Category: Triazoles

Wan, Zhaohua; Wang, Dan; Yang, Zixuan; Zhang, Heng; Wang, Shengchun; Lei, Aiwen published an article in 2020, the title of the article was Electrochemical oxidative C(sp3)-H azolation of lactams under mild conditions.Application In Synthesis of 4-(p-Tolyl)-1H-1,2,3-triazole And the article contains the following content:

An electrochem. oxidative direct C(sp3)-H azolation of lactams was reported under metal catalyst-free and external chem. oxidant-free conditions. This electrochem. C(sp3)-H/N-H coupling was characterized by its broad substrate scope of azoles and lactams under mild conditions at room temperature Mechanistic studies suggested that the reaction possibly involves a radical process. Moreover, the site selectivity was explained by DFT calculations More meaningfully, a gram-scale synthesis method of flow electrochem. was employed to show the scaled-up applicability of this transformation. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Application In Synthesis of 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to azole lactam electrochem oxidative azolation, azolyl lactam preparation, amide azole electrochem oxidative azolation, amido azole preparation, pyrazole urea electrochem oxidative azolation, pyrazolyl urea preparation and other aspects.Application In Synthesis of 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On September 30, 2022, Sandeep, K.; Sanjeeva Kumar, A.; Qureshi, Asif Ali; Kumara Swamy, K. C. published an article.Quality Control of 4-(p-Tolyl)-1H-1,2,3-triazole The title of the article was (3+2) Cycloadditions of Vinyl Sulfonyl Fluorides with Ethyl Diazoacetate or Azides: Metal-Free Synthesis of Pyrazole and Triazole Scaffolds via SO2 Elimination. And the article contained the following:

A (3 +2) cycloaddition reaction between substituted vinyl sulfonyl fluorides RCH=CHS(O)2F (R = Ph, 2,4,6-trimethylphenyl, naphthalen-2-yl, etc.) and 3,4-dihydronaphthalene-2-sulfonyl fluoride and Et diazoacetate or azides R1N3 (R1 = Ph, Bn, 4-nitrophenyl, etc.) for the rapid construction of pyrazole I or triazole cores II (R1 = H, Ph, Bn, 4-nitrophenyl, etc.) via Michael addition and SO2 gas elimination is developed. Trimethylsilyl azide or organic azide selectively attacks at the β-carbon of vinyl sulfonyl fluoride rather than at the S(VI) center and generates C-substituted or C,N-disubstituted triazole II. In contrast, vinyl sulfonyl fluorides react with Et diazoacetate to generate pyrazoles I in good to high yields. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Quality Control of 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to pyrazole preparation chemoselective, ethyl diazoacetate vinyl sulfonyl fluoride cycloaddition michael addition, triazole preparation chemoselective, azide vinyl sulfonyl fluoride cycloaddition michael addition and other aspects.Quality Control of 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Oliva, Cristina G.; Jagerovic, Nadine; Goya, Pilar; Alkorta, Ibon; Elguero, Jose; Cuberes, Rosa; Dordal, Alberto published an article in 2010, the title of the article was N-substituted-1,2,3-triazoles: synthesis, characterization and evaluation as cannabinoid ligands.Synthetic Route of 5301-96-2 And the article contains the following content:

A series of new N1-, N2- and N3-substituted 1,2,3-triazole derivatives has been synthesized by cycloaddition of butyltin azide with substituted alkynes followed by N-alkylation reactions. The regioisomers have been isolated and characterized using NMR techniques. GIAO/B3LYP calculations of the absolute shieldings have been performed to verify the assignments and so the structures have been unequivocally identified. The proportion in which the three isomers are obtained corresponds with the relative order of stability indicated by the energy values calculated at the B3LYP level. CB1 cannabinoid receptor binding assays have been performed but none of the compounds showed significant activity. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Synthetic Route of 5301-96-2

The Article related to tributyltin azide alkyne cycloaddition alkyl bromide alkylation, triazole nitrogen alkyl derivative regioselective preparation calculated chem shift, cannabinoid receptor binding assay alkyl triazole inactive and other aspects.Synthetic Route of 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On May 18, 2017, Cha, Hyojin; Lee, Kyongkyu; Chi, Dae Yoon published an article.Electric Literature of 5301-96-2 The title of the article was Synthesis of N-unsubstituted 1,2,3-triazoles via aerobic oxidative N-dealkylation using copper(II) acetate. And the article contained the following:

A copper-catalyzed aerobic oxidative C-N bond cleavage reaction was developed for the synthesis of 4-substituted-NH-1,2,3-triazoles. Diverse β-ketotriazoles derivatives, which are the starting materials for the aerobic oxidative C-N bond cleavage reaction, were prepared from nine aryl and seven alkyl alkynes and α-azidoacetophenone by a copper(I)-catalyzed [3 + 2] cycloaddition reaction. The aerobic oxidation of α-(1,2,3-triazol-1-yl)acetophenones using a catalytic amount of copper(II) acetate in the presence oxygen under neutral conditions gave the title compounds in high yield [e.g., 1-phenacyl-4-phenyl-1H-1,2,3-triazole → 4-phenyl-1H-1,2,3-triazole (91%) in presence of Cu(OAc)2 and pyridine in PhCF3 under O2]. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Electric Literature of 5301-96-2

The Article related to copper catalyzed oxidative carbon nitrogen bond cleavage triazolylacetophenone, aerobic oxidative dealkylation triazolylacetophenone, triazole synthesis, azidoacetophenone cycloaddition aryl alkyl alkyne and other aspects.Electric Literature of 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On September 30, 2021, Garg, Anirban; Borah, Nobomi; Sultana, Jasmin; Kulshrestha, Akshay; Kumar, Arvind; Sarma, Diganta published an article.Formula: C9H9N3 The title of the article was Silica immobilized copper N-heterocyclic carbene: An effective route to 1,2,3-triazoles via azide-alkyne cycloaddition and multicomponent click reaction. And the article contained the following:

A new silica supported copper N-heterocyclic carbene (Cu-NHC@SiO2) complex is prepared and characterized by SEM (SEM), energy dispersive X-ray spectroscopy (EDX) and XPS analyses. This complex is an efficient and easily retrievable catalyst for 1,2,3-triazole synthesis through direct azide-alkyne cycloaddition reaction as well as one-pot reaction using arylboronic acids. This catalytic system is also suitable for synthesis of 4-aryl-NH-1,2,3-triazoles from diverse benzaldehydes. Further, the catalyst can efficiently be recycled up to fifth cycle for all the three methods of 1,2,3-triazole synthesis through direct azide-alkyne cycloaddition and multi-component reactions. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Formula: C9H9N3

The Article related to silica immobilized copper nitrogen heterocyclic carbene catalyst, triazole preparation azide alkyne cycloaddition multicomponent click reaction, one pot reaction arylboronic acid triazole preparation and other aspects.Formula: C9H9N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On August 31, 2021, Saadat, Mostafa; Azizi, Najmedin; Qomi, Mahnaz published an article.Electric Literature of 5301-96-2 The title of the article was Sulfonic acid-functionalized magnetic carbon nitride as highly efficient ionic composite for sustainable assembly of 1,2,3-triazoles. And the article contained the following:

An efficient and straightforward method for constructing of biol. active 4-aryl-NH-1,2,3-triazoles I [Ar = Ph, 2-BrC6H4, 2-thienyl, etc.] by the 1,3-dipolar cycloaddition reaction of β-nitrostyrene and sodium azide in the presence of acidic graphitic carbon nitride (Fe3O4@g-C3N4-SO3H) ionic nanocomposite had developed. Using a magnetically recoverable acidic ionic catalyst allows eco-friendly and facile conversion and simplifies exptl. setup and work-up procedure that enables the direct synthesis of triazole derivatives under mild conditions. The designed catalytic system provided a broader scope under short reaction times in good to excellent yields. Fe3O4@g-C3N4-SO3H could be simply recovered by magnetic separation using an external magnet, maintaining stable activity up to five cycles without appreciable loss of activity. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Electric Literature of 5301-96-2

The Article related to sulfonic acid functionalized graphitic carbon nitride iron oxide preparation, aryl triazole regioselective green preparation, beta nitrostyrene sodium azide dipolar cycloaddition iron oxide catalyst and other aspects.Electric Literature of 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Ma, Dong; Yin, Yang; Chen, Ying-Lu; Yan, Yi-Tao; Wu, Jun published an article in 2021. The article was titled 《Design, step-economical diversity-oriented synthesis of an N-heterocyclic library containing a pyrimidine moiety: discovery of novel potential herbicidal agents》, and you may find the article in RSC Advances.Application of 288-36-8 The information in the text is summarized as follows:

The step-economical diversity-oriented synthesis of a library of various pyrimidine-N-heterocycle hybrids I [R = 1H-imidazol-1-yl, 1H-1,2,3-triazol-1-yl, 1-methyl-1H-indol-3-yl, etc.] and II [R1 = 5-Me, 4-Cl, 5-Cl, 6-Cl] was developed, in which a 4,6-dimethoxypyrimidine core was incorporated into nine kinds of N-heterocycles. A total of 34 structurally diverse compounds I and II were synthesized via a two-step process from very simple and com. available starting materials. Further, in-vivo biol. screening of this library identified 11 active compounds I [R = 1H-imidazol-1-yl, 1H-1,2,3-triazol-1-yl, 2-(trifluoromethyl)-1H-1,3-benzodiazol-1-yl, 3-methyl-1H-indazol-1-yl, 5-methyl-1H-indazol-1-yl, 2,3,4,9-tetrahydro-1H-carbazol-9-yl, 1H-indol-3-yl, 4-chloro-1H-indol-3-yl, 5-chloro-1H-indol-3-yl, 7-chloro-1H-indol-3-yl] and II [R1 = 5-Cl] that exhibited good post-emergence herbicidal activity against D. sanguinalis at 750 g ai per ha. More importantly, pyrimidine-tetrahydrocarbazole hybrid I [R = 2,3,4,9-tetrahydro-1H-carbazol-9-yl] showed good to excellent herbicidal activity against five test weeds at the same dosage. Pyrimidine-tetrahydrocarbazole hybrids I [R = 9H-carbazol-9-yl, 2,3,4,9-tetrahydro-1H-carbazol-9-yl, 3-chloro-9H-carbazol-9-yl] represented a novel class of herbicidal agents that may become promising lead compounds in the herbicidal discovery process.1H-1,2,3-Triazole(cas: 288-36-8Application of 288-36-8) was used in this study.

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Application of 288-36-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Cui, Xue; Ma, Jianting; Zeng, Tingting; Xu, Junyu; Li, Youbin; Wang, Xuesong published their research in RSC Advances in 2021. The article was titled 《Metal-free cascade synthesis of unsymmetrical 2-aminopyrimidines from imidazolate enaminones》.Formula: C2H3N3 The article contains the following contents:

A convenient metal-free synthesis of unsym. 2-aminopyrimidines I [R1 = cyclopropyl, Ph, 4-MeC6H4, etc.; R2 = Ph, 4-ClC6H4, 4-MeOC6H4, etc.] from imidazolate enaminones had been developed. In this procedure, various structural 2-aminopyrimidines I, as well as 4,5-dihydroisoxazol-5-ols and pyrazoles were synthesized in moderate to excellent yields. A plausible mechanism was also proposed for the cascade reaction. This method represented an effective strategy toward the synthesis of unsym. 2-aminopyrimidines I. In the part of experimental materials, we found many familiar compounds, such as 1H-1,2,3-Triazole(cas: 288-36-8Formula: C2H3N3)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Formula: C2H3N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Molybdenum oxide-based metal-organic framework/polypyrrole nanocomposites for enhancing electrochemical detection of dopamine》 was written by Zhou, Kunfeng; Shen, Defeng; Li, Xiao; Chen, Yuhao; Hou, Liran; Zhang, Yishuai; Sha, Jingquan. Quality Control of 1H-1,2,3-Triazole And the article was included in Talanta in 2020. The article conveys some information:

To overcome the poor conductivities and promote the application in the biosensors of metal-organic frameworks (MOFs), a simple approach was employed to improve their overall conductivity by adjusting the metal centers of MOFs and coating conductive polypyrrole (PPy) in the work. An unprecedented molybdenum oxide-based three-dimensional MOFs with helical channels (CuTRZMoO4) was synthesized based on MoO-4, Cu2+ ions and 1,2,3-trz for the first time, then combined with PPy to fabricate hybrid composites (CuTRZMoO4@PPy-n) with both advantages. The CuTRZMoO4 modified glassy carbon electrode show high sensitivity for detecting the neurotransmitter dopamine (DA), and the CuTRZMoO4@PPy-2 modified glassy carbon electrode has the highest catalytic activity to DA with the linear detection range from 1μM to 100μM and the detection limit of 80 nM (S/N = 3) by differential pulse voltammetry (DPV). Moreover, the developed biosensor has good selectivity, reproducibility and stability. The concept behind the new architecture to modify electrodes should promote the further development of MOF-based biosensors. In the experiment, the researchers used 1H-1,2,3-Triazole(cas: 288-36-8Quality Control of 1H-1,2,3-Triazole)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Quality Control of 1H-1,2,3-Triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics