Category: 61-82-5

An article A cross-platform approach to characterize and screen potential neurovascular unit toxicants WOS:000582635800033 published article about BLOOD-BRAIN-BARRIER; IN-VITRO; CELL-MIGRATION; VASCULAR DEVELOPMENT; MODEL; THALIDOMIDE; DISRUPTION; CHEMICALS; NETWORK; CYTOTOXICITY in [Zurlinden, Todd J.; Saili, Katerine S.; Knudsen, Thomas B.] US EPA, Off Res & Dev, Ctr Computat Toxicol & Exposure, Res Triangle Pk, NC USA; [Baker, Nancy C.] Leidos, Alexandria, VA USA; [Toimela, Tarja; Heinonen, Tuula] Tampere Univ, Fac Med & Hlth Technol, FICAM, Tampere, Finland in 2020.0, Cited 79.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. SDS of cas: 61-82-5

Development of the neurovascular unit (NVU) is a complex, multistage process that requires orchestrated cell signaling mechanisms across several cell types and ultimately results in formation of the blood-brain barrier. Typical high-throughput screening (HTS) assays investigate single biochemical or single cell responses following chemical insult. As the NVU comprises multiple cell types interacting at various stages of development, a methodology combining high-throughput results across pertinent cell-based assays is needed to investigate potential chemical-induced disruption to the development of this complex cell system. To this end, we implemented a novel method for screening putative NVU disruptors across diverse assay platforms to predict chemical perturbation of the developing NVU. HTS assay results measuring chemical-induced perturbations to cellular key events across angiogenic and neurogenic outcomes in vitro were combined to create a cell-based prioritization of NVU hazard. Chemicals were grouped according to similar modes of action to train a logistic regression literature model on a training set of 38 chemicals. This model utilizes the chemical-specific pairwise mutual information score for PubMed MeSH annotations to represent a quantitative measure of previously published results. Taken together, this study presents a methodology to investigate NVU developmental hazard using cell-based HTS assays and literature evidence to prioritize screening of putative NVU disruptors towards a knowledge-driven characterization of neurovascular developmental toxicity. The results from these screening efforts demonstrate that chemicals representing a range of putative vascular disrupting compound (pVDC) scores can also produce effects on neurogenic outcomes and characterizes possible modes of action for disrupting the developing NVU.

SDS of cas: 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Zurlinden, TJ; Saili, KS; Baker, NC; Toimela, T; Heinonen, T; Knudsen, TB or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Ring Opening and Recyclization Reactions with Chromone-3-carbonitrile published in 2019.0. Recommanded Product: 61-82-5, Reprint Addresses Ibrahim, MA (corresponding author), Ain Shams Univ, Fac Educ, Dept Chem, Cairo 11711, Egypt.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Chemical transformations of chromone-3-carbonitrile (1) with some substituted hydrazines, namely, thiosemicarbazide, S-methyl/benzyldithiocarbazate, 7-chloro-4-hydrazinoquinoline, and 3-hydrazino-5,6-diphenyl-1,2,4-triazine, led to substituted pyrazoles 2, 5-8. Ring opening of carbonitrile 1 followed by recyclization with 3-amino-1,2,4-triazole and 2-aminobenzimidazole gave triazolo[1,5-a]pyrimidine 9 and pyrimido[1,2-a]benzimidazole 10, respectively. Treatment of carbonitrile 1 with some heterocyclic amines produced 2-amino-3-substituted-chromones 11 and 12. The novel 3-hydroxychromeno[4,3-b]pyrazolo[4,3-e]pyridin-5(1H)-one (13) was efficiently synthesized from the ring conversion of carbonitrile 1 with cyanoacetohydrazide. A mixture of chromeno[2,3-b]naphthyridine 14 and chromeno[4,3-b]pyridine 15 was obtained from base catalyzed transformation of carbonitrile 1 with malononitrile dimer. A diversity of novel annulated chromeno[2,3-b]pyridines 16-22 was also synthesized. Chromeno[2,3-b]pyrrole-2-carboxylate 23 was obtained from the reaction of carbonitrile 1 with ethyl chloroacetate. Structures of the new synthesized products were deduced on the basis of their analytical and spectral data.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Ibrahim, MA; El-Kazak, AM or concate me.. Recommanded Product: 61-82-5

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article A Tetratricopeptide Repeat Protein Regulates Carotenoid Biosynthesis and Chromoplast Development in Monkeyflowers (Mimulus) WOS:000545741500024 published article about BOX TRANSCRIPTION FACTOR; TOMATO FRUITFULL HOMOLOGS; PHYTOENE SYNTHASE; MITOCHONDRIAL MORPHOLOGY; NEGATIVE REGULATOR; PETUNIA ENCODES; PLASTID NUMBER; GENES CPPDS2/4; PIGMENTATION; MUTANT in [Stanley, Lauren E.; Ding, Baoqing; Mou, Fengjuan; Hill, Connor; Yuan, Yao-Wu] Univ Connecticut, Dept Ecol & Evolutionary Biol, Storrs, CT 06269 USA; [Sun, Wei; Chen, Shilin] China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China; [Mou, Fengjuan] Southwest Forestry Univ, Fac Forestry, Kunming 650224, Yunnan, Peoples R China; [Yuan, Yao-Wu] Univ Connecticut, Inst Syst Genom, Storrs, CT 06269 USA in 2020.0, Cited 101.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. COA of Formula: C2H4N4

Little is known about the factors regulating carotenoid biosynthesis in flowers. Here, we characterized the REDUCED CAROTENOID PIGMENTATION2 (RCP2) locus from two monkeyflower (Mimulus) species, the bumblebee-pollinated species Mimulus lewisii and the hummingbird-pollinated species Mimulus verbenaceus. We show that loss-of-function mutations of RCP2 cause drastic down-regulation of the entire carotenoid biosynthetic pathway. The causal gene underlying RCP2 encodes a tetratricopeptide repeat protein that is closely related to the Arabidopsis (Arabidopsis thaliana) REDUCED CHLOROPLAST COVERAGE proteins. RCP2 appears to regulate carotenoid biosynthesis independently of RCP1, a previously identified R2R3-MYB master regulator of carotenoid biosynthesis. We show that RCP2 is necessary and sufficient for chromoplast development and carotenoid accumulation in floral tissues. Simultaneous down-regulation of RCP2 and two closely related paralogs, RCP2-L1 and RCP2-L2, yielded plants with pale leaves deficient in chlorophyll and carotenoids and with reduced chloroplast compartment size. Finally, we demonstrate that M. verbenaceus is just as amenable to chemical mutagenesis and in planta transformation as the more extensively studied M. lewisii, making these two species an excellent platform for comparative developmental genetics studies of closely related species with dramatic phenotypic divergence.

COA of Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Stanley, LE; Ding, BQ; Sun, W; Mou, FJ; Hill, C; Chen, SL; Yuan, YW or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Synthesis and Characterization of Novel Azole Functionalized Poly(glycidyl methacrylate)s for Antibacterial and Anticandidal Activity WOS:000504668300004 published article about ANTIMICROBIAL ACTIVITY; QUATERNARY AMMONIUM; CHITOSAN; AMINE; MODE in [Rehman, Suriya; Alsalem, Zainab H.] Imam Abdulrahman Bin Faisal Univ, IRMC, Epidem Dis Res Dept, POB 1982, Dammam 31441, Saudi Arabia; [Gunday, Seyda T.; Bozkurt, Ayhan] Imam Abdulrahman Bin Faisal Univ, IRMC, Dept Biophys, POB 1982, Dammam 31441, Saudi Arabia in 2019.0, Cited 35.0. Recommanded Product: 61-82-5. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Background: Presently, rise in the infectious diseases and subsequent development of drug resistance, is a global threat to human health. However, much efforts are being made by scientists, to develop novel antimicrobials, and also to improve the efficacy of available drugs, in order to combat the life-threatening infections. Objective: Synthesis and characterization of azole functional polymer systems for antimicrobial applications. Materials and Methods: Poly(glycidyl methacrylate) (PGMA), was produced by free radical polymerization of the monomer, glycidyl methacrylate (GMA). Different azole functional PGMAs were produced, through chemical modification with imidazole (Im), 1H-1,2,4-triazole (Tri) and 3-amino-1,2,4-triazole (ATri), to get PGMA-Imi, PGMA-Tri and PGMA-ATri, respectively. The structure was confirmed by Fourier transform infrared spectroscopy (FT-IR), thermal properties were investigated by Thermogravimetric Analysis (TGA), and surface morphology was studied by scanning electron microscopy (SEM). Newly synthesized derivatives were further explored, for their antibacterial and anticandidal activities. Results: All the three synthesized and characterized derivatives, displayed a significant activity against the tested microorganisms. The minimum inhibitory concentration (MIC) and minimum bactericidal/fungicidal concentration (MBC/MFC), recorded against Staphylococcus aureus (S. aureus), was 0.5 &1mg/ml for PGMA-Imi, followed by PGMA-ATri & PGMA-Tri, respectively, followed by E. coli with, 1 & 2 mg/ml, 4 & 8 mg/ml, 4& 8 mg/ml, respectively, whereas the maximum MIC & MFC was recorded against C. albicans i.e., 8 & 16 mg/ml, 4 & 8 mg/ml ,4 & 8 mg/ml for PGMA-ATri, PGMA-Tri, PGMA-Imi, respectively. Conclusion: In the present work, we report on the state-of-the-art, azole functional polymer systems for antimicrobial applications. These findings suggest that the synthesized azole functional polymer films have antimicrobial properties, which could be potential candidates for coating applications in the biomedical and wastewater treatment field.

Recommanded Product: 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Rehman, S; Gunday, ST; Alsalem, ZH; Bozkurt, A or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Efficient Route for the Synthesis of Diverse Heteroannelated 5-Cyanopyridines published in 2021.0. Product Details of 61-82-5, Reprint Addresses Volochnyuk, DM; Ryabukhin, SV (corresponding author), Enamine Ltd, 78 Chervonotkatska Str, Kiev, Ukraine.; Volochnyuk, DM; Ryabukhin, SV (corresponding author), Taras Shevchenko Natl Univ Kyiv, 60 Volodymyrska Str, Kiev, Ukraine.; Volochnyuk, DM (corresponding author), Natl Acad Sci Ukraine, Inst Organ Chem, 5 Murmanska Str, Kiev, Ukraine.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

The new efficient, convenient protocol for the synthesis of heteroannelated 3-cyanopyridines and pyrimidines starting from diverse aminoheterocycles and 3,3-dimethoxy-2-formylpropionitrile sodium salt was elaborated. The advantages and improvements of the procedure compared to previously known methods are shown. The scope and limitations of the method are determined. The impact of the structural features on regioselectivity are discussed. The preparativeness, scalability, and application scope of the elaborated protocol are demonstrated by the synthesis of five heteroannelated 3-cyanopyridines in quantities up to 100 grams.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Mityuk, AP; Hrebonkin, A; Lebed, PS; Grabchuk, GP; Volochnyuk, DM; Ryabukhin, SV or concate me.. Product Details of 61-82-5

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recommanded Product: 61-82-5. Zhang, L; Zhang, F; Liu, FB; Shen, J; Wang, JX; Jiang, M; Zhang, DS; Yang, PF; Chen, Y; Song, SY in [Zhang, Liang; Liu, Fangbing; Song, Shiyong] Chinese Acad Sci, CAS Key Lab Plant Germplasm Enhancement & Special, Wuhan Bot Garden, Wuhan 430074, Hubei, Peoples R China; [Zhang, Liang; Liu, Fangbing] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Zhang, Liang; Liu, Fangbing; Song, Shiyong] Chinese Acad Sci, Ctr Econ Bot, Core Bot Gardens, Wuhan 430074, Peoples R China; [Zhang, Fan; Shen, Jun; Wang, Jiaxuan; Jiang, Meng; Chen, Ying; Song, Shiyong] Zhejiang Univ, Inst Crop Sci, State Key Lab Rice Biol, Zhejiang Prov Key Lab Crop Genet Resources, Hangzhou 310058, Peoples R China; [Zhang, Dasheng] Chinese Acad Sci, Shanghai Chenshan Bot Garden, Shanghai Chenshan Plant Sci Res Ctr, Shanghai 201602, Peoples R China; [Yang, Pingfang] Hubei Univ, Sch Life Sci, State Key Lab Biocatalysis & Enzyme Engn, Wuhan 430062, Peoples R China published The lotus NnFTIP1 and NnFT1 regulate flowering time in Arabidopsis in 2021.0, Cited 40.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

In higher plants, floral signals are mainly collected and transduced to FLOWERING LOCUS T (FT) in Arabidopsis and its orthologues. The movement of FT from leaves to the shoot apical meristem (SAM) is partially mediated by FT-INTERACTING PROTEIN1 (FTIP1). Although the functions of OsFTIP1 in rice and DOFTIP1 in orchid in FT transport have also been investigated, the FTIP1 homologue in lotus (Nelumbo nucifera Gaertn.), a type of horticultural plant with high economic and cultural value, has not been isolated, and the mechanism of NnFT1 transport has not been explored. Here, we revealed that NnFTIP1 mediates the transport of NnFT1 in ectopic transgenic lines in Arabidopsis. Overexpression of NnFTIP1 in the ftip1-1 background rescued the late flowering phenotype of ftip1-1, indicating that NnFTIP1 has a conserved function as FTIP1. NnFTIP1 and NnFT1 share similar tissue expression patterns and subcellular localization. NnFTIP1 and NnFT1 interact both in vitro and in vivo. In addition, NnFTIP1 affects NnFT1 transport from leaves to the SAM. Furthermore, we found that NnUOF8, a MYB-like transcription factor, directly regulates the expression of NnFTIP1. Our results suggest that the functions of FTIP1 and FT are conserved during evolution in flowering plants.

Recommanded Product: 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Zhang, L; Zhang, F; Liu, FB; Shen, J; Wang, JX; Jiang, M; Zhang, DS; Yang, PF; Chen, Y; Song, SY or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article Synthesis of C-beta-D-glucopyranosyl derivatives of some fused azoles for the inhibition of glycogen phosphorylase WOS:000455623300004 published article about GLUCOSE ANALOG INHIBITORS; BINDING; NUCLEOSIDES; IMIDAZOLES; REVEAL; MUSCLE in [Szennyes, Eszter; Bokor, Eva; Somsak, Laszlo] Univ Debrecen, Dept Organ Chem, POB 400, H-4002 Debrecen, Hungary; [Docsa, Tibor; Sipos, Adam] Univ Debrecen, Fac Med, Dept Med Chem, Egyet Ter 1, H-4032 Debrecen, Hungary in 2019.0, Cited 37.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. SDS of cas: 61-82-5

Annulated C-beta-D-glucopyranosyl heterocycles were synthesized and tested as inhibitors of glycogen phosphorylase. 2-(beta-D-Glucopyranosyl)-1H-imidazo[4,5-b] pyridine was formed by ring-closure of O-perbenzoylated C-beta-D-glucopyranosyl formic acid with 2,3-diaminopyridine in the presence of triphenylphosphite. Cyclisations of bromomethyl 2,3,4,6-tetra-O-benzoyl-beta-D-glucopyranosyl ketone with a set of 2-aminoheterocycles resulted in constitutionally reversed C-beta-D-glucopyranosyl imidazoles fused by pyridine, pyrimidine, thiazole, 1,3,4-thiadiazole, benzothiazole and benzimidazole. O-Debenzoylation of the above compounds was effected by standard transesterification to get the test compounds. The 1H-imidazo[4,5-b] pyridine proved to be a low micromolar inhibitor (K-i = 21.1 mu M) of rabbit muscle glycogen phosphorylase b, while the other heterocycles displayed weak or no inhibition against the same enzyme.

SDS of cas: 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Szennyes, E; Bokor, E; Docsa, T; Sipos, A; Somsak, L or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

An article beta-N-methylamino-L-alanine Inhibits Human Catalase Activity: Possible Implications for Neurodegenerative Disease Development WOS:000463920200006 published article about AMYOTROPHIC-LATERAL-SCLEROSIS; 2-AMINO-3-(METHYLAMINO)-PROPANOIC ACID BMAA; INDUCED OXIDATIVE STRESS; CYANOBACTERIAL NEUROTOXIN; AMINO-ACIDS; UNLIKELY CAUSE; BRAIN; RELEASE; ALS; EXPOSURE in [van Onselen, Rianita; Downing, Tim G.] Nelson Mandela Univ, Dept Biochem & Microbiol, POB 77000, ZA-6031 Port Elizabeth, South Africa in 2019.0, Cited 62.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Recommanded Product: 61-82-5

The naturally produced, nonprotein amino acid beta-N-methylamino-l-alanine (BMAA) has been proposed as a significant contributor to sporadic neurodegenerative disease development worldwide. However, the existing hypothesized mechanisms of toxicity do not adequately explain the role of BMAA in neurodegenerative disease development. There is evidence for BMAA-induced enzyme inhibition, but the effect of BMAA on human stress response enzymes has received little attention, despite the well-described role of oxidative stress in neurodegenerative disease development. The aim of this study was therefore to investigate the effect of BMAA on human catalase activity and compare it to the known inhibitor 3-amino-1,2,4-triazole. BMAA inhibited human erythrocyte catalase in a cell-free exposure to the same extent as the known inhibitor. Based on enzyme kinetics, the inhibition appears to be noncompetitive, possibly as a result of BMAA binding in the nicotinamide adenine dinucleotide phosphate (NADPH) binding site. BMAA-induced catalase inhibition was also observed in a human cell line culture. We therefore propose that BMAA-induced enzyme inhibition, specifically catalase inhibition, is a mechanism of toxicity that may contribute to the neurotoxicity of BMAA, further supporting the role of BMAA in neurodegenerative disease development.

Recommanded Product: 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact van Onselen, R; Downing, TG or concate me.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

SDS of cas: 61-82-5. In 2019.0 BRAIN RES BULL published article about NICOTINIC ACETYLCHOLINE-RECEPTORS; ENDOGENOUS HYDROGEN-PEROXIDE; CENTRAL ANGIOTENSIN-II; NITRIC-OXIDE; SMOOTH-MUSCLE; RAT-BRAIN; RELEASE; INHIBITION; VASOPRESSIN; EXPRESSION in [Lauar, Mariana R.; Colombari, Debora S. A.; Colombari, Eduardo; De Paula, Patricia M.; De Luca Jr, Laurival A.; Menani, Jose, V] Sao Paulo State Univ UNESP, Dent Sch, Dept Physiol & Pathol, Araraquara, SP, Brazil in 2019.0, Cited 66.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Intracerebroventricular (icv) injection of hydrogen peroxide (H2O2), a reactive oxygen species, or the blockade of catalase (enzyme that degrades H2O2 into H2O and O-2) with icv injection of 3-amino-1,2,4-triazole (ATZ) reduces the pressor effects of angiotensin II also injected icv. In the present study, we investigated the effects of ATZ injected icv or intravenously (iv) on the pressor responses induced by icv injections of the cholinergic agonist carbachol, which similar to angiotensin II induces pressor responses that depend on sympathoexcitation and vasopressin release. In addition, the effects of H2O2 icv on the pressor responses to icv carbachol were also tested to compare with the effects of ATZ. Normotensive non-anesthetized male Holtzman rats (280-300 g, n = 8-9/group) with stainless steel cannulas implanted in the lateral ventricle were used. Previous injection of ATZ (5 nmol/1 mu l) or H2O2 (5 mu mol/1 mu l) icv similarly reduced the pressor responses induced by carbachol (4 nmol/1 mu l) injected icv (13 +/- 4 and 12 +/- 4 mmHg, respectively, vs. vehicle + carbachol: 30 +/- 5 mmHg). ATZ (3.6 mmol/kg of body weight) injected iv also reduced icv carbachol-induced pressor responses (21 +/- 2 mmHg). ATZ icv or iv and H2O2 icv injected alone produced no effect on baseline arterial pressure. The treatments also produced no significant change of heart rate. The results show that ATZ icv or iv reduced the pressor responses to icv carbachol, suggesting that endogenous H2O2 acting centrally inhibits the pressor mechanisms (sympathoactivation and/or vasopressin release) activated by central cholinergic stimulation.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Lauar, MR; Colombari, DSA; Colombari, E; De Paula, PM; De Luca, LA; Menani, JV or concate me.. SDS of cas: 61-82-5

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recently I am researching about ATP CONTENT; HISTONE CROTONYLATION; OXIDATIVE STRESS; GENE-EXPRESSION; IN-VITRO; IDENTIFICATION; DYSFUNCTION; TEMPERATURE; METABOLISM; FERTILITY, Saw an article supported by the National Nature Science Foundation Project of ChinaNational Natural Science Foundation of China (NSFC) [31101714, 81901562, 31372307]. Formula: C2H4N4. Published in SPRINGER HEIDELBERG in HEIDELBERG ,Authors: Luo, YX; Zhuan, QR; Li, J; Du, XZ; Huang, ZY; Hou, YP; Fu, XW. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Type 1 diabetes (T1D) results in decreased oocyte quality and compromised early embryonic development. Procyanidin B2 (PB2) is a natural compound extracted from grape seeds and has strong antioxidant activity in vivo. This study evaluated the effect of PB2 on oocyte maturation in diabetic mice. Diabetic mice were induced by streptozotocin (STZ) injection. PB2 was supplemented in the in vitro maturation medium, and the ratio of germinal vesicle breakdown (GVBD) and polar body extrusion (PBE), reactive oxygen species (ROS) levels, mitochondrial function, developmental ability, as well as crotonylation at H4K5 were determined in oocytes. PB2 can promote the extrusion of PBE (88.34% vs. 75.02%,P < 0.05); reduce the generation of ROS (1.12 vs. 1.96,P < 0.05); and improve the level of mitochondrial membrane potential (0.87 vs. 0.79 Delta phi m,P < 0.05), ATP level (1.31 vs. 0.71 pmol,P < 0.05), and mitochondria temperature (618.25 vs. 697.39 pixels,P < 0.05). The addition of PB2 also improved the level of oocyte crotonylation at H4K5 (crH4K5) (47.26 vs. 59.68 pixels,P < 0.05) and increased the blastocyst rate (61.51% vs. 36.07%,P < 0.05) after parthenogenetic activation. Our results are the first to reveal a role for PB2 in promoting the viability of oocytes by regulating the mitochondrial function. Moreover, we uncover that PB2 can improve the level of crH4K5, which provides a new strategy to combat the decline in oocyte quality of diabetic. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Luo, YX; Zhuan, QR; Li, J; Du, XZ; Huang, ZY; Hou, YP; Fu, XW or concate me.. Formula: C2H4N4

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics