61-82-5 -| Page 132 of 154

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About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Mohamed, HS; Abdel-Latif, MK; Ahmed, SA or concate me.. HPLC of Formula: C2H4N4

HPLC of Formula: C2H4N4. Recently I am researching about DENSITY-FUNCTIONAL THERMOCHEMISTRY; BEARING BRIDGEHEAD NITROGEN; SPECTROSCOPIC CHARACTERIZATION; SMALL-MOLECULE; POTENT; OPTIMIZATION; INHIBITORS; AMETOCTRADIN; POLYMERASE; AGENTS, Saw an article supported by the . Published in MAIK NAUKA/INTERPERIODICA/SPRINGER in NEW YORK ,Authors: Mohamed, HS; Abdel-Latif, MK; Ahmed, SA. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Treatment of 3-methylcyclohexanone with ethyl formate in the presence of sodium methoxide afforded sodium (2-methyl-6-oxocyclohexylidene)methanolate which reacted with aminopyrazoles, aminotriazole, and aminotetrazole to produce fused quinazoline derivatives; its reactions with cyanothioacetamide, cyanoacetamide, and cyanoacetohydrazide gave tetrahydroquinoline-3-carbonitrile derivatives. The reactions of 8-methyl-2-sulfanyl-5,6,7,8-tetrahydroquinoline-3-carbonitrile with alkylating agents led to the formation of thieno[2,3-b]quinoline derivatives. DFT computational studies of the synthesized compounds were carried out using B3LYP/6-311+G** and HF/6-311+G** approximations. The calculated HOMO and LUMO energies showed that charge transfer occurs in their molecules.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Mohamed, HS; Abdel-Latif, MK; Ahmed, SA or concate me.. HPLC of Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An overview of features, applications of compound:61-82-5

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Dawood, DH; Nossier, ES; Ali, MM; Mahmoud, AE or concate me.. Recommanded Product: 1H-1,2,4-Triazol-5-amine

An article Synthesis and molecular docking study of new pyrazole derivatives as potent anti-breast cancer agents targeting VEGFR-2 kinase WOS:000552629800008 published article about GROWTH-FACTOR RECEPTOR-2; BIOLOGICAL EVALUATION; ANTICANCER EVALUATION; INHIBITORS; ANGIOGENESIS; RESISTANCE; MECHANISM; DISCOVERY; DESIGN in [Dawood, Dina H.] Natl Res Ctr, Chem Nat & Microbial Prod Dept, Pharmaceut & Drug Ind Res Div, 33 El Bohouth St,POB 12622, Giza, Egypt; [Nossier, Eman S.] Al Azhar Univ, Fac Pharm Girls, Dept Pharmaceut Chem, POB 11754, Cairo, Egypt; [Ali, Mamdouh M.; Mahmoud, Abeer E.] Natl Res Ctr, Biochem Dept, Genet Engn & Biotechnol Res Div, 33 El Bohouth St,POB 12622, Giza, Egypt in 2020.0, Cited 50.0. Recommanded Product: 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Based on the previous studies that revealed the valuable role of pyrazole scaffold in cancer management and VEGFR-2 inhibition, a new set of pyrazole conjugated with pyrazoline, triazolopyrimidine and pyrazolone moieties were synthesized and investigated for their anticancer efficiency against human breast cancer MCF-7. The anticancer screening revealed the significant sensitivity of breast carcinoma towards compounds 4b, 5c, 6c, 7b, 7c and 12c with IC50 values ranging from 16.50 – 26.73 mu M in comparison with tamoxifen (IC50 = 23.31 mu M). Moreover, the new analogues were further examined for their VEGFR-2 inhibitory activity, among the tested derivatives 5c, 6c, 7b, 7c and 12c displayed prominent inhibitory efficiency versus VEGFR-2 kinase with % inhibition ranging from 70 to 79%. Compounds 6c, 7c and 12c revealed inhibitory efficiency in nanomolar level with IC50 (913.51, 225.17 and 828.23 nM, respectively) comparing to sorafenib (IC50 = 186.54 nM). Flow cytometric analysis revealed that the promising compound 12c prompted pre-G1 apoptosis and cell growth cessation at G2/M phase and stimulated apoptosis via activation of caspase-3. Moreover, molecular docking study of the promising derivatives was performed to highlight their binding modes and interactions with the amino acid residues of VEGFR-2 enzyme.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Dawood, DH; Nossier, ES; Ali, MM; Mahmoud, AE or concate me.. Recommanded Product: 1H-1,2,4-Triazol-5-amine

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About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Zaharani, L; Khaligh, NG; Mihankhah, T; Shahnavaz, Z; Johan, MR or concate me.. Application In Synthesis of 1H-1,2,4-Triazol-5-amine

Authors Zaharani, L; Khaligh, NG; Mihankhah, T; Shahnavaz, Z; Johan, MR in TAYLOR & FRANCIS INC published article about AGENTS in [Zaharani, Lia; Khaligh, Nader Ghaffari; Shahnavaz, Zohreh; Johan, Mohd Rafie] Univ Malaya, Inst Postgrad Studies, Nanotechnol & Catalysis Res Ctr, 3rd Floor,Block A, Kuala Lumpur 50603, Malaysia; [Mihankhah, Taraneh] Iran Univ Sci & Technol, Sch Civil Engn, Dept Water & Environm Engn, Environm Res Lab, Tehran, Iran in 2020.0, Cited 18.0. Application In Synthesis of 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

The viscosity of neat ionic liquids is very important for their application in organic synthesis as a solvent because most of the neat ionic liquids are very viscous, which would result in the less efficient mass transfer of reactants. In the present study, a series of novel dihydro-[1,2,4]triazolo[1,5-a]pyrimidines were prepared using a low viscous and acid-functionalized ionic liquid. Our results showed that new ionic liquid can act as a green solvent and acid catalyst due to low viscosity and acid functionality. The products were simply extracted and the ionic liquid was retrieved several times without reducing its catalytic efficiency. The current application of TMDPS in the one-pot multicomponent reactions as dual solvent-catalyst highlights the importance of low viscous acid-functionalized ionic liquids in organic synthesis, and we hope that further research will be conducted in the future to finding other applications of TMDPS with promising results.

Extended knowledge of 1H-1,2,4-Triazol-5-amine

COA of Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Malode, SJ; Prabhu, KK; Shetti, NP or concate me.

COA of Formula: C2H4N4. In 2020.0 NEW J CHEM published article about WALLED CARBON NANOTUBE; ELECTROCHEMICAL DNA BIOSENSOR; FLUFENAMIC ACID; PASTE ELECTRODE; WATER SAMPLES; AMITROLE; NANOPARTICLES; OXIDATION; PHTHALOCYANINE; DIURON in [Malode, Shweta J.; Prabhu, K. Keerthi; Shetti, Nagaraj P.] KLE Inst Technol, Ctr Electrochem Sci & Mat, Dept Engn Chem, Hubballi 580027, Karnataka, India in 2020.0, Cited 41.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Aminotriazole (AT), an organic heterocyclic compound, is an unselective herbicide used to deal with a large assortment of weeds by preventing the biosynthesis of carotenoids. It is a malignant agent to human beings as well as to animals. This study is focused on the nanomolar detection of AT with multiwalled carbon nanotubes along with calcium-doped zinc oxide nanoparticles adapted for a nano-composite dependent glassy carbon electrode (MWCNTs/Ca-ZnO/GCE). The developed MWCNTs/Ca-ZnO/GCE showed an excellent electrocatalytic response to AT in 3.0 pH of 0.2 M phosphate buffer solution (PBS). There was an increase in the peak current of AT, i.e., 7.726 mu A, with MWCNTs/Ca-ZnO/GCE when it was compared with the peak current of AT at the bare glassy carbon electrode (GCE), 3.478 mu A, due to the semiconducting properties of the doped nanoparticles. Various techniques were employed to study the different parameters such as scan rate, pH variations, and concentration variations by cyclic voltammetry (CV), square wave voltammetry (SWV), and linear sweep voltammetry (LSV) in order to probe the mechanism, number of participating electrons, type of process, detection limit, and quantification limit. The Ca-ZnO nanoparticles (NPs) were synthesized at the proportion of 5.0% and these were characterized by energy dispersive X-ray analysis (EDX), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffraction (XRD). The developed sensor was applied for real sample analysis like soil and water by quantifying the AT in the samples and the output was found to be precise with good recovery results.

COA of Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Malode, SJ; Prabhu, KK; Shetti, NP or concate me.

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Product Details of 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Pisa, R; Cupido, T; Steinman, JB; Jones, NH; Kapoor, TM or concate me.

Product Details of 61-82-5. Pisa, R; Cupido, T; Steinman, JB; Jones, NH; Kapoor, TM in [Pisa, Rudolf; Cupido, Tommaso; Steinman, Jonathan B.; Jones, Natalie H.; Kapoor, Tarun M.] Rockefeller Univ, Lab Chem & Cell Biol, New York, NY 10065 USA; [Pisa, Rudolf; Jones, Natalie H.] Rockefeller Univ, Triinst PhD Program Chem Biol, New York, NY 10065 USA; [Steinman, Jonathan B.] Weill Cornell Rockefeller Sloan Kettering Triinst, New York, NY 10065 USA published Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins in 2019.0, Cited 45.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Drug-like inhibitors are often designed by mimicking cofactor or substrate interactions with enzymes. However, as active sites are comprised of conserved residues, it is difficult to identify the critical interactions needed to design selective inhibitors. We are developing an approach, named RADD (resistance analysis during design), which involves engineering point mutations in the target to generate active alleles and testing compounds against them. Mutations that alter compound potency identify residues that make key interactions with the inhibitor and predict target-binding poses. Here, we apply this approach to analyze how diaminotriazole-based inhibitors bind spastin, a microtubule-severing AAA (ATPase associated with diverse cellular activities) protein. The distinct binding poses predicted for two similar inhibitors were confirmed by a series of X-ray structures. Importantly, our approach not only reveals how selective inhibition of the target can be achieved but also identifies resistance-conferring mutations at the early stages of the design process.

Product Details of 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Pisa, R; Cupido, T; Steinman, JB; Jones, NH; Kapoor, TM or concate me.

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Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Shaikh, M; Siddiqui, S; Zafar, H; Naqeeb, U; Subzwari, F; Imad, R; Khan, KM; Choudhary, MI or concate me.

An article Antiglycation Activity of Triazole Schiff’s Bases Against Fructose-mediated Glycation: In Vitro and In Silico Study WOS:000536018300011 published article about END-PRODUCTS; NONENZYMATIC GLYCATION; MAILLARD REACTION; ACCURATE DOCKING; LENS PROTEINS; INHIBITORS; DERIVATIVES; GLIDE; FRUCTOSYLATION; AMINOGUANIDINE in [Shaikh, Muniza; Zafar, Humaira; Subzwari, Fakiha; Imad, Rehan; Choudhary, Muhammad I.] Univ Karachi, Dr Panjwani Ctr Mol Med & Drug Res, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan; [Siddiqui, Salman; Naqeeb, Uzma; Khan, Khalid M.; Choudhary, Muhammad I.] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan; [Khan, Khalid M.] Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat IRMC, Dept Clin Pharm, POB 31441, Dammam, Saudi Arabia; [Choudhary, Muhammad I.] King Abdulaziz Univ, Dept Biochem, Fac Sci, Jeddah 21412, Saudi Arabia in 2020.0, Cited 59.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Formula: C2H4N4

Background: Advanced glycation end products (AGEs) are known to be involved in the pathophysiology of diabetic complications, neurodegenerative diseases, and aging. Preventing the formation of AGEs can be helpful in the management of these diseases. Objectives: Two classes of previously synthesized traizole Schiff’s bases (4H-1,2,4-triamle-4-Schiff’s bases 1-14, and 4H-1,2,4-triazole-3-Schiff’s bases 15-23) were evaluated for their in vitro antiglycation activity. Methods: In vitro fructose-mediated human serum albumin (HSA) glycation assay was employed to assess the antiglycation activity of triazole Schiff’s bases. The active compounds were subjected to cytotoxicity analysis by MTT assay on mouse fibroblast (3T3) cell line. Molecular docking and simulation studies were carried out to evaluate the interactions and stability of compounds with HSA. Anti-hyperglycemic and antioxidant activities of selected non-cytotoxic compounds were evaluated by in vitro a-glucosidase inhibition, and DPPH free radical scavenging assays, respectively. Results: Compound 1 (IC50 =47.30 +/- 0.38 mu M) from 4H-1,2,4-triazole-4-Schiff’s bases has exhibited antiglycation activity comparable to standard rutin (IC50 =54.5 +/- 0.05 mu M) along with a stable RMSD profile in MD simulation studies. Compound 1 also exhibited a potent a-glucosidase inhibitory activity, and moderate antioxidant property. Other derivatives showed a weak antiglycation activity with IC50 values between 248.1-637.7 mu M. Compounds with potential antiglycation profile were found to be non-cytotoxic in a cellular assay. Conclusion: The study identifies triazole Schiff s bases active against fructose-mediated glycation of HSA, thus indicates their potential against late diabetic complications due to production of advancedend products (AGEs).

Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Shaikh, M; Siddiqui, S; Zafar, H; Naqeeb, U; Subzwari, F; Imad, R; Khan, KM; Choudhary, MI or concate me.

Let`s talk about compound :1H-1,2,4-Triazol-5-amine

HPLC of Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Wu, CB; Yu, GH; Yin, Y; Wang, YZ; Chen, L; Han, Q; Tang, JW; Wang, B or concate me.

An article Mesoporous Polymeric Cyanamide-Triazole-Heptazine Photocatalysts for Highly-Efficient Water Splitting WOS:000558656000001 published article about GRAPHITIC CARBON NITRIDE; HYDROGEN EVOLUTION; FACILE SYNTHESIS; SEMICONDUCTORS; REDUCTION; NITROGEN; PERFORMANCE; PRECURSORS; NANOSHEETS; STRATEGY in [Wu, Chongbei; Yu, Guanhang; Yin, Yue; Wang, Yuze; Chen, Li; Han, Qing; Wang, Bo] Beijing Inst Technol, Key Lab Cluster Sci, Key Lab Photoelect Electrophoton Convers Mat, Minist Educ China,Sch Chem & Chem Engn, Beijing 100081, Peoples R China; [Tang, Junwang] UCL, Dept Chem Engn, London WC1E 7JE, England in 2020.0, Cited 65.0. HPLC of Formula: C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Conjugated polymers are promising light harvesters for water reduction/oxidation due to their simple synthesis and adjustable bandgap. Herein, both cyanamide and triazole functional groups are first incorporated into a heptazine-based carbon nitride (CN) polymer, resulting in a mesoporous conjugated cyanamide-triazole-heptazine polymer (CTHP) with different compositions by increasing the quantity of cyanamide/triazole units in the CN backbone. Varying the compositions of CTHP modulates its electronic structures, mesoporous morphologies, and redox energies, resulting in a significantly improved photocatalytic performance for both H(2)and O(2)evolution under visible light irradiation. A remarkable H(2)evolution rate of 12723 mu mol h(-1)g(-1)is observed, resulting in a high apparent quantum yield of 11.97% at 400 nm. In parallel, the optimized photocatalyst also exhibits an O(2)evolution rate of 221 mu mol h(-1) g(-1), 9.6 times higher than the CN counterpart, with the value being the highest among the reported CN-based bifunctional photocatalysts. This work provides an efficient molecular engineering approach for the rational design of functional polymeric photocatalysts.

HPLC of Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Wu, CB; Yu, GH; Yin, Y; Wang, YZ; Chen, L; Han, Q; Tang, JW; Wang, B or concate me.

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Quality Control of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Seyf, JY; Asgari, M or concate me.

In 2020.0 FLUID PHASE EQUILIBR published article about GREEN; MIXTURES; PARACETAMOL; IBUPROFEN in [Seyf, Jaber Yousefi] Hamedan Univ Technol, Dept Chem Engn, Hamadan, Hamadan, Iran; [Asgari, Mohammad] Sharif Univ Technol, Dept Chem Engn, Hamadan, Hamadan, Iran in 2020.0, Cited 26.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Quality Control of 1H-1,2,4-Triazol-5-amine

The recently reported UNIversal QUAsiChemical Segment Activity coefficient (UNIQUAC-SAC) model [developed by Haghtalab and Yousefi Seyf Ind. Eng. Chem. Res. 2015, 54, 8611] provides a practical thermodynamic framework to be used in VLE, LLE, and SLE calculations. The UNIQUAC-SAC model has the advantage of being independent of area (q) and volume (r) structural parameters used in the combinatorial part. While the UNIFAC or UNIFAC-DMD could not apply to the 47% (44 of 94) of the studied molecules because of the undefined groups. Here, the numbers of solvents with identified segment numbers were extended from 82 to 130 with a slight refinement to the previous values. The model parameters obtained via a large consistent set of VLE (isobaric and isothermal), and LLE experimental data. Also, the model was tested with pharmaceutical solubility experimental data in pure (94 solutes with 6210 solubility data), binary, and ternary solvents. The model provides a robust correlation of pharmaceuticals solubility in a mono-solvent and robust prediction of pharmaceuticals solubility in mixed solvents. The UNIQUAC-SAC model was successfully evaluated in solvent screening in cooling crystallization of ibuprofen and valsartan in both pure and binary solvents mixture (combined cooling and anti-solvent crystallization). The model with 130 solvents as a robust database provides a useful and practical thermodynamic tool in the conceptual design of pharmaceutical processes. A MATLAB based graphical user interface (GUI), finally, was developed to be used in the conceptual segment numbers regression procedure. (C) 2020 Elsevier B.V. All rights reserved.

Quality Control of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Seyf, JY; Asgari, M or concate me.

New learning discoveries about 61-82-5

Recommanded Product: 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Tang, XF; Wang, D; Liu, Y; Lu, MZ; Zhuang, YM; Xie, Z; Wang, CP; Wang, SM; Kong, YZ; Chai, GH; Zhou, GK or concate me.

I found the field of Plant Sciences very interesting. Saw the article Dual regulation of xylem formation by an auxin-mediated PaC3H17-PaMYB199 module in Populus published in 2020.0. Recommanded Product: 61-82-5, Reprint Addresses Chai, GH; Zhou, GK (corresponding author), Chinese Acad Sci, Qingdao Inst BioEnergy & Bioproc Technol, Key Lab Biofuels, Qingdao 266101, Peoples R China.; Chai, GH (corresponding author), Qingdao Agr Univ, Coll Resources & Environm, Qingdao 266109, Peoples R China.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Wood (secondary xylem) formation in tree species is dependent on auxin-mediated vascular cambium activity in stems. However, the complex regulatory networks underlying xylem formation remain elusive. Xylem development in Populus was characterized based on microscopic observations of stem sections in transgenic plants. Transcriptomic, quantitative real-time PCR, chromatin immunoprecipitation PCR, and electrophoretic mobility shift assay analyses were conducted to identify target genes involved in xylem development. Yeast two-hybrid, pull-down, bimolecular fluorescence complementation, and co-immunoprecipitation assays were used to validate protein-protein interactions. PaC3H17 and its target PaMYB199 were found to be predominantly expressed in the vascular cambium and developing secondary xylem in Populus stems and play opposite roles in controlling cambial cell proliferation and secondary cell wall thickening through an overlapping pathway. Further, PaC3H17 interacts with PaMYB199 to form a complex, attenuating PaMYB199-driven suppression of its xylem targets. Exogenous auxin application enhances the dual control of the PaC3H17-PaMYB199 module during cambium division, thereby promoting secondary cell wall deposition. Dual regulation of xylem formation by an auxin-mediated PaC3H17-PaMYB199 module represents a novel regulatory mechanism in Populus, increasing our understanding of the regulatory networks involved in wood formation.

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Name: 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Tang, XF; Wang, D; Liu, Y; Lu, MZ; Zhuang, YM; Xie, Z; Wang, CP; Wang, SM; Kong, YZ; Chai, GH; Zhou, GK or concate me.

Name: 1H-1,2,4-Triazol-5-amine. I found the field of Plant Sciences very interesting. Saw the article Dual regulation of xylem formation by an auxin-mediated PaC3H17-PaMYB199 module in Populus published in 2020.0, Reprint Addresses Chai, GH; Zhou, GK (corresponding author), Chinese Acad Sci, Qingdao Inst BioEnergy & Bioproc Technol, Key Lab Biofuels, Qingdao 266101, Peoples R China.; Chai, GH (corresponding author), Qingdao Agr Univ, Coll Resources & Environm, Qingdao 266109, Peoples R China.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine.