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Machine Learning in Chemistry about C2H4N4

Quality Control of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Sakhno, YI; Murlykina, M; Zbruyev, OI; Kozyryev, AV; Shishkina, S; Sysoiev, D; Musatov, VI; Desenko, SM; Chebanov, VA or concate me.

Quality Control of 1H-1,2,4-Triazol-5-amine. Recently I am researching about HETEROCYCLIZATION REACTIONS; CYCLOCONDENSATION REACTIONS; MULTICOMPONENT REACTION; BIGINELLI REACTION; PYRUVIC ACIDS; AMINOAZOLES; 3-AMINO-1,2,4-TRIAZOLE; TETRAHYDROPYRIMIDINES; 5-AMINOPYRAZOLES; ALDEHYDES, Saw an article supported by the National Academy of Sciences of Ukraine [0119U100727, 0119U100716, 0118U100275]. Published in BEILSTEIN-INSTITUT in FRANKFURT AM MAIN ,Authors: Sakhno, YI; Murlykina, M; Zbruyev, OI; Kozyryev, AV; Shishkina, S; Sysoiev, D; Musatov, VI; Desenko, SM; Chebanov, VA. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

Four-component reactions of 3-amino-1,2,4-triazole or 5-amino-1H-pyrazole-4-carbonitrile with aromatic aldehydes and pyruvic acid or its esters under ultrasonication were studied. Unusual for such a reaction type, a cascade of elementary stages led to the formation of 7-azolylaminotetrahydroazolo[1,5-a]pyrimidines.

Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

What advice would you give a new faculty member or graduate student interested in a career 61-82-5

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Xu, GL; Hou, JZ; Zhao, YN; Bao, J; Yang, M; Fa, HB; Yang, YX; Li, L; Huo, DQ; Hou, CJ or concate me.. Name: 1H-1,2,4-Triazol-5-amine

I found the field of Chemistry; Electrochemistry; Instruments & Instrumentation very interesting. Saw the article Dual-signal aptamer sensor based on polydopamine-gold nanoparticles and exonuclease I for ultrasensitive malathion detection published in 2019.0. Name: 1H-1,2,4-Triazol-5-amine, Reprint Addresses Huo, DQ; Hou, CJ (corresponding author), Chongqing Univ, Key Lab Biorheol Sci & Technol, State & Local Joint Engn Lab Vasc Implants, Minist Educ,Bioengn Coll, Chongqing 400044, Peoples R China.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine

A highly sensitive dual-signal aptamer sensor based on polydopamine-gold nanoparticles (PDA-AuNPs) and exonuclease I (Exo I) was developed for detection of malathion. Compared with traditional sensing elements, aptamer has many advantages, such as high affinity, superior specificity, strong stability and easy modification. The electrodeposition synthesis of PDA-AuNPs gave excellent biocompatibility and electrical conductivity on the sensor. With the addition of malathion, the specific interaction between malathion and its aptamer forced the aptamer to detach from the electrode surface and induced the capture probe to form a hairpin structure on the electrode surface. Exo I was added to motivate the autocatalytic target cycling which remarkably increased the current change of electrochemical signal over 2 times. Therefore, the promising strategy gave rise to an optional dual-signal current readout in both the signal-on of Fc and the signal-off of Tn. In this work, the prepared biosensor exhibited high sensitivity to malathion via the combination of dual-signal design and autocatalytic target cycling amplification. Under the optimized conditions, the proposed sensor showed a wide linear range from 0.5 to 600 ng/L malathion. It also exhibited excellent specificity, acceptable repeatability and good stability. The application of real samples obtained satisfactory recovery results, demonstrating a promising potential in food safety analysis.

What advice would you give a new faculty member or graduate student interested in a career C2H4N4

Application In Synthesis of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Pasyukov, DV; Chernenko, AY; Shepelenko, KE; Kutyrev, VV; Khrustalev, VN; Chernyshev, VM or concate me.

Application In Synthesis of 1H-1,2,4-Triazol-5-amine. Authors Pasyukov, DV; Chernenko, AY; Shepelenko, KE; Kutyrev, VV; Khrustalev, VN; Chernyshev, VM in ELSEVIER published article about in [Pasyukov, Dmitry, V; Chernenko, Andrey Yu; Shepelenko, Konstantin E.; Kutyrev, Vadim V.; Chernyshev, Victor M.] Platov South Russian State Polytech Univ NPI, Novocherkassk 346428, Russia; [Khrustalev, Victor N.] Peoples Friendship Univ Russia, RUDN Univ, Moscow 117198, Russia; [Khrustalev, Victor N.] Russian Acad Sci, ND Zelinsky Inst Organ Chem, Moscow 119991, Russia in 2021.0, Cited 41.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Palladium complexes with N-heterocyclic carbene ligands of a new type containing free NH2 group were obtained by direct palladation of 3-amino-1,4-dialkyl-1,2,4-triazolium salts. These amino-functionalized complexes were found to be a versatile platform for postmodification via reactions of the NH2 group with acyl and sulfonyl chlorides.

Awesome Chemistry Experiments For 1H-1,2,4-Triazol-5-amine

Computed Properties of C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Sayed, GH; Azab, ME; Anwer, KE or concate me.

Computed Properties of C2H4N4. In 2019.0 J HETEROCYCLIC CHEM published article about FACILE SYNTHESIS; DERIVATIVES; EFFICIENT in [Sayed, Galal H.; Azab, Mohammad E.; Anwer, Kuris E.] Ain Shams Univ, Organ Chem Lab, Chem Dept, Fac Sci, Cairo 11566, Egypt in 2019.0, Cited 30.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Under both conventional and microwave methods, 2-amino-4H-pyran-3-carbonitrile derivative 1 was synthesized and reacted with different reagents. Thus, 2-amino-4H-pyran-3-carbonitrile derivative was treated with chloroacetyl chloride, phenyl isocyanate, cyanoacetic acid, benzoyl chloride, triethyl orthoformate, acetic anhydride/H2SO4, arylidene malononitrile, urea, and/or p-aminosulphaguanidine producing chloroacetamide, 3-phenylurea, cyanoacetamide, N-benzoylpyran, ethylformimidate, pyranopyrimidin-4-one, pyranopyridine, pyranopyrimidin-2-one, and pyranopyrimidin-2-imine derivatives, respectively. Meanwhile, compound 1 was reacted with ethyl bromoacetate, phenacyl bromide, phthalic anhydride, different aromatic amines, and/or acetic acid/H2SO4 to produce 5-aminopyrano[2,3-b]pyrrole-6-carboxylate, dihydropyrano[2,3-b]pyrrole-6-yl-(phenyl)methanone, 1,3-dioxoisoindolinyl pyran, 1,4-dihydropyridine, and 2-hydroxy-1,4-dihydropyridine derivatives, respectively. On the other hand, when compound 1 was allowed to react with maleic anhydride and/or hydrazine hydrate, pyran-4-oxobut-2-enoic acid and 3-aminopyranopyrazole derivatives were obtained, respectively. Reaction of pyran-4-oxobut-2-enoic acid with malononitrile under different conditions gave 2-(furan-2-yl)-4H-pyran and 2-(4H-pyran-2-yl)-1H-pyrrole derivatives, while condensation of 3-aminopyranopyrazole with benzaldehyde gave 1,4-dihydropyrano[2,3-c]pyrazol-3-yl-1-phenylmethanimine derivative. The newly synthesized compounds were characterized by the spectroscopic tools IR, H-1-NMR, C-13-NMR, MS, and elemental analysis. Some of these compounds have been screened in vitro for antimicrobial activity against different strains of bacteria and fungi and also were tested against two cancer cell lines: mammary gland breast cancer (MCF-7) and colon cancer (HCT-118).

Computed Properties of C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Sayed, GH; Azab, ME; Anwer, KE or concate me.

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About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Goncharova, OA; Kuznetsov, DS; Andreev, NN; Kuznetsov, YI; Andreeva, NP or concate me.. Name: 1H-1,2,4-Triazol-5-amine

An article Chamber Inhibitors of Corrosion of AMg6 Aluminum Alloy WOS:000603324200010 published article about VOLATILE; STEEL in [Goncharova, O. A.; Kuznetsov, D. S.; Andreev, N. N.; Kuznetsov, Yu, I; Andreeva, N. P.] Russian Acad Sci, Frumkin Inst Phys Chem & Electrochem, Moscow 119071, Russia in 2020.0, Cited 17.0. Name: 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Using a set of physicochemical (ellipsometry and contact angle measurements), electrochemical (potentiometric anode polarization and electrochemical impedance spectroscopy), and corrosion (periodic moisture condensation test) methods, the properties of adsorption films formed on the AMg6 aluminum alloy surface by the chamber method in vapors of some amines of heterocyclic compounds, carboxylic acids, and their salts are studied. It is established that the use of the studied compounds in the chamber processing of the alloy increases-though not effectively enough-its corrosion resistance in a humid atmosphere. The most promising inhibitors are carboxylic acids themselves; the optimum temperature for surface treatment with them is 140 degrees C. One-hour treatment of steel with pairs of oleic, neodecanoic acid, and carboxylic acid A at this temperature gives rise to the formation of nanoscale adsorption films on the AMg6 alloy, which slightly hydrophilize the surface, but possess a protective aftereffect. Apparently, further improvement of chamber protection methods of the AMg6 alloy should consist in the selection of synergists for chamber corrosion inhibitors of the carboxylate type.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Goncharova, OA; Kuznetsov, DS; Andreev, NN; Kuznetsov, YI; Andreeva, NP or concate me.. Name: 1H-1,2,4-Triazol-5-amine

How did you first get involved in researching 1H-1,2,4-Triazol-5-amine

Recommanded Product: 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Halawa, AH; Eskandrani, AA; Elgammal, WE; Hassan, SM; Hassan, AH; Ebrahim, HY; Mehany, ABM; El-Agrody, AM; Okasha, RM or concate me.

An article Rational Design and Synthesis of Diverse Pyrimidine Molecules Bearing Sulfonamide Moiety as Novel ERK Inhibitors WOS:000502786800074 published article about CARBONIC-ANHYDRASE INHIBITORS; BIOLOGICAL EVALUATION; ANTIPROLIFERATIVE ACTIVITY; ANTIMICROBIAL ACTIVITIES; DERIVATIVES; PYRAZOLE; ANTICANCER; DOCKING; COMPLEXES; RELEASE in [Halawa, Ahmed H.; Elgammal, Walid E.; Hassan, Saber M.; Hassan, Ahmed H.; El-Agrody, Ahmed M.] Al Azhar Univ, Fac Sci, Chem Dept, Cairo 11284, Egypt; [Eskandrani, Areej A.; Okasha, Rawda M.] Taibah Univ, Fac Sci, Chem Dept, Medina 30002, Saudi Arabia; [Hassan, Ahmed H.] Jazan Univ, Fac Sci, Chem Dept, Jazan 45142, Saudi Arabia; [Ebrahim, Hassan Y.] Helwan Univ, Fac Pharm, Pharmacognosy Dept, Cairo 11795, Egypt; [Mehany, Ahmed B. M.] Al Azhar Univ, Fac Sci, Zool Dept, Cairo 11284, Egypt in 2019.0, Cited 65.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Recommanded Product: 1H-1,2,4-Triazol-5-amine

Protein kinases orchestrate diverse cellular functions; however, their dysregulation is linked to metabolic dysfunctions, associated with many diseases, including cancer. Mitogen-Activated Protein (MAP) kinase is a notoriously oncogenic signaling pathway in human malignancies, where the extracellular signal-regulated kinases (ERK1/2) are focal serine/threonine kinases in the MAP kinase module with numerous cytosolic and nuclear mitogenic effector proteins. Subsequently, hampering the ERK kinase activity by small molecule inhibitors is a robust strategy to control the malignancies with aberrant MAP kinase signaling cascades. Consequently, new heterocyclic compounds, containing a sulfonamide moiety, were rationally designed, aided by the molecular docking of the starting reactant 1-(4-((4-methylpiperidin-1-yl)sulfonyl)phenyl)ethan-1-one (3) at the ATP binding pocket of the ERK kinase domain, which was relying on the molecular extension tactic. The identities of the synthesized compounds (4-33) were proven by their spectral data and elemental analysis. The target compounds exhibited pronounced anti-proliferative activities against the MCF-7, HepG-2, and HCT-116 cancerous cell lines with potencies reaching a 2.96 mu M for the most active compound (22). Moreover, compounds 5, 9, 10b, 22, and 28 displayed a significant G2/M phase arrest and induction of the apoptosis, which was confirmed by the cell cycle analysis and the flow cytometry. Thus, the molecular extension of a small fragment bounded at the ERK kinase domain is a valid tactic for the rational synthesis of the ERK inhibitors to control various human malignancies.

Simple exploration of C2H4N4

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Sakasai-Sakai, A; Takata, T; Takeuchi, M or concate me.. Safety of 1H-1,2,4-Triazol-5-amine

An article Intracellular Toxic Advanced Glycation End-Products Promote the Production of Reactive Oxygen Species in HepG2 Cells WOS:000557529400001 published article about FATTY LIVER-DISEASE; STRESS-RELATED PARAMETERS; OXIDATIVE STRESS; PROTEIN EXPRESSION; SERUM-LEVELS; AGES; ASSOCIATION; PREDICTOR; FRUCTOSE; RAGE in [Sakasai-Sakai, Akiko; Takata, Takanobu; Takeuchi, Masayoshi] Kanazawa Med Univ, Med Res Inst, Dept Adv Med, 1-1 Daigaku, Kahoku, Ishikawa 9200293, Japan in 2020.0, Cited 46.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Safety of 1H-1,2,4-Triazol-5-amine

Hepatocyte cell death is a key process in the pathogenesis of nonalcoholic steatohepatitis (NASH). However, the factors responsible for and mechanisms underlying NASH-related cell death have not yet been elucidated in detail. We herein investigated the effects of intracellular glyceraldehyde (GA)-derived advanced glycation end-products (AGEs), named toxic AGEs (TAGE), on the production of reactive oxygen species (ROS), which have been implicated in the pathogenesis of NASH. Cell death related to intracellular TAGE accumulation was eliminated in the hepatocyte carcinoma cell line HepG2 by the antioxidant effects of N-acetyl-L-cysteine. The intracellular accumulation of TAGE increased ROS production and the expression of Nrf2, including its downstream gene. These results suggest that ROS are produced in association with the accumulation of TAGE and are a direct trigger for cell death. We also investigated the factors responsible for these increases in ROS. Catalase activity did not decrease with the accumulation of TAGE, while mitochondrial membrane depolarization was enhanced in cells treated with GA. These results indicate that TAGE play an important role in mitochondrial abnormalities and increases in ROS production, both of which are characteristic features of NASH. The suppression of TAGE accumulation has potential as a new therapeutic target in the progression of NASH.

About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Sakasai-Sakai, A; Takata, T; Takeuchi, M or concate me.. Safety of 1H-1,2,4-Triazol-5-amine

What kind of challenge would you like to see in a future of compound:C2H4N4

Computed Properties of C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Holzel, T; Ganter, C or concate me.

An article Influence of ring substituents on the electronic properties of 1,2,4-triazolylidenes WOS:000525896700004 published article about N-HETEROCYCLIC CARBENE; STABLE CARBENES; COMPLEXES; LIGANDS; CATALYSTS; VERSATILE; ACCESS in [Hoelzel, Torsten; Ganter, Christian] Heinrich Heine Univ Dusseldorf, Inst Anorgan Chem & Strukturchem, Univ Str 1, D-40225 Dusseldorf, Germany in 2020.0, Cited 76.0. Computed Properties of C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

Methylation of 3-amino-1,2,4-triazole and 1-methyl-3-nitro-1,2,4-triazole provides access to three NHC-precursors. For the nitro compound only a monomethylation to the triazolium salt 3(OTf) is observed. The aminotriazole could be subsequently converted to mono- and dicationic carbene precursors 1I and 2(OTf)(2), respectively. The nitro group on NHC 3 leads to a decrease of donor strength and a slightly enhanced acceptor character as compared to a related NHC lacking the nitro group. The cationic NHC 2 is the poorest donor within the series and shows a TEP value of 2072 cm(-1). The properties of this species are dominated by its cationic nature while the influence of the NMe2 group is surprisingly small. X-ray diffraction studies suggest a guanidinium-like character for the NMe2 substituted compounds. (C) 2020 Elsevier B.V. All rights reserved.

Computed Properties of C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Holzel, T; Ganter, C or concate me.

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COA of Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Liu, HJ; Dong, LB; Wang, M; Huang, GF or concate me.

Liu, HJ; Dong, LB; Wang, M; Huang, GF in [Liu, Haijian; Dong, Libin; Wang, Miao; Huang, Guofu] Weifang Univ Sci & Technol, Shandong Peninsula Engn Res Ctr Comprehens Brine, Shouguang 262700, Weifang, Peoples R China; [Liu, Haijian; Huang, Guofu] Weifang Univ Sci & Technol, Weifang Key Lab Pollut Control & Resource Utiliza, Shouguang 262700, Weifang, Peoples R China published A new method for cartap detection with high sensitivity and selectivity based on the inner filter effect between GSH-Cu NCs and Au NPs in 2021.0, Cited 30.0. COA of Formula: C2H4N4. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.

Herein, a novel and sensitive fluorescence method for cartap determination is established on the basis of the inner filter effect (IFE) of gold nanoparticles (Au NPs) on the fluorescence of glutathione protected Cu NCs (GSH-Cu NCs). In the presence of Au NPs, the fluorescence of GSH-Cu NCs was strongly quenched by the IFE because the absorption spectra of Au NPs overlap well with the emission spectra of GSH-Cu NCs. Upon addition of cartap, cartap could induce the aggregation of Au NPs whose absorption spectrum does not overlap with the emission spectrum of GSH-Cu NCs. Then, with the increase in cartap concentration, the IFE-decreased fluorescence was gradually recovered, realizing the fluorescence sensing of cartap. Under optimal conditions, the proposed method has a good linear relationship with cartap concentration in the range of 7-100 nM, and the detection limit is 3.34 nM. In addition, satisfactory results were obtained for cartap analysis using tap water and cabbage as real samples, which demonstrated that the method as-developed would have great practical application prospects.

COA of Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Liu, HJ; Dong, LB; Wang, M; Huang, GF or concate me.

More research is needed about C2H4N4

Recommanded Product: 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Mohlala, RL; Coyanis, EM; Fernandes, MA; Bode, ML or concate me.

Authors Mohlala, RL; Coyanis, EM; Fernandes, MA; Bode, ML in PERGAMON-ELSEVIER SCIENCE LTD published article about MULTICOMPONENT REACTIONS; HETEROCYCLIC-SYSTEMS; CONSTRUCTION; UGI; ADDITIONS; ANALOGS; AMINES in [Mohlala, Reagan L.; Coyanis, E. Mabel] MINTEK, Adv Mat Div, Private Bag X3015, ZA-2125 Randburg, South Africa; [Mohlala, Reagan L.; Fernandes, Manuel A.; Bode, Moira L.] Univ Witwatersrand, Sch Chem, Mol Sci Inst, PO Wits, ZA-2050 Johannesburg, South Africa in 2020.0, Cited 60.0. Recommanded Product: 61-82-5. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5

A one-pot reaction of the zwitterion formed from an isocyanide and an acetylenedicarboxylate with different five-membered rings containing both an acidic proton and a suitable nucleophile resulted in the preparation of novel 5-membered ring fused pyrimidine derivatives in yields ranging from 18 to 87%. (C) 2020 Elsevier Ltd. All rights reserved.

Recommanded Product: 61-82-5. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Mohlala, RL; Coyanis, EM; Fernandes, MA; Bode, ML or concate me.