate frameworks can effectively produce high-purity ethylene from ethane in one adsorption step. Exquisite pore-size control by metal alternation was achieved in three metal azolate frameworks for enhanced ethane/ethylene separation The experimental part of the paper was very detailed, including the reaction process of 1H-1,2,3-Triazole(cas: 288-36-8COA of Formula: C2H3N3)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties COA of Formula: C2H3N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Synthesis of Vitamin B12-Antibiotic Conjugates with Greatly Improved Activity against Gram-Negative Bacteria》 was published in Organic Letters in 2020. These research results belong to Zhao, Sheng; Wang, Zhi-Peng; Wen, Xumei; Li, Siyu; Wei, Guoxing; Guo, Jian; He, Yun. Application of 510758-28-8 The article mentions the following:

There is an urgent need to discover new antibiotics and improve the efficacy of known antibiotics against Gram-neg. bacteria. “”Trojan horse”” conjugates are novel and promising antibiotics. Herein we report the design and synthesis of vitamin-B12-ampicillin conjugates, which exhibited more than 500 times improved activity against Escherichia coli compared with ampicillin itself. Our studies demonstrate that the vitamin-B12 uptake pathway could be employed for effective antibiotic delivery and efficacy enhancement. In addition to this study using Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine, there are many other studies that have used Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Application of 510758-28-8) was used in this study.

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Application of 510758-28-8Polytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Organophotoredox-Catalyzed Direct C-H Amination of 2H-Indazoles with Amines》 was published in Organic Letters in 2020. These research results belong to Neogi, Sukanya; Ghosh, Asim Kumar; Majhi, Koushik; Samanta, Sadhanendu; Kibriya, Golam; Hajra, Alakananda. Application In Synthesis of 1H-1,2,3-Triazole The article mentions the following:

A general and practical method for the direct C-H amination of 2H-indazoles with a series of amines including aliphatic primary amines, secondary amines, azoles and sulfoximines via organophotoredox-catalyzed oxidative coupling to gave aryl(amine/imino)indazols I [R1 = 4-Me, 3-OMe, 4-i-Pr, etc.; R2 = H, 5-F, 5-Cl, 5-OMe; R3 = NH2, pyrazol-1-yl, 1-piperidyl, etc.] was disclosed at room temperature under ambient air conditions. Addnl., this protocol was used for free aminated 2H-indazole I [R1 = Me; R2 = H, 5-Cl; R3 = NH2] synthesis. A mechanistic study revealed that a single electron transfer (SET) pathway might be involved in this reaction.1H-1,2,3-Triazole(cas: 288-36-8Application In Synthesis of 1H-1,2,3-Triazole) was used in this study.

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Application In Synthesis of 1H-1,2,3-Triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics