Category: 7411-23-6

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole, A new synthetic method of this compound is introduced below., Application In Synthesis of 3,5-Dibromo-1H-1,2,4-triazole

Two batches of phenyiboronic acid (135 g, 111 mrnol, 1.0 eq), 35-dibromo-iH-i,2,4- triazole (25 g, 110 mmoi, 1.0 eq), Cu( Ac)2 (30 g, 165 mmol, 1.5 eq), pyridine (26.5 g, 335 mmol, 27 mL, 3.0 eq) and 4A MS (5 g, 22,0 mmoi) in toluene (250 mL) was degassed and purged with 02 for three times, and then the mixture was stirred at 80 C for 16 h under 02 atmosphere (15 psi). After completion of the reaction, the two batches of reaction mixture were mixed and filtered, then concentrated under reduced pressure to give a residue. The residue was purified by flash silica gel chromatography (ISCO; 200 g SepaFlash Silica Flash Column, eluent of Oi 0% ethyl acetate/petroleum ether gradient 80 mL/rnin) to give 36 g crude product with 67% purity. 2 g was used for next step directly. The remaining 34 g was diluted with DCM (200 mL) and washed with saturated aqueous NaHCO3 (100 mL x 1), brine (100 mL), dried over anhydrous Na2504, filtered and concentrated under reduced pressure to give 3,5-dibrorno-1-phenvl-i,2,4-triazoie (29.2 g, 37% yield, 85% purity) as a light yellow solid. LCMS (ESI): m/z (M¡ÀH) 303.9.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; AN2H DISCOVERY LIMITED; JOHNSTON, Jennifer; GAROFALO, Albert W.; (194 pag.)WO2017/210694; (2017); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 3,5-Dibromo-1H-1,2,4-triazole

General procedure: 3,5-Dibromo-1,2,4-triazole (1; 658 mg, 2.9 mmol) or 3-chloro-1,2,4-triazole (300 mg, 2.9 mmol), o-quinone methide precursor 2 (2.9mmol), and K2CO3 (1.2 g, 8.7 mmol) were refluxed for 4 h in DMF (10mL). After completion of the reaction, the mixture was cooled, andpoured into H2O (30 mL). The precipitate formed was collected by filtration,washed with H2O, dried, and recrystallized.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 7411-23-6.

Reference:
Article; Osipov, Dmitry V.; Osyanin, Vitaly A.; Voskressensky, Leonid G.; Klimochkin, Yuri N.; Synthesis; vol. 49; 10; (2017); p. 2286 – 2296;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Some common heterocyclic compound, 7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole, molecular formula is C2HBr2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C2HBr2N3

In a 100 mL round-bottomed flask. 3.5-dibromo- 1 H- 1.2.4-triazole (5g, 22.0 mmol. Eq: 1.00), 1 – (chloromethyl)-4-methoxybenzene (3.45 g. 22.0 mmol. Eq: 1) and N-ethyl-N-isopropylpropan-2- amine (5.7 g. 44. 1 mmol. Eq: 2) were combined with acetonitrile (101 ml ) to give a light yellow solution. Potassium iodide (1.83 g, 11.0 mmol, Eq: 0.5) was added. The mixture was heated to reflux for 2 hours. The reaction mixture was cooled and diluted with EtOAc (100 mL), washed with H20 (50 mL) and brine (50 mL). The organic layer was dried over anhydrous MgS04, filtered and volatiles were removed under reduced pressure to yield an oil from which the compound was isolated by column chromatography (Hexanes/EtOAc = 70/30) to give 7.3 g of desired product (95%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 7411-23-6, its application will become more common.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; CHEN, Zhi; CHIN, Elbert; ERICKSON, Shawn David; GABRIEL, Stephen Deems; MERTZ, Eric; WEIKERT, Robert James; WO2014/135483; (2014); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole, This compound has unique chemical properties. The synthetic route is as follows., Safety of 3,5-Dibromo-1H-1,2,4-triazole

To a solution of 3,5-dibromo-lH-l,2,4-triazole (5.00 g, 22.04 mmol) in CH3CN (50 ml) was added 2-(2-bromoethoxy)tetrahydro-2H-pyran (5.07 g, 24.24 mmol) and DIPEA (4.00 ml, 24.24 mmol). The resulting solution was heated at 90 C for 3 h.Subsequently, the mixture was cooled and diluted with EtOAc (100 ml). The resulting solution was then washed with a sat. aq. solution of NaHC03 and brine. The organic layer was dried (MgSC^) and concentrated under reduced pressure. The residue was purified by flash column chromatography over silica gel (eluent: DCM/MeOH(NH3) from 100/0 to 97/3). The product fractions were collected and concentrated in vacuo, yielding 6.00 g of intermediate 56 (77 %).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 7411-23-6.

Reference:
Patent; ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC; DE CLEYN, Michel, Anna, Jozef; VAN BRANDT, Sven, Franciscus, Anna; GIJSEN, Henricus, Jacobus, Maria; BERTHELOT, Didier, Jean-Claude; OEHLRICH, Daniel; WO2011/86098; (2011); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Reference of 7411-23-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below.

General procedure: 3,5-Dibromo-1,2,4-triazole (1; 658 mg, 2.9 mmol) and p-quinonemethide precursor 7 (2.9 mmol) were refluxed for 4 h in DMF (10mL). Products were isolated analogously to compound 4a.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dibromo-1H-1,2,4-triazole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Osipov, Dmitry V.; Osyanin, Vitaly A.; Voskressensky, Leonid G.; Klimochkin, Yuri N.; Synthesis; vol. 49; 10; (2017); p. 2286 – 2296;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Electric Literature of 7411-23-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole, This compound has unique chemical properties. The synthetic route is as follows.

SEM-Cl (808.41 mg, 4.85 mmol, 858.18 mL, 1 eq) was added to a dichloromethane solution (10 mL) of acompound WX073-1 (1.1g, 4.85mmol, 1 eq) and triethylamine (727.00 mg, 7.18mmol, 1 mL, 1.48 eq), and the resultingmixture was reacted 25C for 1 hour. The reaction solution was spin-dried to obtain the target compound WX073-2. ESIm/z: [M-TMS+O]-=300.1.

The chemical industry reduces the impact on the environment during synthesis 3,5-Dibromo-1H-1,2,4-triazole. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Shandong Danhong Pharmaceutical Co., Ltd.; LUO, Zhi; LI, Xiaolin; YANG, Yaxun; YANG, Lele; LI, Peng; HE, Haiying; LI, Jian; CHEN, Shuhui; (155 pag.)EP3626699; (2020); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Electric Literature of 7411-23-6, These common heterocyclic compound, 7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a 250 mL round bottomed flask, 3,5-dibromo-1H-1,2,4-triazole (Int-1, 8.00 g, 35.3 mmol) was dissolved in DMF (80 mL) and the solution was cooled to 0-5 C (ice bath). Sodium hydride (60% dispersion in mineral oil, 1.69 g, 42.3 mmol) was added in portions and the resulting mixture was stirred for 45 min at 0-5 C and for 15 min at room temperature. After that, iodomethane (10.0 g, 4.41 mL, 70.5 mmol) was added dropwise at 0-5 C (ice bath). The resulting mixture was stirred for 18 h at room temperature. After that, it was concentrated in vacuo, the residue was diluted with ethyl acetate (200 mL) and water (200 mL), the aqueous phase was extracted with ethyl acetate (2 x 200 mL). The combined organic layers were dried (sodium sulfate) and concentrated in vacuo to yield the title compound as light yellow solid (8.15 g, 96%). 1H NMR (CDCl3, 300 MHz): delta 3.89 (3 H). MS (ES+) m/z 240.0, 242.0, 244.0 [M+H, 2 Br isotopes].

Statistics shows that 3,5-Dibromo-1H-1,2,4-triazole is playing an increasingly important role. we look forward to future research findings about 7411-23-6.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BARTELS, Bjoern; BERCHTOLD, Stefan; GALLEY, Guido; GOERGLER, Annick; JAKOB-ROETNE, Roland; KRUMMENACHER, Daniela; LIMBERG, Anja; NEIDHART, Werner; RATNI, Hasane; REUTLINGER, Michael; RODRIGUEZ SARMIENTO, Rosa Maria; SCHNIDER, Christian; (309 pag.)WO2018/87018; (2018); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthetic Route of 7411-23-6, The chemical industry reduces the impact on the environment during synthesis 7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole, I believe this compound will play a more active role in future production and life.

In a 50 mL round bottomed flask, 3,5-dibromo-1H-1,2,4-triazole (lnt-1, 500 mg, 2.2 mmol) was dissolved in DMF (8 mL) and potassium carbonate (680 mg, 4.87 mmol) was added. After stirring for 20 min at room temperature, 2,2,3,3, 3-pentafluoropropyl trifluoromethanesulfonate (705 mg, 414 mu, 2.42 mmol) was added and the reaction mixture was stirred for 20 h at room temperature. After that, it was concentrated in vacuo, the residue was purified by column chromatography (silica gel, 50 g, eluting with ethyl acetate / n-heptane, gradient 20:80 to 50:50 v/v) to yield the title compound as white solid (409 mg, 52%). HPLC (methodLCMS_fastgradient) tR= 1.11 min. 1H NMR (CDCl3, 300 MHz): delta 4.78 (t, J = 13.4 Hz, 2 H). MS (ES+) mJz 357.9, 359.9, 361.9 [M+H, 2 Br isotopes].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dibromo-1H-1,2,4-triazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BARTELS, Bjoern; BERCHTOLD, Stefan; GALLEY, Guido; GOERGLER, Annick; JAKOB-ROETNE, Roland; KRUMMENACHER, Daniela; LIMBERG, Anja; NEIDHART, Werner; RATNI, Hasane; REUTLINGER, Michael; RODRIGUEZ SARMIENTO, Rosa Maria; SCHNIDER, Christian; (309 pag.)WO2018/87018; (2018); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7411-23-6 as follows. Application In Synthesis of 3,5-Dibromo-1H-1,2,4-triazole

A Compound WX122-1 (4 g) was dissolved in DMF (100 ml) and the resulting solution was cooled down to0C. NaH (846.3mg) was added in batch. Gas was generated during the process, and after 0.5 hour, MeI (2.6 grams)was added dropwise into the reaction solution which was slowly heated to 25C namely room temperature and stirredfor 12 hours. The reaction solution was poured into a saturated ammonium chloride solution (300ml), and extracted withethyl acetate (50ml33), and the organic phase was washed with a saturated sodium chloride solution (100ml). Theorganic phases were mixed and dried with anhydrous sodium sulfate, filtered, and concentrated under the reducedpressure. This compound was used directly in the next step and did not require purification. ESI m/z: [M+H]+= 242.

According to the analysis of related databases, 7411-23-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shandong Danhong Pharmaceutical Co., Ltd.; LUO, Zhi; LI, Xiaolin; YANG, Yaxun; YANG, Lele; LI, Peng; HE, Haiying; LI, Jian; CHEN, Shuhui; (155 pag.)EP3626699; (2020); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7411-23-6 as follows. Recommanded Product: 7411-23-6

A mixture of salt 1a [6] (1 g, 2.9 mmol), 3,5-dibromo-1,2,4-triazole (0.66 g, 2.9 mmol), and 60% aqueous acetonitrile (15 ml) was refluxed for 2 h. The mixture was cooled and poured into water (50 ml). The precipitate formed was filtered off and recrystallized from ethanol. Yield 0.83 g (74%), colorless crystals; mp 193-194 C. IR spectrum, nu, cm-1: 3500-3100 (OH), 3066 (CH arom.), 2922 (CH2); 1630, 1443, 1331, 1271, 1072, 818. 1H NMR spectrum (DMSO-d6), delta, ppm (J, Hz): 5.68 (2H, s, CH2); 7.16 (1, d, J = 9.2, H Ar); 7.29 (1, t, J = 7.3, H Ar); 7.47 (1, dd, J = 8.3, J = 7.3, H Ar); 7.80 (2H, d, J = 8.7, H Ar); 7.96 (1, d, J = 8.3, H Ar); 10.23 (1H, s, OH). 13C NMR spectrum (DMSO-d6), delta, ppm: 44.8 (CH2); 111.7 (C); 118.3 (CH); 122.8 (CH); 123.3 (CH); 127.5 (CH); 128.5 (C); 129.0 (CH); 131.2 (CH); 131.3 (C); 133.8 (C); 139.4 (C); 155.0 (C). Found, %: 40.88; 2.45; N 10.81. C13H9Br2N3O. Calculated, %: C 40.76; H 2.37; N 10.97.

According to the analysis of related databases, 7411-23-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Osyanin; Osipov; Klimochkin, Yu. N.; Chemistry of Heterocyclic Compounds; vol. 47; 12; (2012); p. 1607 – 1609; Khim. Geterotsikl. Soedin.; vol. 47; 12; (2011); p. 1914 – 1916,3;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics