Category: 61-82-5

I found the field of Chemistry very interesting. Saw the article Synthesis, biological evaluation and DFT calculation of novel pyrazole and pyrimidine derivatives published in 2019.0. Application In Synthesis of 1H-1,2,4-Triazol-5-amine, Reprint Addresses Farag, AM (corresponding author), Cairo Univ, Dept Chem, Fac Sci, Giza 12613, Egypt.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

The utility of the enaminonitriles 3a and 3b for the synthesis of the pyrazole derivatives 5a,b, 7a,b, diaminopyrimidine derivatives 9,11, pyrazolo[1,5-alpha]pyrimidines 12,15, triazolo[4,3-alpha]pyrimidines 13,16, imidazo[1,2-alpha]pyrimidine derivatives 14 and 17, was explored. Most of the synthesized compounds showed excellent in vitro antitumor activity against MCF-7 cell line. They also exhibted high antimicrobial and antioxidant activities. Density functional theory (DFT) calculations at the B3LYP/6-31G level of theory have been carried out to investigate the equilibrium geometry of the novel phenylpyrazolo[1,5-alpha]pyrimidin-6-yl)methanone derivative 12 and phenylpyrazolo[1,5-alpha]pyrimidine derivative 15. The structure-activity relationship (SAR) has been used to correlate the biological activity with the appropriate quantum such as total energy. The energy of the HOMO and LUMO and Mulliken atomic charges were also calculated. (C) 2018 Elsevier B.V. All rights reserved.

Application In Synthesis of 1H-1,2,4-Triazol-5-amine. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2021.0 RES CHEM INTERMEDIAT published article about RAPID COLORIMETRIC ASSAY; GREEN SYNTHESIS; PYRAZOLE; DERIVATIVES; INHIBITORS; DISCOVERY; ANTITUMOR; SURVIVAL; DOCKING; DESIGN in [Pogaku, Vinay; Basavoju, Srinivas] Natl Inst Technol, Dept Chem, Warangal 506004, Telangana, India; [Krishnan, R.] Birla Inst Technol & Sci Pilani, Dept Chem, Hyderabad Campus, Hyderabad 500078, India in 2021.0, Cited 37.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Application In Synthesis of 1H-1,2,4-Triazol-5-amine

A series of new benzo[d][1,2,3]triazol-1-yl-pyrazole-based dihydro-[1,2,4]triazolo[4,3-a]pyrimidine derivatives 4a-p were synthesized and well characterized by using IR, H-1,C-13 NMR and mass spectral data. Finally, the structure of the compound 4l was solved unambiguously by single-crystal X-ray diffraction (SXRD) which confirms all the structures 4a-p. The in vitro alpha-glucosidase inhibition, anticancer (A549 and MCF-7 cell lines) and antioxidant studies of the title compounds 4a-pwere screened. Among all the compounds, 4g, 4h and 4n exhibited significant alpha-glucosidase inhibition activity with the IC(50)values 20.12 +/- 0.19 mu M, 21.55 +/- 0.46 mu M and 24.92 +/- 0.98 mu M. Similarly, the compounds 4h, 4d and 4e showed potent anticancer activity against A549 (human lung carcinoma) cell line with IC(50)values 3.64 mu M, 4.73 mu M and 4.56 mu M, respectively, whereas the compounds 4c and 4 o displayed potent anticancer activity against human breast cancer (MCF-7) cell line with IC50 values of 2.66 mu M and 2.11 mu M. In addition, the antioxidant activity revealed that the compounds 4e and 4h exhibited potent antioxidant activity (IC50: 4.25 mu M and 5.40 mu M). To determine the safety profile of the most active compounds4c,4d,4e,4g,4h,4n and 4o were tested against non-cancer HEK293 cell line (human embryonic kidney 293), results in the lower toxicity of these compounds. [GRAPHICS] .

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. Application In Synthesis of 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Zinc oxide nanoparticles attenuate hepatic steatosis development in high-fat-diet fed mice through activated AMPK signaling axis WOS:000467581100017 published article about INSULIN-RESISTANCE; LIPID-METABOLISM; LIVER; SREBP-1C; LIPOGENESIS; PATHOGENESIS; EXPRESSION; METFORMIN; PROMOTER; PATHWAY in [Dogra, Surbhi; Girdhar, Khyati; Daniel, P. Vineeth; Chatterjee, Swarup; Choubey, Abhinav; Ghosh, Subrata; Mondal, Prosenjit] Indian Inst Technol Mandi, Sch Basic Sci, Mandi, Himachal Prades, India; [Kar, Aditya K.; Patnaik, Satyakam; Ghosh, Debabrata] ITTR, CSIR, Lucknow, Uttar Pradesh, India in 2019.0, Cited 29.0. Quality Control of 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Insulin resistance is thought to be a common link between obesity and Non-Alcoholic Fatty Liver Disease (NAFLD). NAFLD has now reached epidemic status worldwide and identification of molecules or pathways as newer therapeutic strategies either to prevent or overcome insulin resistance seems critical. Dysregulated hepatic lipogenesis (DNL) is a hallmark of NAFLD in humans and rodents. Therefore, reducing DNL accretion may be critical in the development of therapeutics of NAFLD. In our in vivo model (high-fat-diet fed [HFD] obese mice) we found Zinc oxide nanoparticles (ZnO NPs) significantly decreased HFD-induced hepatic steatosis and peripheral insulin resistance. This protective mechanism of ZnO NPs was signaled through hepatic SIRT1-LKB1-AMPK which restricted SREBP-lc within the cytosol limiting its transcriptional ability and thereby ameliorating HFD mediated DNL. These observations indicate that ZnO NP can serve as a therapeutic strategy to improve the physiological homeostasis during obesity and its associated metabolic abnormalities. (C) 2019 Elsevier Inc. All rights reserved.

Quality Control of 1H-1,2,4-Triazol-5-amine. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recently I am researching about SATURATED VAPOR-PRESSURE; BENZOTRIAZOLE; INHIBITION; IMPEDANCE; DERIVATIVES; PREDICTION; ADSORPTION; BEHAVIOR; KINETICS; FILMS, Saw an article supported by the Russian Science FoundationRussian Science Foundation (RSF) [17-13-01413]. Published in MAIK NAUKA/INTERPERIODICA/SPRINGER in NEW YORK ,Authors: Goncharova, OA; Luchkin, AY; Andreev, NN; Kuznetsov, YI; Andreeva, NP. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine. Quality Control of 1H-1,2,4-Triazol-5-amine

Using a set of physicochemical (ellipsometry and contact angle measurements), electrochemical (electrochemical impedance spectroscopy and polarization measurements), and corrosion (periodic moisture condensation and salt fog tests) methods, the properties of adsorption films formed on copper by the chamber method from vapors of benzotriazol (BTA), 1H-1,2,4-triazole, tolyltriazole (TTA), 5-chloro-1,2,3-benzotriazole (CBTA), 3-amino-1H-1,2,4-triazole, and 4-amino-1H-1,2,4-triazole at a temperature of 100 degrees C are studied. It is shown that 1-h chamber treatment of copper with vapors of these compounds leads to the formation of nanoscale hydrophobic adsorption films on it, which inhibits the thermal growth of oxides, but stabilizes the passive state of the metal and increases its corrosion resistance. Among these different triazole compounds tested as chamber corrosion inhibitors, BTA and its substituted derivatives are distinguished. After a 1-h chamber treatment of copper, the protective aftereffect of the adsorption films of triazole derivatives grows symbatically with their saturated vapor pressure at the chamber treatment temperature, i.e., in the following increasing order: CBTA < TTA < BTA. This may indicate that the equilibrium adsorption films do not have time to form at 100 degrees C on the metal within this time period. After a prolonged (24 h or more) chamber treatment of copper with vapors of substituted benzotriazoles, equilibrium adsorption films of inhibitors are formed on it. In this case, the influence of the chamber inhibitor properties on their protective aftereffect alternates. Under such conditions, the least volatile and most hydrophobic substituted benzotriazole, i.e., CBTA, provide the best metal protection. Welcome to talk about 61-82-5, If you have any questions, you can contact Goncharova, OA; Luchkin, AY; Andreev, NN; Kuznetsov, YI; Andreeva, NP or send Email.. Quality Control of 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recommanded Product: 61-82-5. I found the field of Chemistry; Physics very interesting. Saw the article Synthesis of novel AgCl loaded g-C3N5 with ultrahigh activity as visible light photocatalyst for pollutants degradation published in 2020.0, Reprint Addresses Vadivel, S (corresponding author), PSG Coll Technol, Dept Chem, Coimbatore 641004, Tamil Nadu, India.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine.

We report the photocatalytic property of a novel AgCl loaded carbon nitride (AgCl/g-C3N5) composite was prepared by a simple precipitation route. The brown colored g-C3N5 was synthesized by a nano-hard templating method using 3-amino-1,2,4-triazole precursor. The morphology, crystallinity and optical properties of the AgCl/g-C3N5 composite were characterized using the X-ray diffraction analysis (XRD), transmission electron microscopy (TEM), and diffuse reflectance spectroscopy (UV-DRS) spectroscopy. The rhodamine B (RhB) removal efficiency was reached 96% within 30 min, which could be attributed to the effective formation of a heterojunction and excellent visible light absorption of AgCl by g-C3N5 incorporation.

Welcome to talk about 61-82-5, If you have any questions, you can contact Vadivel, S; Hariganesh, S; Paul, B; Rajendran, S; Habibi-Yangjeh, A; Maruthamani, D; Kumaravel, M or send Email.. Recommanded Product: 61-82-5

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Authors Sakhno, YI; Murlykina, M; Zbruyev, OI; Kozyryev, AV; Shishkina, S; Sysoiev, D; Musatov, VI; Desenko, SM; Chebanov, VA in BEILSTEIN-INSTITUT published article about HETEROCYCLIZATION REACTIONS; CYCLOCONDENSATION REACTIONS; MULTICOMPONENT REACTION; BIGINELLI REACTION; PYRUVIC ACIDS; AMINOAZOLES; 3-AMINO-1,2,4-TRIAZOLE; TETRAHYDROPYRIMIDINES; 5-AMINOPYRAZOLES; ALDEHYDES in [Sakhno, Yana, I; Murlykina, Maryna; Zbruyev, Oleksandr, I; Kozyryev, Anton, V; Shishkina, Svetlana; Musatov, Vladimir, I; Desenko, Sergey M.; Chebanov, Valentyn A.] Natl Acad Sci Ukraine, Inst Single Crystals, State Sci Inst, Div Chem Funct Mat, Nauky Av 60, UA-61072 Kharkiv, Ukraine; [Murlykina, Maryna; Shishkina, Svetlana; Desenko, Sergey M.; Chebanov, Valentyn A.] Kharkov Natl Univ, Fac Chem, Svobody Sq 4, UA-61077 Kharkiv, Ukraine; [Sysoiev, Dmytro] Czech Acad Sci, Inst Organ Chem & Biochem, Flemingovo Namesti 542-2, Prague 16610 6, Czech Republic in 2020.0, Cited 37.0. Safety of 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Four-component reactions of 3-amino-1,2,4-triazole or 5-amino-1H-pyrazole-4-carbonitrile with aromatic aldehydes and pyruvic acid or its esters under ultrasonication were studied. Unusual for such a reaction type, a cascade of elementary stages led to the formation of 7-azolylaminotetrahydroazolo[1,5-a]pyrimidines.

Welcome to talk about 61-82-5, If you have any questions, you can contact Sakhno, YI; Murlykina, M; Zbruyev, OI; Kozyryev, AV; Shishkina, S; Sysoiev, D; Musatov, VI; Desenko, SM; Chebanov, VA or send Email.. Safety of 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Quality Control of 1H-1,2,4-Triazol-5-amine. In 2020.0 PLANT PHYSIOL BIOCH published article about R2R3-MYB TRANSCRIPTION FACTOR; R2R3-TYPE MYB GENE; STRESS TOLERANCE; EXPRESSION; REGULATOR; SALINITY; PATHWAY; FRUIT; SOS1 in [Yu, Lei; Liu, Wenjun; Guo, Zhangwen; Li, Zhiqiang; Jiang, Huiyan; Zou, Qi; Mao, Zuolin; Zhang, Zongying; Wang, Nan; Chen, Xuesen] Shandong Agr Univ, Coll Hort Sci, State Key Lab Crop Biol, 61 Daizong Rd, Tai An 271018, Shandong, Peoples R China; [Fang, Hongcheng] Shandong Agr Univ, Coll Forestry, State Forestry & Grassland Adm Key Lab Silvicultu, Tai An, Shandong, Peoples R China in 2020.0, Cited 34.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Salt stress is an important environmental factor affecting the growth and production of agricultural crops and fruits worldwide, including apple (Males x domestica). In this study, we demonstrate that a salt-responsive MYB transcription factor (TF), designated as MdMYB63, promotes survival under salt stress. Overexpression of MdMYB63 in apple calli significantly enhanced salt tolerance. Screening of the AP2/ERF family of TFs identified MdERF106 as an interaction partner of MdMYB63. Further analyses showed that the MdMYB63-MdERF106 complex significantly promotes the expression of downstream MdSOS1, thereby improving the Na+ expulsion and salt tolerance of apple. These functional analyses of MdMYB63 have provided valuable insights into the regulatory network of salt tolerance, and lay a theoretical foundation for the cultivation of new salt-tolerant apple varieties.

Quality Control of 1H-1,2,4-Triazol-5-amine. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recommanded Product: 1H-1,2,4-Triazol-5-amine. Nagarkoti, S; Dubey, M; Sadaf, S; Awasthi, D; Chandra, T; Jagavelu, K; Kumar, S; Dikshit, M in [Nagarkoti, Sheela; Dubey, Megha; Sadaf, Samreen; Awasthi, Deepika; Jagavelu, Kumaravelu; Kumar, Sachin] Cent Drug Res Inst, CSIR, Pharmacol Div, Lucknow, Uttar Pradesh, India; [Chandra, Tulika] King Georges Med Univ, Lucknow, Uttar Pradesh, India; [Dikshit, Madhu] Translat Hlth Sci & Technol Inst, NCR Biotech Sci Cluster, THSTI Natl Chair, 3rd Milestone,Faridabad Gurgaon Expressway, Faridabad 121001, Haryana, India published Catalase S-Glutathionylation by NOX2 and Mitochondrial-Derived ROS Adversely Affects Mice and Human Neutrophil Survival in 2019.0, Cited 70.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Neutrophil survival and oxidative stress during inflammatory conditions are linked to tissue damage. The present study explores less understood role of catalase, the enzyme catalysing hydrogen peroxide decomposition, in neutrophil survival/death. Importantly, inhibition of catalase activity following S-glutathionylation in the PMA, NO, or zymosan-activated neutrophils or treatment with catalase inhibitor led to neutrophil death. On the contrary, introducing reducing environment by TCEP rescued catalase activity and significantly improved neutrophil survival. Furthermore, augmentation in ROS generation by NOX-2 activation or induction of mitochondrial ROS by Antimycin-A induced catalase S-glutathionylation and cell death, which was prevented in the neutrophil cytosolic factor1 (NCF-1-/-) cells or was rescued by MitoTEMPO, a mitochondrial ROS scavenger, thus, suggesting a correlation between catalase S-glutathionylation/activity inhibition and reduced neutrophil survival. Altogether, enhanced NOX2 activation/mitochondrial dysfunction led to reduced survival of human and mice neutrophils, due to H2O2 accumulation, S-glutathionylation of catalase, and reduction in its enzymatic activity. The present study thus demonstrated mitigation of catalase activity under oxidative stress-impacted neutrophil survival.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2020.0 J INORG ORGANOMET P published article about STRUCTURAL-CHARACTERIZATION; ANTICANCER; POLYESTERS; DIHALIDES; ABILITY; ABC/3TC in [Roner, Michael R.; Miller, Lindsey] Univ Texas Arlington, Dept Biol, Arlington, TX 76010 USA; [Carraher, Charles E., Jr.; Mosca, Francisca; Slawek, Paul; Haky, Jerome E.; Frank, Jessica] Florida Atlantic Univ, Dept Chem & Biochem, Boca Raton, FL 33431 USA in 2020.0, Cited 30.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Quality Control of 1H-1,2,4-Triazol-5-amine

The ability to inhibit two important viruses is described. Two groups of polymers exhibited ability to totally inhibit the Zika virus. These polymers are derived from organotin dihalides and camphoric acid and lamivudine. This is the initial report of complete inhibition of the Zika virus by simple drugs. The ability to inhibit vaccinia virus is also reported. The inhibition of the vaccinia virus is shown by a number of organotin drugs including those also derived from lamivudine and camphoric acid and additional drugs derived from 3-amino-1,2,4-triazole, dicumarol, 4,6-diaminopyridine, alpha-cyano-4-hydroxcinnamic acid, and a variety of organotin polyethers including water soluble polymers derived from poly(ethylene glycol). All the drugs described in these studies are rapidly (< 30 s) synthesized using commercially available reactants at room temperature employing the interfacial reaction system that is employed industrially so that scale up to kilograms is relatively straight forward. Quality Control of 1H-1,2,4-Triazol-5-amine. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Authors Fares, IMZ; Mekky, AEM; Elwahy, AHM; Abdelhamid, IA in TAYLOR & FRANCIS INC published article about LIGHT-EMITTING-DIODES; CELL-CYCLE ARREST; QUINAZOLINE DERIVATIVES; STEREOSELECTIVE-SYNTHESIS; BIOLOGICAL EVALUATION; ONE-POT; DESIGN; DOCKING; HETEROCYCLES; INHIBITORS in [Fares, Ibrahim M. Z.; Mekky, Ahmed E. M.; Elwahy, Ahmed H. M.; Abdelhamid, Ismail A.] Cairo Univ, Dept Chem, Fac Sci, Giza 12613, Egypt in 2020.0, Cited 61.0. Category: Triazoles. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

A novel series of bis(tetrahydro[1,2,4]triazolo[5,1-b]quinazolin-8-ones) and bis(tetrahydrobenzo[4,5]imidazo[2,1-b]quinazolinones) containing amide linkages were regionselectively prepared via a three-component reaction of bis(aldehydes) with dimedone and 3-amino-1,2,4-triazole (or 2-aminobenzimidazole) under conventional heating as well as under microwave irradiation.

Category: Triazoles. Welcome to talk about 61-82-5, If you have any questions, you can contact Fares, IMZ; Mekky, AEM; Elwahy, AHM; Abdelhamid, IA or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics