Category: 61-82-5

An article Effect of temperature on toxicity and biodegradability of dissolved organic nitrogen formed during hydrothermal liquefaction of biomass WOS:000497885800016 published article about MICROALGAE CULTIVATION; MAILLARD REACTION; AQUEOUS-PHASE; HILL EQUATION; FATTY-ACIDS; ALGAE; WASTE; OIL; INHIBITION; CONVERSION in [Alimoradi, Sirwan; Sturm, Belinda] Univ Kansas, Civil Environm & Architectural Engn Dept, Lawrence, KS 66045 USA; [Stohr, Hannah; Stagg-Williams, Susan] Univ Kansas, Chem & Petr Engn Dept, Lawrence, KS 66045 USA in 2020.0, Cited 42.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Product Details of 61-82-5

This study investigated the nutrient content and reuse potential of wastewater generated during hydrothermal liquefaction of microalgal biomass. The hydrothermal liquefaction reaction was tested at 270, 300, 330, and 345 degrees C to determine the effect of temperature on the formation of non-biodegradable dissolved organic nitrogen (nbDON). Total nitrogen, ammonium, color, and toxicity were selected as key characteristics for the reuse of hydrothermal liquefaction wastewater. Results indicated that a higher concentration of nbDON(5) (nbDON defined with a 5 day growth assay) and more diverse heterocyclic N-containing organic compounds were associated with greater toxicity as measured by a growth rate assay. For the tested temperature ranges, the total nitrogen content of the hydrothermal liquefaction wastewater slightly decreased from 5020 +/- 690 mg L-1 to 4160 +/- 120 mg L-1, but the % nbDON(5) fraction increased from 57 +/- 3 %DON to 96 +/- 5 %DON. The temperature of hydrothermal liquefaction reactions can be optimized to maximize carbon conversion and nitrogen recovery. (C) 2019 Elsevier Ltd. All rights reserved.

Welcome to talk about 61-82-5, If you have any questions, you can contact Alimoradi, S; Stohr, H; Stagg-Williams, S; Sturm, B or send Email.. Product Details of 61-82-5

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Synthesis and molecular docking study of new pyrazole derivatives as potent anti-breast cancer agents targeting VEGFR-2 kinase WOS:000552629800008 published article about GROWTH-FACTOR RECEPTOR-2; BIOLOGICAL EVALUATION; ANTICANCER EVALUATION; INHIBITORS; ANGIOGENESIS; RESISTANCE; MECHANISM; DISCOVERY; DESIGN in [Dawood, Dina H.] Natl Res Ctr, Chem Nat & Microbial Prod Dept, Pharmaceut & Drug Ind Res Div, 33 El Bohouth St,POB 12622, Giza, Egypt; [Nossier, Eman S.] Al Azhar Univ, Fac Pharm Girls, Dept Pharmaceut Chem, POB 11754, Cairo, Egypt; [Ali, Mamdouh M.; Mahmoud, Abeer E.] Natl Res Ctr, Biochem Dept, Genet Engn & Biotechnol Res Div, 33 El Bohouth St,POB 12622, Giza, Egypt in 2020.0, Cited 50.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Name: 1H-1,2,4-Triazol-5-amine

Based on the previous studies that revealed the valuable role of pyrazole scaffold in cancer management and VEGFR-2 inhibition, a new set of pyrazole conjugated with pyrazoline, triazolopyrimidine and pyrazolone moieties were synthesized and investigated for their anticancer efficiency against human breast cancer MCF-7. The anticancer screening revealed the significant sensitivity of breast carcinoma towards compounds 4b, 5c, 6c, 7b, 7c and 12c with IC50 values ranging from 16.50 – 26.73 mu M in comparison with tamoxifen (IC50 = 23.31 mu M). Moreover, the new analogues were further examined for their VEGFR-2 inhibitory activity, among the tested derivatives 5c, 6c, 7b, 7c and 12c displayed prominent inhibitory efficiency versus VEGFR-2 kinase with % inhibition ranging from 70 to 79%. Compounds 6c, 7c and 12c revealed inhibitory efficiency in nanomolar level with IC50 (913.51, 225.17 and 828.23 nM, respectively) comparing to sorafenib (IC50 = 186.54 nM). Flow cytometric analysis revealed that the promising compound 12c prompted pre-G1 apoptosis and cell growth cessation at G2/M phase and stimulated apoptosis via activation of caspase-3. Moreover, molecular docking study of the promising derivatives was performed to highlight their binding modes and interactions with the amino acid residues of VEGFR-2 enzyme.

Name: 1H-1,2,4-Triazol-5-amine. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Shahnavaz, Z; Khaligh, NG; Zaharani, L; Johan, MR; Hamizi, NA in [Shahnavaz, Zohreh; Khaligh, Nader Ghaffari; Zaharani, Lia; Johan, Mohd Rafie; Hamizi, Nor Aliya] Univ Malaya, Nanotechnol & Catalysis Res Ctr, Inst Postgrad Studies, 3rd Floor,Block A, Kuala Lumpur 50603, Malaysia published The structure elucidation of new ionic liquid and its application for the synthesis of a series of novel triazolo[1,5-a]pyrimidine scaffolds in 2020.0, Cited 35.0. Safety of 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

In the present study, the chemical structure of 4,4′-trimethylene-N,N’-dipiperidinium chlorosulfonate is elucidated by 1D NMR, and 2D NMR, FTIR, Raman analyses, and Mass spectra. It was indicated that the chlorosulfonic acid could not act as a sulfonating agent in the reaction with secondary amines like TMDP due to due more steric hindrance of the sulfur atom by chlorine and oxygen atoms. Raman and FTIR spectra are demonstrated as two high-value optical techniques to the elucidation and identification of chemical structures that confirmed C3(v) symmetry for chlorosulfonate anion in the ionic liquid. Then, the solvent-catalyst activity of ionic liquid was demonstrated in the one-pot synthesis of a series of novel triazolo-pyrimidines under mild conditions. The ionic liquid was retrieved and reused several times without reducing its catalytic efficiency. (C) 2020 Elsevier B.V. All rights reserved.

Safety of 1H-1,2,4-Triazol-5-amine. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Authors Qiu, Q; Wu, YM; Ma, LM; Yu, CR in CELL PRESS published article about OLFACTORY-BULB; LABELED LINES; INHIBITION; ORGANIZATION; REPRESENTATIONS; MECHANISMS; RECEPTORS; PATHWAYS; AMYGDALA; NEURONS in [Qiu, Qiang; Wu, Yunming; Ma, Limei; Yu, C. Ron] Stowers Inst Med Res, 1000 East 50th St, Kansas City, MO 64110 USA; [Yu, C. Ron] Univ Kansas, Med Ctr, Dept Anat & Cell Biol, 3901 Rainbow Blvd, Kansas City, KS 66160 USA; [Yu, C. Ron] Twitter YuLab19, Kansas City, KS 66160 USA in 2021.0, Cited 79.0. Name: 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Odors carrying intrinsic values often trigger instinctive aversive or attractive responses. It is not known how innate valence is encoded. An intuitive model suggests that the information is conveyed through specific channels in hardwired circuits along the olfactory pathway, insulated from influences of other odors, to trigger innate responses. Here, we show that in mice, mixing innately aversive or attractive odors with a neutral odor and, surprisingly, mixing two odors with the same valence, abolish the innate behavioral responses. Recordings from the olfactory bulb indicate that odors are not masked at the level of peripheral activation and glomeruli independently encode components in the mixture. In contrast, crosstalk among the mitral and tufted (M/T) cells changes their patterns of activity such that those elicited by the mixtures can no longer be linearly decoded as separate components. The changes in behavioral and M/T cell responses are associated with reduced activation of brain areas linked to odor preferences. Thus, crosstalk among odor channels at the earliest processing stage in the olfactory pathway leads to re-coding of odor identity to abolish valence associated with the odors. These results are inconsistent with insulated labeled lines and support a model of a common mechanism of odor recognition for both innate and learned valence associations.

Welcome to talk about 61-82-5, If you have any questions, you can contact Qiu, Q; Wu, YM; Ma, LM; Yu, CR or send Email.. Name: 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Effects of sacrificial coordination bonds on the mechanical performance of lignin-based thermoplastic elastomer composites WOS:000675777300005 published article about SOFTWOOD KRAFT LIGNIN; POLYPROPYLENE; POLYETHYLENE; TOUGHNESS; BLENDS in [Huang, Jinhao; Liu, Weifeng; Tu, Zhikai; Li, Jinxing; Lou, Hongming] South China Univ Technol, Guangdong Engn Res Ctr Green Fine Chem, Sch Chem & Chem Engn, Wushan Rd 381, Guangzhou 510640, Guangdong, Peoples R China; [Qiu, Xueqing] Guangdong Univ Technol, Guangzhou Higher Educ Mega Ctr, Sch Chem Engn & Light Ind, Waihuan Xi Rd 100, Guangzhou 510006, Peoples R China in 2021.0, Cited 31.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. COA of Formula: C2H4N4

In this work, the coordination-based energy sacrificial bonds have been constructed in the interphase between lignin and polyolefin elastomer to prepare high performance lignin-based thermoplastic elastomers (TPEs). The strength and toughness of lignin-based TPEs can be adjusted by choosing different nitrogen heterocyclic compounds as reactive assistants and Fe3+ or Zr2+ as metal coordination centers. It was demonstrated that 3-Amino-1,2,4-triazole with three nitrogen atoms in the heterocydic ring and one nitrogen branch chain could form the most efficient coordination bond system and generate the best mechanical performance. The system with ferric iron as coordination center exhibited better enhancement effect than divalent zinc. By adjusting the nitrogen-containing reactive additives or metal salts as coordination centers, the mechanical performance of the lignin-based TPE can be regulated, which provides a method for making green bio-composites with good strength and toughness, and also promotes the high value utilization of lignin in polymer materials. (C) 2021 Elsevier B.V. All rights reserved.

Welcome to talk about 61-82-5, If you have any questions, you can contact Huang, JH; Liu, WF; Qiu, XQ; Tu, ZK; Li, JX; Lou, HM or send Email.. COA of Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recommanded Product: 1H-1,2,4-Triazol-5-amine. In 2020.0 MOLECULES published article about HETEROCYCLES; DERIVATIVES; DESIGN in [El Azab, Islam H.] Taif Univ, Fac Sci, Chem Dept, POB 888, At Taif 2974, Saudi Arabia; [Elkanzi, Nadia A. A.] Jouf Univ, Coll Sci, Chem Dept, POB 2014, Sakaka, Saudi Arabia in 2020.0, Cited 31.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

In search of unprecedented tri and/or tetrapod pharmacophoric conjugates, a series of 32 new 4-ethyl-1H-benzo[b][1,4]diazepin-2(3H)-ones were synthesized and properly elucidated using MS, IR, NMR, and elemental analysis. In vitro investigation of 11 compounds of this series, using a panel of two human tumor cell lines namely; human breast adenocarcinoma (MCF-7), and human colorectal carcinoma (HCT-116), revealed promising cytotoxic activities. Among all synthesized compounds, analogue 9 displayed maximum cytotoxicity with IC50 values of 16.19 +/- 1.35 and 17.16 +/- 1.54 mu M against HCT-116 and MCF-7, respectively, compared to standard drug doxorubicin.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 1H-1,2,4-Triazol-5-amine

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Discovery of new [1,2,4] Triazolo[1,5-a]Pyrimidine derivatives that Kill gastric cancer cells via the mitochondria pathway WOS:000568867400039 published article about BIOLOGICAL EVALUATION; AUTOPHAGY; APOPTOSIS; ROS; DESIGN in [Wang, Shuai; Ma, Xu-Bin; Yuan, Xiao-Han; Yu, Bin; Xu, Yi-Chao; Liu, Hong-Min] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China; [Wang, Shuai; Ma, Xu-Bin; Yuan, Xiao-Han; Yu, Bin; Xu, Yi-Chao; Liu, Hong-Min] Zhengzhou Univ, Key Lab Adv Drug Preparat Technol, Mil Educ, Zhengzhou 450001, Peoples R China; [Wang, Shuai] Massachusetts Gen Hosp, Gordon Ctr Med Imaging, Boston, MA 02129 USA; [Wang, Shuai] Harvard Med Sch, Boston, MA 02129 USA in 2020.0, Cited 33.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Product Details of 61-82-5

Mitochondria are known as powerhouse of cells and play the role of a bridge in redox balance, cell apoptosis, and autophagy. ROS accumulation can cause mitochondria damage, while the injured mitochondria will further enhance ROS levels reciprocally. Herein, we synthesized a novel series of [1,2,4] triazolo[1,5-a]pyrimidine-based compounds 4a-4v and tested their anti-proliferation efficacy against gastric cancer cell line MGC-803. Among them, compounds 4o and 4p inhibited gastric cancer cells at micromolar level. Compound 4o caused G2/M arrest and induced mitochondria-dependent apoptosis in MGC-803 and SGC-7901. However, inhibiting apoptosis pathway cannot prevent the inhibitory activity of compound 4o against gastric cancer cell. To our surprising, ROS level was increased by compound 4o and elevation of ROS could be rescued by NAC. In accordance with that, NAC absolutely prevented the anti-proliferation efficacy of compound 4o. We further found that autophagy inhibitor CQ rather than 3-MA partially reversed inhibitory activity of compound 4o in MGC-803 cells. Taken together, compound 4o exhibited its anti-proliferative activity via increasing ROS level and inducing autophagy, thus leading to apoptosis of gastric cancer cells. Therefore, compound 4o may support further development of lead compounds for gastric cancer therapy via mitochondria pathway. (C) 2020 Elsevier Masson SAS. All rights reserved.

Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.. Product Details of 61-82-5

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Formula: C2H4N4. Recently I am researching about RENEWABLE THERMOPLASTICS; TOUGHENING ELASTOMERS; MECHANICAL-PROPERTIES; HYDROXYPROPYL LIGNIN; MULTIPHASE MATERIALS; NETWORK; COPOLYMERS; BEHAVIOR; FILLERS; BLENDS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21706082]; Science and Technology Program of Guangzhou [201707020025, 201804010140]; Guangdong Province Science FoundationNational Natural Science Foundation of Guangdong Province [2017B090903003]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2017M622693]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Huang, JH; Liu, WF; Qiu, XQ. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

For the first time, the coordination-based energy sacrificial bonds have been constructed in the interface between lignin and polyolefin elastomer for preparing a new class of high performance thermoplastic elastomers (TPEs) with biomass lignin as the hard plastic phase. The coordination bonds not only promoted the dispersion of lignin, but also improved the interfacial interactions between lignin and polyolefin elastomer matrix, and also facilitated the orientation of chain segments during stretching. The synergistic coordination effect of lignin promoted higher energy dissipation, leading to simultaneously enhanced strength and toughness of lignin-based TPEs even with the lignin loading as high as 30 wt %. The lignin-based TPEs also exhibited excellent shape memory performance. Our strategy offers a promising methodology for the facile production of high performance but cost-effective TPE materials using biorenewable resources as plastic phase.

Formula: C2H4N4. Welcome to talk about 61-82-5, If you have any questions, you can contact Huang, JH; Liu, WF; Qiu, XQ or send Email.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recommanded Product: 61-82-5. Halawa, AH; Eskandrani, AA; Elgammal, WE; Hassan, SM; Hassan, AH; Ebrahim, HY; Mehany, ABM; El-Agrody, AM; Okasha, RM in [Halawa, Ahmed H.; Elgammal, Walid E.; Hassan, Saber M.; Hassan, Ahmed H.; El-Agrody, Ahmed M.] Al Azhar Univ, Fac Sci, Chem Dept, Cairo 11284, Egypt; [Eskandrani, Areej A.; Okasha, Rawda M.] Taibah Univ, Fac Sci, Chem Dept, Medina 30002, Saudi Arabia; [Hassan, Ahmed H.] Jazan Univ, Fac Sci, Chem Dept, Jazan 45142, Saudi Arabia; [Ebrahim, Hassan Y.] Helwan Univ, Fac Pharm, Pharmacognosy Dept, Cairo 11795, Egypt; [Mehany, Ahmed B. M.] Al Azhar Univ, Fac Sci, Zool Dept, Cairo 11284, Egypt published Rational Design and Synthesis of Diverse Pyrimidine Molecules Bearing Sulfonamide Moiety as Novel ERK Inhibitors in 2019.0, Cited 65.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Protein kinases orchestrate diverse cellular functions; however, their dysregulation is linked to metabolic dysfunctions, associated with many diseases, including cancer. Mitogen-Activated Protein (MAP) kinase is a notoriously oncogenic signaling pathway in human malignancies, where the extracellular signal-regulated kinases (ERK1/2) are focal serine/threonine kinases in the MAP kinase module with numerous cytosolic and nuclear mitogenic effector proteins. Subsequently, hampering the ERK kinase activity by small molecule inhibitors is a robust strategy to control the malignancies with aberrant MAP kinase signaling cascades. Consequently, new heterocyclic compounds, containing a sulfonamide moiety, were rationally designed, aided by the molecular docking of the starting reactant 1-(4-((4-methylpiperidin-1-yl)sulfonyl)phenyl)ethan-1-one (3) at the ATP binding pocket of the ERK kinase domain, which was relying on the molecular extension tactic. The identities of the synthesized compounds (4-33) were proven by their spectral data and elemental analysis. The target compounds exhibited pronounced anti-proliferative activities against the MCF-7, HepG-2, and HCT-116 cancerous cell lines with potencies reaching a 2.96 mu M for the most active compound (22). Moreover, compounds 5, 9, 10b, 22, and 28 displayed a significant G2/M phase arrest and induction of the apoptosis, which was confirmed by the cell cycle analysis and the flow cytometry. Thus, the molecular extension of a small fragment bounded at the ERK kinase domain is a valid tactic for the rational synthesis of the ERK inhibitors to control various human malignancies.

Recommanded Product: 61-82-5. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Authors Chhetri, S; Adak, NC; Samanta, P; Murmu, NC; Srivastava, SK; Kuila, T in ELSEVIER SCI LTD published article about REDUCED GRAPHENE; NANOCOMPOSITE; NANOPARTICLES; OXIDE in [Chhetri, Suman; Adak, Nitai Chandra; Samanta, Pranab; Murmu, Naresh Chandra; Kuila, Tapas] Council Sci & Ind Res Cent Mech Engn Res Inst, Surface Engn & Tribol Div, Durgapur 713209, India; [Chhetri, Suman; Adak, Nitai Chandra; Samanta, Pranab; Murmu, Naresh Chandra; Kuila, Tapas] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India; [Srivastava, Suneel Kumar] Indian Inst Technol Kharagpur, Dept Chem, Kharagpur 721302, W Bengal, India in 2019.0, Cited 42.0. Product Details of 61-82-5. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Herein, Fe3O4 nano-particles are anchored over nitrogen doped reduced graphene oxide Fe3O4@N-rGO) structure to accommodate electric and magnetic components, so that it could match both the conduction and polarization loss to augment the attenuation of electromagnetic radiation. The formation of condensed heteroaromatic structure and decoration of Fe3O4 particles on r-GO structure are confirmed by photoelectron spectroscopy (XPS). high-resolution transmission electron microscopy (HRTEM), X-ray diffraction (XRD). The Fe3O4@N-rGO hybrid is subsequently dispersed in epoxy matrix, which result in significantly higher electrical conductivity (1.31 s/m) and electromagnetic interference (EMI) shielding efficiency (- 26 dB at 1 mm thickness). It was assumed that presence of electric-magnetic integrated Fe3O4@N-rGO hybrid in epoxy matrix significantly improved the interfacial polarization and anisotropy energy, which was reflected in absorption loss value of -27 dB. The composites also exhibited enhanced mechanical and thermo-mechanical properties coupled with improved thermal stability.

Welcome to talk about 61-82-5, If you have any questions, you can contact Chhetri, S; Adak, NC; Samanta, P; Murmu, NC; Srivastava, SK; Kuila, T or send Email.. Product Details of 61-82-5

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics